Article
Microbiology
Li Dong, Jianran Qin, Luyang Tai, Kangyi Mou, Xiaojun Liao, Fang Chen, Xiaosong Hu
Summary: The curcumin-mediated photodynamic technology (Cur-PDT) was found to effectively inactivate Bacillus subtilis by inducing cell redox state imbalance, damaging DNA, and disrupting membrane structures.
Article
Geriatrics & Gerontology
Jinru Zhang, Kai Li, Xiaobo Wang, Amber M. Smith, Bo Ning, Zhaohui Liu, Chunfeng Liu, Christopher A. Ross, Wanli W. Smith
Summary: Mutations in the LRRK2 gene are common genetic factors contributing to Parkinson's disease, especially the G2385R-LRRK2 mutation in the Chinese population. This study demonstrates that G2385R-LRRK2 induces neurotoxicity through mitochondrial ROS increase and enzyme activation. Additionally, the antioxidant curcumin shows potential in protecting against G2385R-LRRK2-induced neurodegeneration and environmental stressors can exacerbate the neurotoxic effects of both wild-type and mutant LRRK2.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Chenyang Duan, Hanbin Wang, Dian Jiao, Yanqin Geng, Qiaoli Wu, Hua Yan, Chunhui Li
Summary: Curcumin can inhibit oxidative stress and promote neurological recovery after ICH by activating the Nrf2/HO-1 pathway, providing a potential therapeutic target for clinical treatment of ICH.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Wang, Thilina U. Jayawardena, Jimin Hyun, Kaiqiang Wang, Xiaoting Fu, Jiachao Xu, Xin Gao, Youngjin Park, You-Jin Jeon
Summary: Fucoidans isolated from brown seaweeds, such as Turbinaria ornata, have been found to have antioxidant and photoprotective effects. In this study, the fucoidan TO-F10 was shown to protect Vero cells and zebrafish from oxidative stress and photodamage induced by AAPH and UVB irradiation, respectively. These findings suggest that TO-F10 has potential as an ingredient in the cosmetic industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Celia Andres Juan, Jose Manuel Perez de la Lastra, Francisco J. Plou, Eduardo Perez-Lebena
Summary: Living species are constantly exposed to oxidants, leading to oxidative stress and disease. The induction of oxidative stress is caused by an imbalance between radical species and antioxidant defense systems, which can damage cellular biomolecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Victor Pavlovich Chelomin, Valentina Vladimirovna Slobodskova, Sergey Petrovich Kukla, Andrey Alexandrovich Mazur, Nadezda Vladimirovna Dovzhenko, Avianna Fayazovna Zhukovskaya, Alexander Alexandrovich Karpenko, Maxim Alexandrovich Karpenko, Vyacheslav Sergeevich Odintsov
Summary: Marine and ocean water pollution from plastic waste poses a serious threat to future generations, but data on the toxicity of plastic particles are currently incomplete due to their chemical diversity. Organisms have different risks from plastic particles depending on their habitat and feeding habits. We conducted experiments on feeding gastropod scraping mollusk Littorina brevicula with polymethylmethacrylate (PMMA) and polytetrafluoroethylene (PTFE) particles. Results showed that PMMA exposure caused oxidative stress and DNA damage in digestive gland cells, while no similar changes were observed in mollusks fed with PTFE-containing food.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Sritama Baag, Sayantan Mahapatra, Sumit Mandal
Summary: This study investigated the effects of chlorpyrifos on Bellamya bengalensis, finding that long-term exposure significantly altered growth conditions, while both acute and long-term exposure enhanced antioxidant and detoxification enzyme activity. DNA damage increased significantly under long-term exposure, but also escalated under acute severe warming.
