Article
Medicine, Research & Experimental
Madeline T. Olson, Eric N. Aguilar, Cory L. Brooks, Carly C. Isder, Kathryn M. Muilenburg, Geoffrey A. Talmon, Quan P. Ly, Mark A. Carlson, Michael A. Hollingsworth, Aaron M. Mohs
Summary: Surgery is the only potential curative treatment for pancreatic cancer, but various factors make resections difficult. Fluorescence-guided surgery (FGS) has emerged as a method to improve cancer detection during surgery. The imaging agent AR9.6-IRDye800 developed in this study is effective and safe for intraoperative identification of pancreatic cancer.
MOLECULAR PHARMACEUTICS
(2022)
Article
Neurosciences
Jun Muto, Yutaka Mine, Yuya Nishiyama, Kazuhiro Murayama, Seiji Yamada, Daijiro Kojima, Motoharu Hayakawa, Kazuhide Adachi, Mitsuhiro Hasegawa, John Y. K. Lee, Yuichi Hirose
Summary: This study aimed to visualize meningiomas and dural tails intraoperatively using delayed-window indocyanine green (ICG) technique. The results showed that NIR fluorescence could accurately identify meningiomas and was correlated with MRI findings and blood-brain barrier permeability. DWIG had high sensitivity and positive predictive value in tumor identification.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Takeshi Fukuda, Shinya Yokomizo, Stefanie Casa, Hailey Monaco, Sophia Manganiello, Haoran Wang, Xiangmin Lv, Amy Daniel Ulumben, Chengeng Yang, Min-Woong Kang, Kazumasa Inoue, Masahiro Fukushi, Toshiyuki Sumi, Cheng Wang, Homan Kang, Kai Bao, Maged Henary, Satoshi Kashiwagi, Hak Soo Choi
Summary: The residual tumor after surgery is the most important prognostic factor for patients with epithelial ovarian cancer. Currently available contrast-enhancing agents have limitations for clinical use due to their low on-target binding, unfavorable pharmacokinetics, and toxicity. The study introduces a novel ultrabright and stable squaraine fluorophore called OCTL14, which demonstrates optimal pharmacokinetics and rapid cellular uptake. The charged squaraine fluorophores also provide durable intraoperative imaging by being retained in lysosomes in a preclinical murine model of ovarian cancer.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Hangqi Luo, Shuai Gao
Summary: Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is widely used for cancer treatment, but conventional PTT/PDT lack disease recognition ability, resulting in limited therapeutic effects. Integrating fluorescence imaging with PTT/PDT can reveal tumor locations in real-time, enabling early diagnosis and precision treatment. The use of NIR-II fluorescence imaging with PTT/PDT can significantly improve tumor theranostics accuracy and minimize damage to normal tissues.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Oncology
Lu Zhou, Wei-ming Xiao, Cheng-peng Li, Yi-wen Gao, Wei-juan Gong, Guo-tao Lu
Summary: The study found a close association between soft pancreas, fatty pancreas, and postoperative pancreatic fistula. Both body mass index and fatty pancreas are identified as risk factors for the development of pancreatic fistula.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Marcus J. Brookes, Corey D. Chan, Fabio Nicoli, Timothy P. Crowley, Kanishka M. Ghosh, Thomas Beckingsale, Daniel Saleh, Petra Dildey, Sanjay Gupta, Maniram Ragbir, Kenneth S. Rankin
Summary: Sarcomas are rare cancers that often require surgery for treatment. By using a harmless dye called indocyanine green before surgery and a near-infrared camera during the operation, surgeons were able to better identify and remove tumours, reducing the chances of recurrence.
Article
Surgery
Carmen C. Solorzano, Giju Thomas, Eren Berber, Tracy S. Wang, Gregory W. Randolph, Quan-Yang Duh, Frederic Triponez
Summary: Near-infrared fluorescence detection has been widely recognized for identifying or preserving parathyroid glands during thyroid and parathyroid operations, with two main approaches: using near infrared auto-fluorescence to locate parathyroid glands, and using contrast-enhanced near-infrared fluorescence to evaluate gland perfusion.
