Article
Pharmacology & Pharmacy
Yanling Zhang, Chin-Ping Kung, Fotis Iliopoulos, Bruno C. Sil, Jonathan Hadgraft, Majella E. Lane
Summary: In this study, the dermal delivery of niacinamide (NIA) using different vehicles in human subjects was investigated using confocal Raman spectroscopy (CRS) and tape stripping (TS). The results showed that the PG:LA binary system had higher area under curve (AUC) values for NIA compared to other vehicles studied. Additionally, a strong correlation was found between in vitro cumulative permeation of NIA and AUC values from Raman intensity depth profiles. Overall, the findings demonstrate the potential of CRS for dermatopharmacokinetic studies in humans.
Article
Materials Science, Multidisciplinary
Lei Zhou, Shibin Wang, Jian Zhang, Jialin Wang, Chuanwei Li
Summary: A novel approach is presented for determining the anisotropic mechanical properties of human skin in vivo using the indentation method. The skin is considered as an anisotropic elastomer with fiber reinforcement and limiting extensibility. Unlike conventional tests, a special optical system is used to capture real-time contact morphology, revealing that the eccentricity of the elliptical contact region changes with pre-stretch due to its dependence on anisotropy.
MECHANICS OF MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Avnish Patel, Fotis Iliopoulos, Peter J. Caspers, Gerwin J. Puppels, Majella E. Lane
Summary: The composition of topical and transdermal formulations plays a crucial role in determining the drug delivery rate and extent through the skin. This study investigated the effects of commonly used excipients on the percutaneous absorption of ibuprofen, finding PG, DPG, and TPG to be more effective than PEG 300 in drug delivery. Quantitative CRS showed a positive correlation with in vitro diffusion studies, indicating its potential as a powerful tool for evaluating drug and vehicle delivery from dermal formulations.
Article
Pharmacology & Pharmacy
Fotis Iliopoulos, Choon Fu Goh, Tasnuva Haque, Annisa Rahma, Majella E. Lane
Summary: This study evaluated skin absorption of two topical dermatological drug products using confocal Raman spectroscopy (CRS) and tape stripping (TS) methods. The results demonstrate that CRS is capable of distinguishing skin delivery of drugs from different formulations, and support its use for non-invasive evaluation of topical products in vivo.
Article
Chemistry, Multidisciplinary
Xinyue Chen, Russell Hughes, Nic Mullin, Rhoda J. Hawkins, Ingunn Holen, Nicola J. Brown, Jamie K. Hobbs
Summary: The study quantified the micro-mechanical properties of metastatic breast tumors and their surrounding bone microenvironment using atomic force microscopy. It found that metastatic tumors have extremely low elastic modulus and viscosity, making them significantly more compliant than 2D in vitro cultured cancer cells and subcutaneous tumor explants. These findings demonstrate the utility of atomic force microscopy in studying complex tissues and provide new insights into the mechanical properties of cancer metastases in bone.
Article
Pharmacology & Pharmacy
Vijay Kumar Shankar, Anitha Police, Srinivas Ajjarapu, S. Narasimha Murthy
Summary: The study aimed to determine the in-vitro dermal kinetics of various constituents of silymarin in human skin models and develop a topical silymarin formulation. In-vitro studies showed that silymarin had a skin binding range of 2.09% to 12.3% and a half-life of over 15.5 hours in epidermal and dermal cells. Ex-vivo studies demonstrated that the developed silymarin formulation could deliver significant amounts of silymarin constituents into human skin, suggesting its potential for the treatment or management of various dermatological disorders.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Moon Sung Kang, Mina Kwon, Seok Hyun Lee, Won-Hyeon Kim, Gyeong Won Lee, Hyo Jung Jo, Bongju Kim, Seung Yun Yang, Ki Su Kim, Dong-Wook Han
Summary: Recent advances in 3D bioprinting technologies have made it possible to fabricate complex live 3D tissue analogs. In this study, 3D printed skin equivalents with hair follicle structures and different layers were successfully fabricated using GelMA/HAMA bioink. The bioink accurately reproduced the composition of native skin and demonstrated excellent properties for skin tissue engineering and regeneration.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Engineering, Environmental
Shaohan Zhang, Zhipeng Cheng, Ming Yang, Zijin Guo, Leicheng Zhao, Mujtaba Baqar, Yuan Lu, Lei Wang, Hongwen Sun
Summary: Liquid crystal monomers (LCMs) are recognized as emerging persistent, bioaccumulative, and toxic organic pollutants in liquid crystal displays. Dermal exposure was found to be the primary route of exposure for LCMs, but the bioavailability and mechanisms of dermal exposure remain unclear.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Huixin Wei, Xuliang Liu, Linan Li, Chuanwei Li, Wenjian Chen, Shibin Wang, Zhiyong Wang, Jianxiong Ma
Summary: This study developed a hybrid experimental-numerical method to characterize the mechanical properties of human skin, including the dermis and subcutaneous tissue. Through an indentation experiment and finite element analysis, the three-dimensional mechanical properties of in vivo skin were successfully determined, demonstrating the effectiveness of this method.
