Article
Medicine, General & Internal
Su-Hyun Han, Seo-Young Lee, Jae Wook Cho, Jee Hyun Kim, Hye-jin Moon, Hea Ree Park, Yong Won Cho
Summary: This study aimed to investigate the relationship between COVID-19 or vaccination history and sleep and circadian patterns. The results showed that individuals with a history of COVID-19 had a later chronotype, and those who experienced vaccine-related side effects had poorer sleep quality. Therefore, COVID-19 and vaccine side effects have an impact on sleep and circadian patterns.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Wan-Ju Cheng, Liang-Wen Hang, Tomohide Kubo, Paivi Vanttola, Sheng-Che Huang
Summary: The study aimed to examine the effect of sleep timing intervention on sleep quality, attention, and sleepiness at work among night shift workers with shift work disorder. The results showed that participants had longer sleep duration, higher sleep quality, shorter reaction times, and fewer lapses during evening sleep schedules compared to morning sleep schedules. The differences between sleep schedules were most prominent among those with late chronotypes.
Review
Biology
Vanessa F. Vidueira, Josie N. Booth, David H. Saunders, John Sproule, Anthony P. Turner
Summary: Adolescence is a crucial period of development, and changes in circadian rhythmicity have a significant impact on the performance of adolescents. Studies have shown that morning type adolescents tend to outperform evening types in academic achievement, and performance in tests of intelligence and executive functions is generally better at optimal times of the day. However, there are still many factors that need further investigation in understanding the relationship between chronotype and performance in adolescents.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Psychiatry
Francy Cruz-Sanabria, Ugo Faraguna, Miriam Violi, Simone Bruno, Davide Gravina, Chiara Bonelli, Andrea Bazzani, Leonardo Massoni, Laura Musetti, Marly Simoncini, Paolo Frumento, Liliana Dell 'Osso, Claudia Carmassi
Summary: The present study evaluates the effect of exogenous melatonin on sleep and circadian parameters in patients with bipolar disorder and delayed sleep-wake phase disorder. Results indicate that personalized treatment with exogenous melatonin can modify self-reported chronotype, sleep onset time, and sleep efficiency and duration in patients with comorbid bipolar disorder and delayed sleep-wake phase disorder, suggesting potential efficacy in improving sleep patterns in this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Ping Guo, Yu Fang, Min Feng, Yue Shen, Shengliang Yang, Shikai Wang, Mincai Qian
Summary: This study investigated the circadian rhythms of patients with major depressive disorder (MDD) and analyzed possible influencing factors. The results showed that effective antidepressant therapy can adjust circadian rhythm disturbances and improve depressive symptoms.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Lei Yue, Naixue Cui, Li Jiang, Naisong Cui
Summary: This study examined the mediating effect of chronotype and social jetlag in the relationship between screen use before sleep and emotional problems. The results showed that adolescents who reported screen use before sleep exhibited later chronotype and greater social jetlag, which in turn were associated with higher levels of emotional problems. The serial indirect effect of chronotype and social jetlag explained 6.2%-16.7% of the total effect of screen use before sleep on emotional problems.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Peter P. Ujma, Csenge G. Horvath, Robert Bodizs
Summary: A survey of Hungarian adults found that the timing of daily activity is influenced by demographic and health-related factors such as age, sex, and socioeconomic status. The study also identified social jetlag and certain disorders as being associated with an individual's chronotype, while no causal relationship was found between light exposure and mental health.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Magdalena Linke, Konrad S. Jankowski
Summary: Research indicates that individuals with schizophrenia tend to have a more evening chronotype compared to healthy controls, but similar to those with bipolar I disorder. This suggests that eveningness might be a marker for mental health issues in general, beyond just mood disorders.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Clinical Neurology
Andrew M. Reiter, Gregory D. Roach, Charli Sargent
Summary: The effects of delaying main sleep on sleep quality and architecture vary between chronotypes. Early chronotypes experience less total sleep with delayed sleep, while intermediate and late chronotypes have more REM sleep. Circadian processes elevate wakefulness for all chronotypes in the later stages of delayed sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Multidisciplinary Sciences
C. Papatsimpa, L. J. M. Schlangen, K. C. H. J. Smolders, J-P M. G. Linnartz, Y. A. W. de Kort
Summary: Individuals differ in their timing of sleep and daytime activities, defining the "chronotype"; Spending time in relatively dim light conditions during the day leads to a later biological clock and increased interindividual differences in circadian phase; Increasing daytime illuminance results in a narrower distribution of sleep timing and circadian phase.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Guilherme Luiz Fernandes, Julia Ribeiro da Silva Vallim, Vania D'Almeida, Sergio Tufik, Monica Levy Andersen
Summary: Sleepiness is influenced by multiple factors including social jetlag and sleep variability. This study found that the effects of social jetlag on sleepiness may be mediated by sleep debt, highlighting the importance of circadian misalignment and sleep debt for sleep health on a population level.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychology, Developmental
Arcady A. Putilov, Dmitry S. Sveshnikov, Zarina B. Bakaeva, Elena B. Yakunina, Yuri P. Starshinov, Vladimir Torshin, Nikolay N. Alipov, Olga Sergeeva, Elena A. Trutneva, Michael M. Lapkin, Zhanna N. Lopatskaya, Roman O. Budkevich, Elena Budkevich, Alexandra N. Puchkova, Vladimir B. Dorokhov
Summary: This study found that female university students are more likely to feel sleepy compared to male students and have a greater need for longer sleep, potentially making them more susceptible to weekday sleep loss. Therefore, the negative effects of reduced sleep duration may be more common and more detrimental among female students.