Article
Surgery
Elisa Bannone, Giovanni Marchegiani, Charles Vollmer, Giampaolo Perri, Giuseppa Procida, Gaetano Corvino, Sara Peressotti, Pier Giuseppe Vacca, Roberto Salvia, Claudio Bassi
Summary: This study aimed to evaluate the impact of postoperative serum hyperamylasemia (POH), with drain fluid amylase (DFA) and C-reactive protein (CRP), on the accuracy of the Fistula Risk Score (FRS) in assessing the risk of postoperative pancreatic fistula (POPF). The results showed that POH was an independent predictor of POPF and adding POH to the FRS improved the predictive accuracy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Babs G. Sibinga Mulder, Marjory Koller, Evelien W. Duiker, Arantza Farina Sarasqueta, Jakobus Burggraaf, Vincent E. de Meijer, Alexander L. Vahrmeijer, Frederik J. H. Hoogwater, Bert A. Bonsing, Gooitzen M. van Dam, J. Sven D. Mieog, Bobby K. Pranger
Summary: Tumor visualization with near-infrared fluorescence (NIRF) imaging using bevacizumab-IRDye800CW is feasible and safe for pancreatic cancer surgery. However, it is necessary to find a more tumor-specific tracer than bevacizumab-IRDye800CW for better differentiation of pancreatic cancer from normal or inflamed pancreatic tissue.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Naotake Funamizu, Kyosei Sogabe, Mikiya Shine, Masahiko Honjo, Akimasa Sakamoto, Yusuke Nishi, Takashi Matsui, Mio Uraoka, Tomoyuki Nagaoka, Miku Iwata, Chihiro Ito, Kei Tamura, Katsunori Sakamoto, Kohei Ogawa, Yasutsugu Takada
Summary: C-reactive protein-to-albumin ratio (CAR) can be used as a risk factor to predict postoperative pancreatic fistula (POPF) in patients with pancreatic cancer following distal pancreatectomy (DP).
Article
Gastroenterology & Hepatology
Artem Boyev, Laura R. Prakash, Yi-Ju Chiang, Christopher P. Childers, Anish J. Jain, Timothy E. Newhook, Morgan L. Bruno, Elsa M. Arvide, Whitney L. Dewhurst, Michael P. Kim, Naruhiko Ikoma, Jeffrey E. Lee, Rebecca A. Snyder, Matthew H. G. Katz, Ching-Wei D. Tzeng, Jessica E. Maxwell
Summary: This study found an association between postoperative opioid use and the occurrence of clinically relevant postoperative pancreatic fistula (CR-POPF) after distal pancreatectomy. Decreasing perioperative opioid use through enhanced postoperative management may be an effective approach to reduce the rates of CR-POPF.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Zhidong Wang, Lin Mei, Xiao Yang, Tiantian Jiang, Tingkai Sun, Yuanhao Su, Youshen Wu, Yuanyuan Ji
Summary: Near-infrared (NIR) fluorescence imaging-guided surgery is a promising technique in gastrointestinal surgery. Methylene blue (MB) is a safe and widely used fluorescent probe for intraoperative imaging. This study validated MB's usefulness in imaging the stomach and gastric tumors in animal models. The findings suggest that MB can specifically target gastric tissues but not specifically target subcutaneous and orthotopic gastric tumors in xenograft models.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Li Zhang, Yue Liu, Haiyan Huang, Hui Xie, Baozhu Zhang, Wujiong Xia, Bing Guo
Summary: Malignant brain tumors are a group of tumors with high invasiveness and destructiveness, and near-infrared optical imaging techniques show potential in the diagnosis and treatment of brain tumors due to their noninvasiveness, high resolution, and large penetration depth.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Surgery
Kengo Hayashi, Noriyuki Inaki, Yusuke Sakimura, Takahisa Yamaguchi, Yoshinao Obatake, Shiro Terai, Hirotaka Kitamura, Shinichi Kadoya, Hiroyuki Bando
Summary: This study emphasized the importance of pancreatic anatomy in predicting postoperative complications such as postoperative pancreatic fistula and postoperative intra-abdominal infections in patients undergoing laparoscopic or robotic gastrectomy. Careful manipulation of the pancreas during lymphadenectomy is necessary to reduce complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Nanoscience & Nanotechnology
Jiao Song, Huixia Ye, Senwei Jiang, Yuebo Yang, Xiaomao Li
Summary: A new smart nanoparticle (FA-IR780&PFOB-SNPs) was developed for the precise recognition of tumor boundaries in acidic tumor microenvironments through near-infrared fluorescence imaging. Studies confirmed that this nanoparticle can provide accurate real-time navigation for ovarian cancer surgeries, aiding in tumor resection and improving patient prognosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Surgery
