Review
Biochemistry & Molecular Biology
Paromita Sen, Alicia Molinero-Perez, Kenneth J. O'Riordan, Cian P. McCafferty, Ken D. O'Halloran, John F. Cryan
Summary: The article explores how the microbiota influences sleep directly and indirectly, as well as the alterations of the microbiota-gut-brain axis in various sleep disorders and pathologies. Manipulating the gut microbiota could potentially improve sleep quality.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Frank A. J. L. Scheer, Michael F. Hilton, Heather L. Evoniuk, Sally A. Shiels, Atul Malhotra, Rena Sugarbaker, R. Timothy Ayers, Elliot Israel, Anthony F. Massaro, Steven A. Shea
Summary: The study found that asthma patients experience worsened lung function and exacerbation of symptoms at night, often masked by sleep. Asthma patients exhibit significant circadian rhythms throughout the day and are more likely to use bronchodilators during the night.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Reto Huber, Arko Ghosh
Summary: The study found that cognitive and physical activities are dominated by diurnal and infra-radian rhythms, but cognitive performance has a weaker rhythm than physical activity. Before bedtime, people continue to interact with their smartphones while at physical rest, leading to a decline in cognitive performance.
Review
Biochemistry & Molecular Biology
Mengsheng Tang, Xiaoran Song, Weiwei Zhong, Yan Xie, Yanan Liu, Xin Zhang
Summary: Circadian rhythms are crucial in regulating sleep patterns, and increasing dietary fiber intake can help ameliorate sleep disorders. Gut flora communicates with sleep through the gut-brain axis, playing a significant role in modulating sleep disorders.
Article
Multidisciplinary Sciences
Jessica E. Schwarz, Anna N. King, Cynthia T. Hsu, Annika F. Barber, Amita Sehgal
Summary: The study demonstrates that hugin(+) neurons play a critical role in regulating sleep homeostasis by integrating circadian and sleep signals to modulate circadian circuitry and regulate the timing of sleep. Sleep deprivation reduces the activity of hugin(+) neurons, while ablation of these neurons increases sleep promoted by activation of the homeostatic sleep locus, the dorsal fan-shaped body (dFB). This suggests a complex interaction between sleep and circadian rhythms mediated by hugin(+) neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Medicine, General & Internal
Bala S. C. Koritala, Zachary Conroy, David F. Smith
Summary: Obstructive sleep apnea can disrupt the molecular clock and impact various biological rhythms, potentially worsening cardiovascular or cognitive outcomes. Understanding circadian biology in the context of OSA could be crucial for improving diagnosis and treatment methods.
Article
Multidisciplinary Sciences
Momoka Kuroda, Yoshiko Suetsugu, Sachiko Iwata, Masahiro Kinoshita, Fumie Fujita, Yoko Sato, Shinji Saitoh, Osuke Iwata, Seiichi Morokuma
Summary: This study aimed to analyze the influence of mothers' nighttime responses on the sleep-wake rhythm of their 1-month-old infants. Findings showed that immediately picking up 1-month-old infants may result in longer daytime sleep compared to nighttime sleep, possibly due to the stimulating effects of picking up the infant on sleep-wake rhythm formation.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Sheida Zolfaghari, Marieve Cyr, Amelie Pelletier, Ronald B. B. Postuma
Summary: This study aimed to compare sleep symptoms among participants who were interviewed in different seasons and before/after the transition into DST and ST. The results showed no difference in sleep satisfaction, sleep onset, sleep maintenance, and hypersomnolence among participants interviewed in different seasons. However, the transition from DST to ST was associated with an increase in sleep disorders.
Review
Oncology
Annemarie D. Jagielo, Catherine Benedict, David Spiegel
Summary: Circadian, hormonal, and sleep rhythm disruptions are common concerns among cancer patients. Research shows that circadian rhythm disruption is associated with adverse mental health and disease outcomes. Chronomodulated chemotherapy, light therapy, cognitive behavioral therapy for insomnia, and physical activity have shown evidence of effectiveness in improving sleep and occasionally, disease outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Review
Physiology
Dieter Kunz, Henrik Oster, Oliver Rawashdeh, Wolf-Julian Neumann, Thomas Muente, Daniela Berg
Summary: The prevalence of neurodegenerative diseases, particularly Parkinson's disease, in the global north is increasing at an alarming rate, with some even calling it a pandemic. While lifestyle factors are known to contribute, the role of circadian rhythms in these diseases has not been extensively explored. Sleep and circadian rhythm disruption have been found to play a key role in neurodegeneration, particularly during the early stages of the disease. This review summarizes the current knowledge on sleep and circadian rhythm disruptions in neurodegenerative diseases, with a focus on molecular aspects and therapeutic potentials, providing valuable insights into the pathogenesis and potential treatment interventions.
