Article
Cell Biology
Ruohang He, Chaoqun Han, Ying Li, Wei Qian, Xiaohua Hou
Summary: The study demonstrated that bone marrow-derived MSCs could migrate to the colon, inhibit chronic inflammation, and regulate gut microbiome dysbiosis to suppress the development of CAC. The inhibitory effect on tumor initiation and progression was observed by reduced tumor numbers, decreased tumor cell proliferation, and induced tumor cell apoptosis. MSCs also showed the ability to promote gut microbiome normalization and inhibit chronic inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Heng Zhang, Wei Cai, Dan Xu, Jing Liu, Qiu Zhao, Su'E Shao
Summary: Bone marrow mesenchymal stem cells have a certain therapeutic effect on dextran sulfate sodium-induced colitis. It can improve the general signs of colitis in rats and reduce intestinal injury and inflammatory response. The immunoregulatory effect of bone marrow mesenchymal stem cells is achieved by enhancing the function of CD4+CD25+Foxp3+Treg and up-regulating the secretion of immunosuppressive inflammatory factors.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Review
Cell & Tissue Engineering
Gang Guo, Zhaobang Tan, Yaping Liu, Feiyu Shi, Junjun She
Summary: For the treatment of UC and CRC, MSC-Exo can exert beneficial effects through modulating immune responses and inducing anti-tumor responses via different mechanisms.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Yuji Tanimura, Toshiro Fukui, Shunsuke Horitani, Yasushi Matsumoto, Sachi Miyamoto, Ryo Suzuki, Toshihiro Tanaka, Takashi Tomiyama, Tsukasa Ikeura, Yugo Ando, Akiyoshi Nishio, Kazuichi Okazaki
Summary: The study developed an advanced CRC mouse model showing tumor infiltration into the submucosa and invasion into vessels. Furthermore, it re-confirmed the theory that pSmad2/3L-Thr-positive cells may be cancer stem cells.
Article
Integrative & Complementary Medicine
Li Xue-Ming, Yuan Ding-Yi, Liu Ya-Hui, Zhu Lei, Qin Hong-Kun, Yang Yu-Bing, Li Yan, Yan Fang, Wang Ya-Jing
Summary: Colorectal cancer (CRC) is the third most lethal cancer in the world, and its development is closely related to colon inflammatory responses. Panax notoginseng saponins (PNS) have been found to have anti-inflammatory, anti-oxidant, and anti-tumor effects. This study demonstrated that PNS has a protective effect against colitis-associated colorectal cancer (CAC), reducing the severity of colitis and preventing the occurrence of CAC. PNS relieved immunosuppression of Treg cells in the CAC microenvironment by inhibiting the expression of IDO1 mediated by STAT1. Rh1, a metabolite of PNS, showed the strongest inhibitory effect on IDO1 enzyme activity. These findings suggest that PNS has significant chemopreventive and immunomodulatory properties on CAC.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Review
Medicine, Research & Experimental
Meiqi Wang, Jiannan Li, Dongxin Wang, Ying Xin, Zhuo Liu
Summary: Colorectal cancer (CRC) is the third most common cancer worldwide and its prognosis is influenced by molecular subtypes and gene mutations, leading to recurrence, metastasis, and drug resistance. Mesenchymal stem cells (MSCs), characterized by self-renewal, multi-directional differentiation, and tissue re-population capabilities, can be isolated from various tissues and differentiated into different types of cells. MSCs have been used in the study of tissue repair mechanisms, graft-versus-host disease (GVHD), autoimmune-related diseases, and tumor development, due to their anti-inflammatory, multi-lineage differentiation, and homing capabilities. The integration of chemotherapy and MSC therapy could offer a new treatment approach for CRC patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Babak Jahangiri, Mohammad Khalaj-Kondori, Elahe Asadollahi, Leyli Purrafee Dizaj, Majid Sadeghizadeh
Summary: This study found that exosomes derived from mesenchymal stem cells (MSC-Exos) can suppress proliferation, migration, invasion, and metastasis while inducing apoptosis of colorectal cancer (CRC) cells through the miR-100/mTOR/miR-143 axis. These findings suggest that MSC-Exo treatment and miR-100 restoration may be potential therapeutic strategies for CRC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yasushi Matsumoto, Toshiro Fukui, Shunsuke Horitani, Yuji Tanimura, Ryo Suzuki, Takashi Tomiyama, Yusuke Honzawa, Tomomitsu Tahara, Kazuichi Okazaki, Makoto Naganuma
