Review
Biochemistry & Molecular Biology
Sara M. Ortega-Campos, Eva M. Verdugo-Sivianes, Ana Amiama-Roig, Jose R. Blanco, Amancio Carnero
Summary: The molecular machinery of the circadian clock regulates gene expression and cellular activities to adapt to daily light-dark cycles. Disruption of the circadian rhythm is an independent risk factor for cancer and circadian genes may play dual roles as tumor suppressors and oncogenes. Understanding the molecular basis of the circadian clock can help identify new markers and targets for cancer prognosis and therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biochemical Research Methods
Prabina Kumar Meher, Ansuman Mohapatra, Subhrajit Satpathy, Anuj Sharma, Isha Saini, Sukanta Kumar Pradhan, Anil Rai
Summary: A computational method based on Support Vector Machine (SVM) was developed to identify circadian genes, achieving an accuracy of 62.48%. The method was also applied for proteome-wide identification of circadian proteins in two cereal crops and functional annotation with Gene Ontology terms.
Article
Clinical Neurology
Long Niu, Feng Zhang, Xiaojiao Xu, Yuting Yang, Song Li, Hui Liu, Weidong Le
Summary: Chronic sleep deprivation impaired learning and memory, exacerbating disease progression in Alzheimer's disease (AD) mice. Abnormal expression of clock genes in the circadian rhythm-related nuclei, especially in AD mice, was found after chronic sleep deprivation. Moreover, abnormal tau phosphorylation was accompanied by alterations in BMAL1 protein levels in the retrosplenial cortex.
Article
Immunology
Feng Ling, Caijie Zhang, Xin Zhao, Xiangyang Xin, Shaozhen Zhao
Summary: This study identified key genes associated with circadian rhythms and explored potential drugs related to these genes in diabetic retinopathy (DR). The findings contribute to a better understanding of the pathogenesis of DR and provide insights for future therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cesar Rodriguez-Santana, Javier Florido, Laura Martinez-Ruiz, Alba Lopez-Rodriguez, Dario Acuna-Castroviejo, Germaine Escames
Summary: The circadian clock system plays a crucial role in regulating various physiological processes, and disruptions in this system have been linked to diseases such as cancer. Tumor cells exhibit abnormal circadian machinery, which affects cell cycle, repair mechanisms, and energy metabolism. Melatonin, produced by the pineal gland, has been shown to regulate clock gene expression in cancer cells, suggesting its potential anti-neoplastic effects. This review aims to explore the role of clock genes in cancer and the mechanisms through which melatonin regulates the tumor's circadian machinery, with the goal of proposing future clinical treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Raymond E. A. Sanchez, Franck Kalume, Horacio O. de la Iglesia
Summary: Nearly all mammals have robust daily rhythms called circadian rhythms, which are controlled by a master clock in the hypothalamus and affect various biological processes. This review summarizes the current understanding of circadian regulation of sleep, including neural circuitry, molecular mechanisms, and developmental regulation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Bala S. C. Koritala, Yin Yeng Lee, Shweta S. Bhadri, Laetitia S. Gaspar, Corinne Stanforth, Gang Wu, Marc D. Ruben, Lauren J. Francey, David F. Smith
Summary: The study used an IH mouse model to investigate the impact of IH on the circadian gene expression in central and peripheral tissues, revealing that the circadian clock in the liver is less sensitive to IH compared to the brain.
Review
Genetics & Heredity
Chaoran Liu, Xiangrong Tang, Zishan Gong, Wang Zeng, Qiao Hou, Renbin Lu
Summary: Nearly all living organisms have an internal circadian oscillation with a periodicity of approximately 24 hours. Misalignment between circadian rhythms and external environment can lead to circadian rhythm sleep disorders (CRSD), which have been found to be associated with adverse health consequences. Recent studies have made progress in understanding the genetic basis and pathological mechanisms of CRSD, particularly in advanced sleep-wake phase disorder (ASPD) and delayed sleep-wake phase disorder (DSPD).
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Renske Lok, Marisol Duran, Jamie M. Zeitzer
Summary: This study examines the effectiveness of flash therapy, a sequence of light flashes applied during sleep, in shifting the circadian clock. The results show that flash therapy can cause significant delays in the circadian timing, up to 6 hours, with minimal impact on sleep. This finding may have practical implications for shift workers and jet travelers.
SCIENTIFIC REPORTS
(2023)
Review
Clinical Neurology
Georg Nilius, Matthias Richter, Maik Schroeder
Summary: Sleep disorders and circadian dysrhythmias are common in critically ill patients, impacting prognosis. Despite scientific findings, sleep optimization is not a top priority in the ICU. Measuring and evaluating sleep in the ICU is challenging, and treatment focuses on non-pharmacologic and pharmacologic strategies, with pharmacological interventions alone being insufficient.
