Article
Pharmacology & Pharmacy
Hsiang-Hao Hsu, Aline Yen Ling Wang, Charles Yuen Yung Loh, Ashwin Alke Pai, Huang-Kai Kao
Summary: This study found that diabetic ASC-Exo enhance cutaneous wound healing by stimulating dermal cell proliferation, keratinocyte proliferation, and angiogenesis. The diabetic ASC-Exo also stimulate resident monocytes/macrophages to secrete more TGF-beta 1 and activate the TGF-beta/Smad3 signaling pathway.
Article
Cell & Tissue Engineering
Yang Zhou, Bo Zhao, Xin-Liao Zhang, Yi-jun Lu, Shou-Tao Lu, Jian Cheng, Yu Fu, Lin Lin, Ning-Yan Zhang, Pei-Xin Li, Jing Zhang, Jun Zhang
Summary: This study investigated the potential clinical application roles of human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes (hADSC-Exo) in cutaneous wound healing. The combined administration of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration showed additional benefits in promoting wound healing, accelerating re-epithelialization, reducing scar widths, and enhancing angiogenesis and collagen synthesis.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Yang An, Shuyan Lin, Xiaojie Tan, Shiou Zhu, Fangfei Nie, Yonghuan Zhen, Luosha Gu, Chunlei Zhang, Baicheng Wang, Wei Wei, Dong Li, Junhao Wu
Summary: ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling to inhibit scar hyperplasia in wounds. Compared with ADSCs therapeutics, ADSCs-EXOs have high stability, easy storage, immune system non-rejection, homing effect, and easily controlled dosage. In patients with diabetes mellitus, ADSCs-EXOs can improve fat grafting and promote wound healing.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Joanna Wisniewska, Magda Slyszewska, Karolina Stalanowska, Katarzyna Walendzik, Marta Kopcewicz, Sylwia Machcinska, Barbara Gawronska-Kozak
Summary: The study found that exposure of pASCs to hypoxia increased levels of VEGF in the conditioned media, which promoted the migratory ability of skin cells and affected the expression of markers related to wound healing. Hypoxia-conditioned media enhanced skin cell functions, highlighting the potential of using ASCs' paracrine activity to modulate wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Ning Zeng, Hongbo Chen, Yiping Wu, Zeming Liu
Summary: Wound healing in the human body is a complex physiological regulation mechanism, with adipose stem cells playing an important role in regenerative medicine. Adipose stem cells are easy to obtain, high-yielding, rich in components and cytokines, and highly practical.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jing Li, Hong Gao, Yue Xiong, Ling Wang, Haojie Zhang, Fumei He, Jingxin Zhao, Shuna Liu, Liqian Gao, Ying Guo, Wenbin Deng
Summary: This study found that exosomes derived from neural stem cells may enhance wound healing through neurotrophic factors and immunomodulation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Dermatology
Tian Yuan, Li Meijia, Chen Xinyao, Chen Xinyue, Hao Lijun
Summary: Exosomes derived from human adipose-derived stem cells (ADSCs) have shown excellent capability in improving wound healing quality, but their efficacy in clinical applications is still uncertain. This study conducted a systematic review of preclinical studies comparing exosomes from human ADSCs with placebo in animal models of wound closure. The results showed that administration of exosomes derived from human ADSCs significantly improved wound closure compared to controls, with the same effect as ADSCs. The therapeutic effect was further enhanced by modified ADSC-EV. This suggests that exosomes derived from human ADSCs, especially after enrichment for specific non-coding RNA, have promising potential to improve healing efficiency.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Materials Science, Biomaterials
Jia-Lin Liu, De-Lai Kang, Peng Mi, Cheng-Zhi Xu, Lian Zhu, Ben-Mei Wei
Summary: A skin wound is a rupture caused by external damage or underlying pathological conditions, and wound healing processes can be burdensome. Bacterial infection, inflammation, impaired angiogenesis, and scar formation hinder the recovery of skin wounds. Scientists are developing multifunctional nanomedicines to address these challenges. Mesenchymal stem cells (MSCs) have been explored for wound repair due to their self-renewal and multipotency, but immune concerns and legal restrictions need to be resolved. MSC-derived extracellular vesicles (EVs) are promising therapeutics for wound repair, possessing advantages such as abundant sources and convenient administration routes. However, current reviews lack focus on the specific roles of EVs in different stages of wound healing, making it necessary to highlight the significance of MSC-derived EVs in promoting wound healing. This review discusses the advances of MSC-derived EVs in wound repair, particularly their roles in eliminating infections, reducing inflammation, promoting angiogenesis, and minimizing scar formation. The limitations and future prospects of MSC-derived EVs in wound repair are also objectively analyzed.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Honghao Yu, Yiping Wu, Boyu Zhang, Mingchen Xiong, Yi Yi, Qi Zhang, Min Wu