Summary: The AOM/DSS mouse model is a useful tool for studying colitis-associated colorectal cancer. Initial lesions in this model are characterized by micro-neoplastic lesions and changes in cell morphology. Additionally, the linker threonine-phosphorylated Smad2/3 (pSmad2/3L-Thr) is identified as a biomarker for tissue stem cells and cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yushi Abe, Daigo Ochiai, Masako Taguchi, Seiji Kanzaki, Satoru Ikenoue, Yoshifumi Kasuga, Mamoru Tanaka
Summary: Human amniotic fluid stem cells (hAFSCs) can form aggregates with host immune cells and alleviate inflammation. Additionally, hAFSCs can increase regulatory T cells in the acquired immune system. Therefore, hAFSCs play an important role in the treatment of inflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell & Tissue Engineering
Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Hakimeh Zali, Hassan Niknejad
Summary: Human amniotic fluid/membrane mesenchymal stem cells have conflicting roles in cancer treatment, with some studies demonstrating their anticancer effects while others suggesting their potential to promote cancer progression.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Athanasios Patsalias, Zuzana Kozovska
Summary: The study examines the potential of stem cells in cancer treatment, particularly in colorectal cancer. Stem cells can serve as biomarkers, facilitate personalized treatment, and guide the development of targeted therapies. The review suggests that stem cells offer dynamic potential for improving current treatment approaches and enhancing outcomes for cancer patients, specifically in CRC.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell & Tissue Engineering
Ting Yu, Si Chu, Xingxing Liu, Junyi Li, Qianyun Chen, Meng Xu, Hui Wu, Mingyue Li, Yalan Dong, Feng Zhu, Haifeng Zhou, Desheng Hu, Heng Fan
Summary: The study revealed that EphB2-EVs significantly enhanced the homing to the damaged colon, effectively alleviated intestinal mucosal inflammation, repaired damaged colon tissue, reduced oxidative stress, and demonstrated a strong immunomodulatory effect by modulating Th17/Treg balance and restraining STAT3 activation.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Gastroenterology & Hepatology
Jing-Lin Liu, Chu-Yi Wang, Tian-Yu Cheng, Youlutuziayi Rixiati, Cheng Ji, Min Deng, Su Yao, Li-Hua Yuan, Yuan-Yuan Zhao, Tong Shen, Jian-Ming Li
Summary: This study revealed the importance of circadian clock in regulating immune cells and related molecules in inflammatory bowel disease and associated colorectal cancer. Disruption of circadian clock leads to increased susceptibility to colitis and dysfunction of immune cells, which may promote the development of colorectal cancer. Low expression of the Bmal1 gene is associated with poorer prognosis in CRC patients.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Shujie Chen, Lina Fan, Yifeng Lin, Yadong Qi, Chaochao Xu, Qiwei Ge, Ying Zhang, Qiwen Wang, Dingjiacheng Jia, Lan Wang, Jianmin Si, Liangjing Wang
Summary: This study elucidates the functional role of Bifidobacterium adolescentis (B.a) in colorectal cancer (CRC) and its mechanism of action on cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME). Supplementation with B.a suppresses tumor growth by promoting the generation of a subset of CD143(+) CAFs and inhibiting Th2 cell infiltration. CD143(+) CAFs express GAS1 and have a tumor suppressive effect. The level of CD143(+) CAFs correlates with B.a abundance and predicts better survival outcomes in CRC patients.
CANCER COMMUNICATIONS
(2023)
Review
Cell Biology
Yingjie Dong, Qiuli Yang, Ruiying Niu, Zhiyuan Zhang, Yijin Huang, Yujing Bi, Guangwei Liu
Summary: Intestinal macrophages play a crucial role in maintaining intestinal homeostasis, inflammation, and cancer development. Understanding their functions and regulatory mechanisms is of great importance for the treatment of intestinal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)