NATURE AND SCIENCE OF SLEEP
(2021)
Review
Biochemistry & Molecular Biology
Amnon Brzezinski, Seema Rai, Adyasha Purohit, Seithikurippu R. Pandi-Perumal
Summary: Circadian rhythms play a crucial role in controlling reproductive function, with melatonin regulating the reproductive responses of animals to environmental light conditions. Clock genes and circadian rhythms are associated with optimal reproductive performance through the synchronization of endogenous molecular clocks in various tissues throughout the body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Evrim Yildirim, Rachel Curtis, Dae-Sung Hwangbo
Summary: Biological clocks are essential mechanisms that synchronize physiological and behavioral processes with external cues to ensure organisms' fitness and survival. While the central clock in the brain drives daily activity rhythms, peripheral tissues have their own clock systems generating metabolic and physiological rhythms. The fruit fly Drosophila melanogaster has been a widely studied model organism for investigating the mechanism and functions of circadian clocks.
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Jonathan S. Yi, Nicolas M. Diaz, Shane D'Souza, Ethan D. Buhr
Summary: Most organisms have self-sustained circadian clocks that can be synchronized by environmental stimuli or oscillate indefinitely. In mammals, this is true at the molecular level for most cell types, with a core set of clock genes forming a transcriptional/translational feedback loop (TTFL) with a 24-hour period. The TTFL mechanism varies slightly in different cell types, but all involve similar core clock genes. The clock has unique outputs in different tissues, as cells convert the TTFL timing signals into orchestrated transcriptional oscillations of clock-controlled genes and cellular processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Construction & Building Technology
Celine Vetter, P. Morgan Pattison, Kevin Houser, Michael Herf, Andrew J. K. Phillips, Kenneth P. Wright, Debra J. Skene, George C. Brainard, Diane B. Boivin, Gena Glickman
Summary: Architectural lighting has significant biological effects on human health, but current applied lighting practices are limited. This review consolidates key references and terminology, outlining the physiological effects of light and emphasizing the importance of translating laboratory knowledge into practical lighting strategies. Future research is needed to further support human health through integrative lighting solutions with high biological potency during the day and low potency during the night.
Article
Clinical Neurology
Yves Dauvilliers, Lucie Barateau, Benita Middleton, Daan R. van der Veen, Debra J. Skene
Summary: This study identified differences in plasma metabolic profiles between patients with narcolepsy type 1 (NT1) and controls based on their BMI status. Common metabolites driving the differences between NT1 patients and controls were identified, with implications for glycine and serine, arachidonic acid, and tryptophan metabolism pathways. Additionally, potential metabolic diagnostic biomarkers for NT1 were proposed, including glutamate, sarcosine, serotonin, tryptophan, nonaylcarnitine, and some phosphatidylcholines, which could offer targets for obesity treatment in NT1.
Article
Biochemistry & Molecular Biology
Holly-May Lewis, Yufan Liu, Cecile F. Frampas, Katie Longman, Matt Spick, Alexander Stewart, Emma Sinclair, Nora Kasar, Danni Greener, Anthony D. Whetton, Perdita E. Barran, Tao Chen, Deborah Dunn-Walters, Debra J. Skene, Melanie J. Bailey
Summary: The impact of COVID-19 infection on human metabolism has been widely studied, but previous research focused on a single wave of infection. This study found that metabolic disturbance changed partially over the course of the pandemic, reflecting changes in variants, clinical presentation, and treatment regimes. Some metabolites were identified as robust indicators of COVID-19 infection across multiple waves. The research also supports the hypothesis that certain metabolic pathways remain disrupted several months after COVID-19 infection.
