Article
Engineering, Biomedical
Fangjun Liu, Dun Wang, Miao Zhang, Liwei Ma, Cui-Yun Yu, Hua Wei
Summary: The synthesis of PF-based theranostic amphiphilic copolymers with high drug loading efficiency and tumor microenvironment-specific responsiveness for enhanced cancer therapy has been rarely reported. In this study, enzyme-responsive theranostic amphiphilic bottlebrush copolymers were successfully prepared, showing high drug loading efficiency and tumor microenvironment-specific responsiveness. The study developed a universal strategy for the construction of multifunctional polymeric vehicles based on PF and degradable polypeptide, and emphasized the better stability of micelles endowed by the branched hydrophilic brushes.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Shani Ben-Zichri, May Meltzer, Shiran Lacham-Hartman, Sofiya Kolusheva, Uzi Hadad, Niv Papo, Raz Jelinek
Summary: Noncationic, amphiphilic dendrimer nanoparticles embedding curcumin and resveratrol effectively target and slowly release the anticancer polyphenols, exhibiting promising potential as an anticancer therapeutic platform.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Cong Hua, Yi Zhang, Yuanhao Liu
Summary: The research explores the potential of polymer micelles as carriers for chemotherapeutic agents, demonstrating their effectiveness in suppressing tumor growth and reducing systemic toxicity. By manipulating the chemical and physical properties of amphiphilic Y-shaped polypeptides, the self-assembly performance of micelles and the controlled release of drugs can be significantly regulated.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiaolong Zeng, Yufei Wang, Yun-Shuai Huang, Jianxiong Han, Wen Sun, Hans-Juergen Butt, Xing-Jie Liang, Si Wu
Summary: This study reports a new strategy to enhance cellular internalization and tumor penetration of PEGylated anticancer drugs using red-light irradiation.
Article
Pharmacology & Pharmacy
Jialin Chen, Wujun Wang, Yue Wang, Xiushuang Yuan, Chengzhi He, Pengfei Pei, Shengdi Su, Weihong Zhao, Shi-Zhong Luo, Long Chen
Summary: Water insolubility is a significant challenge for many small molecule drugs in clinical applications. Two branched amphiphilic peptides (BAPs) were designed using computer-aided methods for drug-loading through peptide self-assembly. The BAPs could self-assemble into nano-fibrils or bilayer delimited nano-vesicles, and showed high drug-loading efficiency and entrapment efficiency. The carriers could prolong drug release and exhibit pH-triggered release. Moreover, they demonstrated increased cytotoxicity against cancer cells, possibly due to their targeting ability towards cancer overexpressed integrins. The designed BAP carriers represent a promising approach for targeted drug delivery and can improve the clinical use of small molecule drugs with poor water solubility.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Elena Giusto, Ludmila Zarska, Darren Fergal Beirne, Arianna Rossi, Giada Bassi, Andrea Ruffini, Monica Montesi, Diego Montagner, Vaclav Ranc, Silvia Panseri
Summary: This study developed a graphene oxide-based nanocarrier to overcome the limitations of platinum-based chemotherapeutics. The results demonstrated that this nanoplatform has good anti-tumor effects in various cancer cells and potential for inhibiting cell migration.
Article
Chemistry, Applied
Kaikai Xu, Hai Yao, Di Fan, Lin Zhou, Shaohua Wei
Summary: DMSO acts as a solvent for anticancer drugs and participates in disulfide bond crosslinking to form a hydrogel for drug loading, enabling sustained drug release and tumor growth suppression.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Ravi Trivedi, Brinti Mondal, Nandini Garg, Brahmananda Chakraborty
Summary: This study explores the potential of biphenylene as a nanocarrier for the delivery of the anticancer drug cisplatin. It is found that biphenylene offers physical stability, rapid release rate, solubility, and bio-compatibilities compared to other nanocarriers. The adsorption of cisplatin on the surface of biphenylene involves charge transfer from cisplatin to biphenylene. The drug is shown to be released at body temperature in an acidic environment. Biphenylene also exhibits excellent cytotoxicity activity and cellular uptake of the drug. Overall, biphenylene shows promise as a potential nanocarrier for cisplatin delivery.
