Article
Clinical Neurology
Vincent Mysliwiec, Matthew S. Brock, Kristi E. Pruiksma, Casey L. Straud, Daniel J. Taylor, Shana Hansen, Shannon N. Foster, Sara Mithani, Sarah Zwetzig, Kelsi Gerwell, Stacey Young-McCaughan, Tyler Powell, John A. Blue Star, Daniel G. Cassidy, Jim Mintz, Alan L. Peterson
Summary: This study aimed to characterize the sleep disorders of insomnia, obstructive sleep apnea (OSA), and comorbid insomnia and OSA (COMISA) in active duty military personnel. The results showed that military personnel with insomnia only and COMISA had more severe symptoms of sleep disorders, sleep-related impairment, fatigue, and psychiatric disorders compared to those with OSA alone. These findings highlight the importance of comprehensive assessment for sleep-related impairment, sleep, and comorbid disorders in military personnel with clinically significant sleep disturbances.
Article
Psychiatry
Marike Lancel, Hein J. F. van Marle, Maaike M. Van Veen, Annette M. van Schagen
Summary: This article explores the complex relationship between sleep disturbances and PTSD, highlighting the significant impact of disturbed sleep on the outcome of PTSD. It discusses potential underlying neurophysiological mechanisms and presents perspectives on future multidisciplinary research for developing more effective sleep therapies to improve both sleep and PTSD.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Medicine, General & Internal
Colm B. Doody, Lindsay Robertson, Katie M. Cox, John Bogue, Jonathan Egan, Kiran M. Sarma
Summary: A review was conducted on resilience-building programmes for military personnel and frontline emergency workers prior to deployment, which found that interventions using cognitive behavioural therapy and mindfulness were relatively successful in enhancing resilience, however, the effectiveness in reducing symptoms of post-traumatic stress and PTSD remains uncertain.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Clinical Neurology
Bernice M. Wulterkens, Lieke W. A. Hermans, Pedro Fonseca, Jerryll Asin, Nanny Duis, Hennie C. J. P. Janssen, Sebastiaan Overeem, Merel M. van Gilst
Summary: This study investigated the differences in sleep structure between patients with OSA, insomnia, and COMISA, and found that patients with COMISA have specific characteristics of insomnia, including prolonged awakenings. This variable is distinctive compared to patients with OSA. The combination of prolonged awakenings and sleep-disordered breathing leads to increased sleep disturbance.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Psychiatry
Gregory M. Sullivan, R. Michael Gendreau, Judith Gendreau, Perry Peters, Ashild Peters, Jean Engels, Bruce L. Daugherty, Benjamin Vaughn, Frank W. Weathers, Seth Lederman
Summary: This study suggests that TNX-102 SL 5.6 mg reduces PTSD symptoms, improves sleep and psychosocial function, and is well tolerated.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Yujin Choi, Byunwoo Son, Woo-Chul Shin, Seong-uk Nam, Jaehong Lee, Jinwoong Lim, Sungha Kim, Changsop Yang, Hyeonhoon Lee
Summary: Dietary behaviors are associated with poor sleep quality and an increased risk of obstructive sleep apnea (OSA) among military service members. Skipping breakfast 1-2 times weekly and eating night meals daily are associated with poor sleep quality, while skipping breakfast daily and eating night meals daily are related to an increased risk of OSA.
NATURE AND SCIENCE OF SLEEP
(2022)
Editorial Material
Psychiatry
Jason C. DeViva, Elissa McCarthy, Gia M. Santoro
Summary: This study compared polysomnography results of 200 consecutive VA sleep clinic referrals with different mental health diagnoses and found differences in sleep variables among patients with PTSD, OTHMH, and NOMH. PTSD patients were younger and NOMH patients had shorter sleep duration and higher apnea-hypopnea index compared to OTHMH patients.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Brian A. Moore, Lynn M. Tison, Javier G. Palacios, Alan L. Peterson, Vincent Mysliwiec
Summary: This study found a significant increase in the incidence rates of insomnia and obstructive sleep apnea (OSA) in the U.S. military since 2005, with army personnel having higher diagnosis rates compared to other branches. Female service members were underdiagnosed in both disorders.