Mahdi Al-Taher, Bob Knapen, Manuel Barberio, Eric Felli, Sylvain Gioux, Nicole D. Bouvy, Laurents P. S. Stassen, Jacques Marescaux, Michele Diana
Summary: This systematic review provides an overview of the literature on the use of near-infrared fluorescence imaging technique with contrast agents for visualizing the urethra. The review suggests that this technique is feasible for early identification of the urethra and can help prevent iatrogenic injury.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Surgery
Mahdi Al-Taher, Manuel Barberio, Eric Felli, Vincent Agnus, Anila Hoskere Ashoka, Sylvain Gioux, Andrey Klymchenko, Nicole Bouvy, Laurents Stassen, Jacques Marescaux, Michele Diana
Summary: This study evaluated the applicability of IRDye (R) 800BK in simultaneous assessment of bowel perfusion, lymphography, ureter, and bile duct delineation. The results showed excellent visualization under NIRF imaging and demonstrated the potential of this fluorophore as a powerful and versatile image-guided surgery tool.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Biochemical Research Methods
Anne Koenig, Nils Petitdidier, Henri Grateau, Samarmar Characoun, Abdallah Ghaith, Samuel Verges, Stephane Doutreleau, Sadok Gharbi, Remi Gerbelot, Sylvain Gioux, Jean-Marc Dinten
Summary: A low-cost system for long-term monitoring of skin physiological parameters was developed, showing good accordance with commercial devices in a first-in-human clinical trial.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Letter
Biochemical Research Methods
Ruben P. J. Meijer, Labrinus van Manen, Henk H. Hartgrink, Jacobus Burggraaf, Sylvain Gioux, Alexander L. Vahrmeijer, J. Sven D. Mieog
Summary: This study highlights the challenges in quantifying NIR fluorescence imaging for perfusion analysis through the description of four patients with possible compromised bowel perfusion. Different fluorescence dynamics patterns were observed in affected bowel segments compared to unaffected reference segments, suggesting difficulties in interpreting uncorrected fluorescence signals. Real-time quantification and standardization of NIR fluorescence perfusion imaging could potentially assist surgeons in making informed treatment decisions.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Biochemical Research Methods
Agathe Marmin, Gabrielle Laloy-Borgna, Sybille Facca, Sylvain Gioux, Stefan Catheline, Amir Nahas
Summary: Transient shear-wave elastography provides quantitative stiffness maps, reducing artifacts compared with time-of-flight reconstructions; the noise-correlation-inspired method effectively processes data from spatially coherent sources, successfully resolving the detection of soft inclusions; experimental validation demonstrates the feasibility and accuracy of the NCi approach on biological tissues.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Review
Oncology
J. Sven D. Mieog, Friso B. Achterberg, Aimen Zlitni, Merlijn Hutteman, Jacobus Burggraaf, Rutger-Jan Swijnenburg, Sylvain Gioux, Alexander L. Vahrmeijer
Summary: Fluorescence-guided surgery (FGS) using tumor-targeted imaging agents has emerged as a promising method for intraoperative cancer detection in the past decade, but its clinical implementation is still in the early stages. The key to success lies in the coordination of target selection, imaging agents, and detection systems to achieve real-time intraoperative visualization for the benefit of cancer patients.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Eric Felli, Mahdi Al-Taher, Toby Collins, Richard Nkusi, Emanuele Felli, Andrea Baiocchini, Veronique Lindner, Cindy Vincent, Manuel Barberio, Bernard Geny, Giuseppe Maria Ettorre, Alexandre Hostettler, Didier Mutter, Sylvain Gioux, Catherine Schuster, Jacques Marescaux, Jordi Gracia-Sancho, Michele Diana
Summary: The study utilized hyperspectral imaging and artificial intelligence to evaluate liver viability in a hepatic artery occlusion model, showing promising potential for future clinical applications.
Article
Oncology
Lorenzo Cinelli, Eric Felli, Luca Baratelli, Silvere Segaud, Andrea Baiocchini, Nariaki Okamoto, Maria Rita Rodriguez-Luna, Ugo Elmore, Riccardo Rosati, Stefano Partelli, Jacques Marescaux, Sylvain Gioux, Michele Diana
Summary: Anastomotic leak is a serious complication post-esophagectomy, linked to inadequate intraoperative perfusion. The innovative optical technique SSOP shows promise in quantifying tissue oxygenation, potentially improving intraoperative assessment.
