Article
Clinical Neurology
Simon J. Schreiner, Esther Werth, Leonie Ballmer, Philipp O. Valko, Kai M. Schubert, Lukas L. Imbach, Christian R. Baumann, Angelina Maric, Heide Baumann-Vogel
Summary: This study found that excessive daytime sleepiness (EDS) in Parkinson disease (PD) is associated with nocturnal sleep disturbance, as indicated by reduced overnight slow-wave activity (SWA) decline and reduced spindle frequency activity.
Article
Otorhinolaryngology
Sang Hoo Park, Woo Yong Bae, Sangjun Kim, Young Gun Kim, Young Bin Yun, Hyung Geun Lee, Bok Joo Kim, Jung-han Kim
Summary: This study aimed to compare the improvement and non-improvement groups of excessive daytime sleepiness in patients with obstructive sleep apnea (OSA). The results showed significant differences between the groups in Social Avoidance and Distress Scale (SADS), Fear of Negative Evaluation (FNE), apnea index (AI), apnea-hypopnea index (AHI), percentage of stage 2 non-REM sleep (N2%), and frequency of 3% oxygen desaturation (ODI3).
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Clinical Neurology
David Landzberg, Kanika Bagai
Summary: A study on the relationship between mild obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) found that 36% of mild OSA patients had objective EDS. Patients with objective EDS had better sleep parameters compared to those without. Epworth Sleepiness Scale (ESS) showed weak correlation with objective EDS.
SLEEP AND BREATHING
(2022)
Article
Clinical Neurology
Yezhou Li, Jing Wang, Lirong Ji, Chaohong Cheng, Tong Su, Shuqing Wu, Fei Han, Daniel J. Cox, Erlei Wang, Rui Chen
Summary: This study aims to investigate the effects of excessive daytime sleepiness on cortical thickness in patients with obstructive sleep apnoea. It was found that the cortical thickness was significantly thinner in the sleepiness group, particularly in the left temporal, frontal, and parietal lobe, and bilateral pre- and postcentral gyri. There was a significant negative correlation between the cortical thickness and the Epworth Sleepiness Scale score.
FRONTIERS IN NEUROLOGY
(2023)
Article
Behavioral Sciences
Yuan Shen, Haicun Shi, JianGuo Zhong, PingLei Pan, ShuFang Wang, MingZhu Chen, ZhiPeng Chen, ChunFeng Liu
Summary: This study aimed to explore the factors correlated with excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD). The findings revealed that fatigue and respiratory-related microarousal index were independent risk factors for EDS in PD patients. Fragmented sleep and pathological abnormalities of the central nervous system resulting in changes in arousal are speculated to be major influencing factors of EDS in PD.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Ajay K. Verma, Ying Yu, Sergio F. Acosta-Lenis, Tyler Havel, David Escobar Sanabria, Gregory F. Molnar, Colum D. MacKinnon, Michael J. Howell, Jerrold L. Vitek, Luke A. Johnson
Summary: Excessive daytime sleepiness is a common problem for Parkinson's disease patients, and current treatment options are limited. This study investigated the possibility of using deep brain stimulation (DBS) to monitor and classify daytime sleep-wake states in nonhuman primates. The results showed that spectral features extracted from DBS lead recordings could reasonably classify sleep and wake states, suggesting the potential for developing closed-loop DBS approaches for automatic detection and disruption of sleep-related neural oscillations in Parkinson's disease.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Anatilde Trindade, Catarina Custodio, Jorge Cabral, Telma Lopes, Vera Martins, Margarida Aguiar, Ines Goncalves, Sofia Furtado
Summary: This study aimed to compare the adherence to positive airway pressure (PAP) therapy between patients with or without excessive daytime sleepiness (EDS) in different severities of obstructive sleep apnea (OSA). The results showed that there were differences in adherence between patients with different severities of OSA but without EDS. However, there was no difference in adherence between patients with or without EDS, regardless of the severity.