Summary: This study demonstrated that E2F1-deficient ADSC-Exos promote wound healing by enhancing collagen formation and angiogenesis, and by regulating miRNA to enhance fibroblast activities. This finding provides a novel strategy of gene-engineered stem cell exosomes for accelerating wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Biomedical
Dequan Zhang, Qiang Fu, Huijuan Fu, Jinshi Zeng, Litao Jia, Minliang Chen
Summary: 3D-printed bioactive scaffolds produced through 3D printing can provide an individualized approach to treating full-thickness skin defects. Adipose tissues obtained by liposuction are rich in adipose-derived bioactive materials, which can support wound healing.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Chemistry, Multidisciplinary
Yunchuan Wang, Yue Zhang, Ting Li, Kuo Shen, Ke Jia Wang, Chenyang Tian, Dahai Hu
Summary: Engineered skin substitutes derived from human skin reduce inflammatory reactions and are easier to use in clinics. Type I collagen and platelet-rich plasma are mixed to form a stable scaffold, while adipose mesenchymal stem cell derived exosomes improve the performance of the engineered skin. This method provides a new therapeutic strategy and theoretical basis for tissue regeneration and wound repair.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Seung-Hwa Woo, Joon Hyuk Choi, Yun Jeong Mo, Yun-Il Lee, Won Bae Jeon, Young-Sam Lee
Summary: This study proposes a method using extracellular matrix mimetic biomaterials for enhancing wound healing in diabetic patients. By using biosynthesized REPs, the efficacy of stem cells can be improved, leading to accelerated wound closure and improved skin elasticity, which is of great importance for the treatment of diabetes patients.
Article
Engineering, Biomedical
Nan Hu, Zhengwei Cai, Xudong Jiang, Chuang Wang, Tao Tang, Tianze Xu, Hong Chen, Xiaoqiang Li, Xiaolong Du, Wenguo Cui
Summary: Adipose-derived stem cell (ADSC)-originating exosomes (ADSC-Exos) have potential in diabetic wound repair, but their disadvantages limit their clinical application. This study developed hypoxia-pretreated ADSC-Exo (ADSC-HExo)-embedded GelMA hydrogels (GelMA-HExo) and demonstrated their therapeutic effects in promoting diabetic wound healing. These findings suggest a new therapeutic strategy for diabetic ulcers.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
Summary: Chronic wound infections have become a significant issue, and the development of functional wound dressings has made progress. Antimicrobial peptides are attracting attention as an emerging therapeutic option for wound healing.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Immunology
Qingyi Jia, Hanxing Zhao, Yixi Wang, Ying Cen, Zhenyu Zhang
Summary: Wound healing is a complex process that involves multiple phases, including inflammation, proliferation, and remodeling. Abnormal inflammation can impede wound healing under certain pathological conditions. Adipose-derived stem cells (ADSCs) and their secreted extracellular vesicles (ADSC-EVs) have shown potential in promoting wound healing by inhibiting abnormal inflammation responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Charlotte Lequeux, Jonathan Rodriguez, Fabien Boucher, Ondine Rouyer, Odile Damour, Ali Mojallal, Celine Auxenfans
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2015)
Article
Cell & Tissue Engineering
Jonathan Rodriguez, Anne-Sophie Pratta, Nacira Abbassi, Hugo Fabre, Fanny Rodriguez, Cyrille Debard, Jacqueline Adobati, Fabien Boucher, Frederic Mallein-Gerin, Celine Auxenfans, Odile Damour, Ali Mojallal
STEM CELLS INTERNATIONAL
(2017)
Article
Biochemistry & Molecular Biology
Roxane M. Pommier, Johann Gout, David F. Vincent, Carla E. Cano, Bastien Kaniewski, Sylvie Martel, Jonathan Rodriguez, Genevieve Fourel, Ulrich Valcourt, Julien C. Marie, Juan L. Iovanna, Laurent Bartholin
BIOCHEMICAL JOURNAL
(2012)
Article
Virology
Christophe Ramiere, Jonathan Rodriguez, Liviu S. Enache, Vincent Lotteau, Patrice Andre, Olivier Diaz
JOURNAL OF VIROLOGY
(2014)
Article
Hematology
O. Hequet, Q. H. Le, J. Rodriguez, P. Dubost, D. Revesz, A. Clerc, D. Rigal, G. Salles, B. Coiffier
TRANSFUSION AND APHERESIS SCIENCE
(2014)
Article
Cell & Tissue Engineering
Hugo Fabre, Maxime Ducret, Olivier Degoul, Jonathan Rodriguez, Emeline Perrier-Groult, Elisabeth Aubert-Foucher, Marielle Pasdeloup, Celine Auxenfans, Colin Mcguckin, Nico Forraz, Frederic Mallein-Gerin
STEM CELLS INTERNATIONAL
(2019)