期刊
SKIN PHARMACOLOGY AND PHYSIOLOGY
卷 27, 期 6, 页码 311-315出版社
KARGER
DOI: 10.1159/000359974
关键词
Niacinamide
Niacinamide, an amide of vitamin B-3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given a sufficient bioavailability, niacinamide has antipruritic, anti-microbial, vasoactive, photo-protective, sebostatic and lightening effects depending on its concentration. Within a complex metabolic system niacinamide controls the NF kappa B-mediated transcription of signalling molecules by inhibiting the nuclear poly (ADP-ribose) polymerase-1 (PARP-1). Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically founded evaluation, it can be stated that the use of niacinamide in galenic preparations for epicutaneous application offers most interesting prospects. (C) 2014 S. Karger AG, Basel
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