MECHANICS OF MATERIALS
(2021)
Article
Engineering, Biomedical
Thomas I. R. Hopkins, Victoria L. Bemmer, Stephen Franks, Carina Dunlop, Kate Hardy, Iain E. Dunlop
Summary: Follicle development in the ovary is tightly regulated and mechanically influenced, with significant variations in tissue stiffness across different regions. Large developmentally-advanced follicles are found to be mechanically dominant structures in the ovary. This study provides new insights for ovarian biomechanics and follicle tissue engineering.
Article
Medicine, Research & Experimental
Wannita Klinngam, Phetploy Rungkamoltip, Saowarose Thongin, Jaruwan Joothamongkhon, Phattharachanok Khumkhrong, Mattaka Khongkow, Katawut Namdee, Surapun Tepaamorndech, Puxvadee Chaikul, Mayuree Kanlayavattanakul, Nattaya Lourith, Kitiya Piboonprai, Uracha Ruktanonchai, Udom Asawapirom, Tawin Iempridee
Summary: Polymethoxyflavones extracted from Kaempferia parviflora can inhibit skin aging by reducing reactive oxygen species, promoting tropocollagen synthesis, and restoring essential components of the extracellular matrix, leading to anti-aging effects and increased skin stability.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Cornelia M. Keck, Ayat Abdelkader, Olga Pelikh, Sabrina Wiemann, Vasudha Kaushik, David Specht, Ralph W. Eckert, Reem M. Alnemari, Henriette Dietrich, Jana Bruessler
Summary: The study showed that post-mortem changes in porcine ears can affect the penetration efficacy of chemical compounds. Regardless of the post-slaughter storage time, all types of ears are suitable for dermal penetration testing. SmartFilms and nanostructured lipid carriers were found to be superior strategies for efficient delivery of curcumin through the skin.
Editorial Material
Surgery
Colton J. Ross, Bradley A. Miyake, Henry R. Marsh, Parker R. Bryant, Chung-Hao Lee, Guilherme C. Barreiro
Summary: Wound dehiscence in plastic surgery is often underreported and can be a sign of increased mortality and remission rates. The authors developed a lasso suture as a stronger alternative with a shorter operating time than the current standard. The lasso suture showed superior mechanical properties and faster performance compared to traditional sutures, making it a potential method for preventing wound dehiscence.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Dermatology
Taihao Quan, Yaping Xiang, Yingchun Liu, Zhaoping Qin, Yan Yang, George Bou-Gharios, John J. Voorhees, Andrzej A. Dlugosz, Gary J. Fisher
Summary: The aging process affects the structure and function of dermal collagen, leading to thinning, fragility, wrinkles, laxity, impaired wound healing, and a microenvironment conducive to cancer. CCN1 protein is elevated in aged human skin, and transgenic mice expressing CCN1 in dermal fibroblasts display accelerated skin dermal aging. This mouse model provides a novel tool for understanding and studying the mechanisms of skin aging.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Engineering, Biomedical
Xu Feng, Guo-Yang Li, Antoine Ramier, Amira M. Eltony, Seok-Hyun Yun
Summary: Traveling-wave optical coherence elastography is a promising technique for measuring tissue stiffness. This study develops a broadband Rayleigh-wave OCE technique to measure the elastic moduli of different skin layers and demonstrates its accuracy through analysis of surface waves.