Review
Biochemistry & Molecular Biology
Sahdeo Prasad, Dan DuBourdieu, Ajay Srivastava, Prafulla Kumar, Rajiv Lall
Summary: Curcumin, an active compound in turmeric, has various pharmacological properties, but its effectiveness is limited by its nature. Metal-curcumin complexes have been developed to enhance solubility and absorption, showing positive effects against chronic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Iteb Boughattas, Nesrine Zitouni, Marouane Mkhinini, Omayma Missawi, Sondes Helaoui, Sabrine Hattab, Moncef Mokni, Noureddine Bousserrhine, Mohamed Banni
Summary: This study investigated the effects of biochar on earthworms in soil remediation. The results showed that in the presence of biochar, the bioavailability of Cd and 2,4-D increased in earthworms, along with an increase in micronuclei frequency and a decrease in lysosomal membrane stability. Histopathological examination revealed numerous alterations in animals exposed to contaminants without any amelioration when biochar was added. The biochemical response of earthworms demonstrated that in the presence of biochar, animals tended to alleviate the toxicity of Cd and 2,4-D.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Polymer Science
Lei Wang, Xiaoting Fu, Jimin Hyun, Jiachao Xu, Xin Gao, You-Jin Jeon
Summary: In this study, the anti-inflammatory and antioxidant activities of agaro-oligosaccharides (AO) from Gracilaria lemaneiformis were investigated. AO showed significant scavenging abilities for various radicals and protected cells against oxidative damage. In vivo experiments demonstrated that AO reduced intracellular reactive oxygen species levels and lipid peroxidation in zebrafish, suggesting its potential applications in cosmetics and functional foods.
Review
Medicine, Research & Experimental
Chi Zhang, Hao Li, Jie Li, Jiajin Hu, Keda Yang, Lin Tao
Summary: Osteoporosis is a major concern and high-risk populations need regular bone mineral density testing and appropriate preventive treatment. Oxidative stress, including the direct effect of reactive oxygen species and the reduction of antioxidant enzyme activity, plays a significant role in the development of osteoporosis. Understanding the impact of oxidative stress on osteoporosis can greatly optimize therapeutic schedules.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Materials Science, Biomaterials
Qingyan Zhang, Ying Huang, Ruoxi Yang, Junmei Mu, Zhanwei Zhou, Minjie Sun
Summary: This study developed a poly-antioxidant to deliver anti-miR-155 for synergistic treatment of metastatic breast cancer by scavenging reactive oxygen species and inhibiting miR-155. The novel nanoplatform effectively blocked the NF-kappa B pathway, demonstrating strong anti-metastatic ability both in vitro and in vivo.
BIOMATERIALS SCIENCE
(2022)
Review
Medicine, Research & Experimental
Hajar Heidari, Mehrnaz Shojaei, Gholamreza Askari, Muhammed Majeed, Mohammad Bagherniya, George E. Barreto, Amirhossein Sahebkar
Summary: Migraine is a neurovascular condition that affects about 15% of the global population. The exact pathophysiology and etiology of migraine are still unclear, but oxidative stress, inflammation, and neuroendocrine imbalances are identified as critical risk factors. Curcumin, extracted from turmeric, shows promise in preventing and controlling migraine due to its anti-inflammatory, antioxidative, antiprotein aggregate, and analgesic effects. More studies are needed to fully understand the efficacy of curcumin on clinical symptoms of migraine and its potential mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Sanni Kumar, Juhi Saxena, Vijay Kumar Srivastava, Sanket Kaushik, Himadri Singh, Khaled Abo-El-Sooud, Mohamed M. Abdel-Daim, Anupam Jyoti, Rohit Saluja
Summary: The antioxidant defense system plays a crucial role in reducing oxidative stress by limiting the amount of reactive oxygen species in sepsis. Despite a strong relationship between scavengers of ROS and antioxidants, the comprehensive understanding of ROS scavenging in cellular antioxidant signaling remains lacking in sepsis research.
Article
Engineering, Marine
Nadezda Vladimirovna Dovzhenko, Victor Pavlovich Chelomin, Andrey Alexandrovich Mazur, Sergey Petrovich Kukla, Valentina Vladimirovna Slobodskova, Aleksandra Anatolievna Istomina, Avianna Fayazovna Zhukovskaya
Summary: The ingress of nanoparticles of metal oxides and microfragments of synthetic polymers into a marine environment causes unpredictable consequences. However, the effects of these particles are difficult to predict due to a lack of ecotoxicological information. In a laboratory experiment on Mytilus trossulus, it was found that both CuO-NPs and mu PSs induced oxidative stress and had varying degrees of impact on the mollusks.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Chongshan Dai, Hui Li, Yang Wang, Shusheng Tang, Tony Velkov, Jianzhong Shen
Summary: Baicalein protects against CCl4-induced acute liver injury by enhancing antioxidant defense pathways, reducing oxidative stress, apoptosis, inflammation, and ferroptosis through the activation of the Nrf2 pathway and inhibition of the ALOX12 and NF-kappa B pathways.