JOURNAL OF ADOLESCENCE
(2021)
Article
Oncology
Julie Von Behren, Debbie Goldberg, Susan Hurley, Jessica Clague DeHart, Sophia S. Wang, Peggy Reynolds
Summary: A prospective study based on the California Teachers Study found associations between poor sleep quality, evening chronotype, and increased risk of breast cancer.
CANCER CAUSES & CONTROL
(2023)
Review
Endocrinology & Metabolism
Rui Zhang, Xiaoling Cai, Chu Lin, Wenjia Yang, Fang Lv, Jing Wu, Linong Ji
Summary: This study evaluated the association between evening chronotype and social jetlag (SJL) with obesity, blood glucose, and lipid levels in non-shift working adults. The results showed that evening chronotype and large SJL were associated with obesity and unfavorable metabolic parameters.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychology, Social
M. Mahmudul Hasan, Konrad S. Jankowski, Mozibul H. A. Khan
Summary: Social obligations have a negative impact on sleep behavior. The COVID-19 lockdown provided an opportunity to study sleep-wake behavior. The study found that changing sleep-wake timing was associated with mood and well-being.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2022)
Article
Medicine, General & Internal
Ana Adan, Jose Francisco Navarro
Summary: The protocol aims to characterize patients with dual disorders, substance use disorder, and severe mental illness in terms of clinical and personality characteristics, genetic polymorphism, and neuropsychological performance in order to obtain a clinical endophenotype. Different treatment approaches will be tested to analyze their impact on patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Lorenzo Tonetti, Marco Fabbri, Sara Giovagnoli, Monica Martoni, Miranda Occhionero, Vincenzo Natale
Summary: Sleep inertia refers to the gradual recovery of waking-like status after morning awakening. This study investigates the dissipation of sleep inertia in motor activity after spontaneous waking up and finds that age significantly influences motor activity levels.
Review
Environmental Sciences
Andy Deprato, Himasha Rao, Hannah Durrington, Robert Maidstone, Ana Adan, Jose Francisco Navarro, Anna Palomar-Cros, Barbara N. Harding, Prasun Haldar, Saibal Moitra, Tanusree Moitra, Lyle Melenka, Manolis Kogevinas, Paige Lacy, Subhabrata Moitra
Summary: This study aims to systematically evaluate the association between artificial light at night (ALAN) exposure and asthma and allergy, mental health, and cancer outcomes. By conducting comprehensive literature searches, screenings, and data analyses, we hope to understand how ALAN exposure may affect these health outcomes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Mar Ariza, Neus Cano, Barbara Segura, Ana Adan, Nuria Bargallo, Xavier Caldu, Anna Campabadal, Maria Angeles Jurado, Maria Mataro, Roser Pueyo, Roser Sala-Llonch, Cristian Barrue, Javier Bejar, Claudio Ulises Cortes, Carme Junque, Maite Garolera
Summary: Cognitive impairment is a prevalent symptom in individuals with post-COVID condition, and routine tests can effectively identify this impairment regardless of cognitive complaints.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Iman Hashemzadeh, Jose Francisco Navarro, Ana Adan
Summary: Sleep disturbances are closely related to mental diseases such as substance use disorder (SUD) and schizophrenia (SZ). This study examined the circadian characteristics and quality of life (QOL) in patients with SUD and comorbid SZ (SUD + SZ). The findings showed that SUD + SZ patients had a more evening chronotype and poorer QOL compared to SUD patients. Treatment targeting circadian adjustments and lifestyle improvement may be beneficial for these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Environmental Sciences
Lorenzo Tonetti, Alice Andreose, Valeria Bacaro, Martina Grimaldi, Vincenzo Natale, Elisabetta Crocetti
Summary: The aim of this study was to investigate the associations between social jetlag and weekend catch-up sleep with well-being and physical health in adolescents. The study found that in adolescents sleeping less than 7 hours, longer duration of weekend catch-up sleep (>120 minutes) was associated with lower subjective well-being. This highlights the detrimental effect of long weekend catch-up sleep on self-reported well-being in adolescents who do not get enough sleep.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Chemistry, Multidisciplinary
Miranda Occhionero, Lorenzo Tonetti, Sara Giovagnoli, Vincenzo Natale
Summary: This study examines the distribution of early memory recall in young adults and found that early memories are often vague, but they become more abundant over time. The types of memories include perceptual-visual fragments, semantic memories, and repeated events. The study also found that as the number of memory types increases, the likelihood of memory being structured as episodic decreases, and elements of perceptual-visual fragments, semantic memories, and repeated events become more prominent. These results suggest the importance of episodic memory in organizing experiences and its role in less structured forms of memory.
