期刊
SKIN PHARMACOLOGY AND PHYSIOLOGY
卷 26, 期 4-6, 页码 331-342出版社
KARGER
DOI: 10.1159/000351815
关键词
Drug delivery; Transdermal patch; Skin; Heat-activated delivery; Iontophoresis
Despite its remarkable barrier function, the skin remains an attractive site for systemic drug delivery given its easy accessibility, large surface area and the possibility to bypass the gastrointestinal tract and the liver and so modify drug absorption kinetics. The pioneering work of Scheuplein, Higuchi and others in the 1960s helped to explain the processes involved in passive percutaneous absorption and led to the development of mathematical models to describe transdermal drug delivery. The intervening years have seen these theories turned to practice and a significant number of transdermal systems are now available including some that employ active drug delivery. This review briefly discusses the evolution of transdermal therapeutic systems over the years and the potential of newer transdermal technologies to deliver hydrophilic drugs and macromolecules through the skin. (C) 2013 S. Karger AG, Basel
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