Article
Psychology, Multidisciplinary
Stacey Young-McCaughan, Casey L. Straud, Susannah Bumstead, Kristi E. Pruiksma, Daniel J. Taylor, Vanessa M. Jacoby, Jeffrey S. Yarvis, Alan L. Peterson, STRONG STAR Consortium
Summary: This study investigated the relationships between physical exercise, sleep, and PTSD. The results showed that adding exercise to PTSD treatment could reduce insomnia, but changes in insomnia did not predict changes in PTSD symptoms, nor did it significantly impact the relationship between exercise and PTSD symptom reductions.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Philine Rojczyk, Johanna Seitz-Holland, Elisabeth Kaufmann, Valerie J. Sydnor, Cara L. Kim, Lisa F. Umminger, Tim L. T. Wiegand, Jeffrey P. Guenette, Fan Zhang, Yogesh Rathi, Sylvain Bouix, Ofer Pasternak, Catherine B. Fortier, David Salat, Sidney R. Hinds, Florian Heinen, Lauren J. O'Donnell, William P. Milberg, Regina E. McGlinchey, Martha E. Shenton, Inga K. Koerte
Summary: Sleep disturbances are strongly associated with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD), and poor sleep quality has a compounding effect on white matter (WM) microstructure in veterans with comorbid PTSD+mTBI. Veterans with PTSD and comorbid PTSD+mTBI reported poorer sleep quality than those with mTBI or no history of PTSD or mTBI. Poor sleep quality fully mediated the association between greater PTSD symptom severity and impaired WM microstructure. Sleep-targeted interventions are necessary for improving brain health in veterans with PTSD+mTBI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Ross J. Marriott, Bhajan Singh, Nigel McArdle, Ellie Darcey, Stuart King, Daniela Bond-Smith, Ayesha Reynor, William Noffsinger, Kim Ward, Sutapa Mukherjee, David R. Hillman, Gemma Cadby
Summary: The severity of obstructive sleep apnea (OSA) is associated with cancer prevalence and incidence, although this association seems to be secondary to other risk factors for cancer development. Nocturnal hypoxemia is independently associated with prevalent cancer, but AHI is not independently associated with cancer prevalence.
Review
Behavioral Sciences
Reihaneh Ahmadi, Sama Rahimi-Jafari, Mahnaz Olfati, Nooshin Javaheripour, Farnoosh Emamian, Mohammad Rasoul Ghadami, Habibolah Khazaie, David C. Knight, Masoud Tahmasian, Amir A. Sepehry
Summary: Posttraumatic stress disorder (PTSD) is strongly associated with insomnia, and the prevalence of insomnia in PTSD patients is high. Screening and managing insomnia in PTSD patients are of great importance.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Zachary A. Haynes, Ian J. Stewart, Eduard A. Poltavskiy, Aaron B. Holley, Jud C. Janak, Jeffrey T. Howard, Jessica Watrous, Lauren E. Walker, Emerson M. Wickwire, Kent Werner, Lee Ann Zarzabal, Alan Sim, Adi Gundlapalli, Jacob F. Collen
Summary: This study investigates the incidence and predictors of obstructive sleep apnea among survivors of combat-related traumatic injury and a matched control group. The results show that traumatic brain injury, posttraumatic stress disorder, depression, anxiety, insomnia, and obesity were associated with the development of obstructive sleep apnea. The higher incidence in injured service members compared to uninjured ones appears to be driven by traumatic brain injury and the long-term mental health sequelae of injury.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Review
Clinical Neurology
Miguel Meira e Cruz, Meir H. Kryger, Charles M. Morin, Luciana Palombini, Cristina Salles, David Gozal
Summary: Although sleep-disordered breathing (SDB) and insomnia are often seen as distinct conditions, they share many common symptoms that may hinder diagnosis and treatment. In addition to possible bidirectional pathways, other factors such as circadian timing may play a role in their interrelationship.
Article
Oncology
Marn Joon Park, Kyung-Do Han, Jae Hoon Cho, Ji Ho Choi
Summary: Obstructive sleep apnea (OSA) may not affect the incidence of testicular cancer in the general adult population, but males over 65 may be more susceptible to OSA-related testicular cancer compared to younger individuals.