Article
Clinical Neurology
Valeria A. Sansone, Paola Proserpio, Luca Mauro, Andrea Lizio Biostat, Erica Frezza, Andrea Lanza, Paola Rogliani, Gabriella Pezzuto, Elisa Falcier, Carola Ferrari Aggradi, Alice Pirola, Fabrizio Rao, Elisabetta Roma, Claudia Galluzzi, Matteo Spanetta, Federica Cattaneo, Annalisa Rubino, Elio Clemente Agostoni, Federica Amico, Alice Zanolini, Francesca Izzi, Giulia Greco, Andrea Romigi, Claudio Liguori, Lino Nobili, Fabio Placidi, Roberto Massa
Summary: The study highlights the high prevalence of excessive daytime sleepiness in adult-onset myotonic dystrophy type 1 patients, with low concordance between different sleep assessments. Patients with daytime sleepiness had shorter disease duration, better sleep quality, and higher self-reported fatigue.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Clinical Neurology
Henrik Holtstrand Hjalm, Erik Thunstrom, Helena Glantz, Martin Karlsson, Yeliz Celik, Yuksel Peker
Summary: There is an independent and dose-response relationship between the severity of obstructive sleep apnea (OSA) and prevalent atrial fibrillation (AF), especially among individuals without excessive daytime sleepiness (EDS).
Article
Psychiatry
Stephanie Bioulac, Patricia Sagaspe, Eleonore Tron, Antoine Benard, Christian Berthomier, Marie Brandewinder, Pierre Philip, Jacques Taillard
Summary: This study investigated the objective excessive daytime sleepiness (EDS) in drug-free adults with ADHD and controls. The results showed that ADHD patients had significantly shorter sleep latency on the Maintenance of Wakefulness Test (MWT) compared to controls, but no significant differences in homeostatic sleep pressure buildup were observed. Limitations include a small sample size and lack of consideration of psychiatric comorbidities and circadian regulation.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Changxiu Ma, Ying Zhang, Jiuyu Liu, Gengyun Sun
Summary: The study evaluated the new parameter AHT% for assessing nocturnal hypoxaemia and excessive daytime sleepiness in patients with obstructive sleep apnoea, comparing it with the traditional AHI. Results showed that AHT% was superior to AHI in predicting excessive daytime sleepiness and better reflected the clinical characteristics of patients with obstructive sleep apnoea.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Charley Ximing Jin, Kate Sutherland, Thorarinn Gislason, Elin Helga Thorarinsdottir, Lia Bittencourt, Sergio Tufik, Bhajan Singh, Nigel McArdle, Peter Cistulli, Yu Sun Bin
Summary: Social jetlag is associated with daytime sleepiness in patients with obstructive sleep apnea (OSA). The study found that social jetlag of over 2 hours was significantly associated with higher levels of daytime sleepiness. Improving sleep timing could be a simple therapeutic target for reducing the impact of OSA.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Medicine, General & Internal
Michael A. Grandner, Jae S. Min, Ragy Saad, Eileen B. Leary, Lev Eldemir, Danielle Hyman
Summary: Approximately 1 billion people worldwide have obstructive sleep apnea (OSA) and experience excessive daytime sleepiness (EDS), which has negative impacts on their health, behavioral choices, and lifestyle. This study reveals that people with OSA and EDS have higher rates of anxiety, depression, insomnia, and impairments in daytime functioning. EDS also prevents physical activity and influences dietary choices.
POSTGRADUATE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Jiahe Wang, Xiang Li, Siyuan Yang, Tianyi Wang, Zhongmou Xu, Jianguo Xu, Heng Gao, Gang Chen
Summary: Pitolisant demonstrated efficacy and controllable safety in treating excessive daytime sleepiness in patients with narcolepsy and OSA, showing reductions in ESS score, increased sleep latency, and improved quality of life. However, treatment with pitolisant may lead to insomnia as a treatment-emergent adverse event, emphasizing the importance of monitoring and management.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Muhammed Tunc, Pinar Soysal, Ozge Pasin, Lee Smith, Masoud Rahmati, Veliye Yigitalp, Sevnaz Sahin, Moustapha Drame
Summary: The aim of this study was to investigate the relationship between serum magnesium levels and insomnia and excessive daytime sleepiness (EDS) in older adults. It found that hypomagnesemia was associated with a higher prevalence of EDS but not insomnia in older outpatients. Other health conditions such as hypertension and diabetes mellitus were also more common in the hypomagnesemia group. These findings suggest that hypomagnesemia should be considered when evaluating older adults with EDS.