Article
Environmental Sciences
Rui F. O. Silva, Brigida R. Pinho, Miguel M. Santos, Jorge M. A. Oliveira
Summary: Behavioural disruptions can serve as sensitive indicators of abnormal animal physiology and are valuable for toxicity assessment. Zebrafish, a small vertebrate, is a commonly used model organism for toxicological studies. This study validates the use of an infrared-based Locomotor Activity Monitor (LAM) to assess zebrafish behaviour, and demonstrates the feasibility of using this method to evaluate multi parameter behavioural disruptions in zebrafish. The findings have broad applicability and may contribute to the development of standard methods for toxicity testing.
Article
Neurosciences
Aileen Seidler, Katy Sarah Weihrich, Frederik Bes, Jan de Zeeuw, Dieter Kunz
Summary: This study investigated the seasonal variation in objective sleep measures in a cohort of patients living in an urban environment. The results showed longer sleep duration and shorter REM-sleep latency during winter. The findings suggest that there is a seasonal variation in sleep architecture even in individuals with sleep disturbances living in an urban environment.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Cardiac & Cardiovascular Systems
Mariana G. Figueiro, David Pedler
Summary: The advent of electric lighting has greatly changed human perception of light and darkness, but it often fails to stimulate and synchronize the circadian system. This can lead to poor sleep and may contribute to the increased incidence of cardiovascular diseases. This contribution suggests incorporating daily exposures to light and darkness as lifestyle factors to reduce the risk and progression of cardiovascular diseases.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Article
Geriatrics & Gerontology
Sarah T. Stahl, Stephen F. Smagula, Juleen Rodakowski, Mary Amanda Dew, Jordan F. Karp, Steven M. Albert, Meryl Butters, Ariel Gildengers, Charles F. Reynolds
Summary: The study identified two trajectories of inflammation in older adults, with one group showing consistently lower levels and the other group showing consistently higher levels. Poor sleep quality may lead to consistently elevated levels of inflammation.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Physiology
Ciaran J. McMullan, Andrew W. McHill, Joseph T. Hull, Wei Wang, John P. Forman, Elizabeth B. Klerman
Summary: Prolonged exposure to chronic sleep restriction and shiftwork can lead to hypertension and cardiovascular diseases. This study found that rotating sleep schedules caused circadian disruption, resulting in increased blood pressure, renal sodium retention, and aldosterone excretion. These findings provide mechanistic insights into the adverse effects of shiftwork on cardiovascular and renal health.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gareth B. Kitchen, Thomas Hopwood, Thanuja Gali Ramamoorthy, Polly Downton, Nicola Begley, Tracy Hussell, David H. Dockrell, Julie E. Gibbs, David W. Ray, Andrew S. Loudon
Summary: Robust inflammatory responses are crucial for survival after respiratory infections, and Epigenetic factors are increasingly being recognized as important determinants of immune responses. EZH2 acts differently in macrophages and neutrophils, affecting inflammatory responses and chemotaxis. Targeting EZH2 may have implications for mucosal immunity and conditions driven by pulmonary neutrophil influx.
Article
Psychology, Clinical
E. E. Levitt, A. Oshri, M. Amlung, L. A. Ray, S. Sanchez-Roige, A. A. Palmer, J. MacKillop
Summary: This study examines the relationship between delay discounting and multiple psychiatric conditions and finds significant associations between delay discounting and several disorders. The findings provide support for delay discounting as a transdiagnostic indicator and suggest further research is warranted.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Genetics & Heredity
Jennifer Zou, Shyam Gopalakrishnan, Clarissa C. Parker, Jerome Nicod, Richard Mott, Na Cai, Arimantas Lionikas, Robert W. Davies, Abraham A. Palmer, Jonathan Flint
Summary: Combining samples in genetic association studies for complex traits can identify more loci, but replication between studies may be challenging. The Winner's Curse effect, study heterogeneity, and trait differences are factors that affect replication, and integrating various information can assign variants to different confidence levels.
G3-GENES GENOMES GENETICS
(2022)
Article
Behavioral Sciences
Sandra Sanchez-Roige, Samuel A. Barnes, Jazlene Mallari, Rebecca Wood, Oksana Polesskaya, Abraham A. Palmer
Summary: The membrane glycoprotein M6B (Gpm6b) is involved in neuronal differentiation, myelination, and inactivation of the serotonin transporter. Recent studies have shown its association with psychiatric disorders. A mutant allele of Gpm6b was created in mice, leading to deficits in delay discounting but enhanced reward sensitivity and behavioral flexibility.
