Article
Pediatrics
Eduardo Machado Rossi-Monteiro, Laura Rodrigues Sefair, Marcos Correia Lima, Maria Fernanda Lima Nascimento, Daniel Mendes-Pinto, Lukas Anschuetz, Maria Gloria Rodrigues-Machado
Summary: This study aimed to compare cardiovascular parameters between healthy children and those with obstructive sleep-disordered breathing (oSDB), as well as identify predictors of arterial stiffness indices in children with oSDB. Children with oSDB showed higher reflection coefficient and augmentation index compared to controls, indicating increased arterial stiffness. Multiple regression analysis revealed age, female sex, reflection coefficient, and systolic volume as independent predictors of augmentation index, while higher pulse wave velocity was associated with poorer quality of life.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Clinical Neurology
Sarah Maessen, Elizabeth Schaughency, Patrick Dawes, Barbara Galland
Summary: This study aimed to explore the feasibility and treatment sensitivity of measures of preschool oral language and emergent literacy and numeracy in assessing developing skills of preschool children with sleep disordered breathing (SDB) in New Zealand. The results showed that the tasks were sensitive to treatment effects in oral language and emergent literacy, but not in early numeracy. Prior to surgery, case children exhibited more symptoms of SDB and behavioral and emotional difficulties compared to matched controls, with improvements observed in these areas post-surgery.
Article
Otorhinolaryngology
Tiffany T. Pham, Shanlee M. Davis, Suhong Tong, Khaled A. Campa, Norman R. Friedman, Sarah A. Gitomer
Summary: A retrospective cross-sectional study found a high prevalence of obstructive sleep-disordered breathing (oSDB) in young patients with Turner syndrome (TS), with a four-fold increased risk compared to the general pediatric population. Risk factors for oSDB in TS included adenoid, tonsillar, and inferior turbinate hypertrophy, birthweight, failure to thrive, and older age at the last clinic visit. Screening for oSDB and performing polysomnography in TS patients with associated risk factors and symptoms is crucial due to the potential exacerbation of behavioral problems, neurocognitive deficits, and growth impairment associated with oSDB.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Clinical Neurology
Janna R. Raphelson, Kimberly Y. Kreitinger, Atul Malhotra
Summary: Obstructive sleep apnea (OSA) is a common condition with significant neurocognitive and cardiovascular effects. Positive airway pressure (PAP) therapy can help prevent airway collapse and improve oxygen levels, carbon dioxide levels, and sleep quality. While adherence to PAP therapy was once seen as a barrier, in reality, adherence rates are likely higher than commonly believed, with various strategies available to help improve patient adherence.
Article
Critical Care Medicine
Ankit Parekh, Thomas M. Tolbert, Anne M. Mooney, Jaime Ramos-Cejudo, Ricardo S. Osorio, Marcel Treml, Simon-Dominik Herkenrath, Winfried J. Randerath, Indu Ayappa, David M. Rapoport
Summary: This study derives an automated breath-by-breath probability of obstruction using hallmarks of upper airway obstruction visible on clinical sleep studies, to assist in determining the type of sleep apnea in individuals. Results show that the breath-by-breath probability of obstruction can reliably predict the overall burden of obstructed breaths in individual subjects.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Phoebe K. Yu, Jerilynn Radcliffe, H. Gerry Taylor, Raouf S. Amin, Cristina M. Baldassari, Thomas Boswick, Ronald D. Chervin, Lisa M. Elden, Susan L. Furth, Susan L. Garetz, Alisha George, Stacey L. Ishman, Erin M. Kirkham, Christopher Liu, Ron B. Mitchell, S. Kamal Naqvi, Carol L. Rosen, Kristie R. Ross, Jay Shah, Ignacio E. Tapia, Lisa R. Young, David A. Zopf, Rui Wang, Susan Redline
Summary: The relationship between the severity of obstructive sleep apnea and neurobehavioral morbidity is unclear. This study compares the neurobehavioral symptoms of mild sleep-disordered breathing and obstructive sleep apnea, finding that children with mild sleep-disordered breathing have more abnormal executive function scores and higher rates of inattention and hyperactivity compared to children with obstructive sleep apnea.
