Article
Infectious Diseases
Adrienne N-N Leussa, Marina Rautenbach
Summary: Previous research has found that cyclodecapeptides from the tyrothricin complex have strong activity against chloroquine sensitive Plasmodium falciparum. The aromatic residues in these cyclodecapeptides play an important role in their activity. However, the activity and resistance of these peptides may vary depending on the different modes of target interaction and the position of aromatic residues. This new insight could be useful for the design of small peptidomimetics with modulated activity and resistance.
Review
Dermatology
Franziska Rademacher, Regine Glaser, Jurgen Harder
Summary: The skin microbiota plays a crucial role in maintaining skin homeostasis, and dysbiosis may lead to cutaneous inflammation. Antimicrobial peptides (AMPs) may influence the microbiota by controlling their growth. A fine-tuned and well-balanced interplay between AMPs and the microbiota on the skin surface may be crucial for skin health.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Brittany Woodby, Erika Pambianchi, Francesca Ferrara, Jean-Philippe Therrien, Alessandra Pecorelli, Nicolo' Messano, Mary Ann Lila, Giuseppe Valacchi
Summary: Exposure to O3 is reported to affect AMP levels in the skin, playing a role in skin inflammatory conditions, indicating a possible defensive strategy against pollution-associated skin conditions.
Article
Biotechnology & Applied Microbiology
Lin Hou, Wei Wang, Mei-Kun Wang, Xue-Song Song
Summary: This study reports a multifunctional composite wound dressing loaded with chitosan-binding bFGF and antimicrobial peptides. The dressing exhibited excellent antibacterial activity, effectively inhibiting the growth of bacteria, and accelerated wound healing. Cell experiments and animal experiments demonstrated the positive effects of the composite dressing on cell growth and tissue repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Piotr Brzoza, Urszula Godlewska, Arkadiusz Borek, Agnieszka Morytko, Aneta Zegar, Patrycja Kwiecinska, Brian A. Zabel, Artur Osyczka, Mateusz Kwitniewski, Joanna Cichy
Summary: This review focuses on exploring cysteine-based redox active antimicrobial proteins/peptides in the skin and intestine, discussing the causal links between different redox environments of these barrier tissues and the ability of AMPs to control cutaneous and intestinal microbes, and highlighting how bacteria can influence the bactericidal potential of redox-sensitive AMPs through intrinsic mechanisms.
Article
Infectious Diseases
Anna Ramata-Stunda, Martins Boroduskis, Elza Kaktina, Liene Patetko, Uldis Kalnenieks, Zane Lasa, Marta Rubina, Inese Strazdina, Gints Kalnins, Reinis Rutkis
Summary: Skin and soft tissue infections (SSTIs) and acne are common skin conditions. Antibiotic resistance in pathogens causing SSTIs and acne is increasing, making treatment challenging. This study designed and compared six new antimicrobial peptides (AMPs) with existing ones. RP556 showed broad-spectrum antibacterial activity without cytotoxicity or hemolysis and stimulated IL-10 production. Four new AMPs showed specific activity against Cutibacterium acne below cytotoxic or hemolytic concentrations.
Review
Medicine, General & Internal
A. Riera-Mestre, P. Cerda, A. Iriarte, M. Graupera, F. Vinals
Summary: Translational Medicine plays a crucial role in bridging the gap between basic and clinical research, providing new tools and treatment methods that have important implications for disease management and future developments.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Antonio Maldonado-Barragan, Estibaliz Alegria-Carrasco, Maria del Mar Blanco, Ana Isabel Vela, Jose Francisco Fernandez-Garayzabal, Juan Miguel Rodriguez, Alicia Gibello
Summary: Lactococcus garvieae is an emerging pathogen that causes infectious diseases in animals and potentially in humans. In this study, two gene clusters encoding novel bacteriocins were identified in a plasmid of a clinical isolate. These bacteriocins exhibited inhibitory activity against L. garvieae strains and other bacteria, and they may use a mannose uptake system as a receptor. Interestingly, they were highly active against their own host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marija Petkovic, Michelle Vang Mouritzen, Biljana Mojsoska, Havard Jenssen
Summary: Cutaneous wound healing is a crucial biological process, with chronic wounds often arising from persistent inflammatory conditions caused by factors such as autoimmune diseases. Host defense peptides play a significant role in modulating immune skin function and offer potential for inspiring topical treatments for chronic wounds.