GENES BRAIN AND BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Thomas A. Sasani, David G. Ashbrook, Annabel C. Beichman, Lu Lu, Abraham A. Palmer, Robert W. Williams, Jonathan K. Pritchard, Kelley Harris
Summary: This study used BXD mouse lines to identify loci that influence germline mutagenesis. They found that a quantitative trait locus on chromosome 4 affects the accumulation rate of C>A germline mutations in mice, primarily due to the activity of different alleles of the DNA repair gene Mutyh. These alleles are also present in wild populations, indicating that common genetic variation modulates germline mutagenesis.
Review
Neurosciences
Cynthia M. Bulik, Jonathan R. Coleman, J. Andrew Hardaway, Lauren Breithaupt, Hunna J. Watson, Camron D. Bryant, Gerome Breen
Summary: This review summarizes the progress in genetics, neuroimaging, and animal models of eating disorders and calls for a more unified science in this field.
NATURE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Polly Downton, Fabio Sanna, Robert Maidstone, Toryn M. Poolman, Edward A. Hayter, Suzanna H. Dickson, Nick A. Ciccone, James O. Early, Antony Adamson, David G. Spiller, Devin A. Simpkins, Matthew Baxter, Roman Fischer, Magnus Rattray, Andrew S. I. Loudon, Julie E. Gibbs, David A. Bechtold, David W. Ray
Summary: Chronic inflammation is associated with metabolic dysfunction, with a temporal crosstalk between inflammatory and metabolic processes. Research has shown that arthritis drives changes in lipid metabolism and mitochondrial function, leading to the accumulation of bioactive lipid species.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
A. Louise Hunter, Toryn M. Poolman, Donghwan Kim, Frank J. Gonzalez, David A. Bechtold, Andrew S. Loudon, Mudassar Iqbal, David W. Ray
Summary: Hepatocyte nuclear factor 4A (HNF4A) plays a critical role in the liver-specific action of glucocorticoid receptor (GR). Loss of chromatin accessibility at HNF4A-marked sites leads to loss of GR binding at weak GRE motifs, while strong GRE motifs show increased GR binding and recruitment in non-liver tissues. Transcriptional response to glucocorticoid treatment is altered in the Hnf4a-null liver.
Article
Biology
Alex A. Koch, James S. Bagnall, Nicola J. Smyllie, Nicola Begley, Antony D. Adamson, Jennifer L. Fribourgh, David G. Spiller, Qing-Jun Meng, Carrie L. Partch, Korbinian Strimmer, Thomas A. House, Michael H. Hastings, Andrew S. Loudon
Summary: This study develops a quantitative model to explain how a finite pool of BMAL1 protein regulates gene expression at thousands of target sites over daily time scales. By tracking dynamic changes in endogenous labeled proteins in tissues, the researchers determine the contribution of multiple rhythmic processes in coordinating BMAL1 DNA binding. The results also reveal the role of nuclear BMAL1 concentration in determining CLOCK and the mechanism of repression of CLOCK:BMAL1 through interactions with PER2:CRY1 and BMAL1:CRY1.
Article
Biochemistry & Molecular Biology
Matthew Baxter, Toryn Poolman, Peter Cunningham, Louise Hunter, Maria Voronkov, Gareth B. Kitchen, Laurence Goosey, Nicola Begley, Danielle Kay, Abby Hespe, Robert Maidstone, Andrew S. Loudon, David W. Ray
Summary: The MLL3 methyltransferase activity is not essential for circadian oscillations, but may influence the inflammatory response.
