期刊
SMALL
卷 4, 期 11, 页码 1986-1992出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200701279
关键词
aggregation; fluorescence; fullerenes; nanoparticles
类别
资金
- NSF [CBET-0736037]
- Academy of Finland
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0744040] Funding Source: National Science Foundation
Carbon-based nanomaterials possess unique structural mechanical and electronic properties that are exploited innumerous applications. The fate of nanomaterials in living systems and in the environment is largely unknown, though there is a reason for concern. Here it is shown how the interaction of fullerene with natural phenolic acid induces cell contraction. This phenomenon has a general applicability to carbon-based nanomaterials interacting with natural amphiphiles. Atomistic simulations reveal that the self-assembly of C-70-gallic acid (GA) favors aggregation. Confocal fluorescence microscopy shows that C-70-GA complexes translocate across the membranes of HT-29 cells and enter nuclear membranes. Confocal imaging further reveals the real-time uptake of C-70-GA and the consequent contraction of the cell membranes. This contraction is attributed to the aggregation of nanoparticles into microsized particles promoted by cell surfaces, a new physical mechanism for deciphering nanotoxicity.
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