期刊
SCIENTIFIC REPORTS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep13114
关键词
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资金
- National Cancer Institute of the National Institutes of Health [R01CA160998, P01CA084203]
- Precursory Research for Embryonic Science and Technology (PRESTO) of the Japan Science and Technology Agency (JST)
- KAKENHI from Japan Society for the Promotion of Science (JSPS) [21687011, 25713009]
- Grants-in-Aid for Scientific Research [25713009, 21687011] Funding Source: KAKEN
In photodynamic therapy (PDT), cells are impregnated with a photosensitizing agent that is activated by light irradiation, thereby photochemically generating reactive oxygen species (ROS). The amounts of ROS produced depends on the PDT dose and the nature of the photosensitizer. Although high levels of ROS are cytotoxic, at physiological levels they play a key role as second messengers in cellular signaling pathways, pluripotency, and differentiation of stem cells. To investigate further the use of photochemically triggered manipulation of such pathways, we exposed mouse osteoblast precursor cells and rat primary mesenchymal stromal cells to low-dose PDT. Our results demonstrate that low-dose PDT can promote osteoblast differentiation via the activation of activator protein-1 (AP-1). Although PDT has been used primarily as an anti-cancer therapy, the use of light as a photochemical molecular switch to promote differentiation should expand the utility of this method in basic research and clinical applications.
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