Editorial Material
Neurosciences
Elizabeth G. Atkinson, Sevim B. Bianchi, Gordon Y. Ye, Jose Jaime Martinez-Magana, Grace E. Tietz, Janitza L. Montalvo-Ortiz, Paola Giusti-Rodriguez, Abraham A. Palmer, Sandra Sanchez-Roige
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Axel Guilbaud, Farzan Ghanegolmohammadi, Yijun Wang, Jiapeng Leng, Alexander Kreymerman, Jacqueline Gamboa Varela, Jessica Garbern, Hannah Elwell, Fang Cao, Elisabeth M. Ricci-Blair, Cui Liang, Seetharamsing Balamkundu, Charles Vidoudez, Michael S. Demott, Kenneth Bedi, Kenneth B. Margulies, David A. Bennett, Abraham A. Palmer, Amanda Barkley-Levenson, Richard T. Lee, Peter C. Dedon
Summary: DNA damage is a major cause of genomic instability in various diseases. Traditional analytical methods provide limited insight into the spectrum of DNA lesions in living organisms. In this study, untargeted chromatography-coupled tandem mass spectrometry (LC-MS/MS) was used to explore the landscape of DNA modifications in rat and human tissues. A total of 114 potential DNA adducts were identified in heart, liver, brain, and kidney tissues of rats, and 111 in human heart and brain tissues using the LC-MS/MS approach. Subsequent targeted analysis revealed species, tissue, age, and sex biases in the DNA adducts. This study demonstrates the potential of adductomics in discovering disease-driving DNA adducts and provides a valuable resource for characterizing new forms of DNA damage and developing biomarkers for aging and disease.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Neurosciences
Kristyn N. Borrelli, Kelly K. Wingfield, Emily J. Yao, Catalina A. Zamorano, Katherine D. Sena, Jacob A. Beierle, Michelle A. Roos, Huiping Zhang, Elisha M. Wachman, Camron D. Bryant
Summary: Prenatal opioid exposure is a major health concern in the United States, with the incidence of neonatal opioid withdrawal syndrome (NOWS) escalating in recent years. Research found that injection of morphine during the neonatal period can cause significant behavioral and transcriptomic adaptations, but has no significant long-term effects on adult behaviors.
Article
Biology
Ann Louise Hunter, Antony D. Adamson, Toryn M. Poolman, Magdalena Grudzien, Andrew S. Loudon, David W. Ray, David A. Bechtold
Summary: Chromatin immunoprecipitation (ChIP) maps enable the identification of transcription factor binding sites and chromatin-associated proteins, providing valuable insights into gene regulation mechanisms. The success of ChIP experiments relies on the availability of high-quality antibodies. The HaloTag(R) system, a modified enzyme, can be used for ChIP to accurately map the cistrome of dynamic mouse transcription factors in vivo.
Letter
Biotechnology & Applied Microbiology
Channabasavaiah B. Gurumurthy, Aidan R. O'Brien, Rolen M. Quadros, John Adams, Pilar Alcaide, Shinya Ayabe, Johnathan Ballard, Surinder K. Batra, Marie-Claude Beauchamp, Kathleen A. Becker, Guillaume Bernas, David Brough, Francisco Carrillo-Salinas, Wesley Chan, Hanying Chen, Ruby Dawson, Victoria DeMambro, Jinke D'Hont, Katharine Dibb, James D. Eudy, Lin Gan, Jing Gao, Amy Gonzales, Anyonya Guntur, Huiping Guo, Donald W. Harms, Anne Harrington, Kathryn E. Hentges, Neil Humphreys, Shiho Imai, Hideshi Ishii, Mizuho Iwama, Eric Jonasch, Michelle Karolak, Bernard Keavney, Nay-Chi Khin, Masamitsu Konno, Yuko Kotani, Yayoi Kunihiro, Imayavaramban Lakshmanan, Catherine Larochelle, Catherine B. Lawrence, Lin Li, Volkhard Lindner, Xian-De Liu, Gloria Lopez-Castejon, Andrew Loudon, Jenna Lowe, Loydie Jerome-Majeweska, Taiji Matsusaka, Hiromi Miura, Yoshiki Miyasaka, Benjamin Morpurgo, Katherine Motyl, Yo-ichi Nabeshima, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata, Sanae Ogiwara, Mariette Ouellet, Leif Oxburgh, Sandra Piltz, Ilka Pinz, Moorthy P. Ponnusamy, David Ray, Ronald J. Redder, Clifford J. Rosen, Nikki Ross, Mark T. Ruhe, Larisa Ryzhova, Ane M. Salvador, Sabrina Shameen Alam, Radislav Sedlacek, Karan Sharma, Chad Smith, Katrien Staes, Lora Starrs, Fumihiro Sugiyama, Satoru Takahashi, Tomohiro Tanaka, Andrew Trafford, Yoshihiro Uno, Leen Vanhoutte, Frederique Vanrockeghem, Brandon J. Willis, Christian S. Wright, Yuko Yamauchi, Xin Yi, Kazuto Yoshimi, Xuesong Zhang, Yu Zhang, Masato Ohtsuka, Satyabrata Das, Daniel J. Garry, Tino Hochepied, Paul Thomas, Jan Parker-Thornburg, Antony D. Adamson, Atsushi Yoshiki, Jean-Francois Schmouth, Andrei Golovko, William R. Thompson, K. C. Kent Lloyd, Joshua A. Wood, Mitra Cowan, Tomoji Mashimo, Seiya Mizuno, Hao Zhu, Petr Kasparek, Lucy Liaw, Joseph M. Miano, Gaetan Burgio