ACTA BIOMATERIALIA
(2022)
Review
Biochemistry & Molecular Biology
Alfred Quillon, Berengere Fromy, Romain Debret
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2015)
Article
Chemistry, Physical
Federica Boraldi, Angelica Bartolomeo, Giulia Annovi, Romain Debret, Daniela Quaglino
Article
Geriatrics & Gerontology
Lea Moulin, Valerie Cenizo, Alengo Nyamay Antu, Valerie Andre, Sabine Pain, Pascal Sommer, Romain Debret
REJUVENATION RESEARCH
(2017)
Article
Dermatology
Carine Mainzer, Noelle Remoue, Jennifer Molinari, Patricia Rousselle, Carla Barricchello, Juliana C. Lago, Pascal Sommer, Dominique Sigaudo-Roussel, Romain Debret
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Engineering, Biomedical
Chloe Lorion, Clement Faye, Barbara Maret, Thomas Trimaille, Thomas Regnier, Pascal Sommer, Romain Debret
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2014)
Article
Dermatology
Romain Debret, Valerie Cenizo, Geraldine Aimond, Valerie Andre, Martine Devillers, Isabelle Rouvet, Andre Megarbane, Odile Damour, Pascal Sommer
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2010)
Article
Engineering, Biomedical
C. Pailler-Mattei, R. Debret, R. Vargiolu, P. Sommer, H. Zahouani
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2013)
Article
Engineering, Biomedical
C. Pailler-Mattei, L. Laquieze, R. Debret, S. Tupin, G. Aimond, P. Sommer, H. Zahouani
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2014)
Article
Chemistry, Applied
C. Mainzer, C. Barrichello, R. Debret, N. Remoue, D. Sigaudo-Roussel, P. Sommer
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2014)
Article
Dermatology
Choua Ya, Mariana Carranca, Dominique Sigaudo-Roussel, Philippe Faure, Berengere Fromy, Romain Debret
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2019)
Article
Engineering, Biomedical
Mariana Carranca, Louise Griveau, Noelle Remoue, Chloe Lorion, Pierre Weiss, Valerie Orea, Dominique Sigaudo-Roussel, Clement Faye, Daniel Ferri-Angulo, Romain Debret, Jerome Sohier
Summary: Reticulating PEG with DGL can provide intrinsic cell functionalities to PEG-based hydrogels and tailor the mechanical properties of the hydrogels. Cell adhesion is influenced by the concentration of DGL, cell viability depends on the ratio of DGL and PEG, and cell morphology and proliferation are mainly related to the hydrogel rigidity.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Silvia Stella Ramirez Caballero, Daniel Ferri-Angulo, Romain Debret, Fabien Granier, Sebastien Marie, Francois-Xavier Lefevre, Jean-Michel Bouler, Christelle Despas, Jerome Sohier, Bruno Bujoli
Summary: The study explores combining CPC with organic monomers to form a continuous biocompatible 3D polymeric subnetwork, increasing CPC permeability and accelerating its in vivo degradation. By forming polymers in the CPC microstructure, the size, density, and arrangement of apatite crystals can be manipulated, offering a new route to modulate the microstructure and porosity of apatitic cements.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Marie Hoareau, Naima El Kholti, Romain Debret, Elise Lambert
Summary: Elastic tissues require elastic fibers for proper function, and the lack of these fibers can lead to vascular pathologies. The zebrafish model organism is a compelling alternative to study these pathologies, especially for large-scale investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Louise Griveau, Marianne Lafont, Heloise Le Goff, Clemence Drouglazet, Baptiste Robbiani, Aurore Berthier, Dominique Sigaudo-Roussel, Najma Latif, Catherine Le Visage, Vincent Gache, Romain Debret, Pierre Weiss, Jerome Sohier
Summary: This study introduces an injectable hydrogel that forms porosity in vivo through a controlled effervescent reaction. The hydrogel, crosslinked by the reaction of polyethylene glycol with lysine dendrimers, forms highly interconnected porous networks by entrapping CO2 bubbles. The resulting hydrogels have cytocompatibility, modular mechanical properties, and support tissue remodeling and neovascularization, making them promising for clinical tissue repair.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Quentin Boete, Ming Lo, Kiao-Ling Liu, Guillaume Vial, Emeline Lemarie, Maxime Rougelot, Iris Steuckardt, Olfa Harki, Axel Couturier, Jonathan Gaucher, Sophie Bouyon, Alexandra Demory, Antoine Boutin-Paradis, Naima El Kholti, Aurore Berthier, Jean-Louis Pepin, Anne Briancon-Marjollet, Elise Lambert, Romain Debret, Gilles Faury
Summary: Elastic fibers are essential for arterial elasticity, and synthetic elastic protein treatment can enhance elastin synthesis, improve arterial structure and function in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)