APPLIED SCIENCES-BASEL
(2023)
Article
Neurosciences
Valeria Bacaro, Alice Andreose, Martina Grimaldi, Vincenzo Natale, Lorenzo Tonetti, Elisabetta Crocetti
Summary: This study aimed to explore the association between sleep patterns and adolescents' school experience. The results showed that short sleep duration, later bedtimes during weekdays and weekends, and a higher amount of social jetlag were negatively related to school performance. Additionally, adolescents who did not use any sleep-recovery strategies had lower levels of educational in-depth exploration compared to those who used catch-up sleep but not social jetlag.
Article
Clinical Neurology
Ana Adan, Julia E. Marquez-Arrico, Laura Rio-Martinez, Jose Francisco Navarro, Antonio Martinez-Nicolas
Summary: Circadian rhythmicity is associated with clinical variables in both schizophrenia and substance use disorders. The study found that patients with SZ+ and SZ diagnoses had longer sleep duration and intermediate circadian typology, while patients with SUD had shorter sleep duration and morning circadian typology.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Mar Ariza, Neus Cano, Barbara Segura, Ana Adan, Nuria Bargallo, Xavier Caldu, Anna Campabadal, Maria Angeles J. Jurado, Maria Mataro, Roser Pueyo, Roser Sala-Llonch, Cristian Barrue, Javier Bejar, Claudio Ulises Cortes, Maite Garolera, Carme Junque
Summary: Patients with post-COVID-19 conditions often experience cognitive problems, with severe cases leading to long-term cognitive damage. This study aimed to clarify the relationship between COVID-19 severity and long-term cognitive outcomes, as well as determine if initial symptoms can predict long-term cognitive problems. Cognitive evaluations were conducted on healthy controls and post-COVID individuals categorized into severity groups. The severe group exhibited significant deficits in executive function, and several initial symptoms predicted long-term sequelae, suggesting the role of systemic inflammation and neuroinflammation in COVID-19's acute-phase symptoms.
JOURNAL OF NEUROLOGY
(2023)
Article
Chemistry, Analytical
Miranda Occhionero, Lorenzo Tonetti, Andreas Conca, Sara Giovagnoli, Giancarlo Giupponi, Marina Zoppello, Vincenzo Natale
Summary: Prospective memory (PM) performance is lower in individuals diagnosed with attention deficit hyperactivity disorder (ADHD), regardless of age. The deficits in PM are more pronounced in children with ADHD. These findings indicate that PM efficiency can be considered as a neuropsychological marker of ADHD.
Article
Allergy
Subhabrata Moitra, Ana Adan, Metin Akgun, Augustus Anderson, Amanda Brickstock, Allie Eathorne, Ali Farshchi Tabrizi, Prasun Haldar, Linda Henderson, Aditya Jindal, Surinder Kumar Jindal, Bugra Kerget, Fadi Khadour, Lyle Melenka, Saibal Moitra, Tanusree Moitra, Rahul Mukherjee, Alex Semprini, Alice M. Turner, Nicola Murgia, Giovanni Ferrara, Paige Lacy
Summary: This study aimed to investigate the impact of social deprivation on health-related quality of life (HRQoL) in asthma. Through a survey of 691 adult asthmatics in New Zealand and the United Kingdom, it was found that social deprivation was directly and indirectly associated with HRQoL, with mediation through anxiety, depression, and alcohol abuse. Lower social deprivation was associated with better physical function, less dyspnea and fatigue, and better emotional function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Editorial Material
Medicine, General & Internal
Marta Torrens, Ana Adan
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Nuria Miguel, Julia E. Marquez-Arrico, Merce Jodar, Jose Francisco Navarro, Ana Adan
Summary: Major depression disorder (MDD) and bipolar disorder (BD) often coexist with substance use disorders (SUD), known as dual disorder (DD). Cognitive impairment is associated with MDD, BD, and SUD, which may have a greater impact on functional impairment in DD. Studies suggest that attention and executive functions are the most affected cognitive domains in BD + SUD patients, while MDD + SUD patients show a similar cognitive impairment pattern. More research is needed to understand the influence of depression on cognitive performance in DD patients.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Lorenzo Tonetti, Miranda Occhionero, Marco Fabbri, Sara Giovagnoli, Martina Grimaldi, Monica Martoni, Vincenzo Natale
Summary: This study investigated the time course of motor activity sleep inertia (maSI) dissipation from middle childhood to late adulthood using actigraphy. The results showed that maSI dissipated in 70 minutes and was more evident in younger participants. Additionally, lower age was significantly associated with greater motor activity during the wakefulness period.
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.