Review
Medicine, Research & Experimental
Patrick J. Smith, Rhonda M. Merwin
Summary: Physical activity has therapeutic potential in managing mental health disorders, with evidence supporting its efficacy in treating depression and anxiety. However, individual differences in response to exercise, the importance of sustained engagement, and disagreements on therapeutic mechanisms limit its use in mental health treatment. Understanding the interplay of neurobiological and behavioral mechanisms can inform personalized treatments for mental health. Future studies should leverage individual differences to optimize mental health benefits.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Respiratory System
C. Virginia O'Hayer, Caitlin M. O'Loughlin, Chelsi N. Nurse, Patrick J. Smith, Michael J. Stephen
Summary: This study examined the use of Acceptance and Commitment Therapy (ACT) delivered via telehealth to improve anxiety and depressive symptoms among individuals with cystic fibrosis. Results showed a significant reduction in psychological distress post-treatment, but this effect was not sustained at 3 months. Telehealth-delivered ACT was as effective as in-person treatment, and reductions in cognitive fusion were related to improvements in psychosocial functioning.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Geriatrics & Gerontology
Deborah M. Oyeyemi, Mary Cooter, Stacey Chung, Heather E. Whitson, Jeffrey N. Browndyke, Michael J. Devinney, Patrick J. Smith, Grant E. Garrigues, Eugene Moretti, Judd W. Moul, Harvey Jay Cohen, Joseph P. Mathew, Miles Berger
Summary: This study investigated the relationship between affective measures and cognition before and after non-cardiac surgery in older adults. The findings showed that greater depression and anxiety severity were associated with poorer cognitive performance both before and after surgery. However, baseline levels and postoperative changes in these affective symptoms were not associated with cognitive changes after surgery.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2022)
Article
Surgery
Joshua M. Diamond, Andrew M. Courtwright, Priya Balar, Michelle Oyster, Derek Zaleski, Joe Adler, Melanie Brown, Steven R. Hays, Nicole Sutter, Chris Garvey, Jasleen Kukreja, Ying Gao, Allan Bruun, Patrick J. Smith, Jonathan P. Singer
Summary: The study evaluated the feasibility, safety, and efficacy of a mHealth-supported physical rehabilitation intervention for frail lung transplant recipients. Utilization of the mHealth rehabilitation platform was found to be safe and well received, resulting in improvements in frailty, physical activity, and disability levels.
CLINICAL TRANSPLANTATION
(2021)
Article
Surgery
Marci M. Loiselle, Shaina Gulin, Terra Rose, Eileen Burker, Lauren Bolger, Patrick Smith
Summary: The study found that marijuana use in living kidney donor candidates is associated with various psychosocial risk factors, impacting behavioral adherence following kidney donation and reducing chances of committee approval for donation. This highlights the importance of considering potential overlay between psychosocial risk factors and marijuana use when evaluating kidney donors.
CLINICAL TRANSPLANTATION
(2021)
Review
Surgery
Patrick J. Smith, Guy Potter, Maria Manson, Michael Martin, Linda C. Cendales
Summary: The Duke HT program conducts comprehensive psychosocial assessments and collects psychometric data from 80 potential HT candidates, emphasizing the potential utility of this evaluation method.
CLINICAL TRANSPLANTATION
(2021)
Article
Surgery
Claire L. DeBolt, Ying Gao, Nicole Sutter, Allison Soong, Lorriana Leard, Golden Jeffrey, Mary Ellen Kleinhenz, Daniel Calabrese, John Greenland, Aida Venado, Steven R. Hays, Rupal Shah, Jasleen Kukreja, Binh Trinh, Nicholas A. Kolaitis, Vanja Douglas, Joshua M. Diamond, Patrick Smith, Jonathan Singer
Summary: Post-operative delirium after lung transplantation is common and associated with health-related quality of life and depressive symptoms. Delirium is linked to attenuated improvements in SF12-PCS but not SF12-MCS and GDS, and is also associated with an increased risk of mortality.
CLINICAL TRANSPLANTATION
(2021)
Article
Biophysics
Patrick J. Smith, Meagan Lew, Yen Lowder, Kristi Romero, Jillian C. Thompson, Lauren Bohannon, Alyssa Pittman, Alexandra Artica, Sendhilnathan Ramalingam, Taewoong Choi, Cristina Gasparetto, Mitchell Horwitz, Gwynn Long, Richard Lopez, David Rizzieri, Stefanie Sarantopoulos, Keith Sullivan, Nelson Chao, Anthony D. Sung
Summary: Neurocognitive impairments are common among adults undergoing HCT, with performance patterns varying by age. Pre-transplant frailty is associated with neurocognitive functioning and may predict poorer early clinical outcomes post-transplant.