Article
Microbiology
Chao Ma, Yuhan Li, Yanan Zong, Tony Velkov, Chenxi Wang, Xinyu Yang, Ming Zhang, Zhimin Jiang, Haoran Sun, Qi Tong, Honglei Sun, Juan Pu, Munir Iqbal, Jinhua Liu, Chongshan Dai, Yipeng Sun
Summary: The influenza A virus (IAV) can activate p21 through a p53-independent pathway. p21 directly binds to the viral polymerase acidic protein, limiting IAV polymerase activity by disrupting the formation of the ribonucleoprotein complex. p21 activation promotes IRF3 activation by blocking the degradation of HO-1, leading to the activation of the type I interferon pathway.
Article
Food Science & Technology
Chongshan Dai, Meng Li, Tun Sun, Yuan Zhang, Yang Wang, Zhangqi Shen, Tony Velkov, Shusheng Tang, Jianzhong Shen
Summary: Colistin therapy can induce oxidative stress, mitochondrial dysfunction, and apoptosis by activating the TGF-beta/NOX4/mtROS pathway while inhibiting the Akt/mTOR pathway in lung tissues.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chongshan Dai, Jiahao Lin, Hui Li, Zhangqi Shen, Yang Wang, Tony Velkov, Jianzhong Shen
Summary: Curcumin, an important component of turmeric, is considered a safe oral treatment for bacterial infections and has exhibited antibacterial activities against both Gram-negative and Gram-positive bacteria. Its antibacterial actions include disrupting bacterial membranes, inhibiting the production of bacterial virulence factors and biofilm formation, as well as inducing oxidative stress. Additionally, curcumin acts as a broad-spectrum antibacterial adjuvant, showing marked additive or synergistic effects with conventional antibiotics or non-antibiotic compounds.
Article
Biochemistry & Molecular Biology
Yuan Zhang, Tun Sun, Meng Li, Yanling Lin, Yue Liu, Shusheng Tang, Chongshan Dai
Summary: Ivermectin can induce apoptotic cell death in human neuroblastoma cells, promoting ROS production, mitochondrial dysfunction, and autophagy, while inhibiting the Akt/mTOR pathway. Autophagy inhibition improved Ivermectin-induced oxidative stress and apoptotic cell death in these cells.
Article
Biochemistry & Molecular Biology
Chongshan Dai, Qinzhi Zhang, Linjie Shen, Gaurav Sharma, Haiyang Jiang, Zhanhui Wang, Jianzhong Shen
Summary: This study reveals that quercetin can protect human cells from damage caused by quinocetone (QCT) through activating the p38/Nrf2/HO-1 pathway and inhibiting the ROS/mitochondrial apoptotic pathway.
Article
Microbiology
Tun Sun, Qinzhi Zhang, Meng Li, Shusheng Tang, Chongshan Dai
Summary: In this study, the cytotoxicity of T-2 toxin and its underlying molecular mechanisms were investigated using the mouse microglia BV2 cell line. The results suggest that T-2 toxin induces cytotoxicity in BV2 cells through the production of reactive oxygen species, activation of the mitochondrial apoptotic pathway, and inhibition of the Nrf2/HO-1 pathway.
Article
Food Science & Technology
Chongshan Dai, Subhajit Das Gupta, Zhanhui Wang, Haiyang Jiang, Tony Velkov, Jianzhong Shen
Summary: In this review, the authors summarized the current knowledge and challenges related to T-2 toxin-induced cardiotoxicity, and discussed potential treatment approaches. The cardiotoxicity caused by T-2 toxin involves various cellular pathways and mechanisms, including oxidative stress, mitochondrial dysfunction, and inflammatory responses. Antioxidant supplementation, induction of autophagy, and blockade of inflammatory signaling may provide protective effects against T-2 toxin-induced cardiac toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chongshan Dai, Erjie Tian, Zhihui Hao, Shusheng Tang, Zhanhui Wang, Gaurav Sharma, Haiyang Jiang, Jianzhong Shen
Summary: Aflatoxins (AFTs) are a significant class of mycotoxins that can cause various harmful outcomes, with aflatoxin B1 (AFB1) being the most harmful to humans and animals. The mechanisms of AFB1-induced toxicity are linked to various cellular signaling pathways, including p53, PI3K/Akt/mTOR, Nrf2/ARE, NF-kappa B, NLRP3, MAPKs, and Wnt/beta-catenin. Curcumin, a natural product with multiple therapeutic activities, may counteract AFB1-induced harmful effects by targeting these pathways.