Article
Biochemical Research Methods
Pranav Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Herve, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Michal Kacprzak, Piotr Sawosz, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frederic Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Kalyanov Alexander, Martin Wolf, Sanathana Konugolu Venkata Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Lorenzo Frabasile, Pietro Levoni, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Paola Taroni, Alberto Tosi, Alessandro Torricelli, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi
Summary: This study presents the largest multi-laboratory comparison of performance assessment in near-infrared diffuse optics, providing a detailed assessment of the instruments and establishing a basis for reference grading. The results highlight substantial differences in hardware performances and quantify the performance of each instrument.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Surgery
Maria Rita Rodriguez-Luna, Nariaki Okamoto, Lorenzo Cinelli, Luca Baratelli, Silvere Segaud, Adriana Rodriguez-Gomez, Deborah S. Keller, Elham Zonoobi, Elisa Bannone, Jacques Marescaux, Michele Diana, Sylvain Gioux
Summary: This study evaluates the accuracy of multispectral single snapshot imaging of optical properties (SSOP) in quantifying bowel ischaemia. The results show that multispectral SSOP can accurately assess small bowel perfusion and provide real-time measurement of tissue oxygenation.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Emanuele Felli, Lorenzo Cinelli, Elisa Bannone, Fabio Giannone, Edoardo Maria Muttillo, Manuel Barberio, Deborah Susan Keller, Maria Rita Rodriguez-Luna, Nariaki Okamoto, Toby Collins, Alexandre Hostettler, Catherine Schuster, Didier Mutter, Patrick Pessaux, Jacques Marescaux, Sylvain Gioux, Eric Felli, Michele Diana
Summary: Hyperspectral imaging (HSI) has been used to predict short-term post-operative outcomes in major hepatectomy. This non-invasive technology allows for the detection of liver dysfunction and is associated with post-operative complications and liver failure.
Article
Biochemistry & Molecular Biology
Cathal Caulfield, Dan Wu, Ian S. Miller, Annette T. Byrne, Pol Mac Aonghusa, Sergiy Zhuk, Lorenzo Cinelli, Elisa Bannone, Jacques Marescaux, Sylvain Gioux, Michele Diana, Taryn L. March, Alexander L. Vahrmeijer, Ronan Cahill, Donal F. O'Shea
Summary: A series of near-infrared fluorophores with mono- and bis-polyethylene glycol (PEG) substitution were synthesized for fluorescence guided intraoperative imaging, primarily for ureter identification. The bis-PEGylation improved the aqueous fluorescence quantum yields, with optimal PEG chain lengths of 2.9 to 4.6 kDa. Successful fluorescence identification of ureters was achieved in rodent and porcine models, with 3-D emission heat map imaging revealing spatial and temporal changes in intensity. These fluorophores can be spectrally distinguished from the clinically-used dye indocyanine green, suggesting their potential for intraoperative color coding of different tissues.
Review
Cell Biology
Lorenzo Cinelli, Edoardo Maria Muttillo, Emanuele Felli, Andrea Baiocchini, Fabio Giannone, Jacques Marescaux, Didier Mutter, Michel De Mathelin, Sylvain Gioux, Eric Felli, Michele Diana
Summary: This study reviewed surgical experiments on liver regeneration in pigs to standardize experimental methodologies. A total of 41 articles involving 689 pigs were included in the study. Most studies focused on partial hepatectomy, and some also examined the effects of other liver procedures. However, the mechanisms of liver regeneration and the chronic pathological aspects of the liver are still poorly understood.
Article
Biotechnology & Applied Microbiology
Martina De Landro, Lorenzo Cinelli, Nicola Marchese, Giulia Spano, Manuel Barberio, Cindy Vincent, Jacques Marescaux, Didier Mutter, Michel De Mathelin, Sylvain Gioux, Eric Felli, Paola Saccomandi, Michele Diana
Summary: Hyperspectral imaging (HSI) is an optical-based tool that has been used in medical and basic research fields to identify tumor markers and quantify antibodies. This study successfully demonstrated HSI's ability to quantify anti-high mobility group B1 (HMGB1) antibodies through an in vitro experiment. The results showed a positive correlation between relative absorbance and volume, indicating the potential of HSI in quantifying HMGB1.
BIOENGINEERING-BASEL
(2023)
Proceedings Paper
Engineering, Biomedical
Silvere Segaud, Luca Baratelli, Enagnon Aguenounon, Labrinus van Manen, Lysanne D. A. N. de Muynck, J. Sven D. Mieog, Alexander Vahrmeijer, Michele Diana, Sylvain Lecler, Sylvain Gioux
Summary: This imaging platform can be used to assess tissue status, particularly in terms of blood perfusion and tumor margin assessment.
TRANSLATIONAL BIOPHOTONICS: DIAGNOSTICS AND THERAPEUTICS
(2021)