Article
Oncology
Mingyang Song, I-Min Lee, JoAnn E. Manson, Julie E. Buring, Rimma Dushkes, David Gordon, Joseph Walter, Kana Wu, Andrew T. Chan, Shuji Ogino, Charles S. Fuchs, Jeffrey A. Meyerhardt, Edward L. Giovannucci, JoAnn E. Manson, Julie E. Buring, Nancy R. Cook, I-Min Lee, William Christen, Shari S. Bassuk, Samia Mora, Heike Gibson, David Gordon, Trisha Copeland, Denise D'Agostino, Georgina Friedenberg, Claire Ridge, Vadim Bubes, Edward L. Giovannucci, Walter C. Willett, John Baron, Michael Holick, Bruce Hollis, Christine M. Albert, Diane Gold, Meryl LeBoff, Olivia Okereke, Aruna Pradhan, Howard Sesso, Wendy Chen, Paulette Chandler, J. Michael Gaziano, Olga Demler, Kathryn Rexrode, Karen Costenbader, John Forman, Erik Alexander, Sonia Friedman, Jeffrey Katz, Shumin Zhang, Jennifer Lin, Joseph Walter, Julie Duszlak, Kate Kalan, Jean MacFadyen, Natalya Gomelskaya, David Bates, Ara Sarkissian, Mary Breen, Yeulolani Andrade, Manickavasagar Vinayagamoorthy, Chunying Li, Eunjung Kim, Franco Giulianini, Gregory Kotler, Marty Van Denburgh, Rimma Dushkes, Yanyan Liu, Eduardo Pereira, Lisa Fields-Johnson, George Menjin, Lucy Liu, Lauren Girard, Scott Zeller, Naomi Riches, Katelyn Hasson, Ellen Bhang, Maria Revilla, Elena McCarthy, Alex Moran, Kristen Haise, Leah Arsenault, Philomena Quinn, Sancia Grimes, Ivan Fitchorov, Kurt Schwerin, Shamikhah Curry, Annie Murray, Angela Zhang, Diana Walrond-Williams, Alison Weinberg, Chris Pfeffer, Margarette Haubourg, Viviane Nguyen, Henry Ouellette, Rolando Rodriguez, Tony Montgomery, Keith Morse, Vincent Guzman, Megan Perry, Sandra Weekes, Doug Smith, Allison Clar, Sara Curran, Yaneve Fonge, David Hibbert, Louisa Paine, Kelly Royce, Courtney Splaine, Jennifer McMahon, David Eldridge, Laura Hand, Kay Inandan, Meghan Rieu Werden, Harriet Samuelson, Andrea Hrbek, Megan Mele, Eileen Bowes, Mary Anne Ryan, Carlos Camargo, Jacqueline Danik, Ravi Thadhani, Thomas Wang, Raj C. Shah, Michelle A. Albert, Carlos Kase, Hubert Vesper, Julianne Botelho, Lawrence S. Cohen, Theodore Colton, Mark A. Espeland, Craig Henderson, Alice H. Lichtenstein, Rebecca A. Silliman, Nanette Wenger, Josephine Boyington, Rebecca Costello, Cindy Davis, Peter Greenwald, Gabriela Riscuta, Harold Seifried
Article
Peripheral Vascular Disease
Enayet K. Chowdhury, Mark R. Nelson, Michael E. Ernst, Karen L. Margolis, Lawrence J. Beilin, Colin I. Johnston, Robyn L. Woods, Anne M. Murray, Rory Wolfe, Elsdon Storey, Raj C. Shah, Jessica E. Lockery, Andrew M. Tonkin, Anne B. Newman, Jeff D. Williamson, Walter P. Abhayaratna, Nigel P. Stocks, Sharyn M. Fitzgerald, Suzanne G. Orchard, Ruth E. Trevaks, Geoffrey A. Donnan, Richard Grimm, John J. McNeil, Christopher M. Reid
AMERICAN JOURNAL OF HYPERTENSION
(2020)
Article
Psychology, Clinical
Joanne Ryan, Robyn L. Woods, Anne M. Murray, Raj C. Shah, Carlene J. Britt, Christopher M. Reid, Rory Wolfe, Mark R. Nelson, Jessica E. Lockery, Suzanne G. Orchard, Ruth E. Trevaks, Trevor J. Chong, John J. McNeil, Elsdon Storey
Summary: The study aimed to provide normative performance data on the HVLT-R for community-dwelling older individuals in Australia and the United States, based on ethno-racial group, age, gender, and education level. Results showed that performance on the HVLT-R differed by demographic variables, with female gender, younger age, and higher education associated with better cognitive performance in this population.