BONE MARROW TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
James A. Blumenthal, Patrick J. Smith, Wei Jiang, Alan Hinderliter, Lana L. Watkins, Benson M. Hoffman, William E. Kraus, Stephanie Mabe, Lawrence Liao, Jonathan Davidson, Andrew Sherwood
Summary: The UNWIND randomized clinical trial showed that 12-week treatment of escitalopram was effective in reducing anxiety in patients with coronary heart disease (CHD), and these beneficial effects were sustained for 6 months posttreatment. However, exercise was not an effective treatment for anxiety in patients with CHD.
AMERICAN HEART JOURNAL
(2022)
Article
Geriatrics & Gerontology
Tara Dalton, Laurie D. Snyder, Erika Bush Buckley, Patrick J. Smith
Summary: This study investigated the relationship between pretransplant physical frailty, postoperative delirium, and short-term lung transplantation outcomes. The study found that lower pretransplant physical frailty was associated with a lower incidence of postoperative delirium, and that postoperative delirium was associated with fewer days alive outside of the hospital.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Neurosciences
Patrick J. Smith, Andrew Sherwood, Alan L. Hinderliter, Stephanie Mabe, Crystal Tyson, Forgive Avorgbedor, Lana L. Watkins, Pao-Hwa Lin, William E. Kraus, James A. Blumenthal
Summary: This study demonstrated the associations between impaired cerebrovascular reactivity (CVR) and cardiometabolic risk, obesity, vascular function, and cardiometabolic fitness among hypertensive individuals. Additionally, cardiometabolic fitness and dietary patterns were found to be related to changes in CVR, and the association between CVR and cognition was moderated by the duration of hypertension.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Respiratory System
Nicholas A. Kolaitis, Ying Gao, Allison Soong, John R. Greenland, Steven R. Hays, Jeffrey A. Golden, Aida Venado, Lorriana E. Leard, Rupal J. Shah, Mary Ellen Kleinhenz, Patricia P. Katz, Jasleen Kukreja, Paul D. Blanc, Patrick J. Smith, Jonathan Paul Singer
Summary: This study aimed to investigate the association between depressive symptoms over multiple assessments and allograft dysfunction and mortality following lung transplantation. The results showed that worsening depressive symptoms were associated with declines in lung function and increased mortality, highlighting depression as a modifiable risk factor for chronic lung allograft dysfunction and death.
Article
Peripheral Vascular Disease
Patrick J. Smith, Andrew Sherwood, Alan L. Hinderliter, Stephanie Mabe, Lana L. Watkins, Linda Craighead, Krista Ingle, Crystal Tyson, Forgive Avorgbedor, Pao-Hwa Lin, William E. Kraus, Lawrence Liao, James A. Blumenthal
Summary: Lifestyle modification in patients with resistant hypertension can improve cognitive function, which may be associated with reduced ambulatory blood pressure changes through weight loss.
JOURNAL OF HYPERTENSION
(2022)
Article
Surgery
Brittany Koons, Michaela R. Anderson, Patrick J. Smith, John R. Greenland, Jonathan P. Singer
Summary: Older adults, aged 65 and above, are the fastest growing age group undergoing lung transplantation. Emerging evidence suggests that measures of physiological age, such as frailty and neurocognitive function, may better predict poor transplant outcomes than chronological age. Efforts are needed to improve outcomes for this growing cohort of older lung transplant patients through better risk assessment and interventions targeting physiological aging.
CURRENT TRANSPLANTATION REPORTS
(2022)
Article
Surgery
Lillian M. Christon, Patrick J. Smith
Summary: This review summarizes the purpose and importance of pre-surgical psychosocial evaluation for lung transplantation and proposes a biopsychosocial model of phenotypes of risk and resilience. Evaluation domains include psychological, behavioral, cognitive, and social/environmental aspects. The psychosocial evaluation is an important component of the multidisciplinary evaluation process and can help identify areas for optimization before surgery.
CURRENT TRANSPLANTATION REPORTS
(2022)