Article
Biology
Barbara N. Harding, Debra J. Skene, Ana Espinosa, Benita Middleton, Gemma Castano-Vinyals, Kyriaki Papantoniou, Jose Maria Navarrete, Patricia Such, Antonio Torrejon, Manolis Kogevinas, Marissa G. Baker
Summary: This study investigated the effects of rotating shift work on metabolic processing by analyzing plasma samples from male car factory shift workers. The findings suggest that night shift work is associated with changes in metabolites and disruptions in metabolic and biochemical pathways related to various health outcomes.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Matt Spick, Amy Campbell, Ivona Baricevic-Jones, Johanna von Gerichten, Holly-May Lewis, Cecile F. Frampas, Katie Longman, Alexander Stewart, Deborah Dunn-Walters, Debra J. Skene, Nophar Geifman, Anthony D. Whetton, Melanie J. Bailey
Summary: Treatments for COVID-19 infections have improved, with glucocorticoids playing a key role in reducing mortality rates. However, a study has found that glucocorticoids are not fully effective in addressing the diverse range of 'omics dysregulation caused by COVID-19 infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kirsten N. Redman, Katie E. O'Brien, Francieli S. Ruiz, Dale E. Rae, F. Xavier Gomez-Olive, Malcolm von Schantz, Karine Scheuermaier
Summary: People living with HIV have poorer sleep quality, shorter sleep duration, and earlier sleep phase, which has significant implications for their health and well-being.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Cecile F. Frampas, Katie Longman, Matt Spick, Holly-May Lewis, Catia D. S. Costa, Alex Stewart, Deborah Dunn-Walters, Danni Greener, George Evetts, Debra J. Skene, Drupad Trivedi, Andy Pitt, Katherine Hollywood, Perdita Barran, Melanie J. Bailey
Summary: Saliva metabolomics, particularly amino acids, can differentiate between high severity and low severity COVID-19 patients, expanding the understanding of COVID-19 metabolic dysregulation and potentially providing a non-invasive means of sampling patients for timely treatment.
Article
Biochemistry & Molecular Biology
Cheryl M. Isherwood, Daan R. van der Veen, Hana Hassanin, Debra J. Skene, Jonathan D. Johnston
Summary: This study suggests that the human circadian system can anticipate large meals. It also demonstrates that the timing of a three-meal daily feeding pattern can synchronize with circadian rhythms. Furthermore, the research shows that glucose concentrations decrease before the first meal and hunger increases before the predicted meal times in the large meal group.
Article
Biochemistry & Molecular Biology
Andreas Psomas, Namrata R. Chowdhury, Benita Middleton, Raphaelle Winsky-Sommerer, Debra J. Skene, Menno P. Gerkema, Daan R. van Der Veen
Summary: This study investigated the metabolic rhythms in the plasma metabolome of voles and found that there were both 24-hour circadian rhythms and faster 2-4 hour ultradian rhythms. These ultradian rhythms were synchronized with the circadian rhythms and were not aligned with meal timing, indicating their importance in metabolic regulation.
Article
Multidisciplinary Sciences
Tom Woelders, Victoria L. Revell, Benita Middleton, Katrin Ackermann, Manfred Kayser, Florence I. Raynaud, Debra J. Skene, Roelof A. Hut
Summary: Circadian rhythms have a significant impact on the human body, and estimating individual body time is crucial for optimizing behavior and for treating circadian rhythm disorders. This study presents a machine learning approach using plasma-derived metabolomics data to estimate circadian phase, which shows promising results compared to existing methods. Further validation is needed, but this technique has the potential to contribute to personalized optimization of behavior and clinical treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Nutrition & Dietetics
Paul W. Jefcoate, M. Denise Robertson, Jane Ogden, Jonathan D. Johnston
Summary: Time-restricted eating (TRE), which restricts energy intake to a 12-hour window per day, is a behavioral intervention that can help with weight management and improve cardiometabolic health. This study found that adherence to a prescribed TRE protocol was estimated to be around 63% based on continuous glucose monitoring data, and 61% based on subjective participant responses. Barriers to adherence were identified, including work schedules, social events, and family life.
Article
Biochemistry & Molecular Biology
Anthony Onoja, Johanna von Gerichten, Holly-May Lewis, Melanie J. Bailey, Debra J. Skene, Nophar Geifman, Matt Spick
Summary: The global COVID-19 pandemic has led to rapid advancements in vaccine development, diagnostic testing, and treatment. This study evaluates the robustness of proposed biomarker panels in distinguishing COVID-19-positive and negative patients in a hospital setting. The best-performing panel consists of nine biomarkers and shows promising results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Jefferson Souza Santos, Debra Jean Skene, Cibele Aparecida Crispim, Claudia Roberta de Castro Moreno
Summary: This study investigated the seasonal variation in food intake times and the differences between regions. The findings revealed that people in high-latitude regions tend to have later food intake times, while those in low-latitude regions tend to have earlier food intake times.
Article
Biochemistry & Molecular Biology
Juliane Hannemann, Debra J. Skene, Benita Middleton, Edzard Schwedhelm, Anika Laing, Rainer Boeger
Summary: Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) interfere with nitric oxide (NO) formation from L-arginine via different mechanisms. The plasma concentrations of L-arginine-related amino acid metabolites show diurnal variation, with L-arginine and homoarginine concentrations having a 12-hour period. ADMA and SDMA show a 24-hour rhythmicity. Night shift work does not significantly affect the central suprachiasmatic nuclei clock timing, melatonin and cortisol levels, or blood pressure patterns.