APPLIED SURFACE SCIENCE
(2024)
Review
Medicine, Research & Experimental
Rahul Bhattacharjee, Tanima Dey, Lamha Kumar, Sulagna Kar, Ritayan Sarkar, Mimosa Ghorai, Sumira Malik, Niraj Kumar Jha, Balachandar Vellingiri, Kavindra Kumar Kesari, Jose M. Perez de la Lastra, Abhijit Dey
Summary: This review discusses the causes, mechanisms, and potential therapeutic strategies for cisplatin resistance in cervical cancer. Strategies such as the use of nanocarriers, miRNA, CRISPR/Cas system, and combination therapy with chemotherapeutics show promise in overcoming drug resistance and improving the efficacy of cisplatin. Furthermore, the review examines the signaling network of cisplatin-resistant cells in cervical cancer and the impact of tumor microenvironment on drug resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Applied
Jose P. Ceron-Carrasco, Natalia Sanchez, Denis Jacquemin
Summary: In this study, curcuminoid analogues were combined with cisplatin to design a series of prodrugs that can be photo-activated by visible light. The simulations revealed two novel complexes absorbing in the first phototherapeutic window (600-800 nm). The optimization of these structures for photoactivated chemotherapy is discussed.
Article
Cell Biology
Hardik Mody, Tanaya R. Vaidya, Lawrence J. Lesko, Sihem Ait-Oudhia
Summary: The study aimed to quantitatively characterize the anticancer effects of cisplatin and cimetidine and determine their nature of interactions in two cancer cell lines. The results showed that in the OCT2-negative Huh7 cell line, cisplatin and cimetidine exhibited modest synergistic or additive effects, while in the OCT2-positive MDA-MB-468 cell line, they had antagonistic effects. These findings were consistent with the cell-level pharmacodynamic modeling analysis.
Article
Biochemistry & Molecular Biology
Selvaraj Sengottiyan, Alicja Mikolajczyk, Tomasz Puzyn
Summary: The lack of knowledge about the uptake of NPs by biological cells is a significant problem for drug delivery. In order to address this problem, molecular modeling studies have been conducted to describe the mechanism of cellular uptake of drug-loaded nanoparticles. In this study, three different models were developed to predict the cellular uptake mechanism of drug-loaded nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Zoltan Kollo, Miklos Garami, Istvan Vincze, Barna Vasarhelyi, Gellert Balazs Karvaly
Summary: Orally administered, small-molecule anticancer drugs with tumor-specific cellular protein targets (OACD) have revolutionized oncological pharmacotherapy. The therapeutic drug monitoring (TDM) of OACDs in therapeutically relevant peripheral fluid compartments is essential for successful treatment. This study summarizes the available knowledge on exposure to OACD concentrations in various peripheral fluid spaces and highlights the importance of TDM for efficient and safe treatments.
Review
Biochemistry & Molecular Biology
Mara Di Filippo, Marcus Baumann
Summary: Continuous flow chemistry has become an established and valued synthesis technology used in academic and industrial laboratories to improve the preparation of various molecular structures. Recent research focuses on using continuous flow protocols to synthesize anticancer drugs, with the aim of showcasing the impact of this technology on the generation of important pharmaceuticals.
Article
Biophysics
Lizhen Wang, Xiaolan Liu, Changqing Zhang, Xiqiang Chen, Wenlong Sheng, Peihai Li, Dawei Qin, Fang Wang
Summary: This paper developed a novel amphiphilic carrier, Lau-Leu-HES, for loading camptothecin to overcome its limitations. The carrier was successfully applied to prepare camptothecin-loaded nanoparticles, which exhibited high drug loading efficiency and encapsulation efficiency. The nanoparticles could be rapidly released and showed good inhibition effect on hepatocellular carcinoma cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