CLINICAL NEUROPSYCHOLOGIST
(2021)
Article
Multidisciplinary Sciences
Mark Pinese, Paul Lacaze, Emma M. Rath, Andrew Stone, Marie-Jo Brion, Adam Ameur, Sini Nagpal, Clare Puttick, Shane Husson, Dmitry Degrave, Tina Navin Cristina, Vivian F. S. Kahl, Aaron L. Statham, Robyn L. Woods, John J. McNeil, Moeen Riaz, Margo Barr, Mark R. Nelson, Christopher M. Reid, Anne M. Murray, Raj C. Shah, Rory Wolfe, Joshua R. Atkins, Chantel Fitzsimmons, Heath M. Cairns, Melissa J. Green, Vaughan J. Carr, Mark J. Cowley, Hilda A. Pickett, Paul A. James, Joseph E. Powell, Warren Kaplan, Greg Gibson, Ulf Gyllensten, Murray J. Cairns, Martin McNamara, Marcel E. Dinger, David M. Thomas
NATURE COMMUNICATIONS
(2020)
Editorial Material
Medicine, General & Internal
Raj C. Shah, David A. Bennett
ANNALS OF INTERNAL MEDICINE
(2020)
Article
Oncology
John J. McNeil, Peter Gibbs, Suzanne G. Orchard, Jessica E. Lockery, Wendy B. Bernstein, Yin Cao, Leslie Ford, Andrew Haydon, Brenda Kirpach, Finlay Macrae, Catriona McLean, Jeremy Millar, Anne M. Murray, Mark R. Nelson, Galina Polekhina, Christopher M. Reid, Ellen Richmond, Luz Maria Rodriguez, Raj C. Shah, Jeanne Tie, Asad Umar, G. J. van Londen, Kathlyn Ronaldson, Rory Wolfe, Robyn L. Woods, John Zalcberg, Andrew T. Chan
Summary: The study found that long-term use of low-dose aspirin in older adults may increase the risk of cancer metastasis and late-stage diagnosis, leading to higher mortality rates in cancer patients.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Article
Public, Environmental & Occupational Health
J. Bishop-Royse, B. Lange-Maia, L. Murray, R. C. Shah, F. DeMaio
Summary: The study examined the relationship between IMRs and structural racism and socio-economic marginalization in Chicago, showing a significant association between ICE measures and community-level IMRs. Neighbourhoods with higher concentrations of Black residents compared to White residents had significantly higher IMRs, indicating the impact of structural racism on health outcomes.
Article
Biochemistry & Molecular Biology
Michael Berk, Bruno Agustini, Robyn L. Woods, Mark R. Nelson, Raj C. Shah, Christopher M. Reid, Elsdon Storey, Sharyn M. Fitzgerald, Jessica E. Lockery, Rory Wolfe, Mohammadreza Mohebbi, Seetal Dodd, Anne M. Murray, Nigel Stocks, Paul B. Fitzgerald, Catherine Mazza, John J. McNeil
Summary: The study found that aspirin did not have any long-term benefits on late-life depression in a sample of older adults over a 5-year period. On the contrary, it showed a negative impact on the course of depression in those with pre-existing depressive symptoms.