Article
Clinical Neurology
Shu-Juan Liu, Zhen-Zhen Liu, Ze-Ying Wang, Bao-Peng Liu, Shuo Cheng, Xianchen Liu, Cun-Xian Jia
Summary: The study found that symptoms of sleep disordered breathing (SDB) are an independent and significant predictor of depressive symptoms in adolescents. 4.5% of adolescents had persistent depressive symptoms, and the incidence rate of depressive symptoms at 1-year follow-up was 6.5%. Elevated frequency of any SDB symptoms was significantly associated with incident depressive symptoms after adjusting for potential confounders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Pediatrics
Eszter Csabi, Veronika Gaal, Emese Hallgato, Rebeka Anna Schulcz, Gabor Katona, Palma Benedek
Summary: This study aimed to assess the behavioral consequences of sleep disturbances in children with sleep-disordered breathing. The results showed that children with sleep-disordered breathing exhibited higher levels of inattentiveness, hyperactive behavior, and internalizing and externalizing problems. The study suggests that even mild sleep-disordered breathing, such as snoring and mild obstructive sleep apnea, may increase the risk of behavioral and emotional dysfunctions in children.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Article
Psychology, Multidisciplinary
Rebecca Harding, Elizabeth Schaughency, Jillian J. Haszard, Amelia Gill, Rebekah Luo, Carmen Lobb, Patrick Dawes, Barbara Galland
Summary: The study found that early sleep disordered breathing is associated with poorer academic performance, particularly in oral language. Improving sleep disordered breathing can lead to better oral reading fluency, but difficulties in specific tasks involving oral language may persist.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Dien Tran-Minh, Anh Phi-Thi-Quynh, Phuc Nguyen-Dinh, Sy Duong-Quy
Summary: The prevalence of obstructive sleep apnea (OSA) is high in children with adenotonsillar hypertrophy, and it is related to the blockage of the upper airway. Adenotonsillectomy is the main treatment for OSA in these children, but it is an invasive method with varying success rates. Therefore, the indications for tonsillectomy remain debatable, and non-invasive treatment is still a potential choice.
FRONTIERS IN NEUROLOGY
(2022)
Article
Critical Care Medicine
Sunil Sharma, Robert Stansbury
Summary: Sleep disorders, particularly sleep apnea, have become a significant health issue in the United States. Screening and identifying SDB in hospitalized patients can have a positive impact on the disease outcomes and treatment of patients.
Article
Pediatrics
Faustine D. Ramirez, Judith A. Groner, Joel L. Ramirez, Cindy T. McEvoy, Judith A. Owens, Charles E. McCulloch, Michael D. Cabana, Katrina Abuabara
Summary: The study showed that both prenatal and childhood tobacco smoke exposure were independently associated with mild sleep-disordered breathing (SDB) symptoms throughout early childhood in a dose-dependent manner. There was a dose-response effect between exposure levels and SDB symptoms, with individuals exposed during both prenatal and childhood periods at higher risk for apnea and snoring.
ACADEMIC PEDIATRICS
(2021)
Review
Critical Care Medicine
Salam Zeineddine, James A. Rowley, Susmita Chowdhuri
Summary: Sleep-disordered breathing (SDB) has significant cardiovascular and neurological effects, with supplemental oxygen therapy showing mixed results in improving oxygen saturation and apnea severity compared to positive airway pressure therapy. Further research is needed to clarify the optimal dose and duration of nocturnal supplemental oxygen (NSO) and its combination with PAP in improving cardiovascular, sleep, and cognitive outcomes in SDB patients.
Article
Medicine, General & Internal
Hao Cui, Hartzell Schaff, Virend K. Somers, Rick A. Nishimura, Joseph A. Dearani, Jeffrey B. Geske, Katherine S. King, Steve R. Ommen
Summary: In patients with hypertrophic cardiomyopathy, more than half were found to have sleep-disordered breathing, which was mainly associated with aging, overweight, and male sex. However, sleep-disordered breathing did not impact survival following septal myectomy.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Clinical Neurology
Ville Rimpila, Laura Lampio, Nea Kalleinen, Tero Vahlberg, Arho Virkki, Tarja Saaresranta, Olli Polo
Summary: The study aimed to investigate the impact of sleep-disordered breathing and menopause on the increase in blood pressure during menopausal transition. Additionally, the study sought to identify new markers related to sleep-disordered breathing that could predict the development of hypertension. The findings indicated that changes in the apnea-hypopnea index and serum follicle stimulating hormone did not significantly affect blood pressure change. However, an increase in morning blood pressure was associated with higher body mass index, while an increase in evening blood pressure was linked to an increase in inspiratory flow-limitation during non-rapid eye movement sleep. Incident hypertension during the follow-up was associated with hypopnea during rapid eye movement sleep at baseline. The use of menopausal hormone therapy was found to have a minimal effect on blood pressure.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Surgery
Monique A. Slaats, Jozef De Dooy, Kim Van Hoorenbeeck, Paul E. Y. Van Schil, Stijn L. Verhulst, Jeroen M. H. Hendriks
Summary: This study found that the intrapleural treatment of dornase alfa and tissue plasminogen activator was safe in ten children with empyema. There were no serious adverse events, bleeding, or mortality, and no additional interventions were needed. This treatment may improve the management of pediatric empyema if confirmed in further studies.