Article
Immunology
Aaroh Anand Joshi, Marc Vocanson, Jean-Francois Nicolas, Peter Wolf, Vijaykumar Patra
Summary: Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient's quality of life. Disrupted skin barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with increased Staphylococcus aureus colonization are critical components of AD pathogenesis. Decreased expression of AMPs in AD patients leads to increased colonization by Staphylococcus aureus. AMPs derived from the host and skin microbiome play a crucial role in defining the skin microbial landscape and maintaining immune homeostasis, making them potential therapeutics for AD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biophysics
Emanuelle D. Freitas, Rogerio A. Rataglioli, Josephine Oshodi, Marisa M. Beppu
Summary: The coronavirus pandemic has highlighted the importance of bioactive materials in mitigating viral infections. Bioinspired antimicrobial peptides (AMPs) have emerged as suitable building blocks for antimicrobial coatings due to their versatile design and environmentally friendly features. This review discusses the advances and opportunities in using AMPs to create virucidal coatings, including the fundamental characteristics of peptide structure, advances in coating medical devices, and the role of different materials in designing antiviral coatings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biology
Petros Ioannou, Stella Baliou, Diamantis P. Kofteridis
Summary: The article summarizes recent advancements in medical research and clinical practice, highlighting the significant limitations of antimicrobial resistance (AMR) on therapeutics for infectious diseases. It emphasizes the urgent need for novel treatments, particularly in the era of increasing AMR. Ongoing research is exploring non-classical therapies, such as bacteriophages or antimicrobial peptides (AMPs), that utilize alternative antimicrobial mechanisms to combat pathogens.
Article
Immunology
Alexander Humberg, Lisa Neuenburg, Hannah Boeckel, Mats Ingmar Fortmann, Christoph Haertel, Egbert Herting, Heilwig Hinrichs, Franziska Rademacher, Juergen Harder
Summary: This study examined the expression of antimicrobial peptides (AMPs) in the skin of preterm infants and found that the expression of AMPs was decreased in preterm infants compared to term infants. Preterm infants with infections or inflammation had higher concentrations of AMPs. These findings are significant for understanding the susceptibility to infection in preterm infants and developing new prevention strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Christina Van Anh Pham, Franziska Rademacher, Heilwig Hinrichs, Vera Beck-Jendroschek, Melanie Harder, Jochen Brasch, Regine Glaeser, Juergen Harder
Summary: The study focused on analyzing the secretion of relevant antimicrobial peptides and proteins (AMPs), especially RNase 7, human beta-defensin-2 (hBD-2), and the S-100 protein psoriasin (S100A7), in patients with confirmed tinea pedis. It was found that the AMP concentrations were significantly higher in the lesional skin of tinea pedis patients compared to non-lesional skin and healthy skin of controls, with elevated concentrations of hBD-2 and psoriasin.
Review
Immunology
Jingyan Guan, Congxiao Wu, Yunfan He, Feng Lu
Summary: The skin acts as a critical barrier tissue against external pathogens, with its uppermost epidermal layer and skin barrier immunity playing a vital role in maintaining its barrier function. The integrity and effectiveness of skin barrier immunity depend on the close interaction and communication between immune cells and the skin environment. Skin-associated adipocytes have been found to modulate skin immune responses and infection through the secretion of cytokines, adipokines, and antimicrobial peptides. This review summarizes recent research on the interactions between skin-associated adipocytes and other skin cells in maintaining the integrity and effectiveness of skin barrier immunity.
FRONTIERS IN IMMUNOLOGY
(2023)