Article
Biochemistry & Molecular Biology
Yanling Lin, Qinzhi Zhang, Baofu Xie, Haiyang Jiang, Jianzhong Shen, Shusheng Tang, Chongshan Dai
Summary: In this study, the cytotoxicity of Chelerythrine (CHE) was investigated using human HepG2 cells. The results showed that CHE treatment induced dose-dependent cytotoxicity and oxidative stress in HepG2 cells. Moreover, CHE treatment activated the mitochondrial apoptotic pathway and inhibited the Akt pathway, leading to cell apoptosis. N-acetylcysteine supplementation attenuated CHE-induced cytotoxicity. These findings provide new insights into the toxic mechanisms and health risks of CHE.
Article
Environmental Sciences
Chongshan Dai, Meng Li, Yue Liu, Diem Hong Tran, Haiyang Jiang, Shusheng Tang, Jianzhong Shen
Summary: This study investigated the protective effects of curcumin on copper sulfate-induced renal damage in a mouse model. Results showed that curcumin supplementation significantly reduced Cu accumulation, improved renal dysfunction, and alleviated oxidative stress and tubular necrosis. Moreover, curcumin supplementation inhibited p53 and NF-kappa B pathways and activated Nrf2/HO-1 pathway to ameliorate Cu overload-induced nephrotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Bo Liu, Yue Yang, Haiyan Wu, Sihan Wang, Jijing Tian, Chongshan Dai, Tianlong Liu
Summary: The self-preservation and intelligent survival abilities of methicillin-resistant Staphylococcus aureus (MRSA) make it difficult to treat with antibiotics. Nano-drug delivery systems, such as ZIF-8 nanoparticles (ZIF-8 NPs), have emerged as a new strategy to overcome MRSA infection. This study reveals that ZIF-8 NPs inhibit arginine biosynthesis, produce ROS, disrupt energy metabolism, and damage cell membranes, leading to the killing of MRSA isolates. Additionally, ZIF-8 NPs show promising effects in treating MRSA-infected wounds in a mouse model.
Article
Biochemistry & Molecular Biology
Chongshan Dai, Mingchao Liu, Qinzhi Zhang, Subhajit Das Gupta, Shusheng Tang, Jianzhong Shen
Summary: Nootkatone (NKT), a major ingredient of Alpinia oxyphylla, has potential nephroprotective effects by inhibiting NOX4 and NF-kappa B pathways and activating Nrf2/HO-1 pathway. This study showed that NKT pretreatment significantly attenuated CCl4-induced kidney injury, oxidative stress, and inflammatory response in mice. NKT also downregulated the expression of pro-inflammatory proteins and upregulated the expression of antioxidant enzymes in kidney tissues. These findings suggest the therapeutic application of NKT for kidney diseases.
Article
Biochemistry & Molecular Biology
Chongshan Dai, Xueyong Zhang, Jiahao Lin, Jianzhong Shen
Summary: The purpose of this study was to investigate the protective effects of nootkatone (NOOT) on carbon tetrachloride (CCl4)-caused acute liver injury in mice. The results showed that NOOT supplementation significantly ameliorated CCl4-induced liver injury by reducing serum AST and ALT levels, hepatocyte necrosis, inflammatory response, oxidative stress, and caspases-9 and -3 activities. Moreover, NOOT supplementation regulated Nrf2/HO-1 and NF-kappa B pathways to provide protective effects against oxidative stress and inflammatory response.
Review
Biochemistry & Molecular Biology
Erjie Tian, Gaurav Sharma, Chongshan Dai
Summary: This review provides insights into the neuroprotective properties of berberine, elucidates its underlying molecular mechanisms, and assesses its clinical safety and efficacy. Berberine exerts neuroprotective effects through multiple pathways and engages various signaling pathways.