ACTA CHIRURGICA BELGICA
(2021)
Article
Respiratory System
Michel Toussaint, Michelle Chatwin, Stijn Verhulst, Gregory Reychler
CLINICAL RESPIRATORY JOURNAL
(2020)
Article
Pediatrics
Mariska De Lausnay, Stijn Verhulst, Lieve Boel, Marek Wojciechowski, An Boudewyns, Kim Van Hoorenbeeck
PEDIATRIC PULMONOLOGY
(2020)
Article
Pediatrics
Glenn Leemans, Dennis Belmans, Cedric Van Holsbeke, Brian Becker, Dirk Vissers, Kris Ides, Stijn Verhulst, Kim Van Hoorenbeeck
PEDIATRIC PULMONOLOGY
(2020)
Article
Pediatrics
Tessi Beyltjens, Sophie R. de Leede, Ine van Eekelen, Fleur F. W. van Ginneken, Evelyn Wyckmans, Sophie Installe, Kim Van Hoorenbeeck, Stijn Verhulst
PEDIATRIC PULMONOLOGY
(2020)
Review
Genetics & Heredity
Amber van Baelen, Louise Verhoustraeten, Sandra Kenis, Marije Meuwissen, An Boudewyns, Kim van Hoorenbeeck, Stijn Verhulst
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2020)
Article
Nutrition & Dietetics
Eline Vermeiren, Marijke Ysebaert, Kim Van Hoorenbeeck, Luc Bruyndonckx, Kristof Van Dessel, Maria Van Helvoirt, Ann De Guchtenaere, Benedicte De Winter, Stijn Verhulst, Annelies Van Eyck
Summary: Obesity and age can affect the reliability of DEXA and BIS measurements. This study compared the two methods in evaluating body composition in obese children before and after weight loss. Results showed that while BIS is a viable alternative to DEXA for group-level obesity studies, it is not superior for monitoring individual changes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Cardiac & Cardiovascular Systems
K. Vanhaverbeke, A. Van Eyck, K. Van Hoorenbeeck, B. De Winter, A. Snoeckx, T. Mulder, S. Verhulst
RESPIRATORY MEDICINE
(2020)
Editorial Material
Clinical Neurology
Stijn Verhulst
Review
Pediatrics
Mariska De Lausnay, Kris Ides, Mark Wojciechowski, An Boudewyns, Stijn Verhulst, Kim Van Hoorenbeeck
Summary: Children with Down syndrome frequently encounter lower airway problems such as airway anomalies, dysphagia, aspiration, lower respiratory tract infections, pulmonary hypertension, and other rare conditions. These complex issues highlight the importance of a multidisciplinary approach for prompt diagnosis, proper management, and improved long-term outcomes.
PAEDIATRIC RESPIRATORY REVIEWS
(2021)
Review
Cardiac & Cardiovascular Systems
Eline Vermeiren, Luc Bruyndonckx, Benedicte De Winter, Stijn Verhulst, Annelies Van Eyck, Kim Van Hoorenbeeck
Summary: This study examined the impact of weight regain on cardiometabolic health in children with obesity, finding that some indicators either recovered or continued to improve after weight regain. However, research in this area is limited.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Sanae Makhout, An Boudewyns, Kim Van Hoorenbeeck, Stijn Verhulst, Annelies Van Eyck
Summary: This study evaluated the validity of nocturnal oximetry as a diagnostic tool for OSA in infants with laryngomalacia. The results showed that overnight pulse oximetry has high sensitivity and positive predictive value to diagnose OSA in these infants, but low specificity and negative predictive value.
Article
Medicine, General & Internal
Sanae Makhout, Eline Vermeiren, Karolien van de Maele, Luc Bruyndonckx, Benedicte Y. De Winter, Kim Van Hoorenbeeck, Stijn L. Verhulst, Annelies Van Eyck
Summary: The study found that BDNF levels were comparable in children with obesity, both with and without OSA, and showed an interaction effect of OSA and endothelial function on BDNF levels. However, after one year of weight loss therapy, there was no change in BDNF levels.
FRONTIERS IN MEDICINE
(2022)
Review
Genetics & Heredity
Evelien Van Dijck, Sigri Beckers, Sara Diels, Tammy Huybrechts, An Verrijken, Kim Van Hoorenbeeck, Stijn Verhulst, Guy Massa, Luc Van Gaal, Wim Van Hul
Summary: Recent research suggests that heterozygous PCSK1 variants may increase the risk of obesity. However, in this specific study, a rare variant was found to have no significant association with obesity. Furthermore, the role of PCSK1 variants in obesity remains inconclusive.
Meeting Abstract
Critical Care Medicine
E. Lauwers, D. Belmans, B. Mignot, K. Ides, K. Van Hoorenbeeck, C. Van Holsbeke, G. Leemans, J. De Backer, S. L. Verhulst
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