MOLECULAR PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Xiaoping Lin, Jane Banaszak-Holl, Jing Xie, Stephanie A. Ward, Henry Brodaty, Elsdon Storey, Raj C. Shah, Anne Murray, Joanne Ryan, Suzanne G. Orchard, Sharyn M. Fitzgerald, John J. McNeil
Summary: Older adults with newly detected cognitive impairment or dementia in the ASPREE trial had a higher mortality risk compared to those without cognitive impairment. The mortality rates were similar between those meeting DSM-IV criteria for dementia and those who triggered for a dementia evaluation but did not meet the criteria. This group was more likely to die from sepsis, respiratory disease, and dementia, but less likely to die from cancer compared to the group without triggers.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Jo Wrigglesworth, Nurathifah Yaacob, Phillip Ward, Robyn L. Woods, John McNeil, Elsdon Storey, Gary Egan, Anne Murray, Raj C. Shah, Sharna D. Jamadar, Ruth Trevaks, Stephanie Ward, Ian H. Harding, Joanne Ryan
Summary: In this study, the difference between brain age and chronological age (brain-PAD) was found to be negatively associated with psychomotor speed in relatively healthy older adults, but not with other cognitive functions at baseline or longitudinally. Further research into longitudinal changes in brain-PAD is needed to fully understand its relationship with cognitive function.
NEUROBIOLOGY OF AGING
(2022)
Article
Pharmacology & Pharmacy
Jonathan C. Broder, Joanne Ryan, Raj C. Shah, Jessica E. Lockery, Suzanne G. Orchard, Julia F. M. Gilmartin-Thomas, Michelle A. Fravel, Alice J. Owen, Robyn L. Woods, Rory Wolfe, Elsdon Storey, Anne M. Murray, Michael E. Ernst
Summary: The study found that anticholinergic burden is associated with cognitive decline in older adults, particularly affecting executive function and memory function.
Article
Multidisciplinary Sciences
Ana W. Capuano, Raj C. Shah, Paul Blanche, Robert S. Wilson, Lisa L. Barnes, David A. Bennett, Zoe Arvanitakis
Summary: This study aimed to develop a rapid and simple assessment tool for predicting dementia risk in older adults and validate it. The results showed that this assessment tool could effectively predict dementia risk in older adults within 3 years.
Article
Geriatrics & Gerontology
Melinda C. Power, Victoria Willens, Christina Prather, Ali Moghtaderi, Yi Chen, Kan Z. Gianattasio, Francine Grodstein, Raj C. Shah, Bryan D. James
Summary: Diagnostic delay in dementia is common in the U.S. and is driven by misconceptions, stigma, concerns about autonomy, the nature of the diagnostic process, and provider-related factors. More research is needed to understand the benefits and harms of early diagnosis.
GERONTOLOGY AND GERIATRIC MEDICINE
(2023)
Article
Cell Biology
Bruno Agustini, Mojtaba Lotfaliany, Mohammadreza Mohebbi, Robyn L. Woods, John J. McNeil, Mark R. Nelson, Raj C. Shah, Anne M. Murray, Christopher M. Reid, Andrew Tonkin, Joanne Ryan, Lana J. Williams, Malcolm P. Forbes, Michael Berk
Summary: With the progressive aging of the world's population, prolongation of a healthy lifespan in old age has become a medical research priority. The presence of depressive symptoms in later life is associated with poor health prognosis and increased mortality. Here we explore distinct trajectories of depressive symptoms in later life and their association with several health-related outcomes in 19,110 older individuals followed for a median of 4.7 years. Membership of any group with depressive symptoms was associated with a higher likelihood of health events, including physical disability, cancer, and major bleeding episodes. The course of depressive symptoms in older individuals can vary widely and depend on several factors. The presence of depressive symptoms, including those that do not meet criteria for major depression, can flag a poor prognosis and risk for specific health conditions. Systematic assessment of depressive symptoms may facilitate early identification of at-risk populations.
Article
Gerontology
Fayron Epps, Glenna Brewster, Judy S. Phillips, Rachel Nash, Raj C. Shah, Kenneth Hepburn
Summary: The Handshake Protocol successfully increased the enrollment rate of minority participants through warm handoffs. Within the first month of implementation, the team achieved a 97% efficiency in meeting its goals, showcasing the success of this innovative approach.
JOURNAL OF APPLIED GERONTOLOGY
(2022)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.
