Article
Biochemistry & Molecular Biology
Tehila Daniel, Michaella Ben-Shachar, Elyashiv Drori, Sharleen Hamad, Anna Permyakova, Elad Ben-Cnaan, Joseph Tam, Zohar Kerem, Tovit Rosenzweig
Summary: Grape pomace has the potential to improve insulin sensitivity and reduce fat deposition in the liver, which may have beneficial health outcomes for the prevention and treatment of hepatic steatosis and other obesity-related pathologies.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, Maria Collantes, Philipp Kaldis, Jose Alfredo Martinez, Gema Medina-Gomez, Maria Jesus Moreno-Aliaga, Xavier Escote
Summary: The aim of this study was to investigate the effect of p27 deletion on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose homeostasis disturbances in mice. The results showed that p27 knockout mice were more prone to obesity and insulin resistance. The study suggested that p27 may play a role in brown adipose tissue activation and the development of obesity and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Christine Rouault, Genevieve Marcelin, Solia Adriouch, Cindy Rose, Laurent Genser, Marc Ambrosini, Jean-Christophe Bichet, Yanyan Zhang, Florian Marquet, Judith Aron-Wisnewsky, Christine Poitou, Sebastien Andre, Genevieve Derumeaux, Michele Guerre-Millo, Karine Clement
Summary: The study investigated adipose tissue senescent status and its relationships with metabolic complications in human obesity. Results indicated that senescent cells in subcutaneous adipose tissue are significantly linked to altered glucose metabolism and body fat distribution, and elimination of these cells could alleviate metabolic complications in severely obese individuals.
Article
Multidisciplinary Sciences
Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
Summary: Limited expandability of subcutaneous adipose tissue may be a characteristic of first-degree relatives of type 2 diabetes. This study found an association between family history of type 2 diabetes (FHD) and reduced subcutaneous fat mass in young Japanese women, suggesting impaired adipose tissue expandability.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Bluher, Andre Kleinridders
Summary: The intake of high-fat diets leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium can protect against the development of diet-induced insulin resistance. However, selenium might not be able to attenuate insulin resistance in the presence of obesity.
Review
Peripheral Vascular Disease
Dominic J. Chartrand, Adrien Murphy-Despres, Natalie Almeras, Isabelle Lemieux, Eric Larose, Jean-Pierre Despres
Summary: This article reviews the impact of obesity on cardiovascular disease and type 2 diabetes, highlighting the importance of visceral adiposity in these risk factors. It also proposes simple tools to improve cardiometabolic risk assessment in individuals with overweight/obesity.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Article
Endocrinology & Metabolism
Francisco Javier Ruiz-Ojeda, Jiefu Wang, Theresa Baecker, Martin Krueger, Samira Zamani, Simon Rosowski, Tim Gruber, Yasuhiro Onogi, Annette Feuchtinger, Tim J. Schulz, Reinhard Faessler, Timo D. Mueller, Cristina Garcia-Caceres, Matthias Meier, Matthias Blueher, Siegfried Ussar
Summary: The study shows that integrin signaling regulates white adipocyte insulin action and systemic metabolism. Loss of adipose integrin activity, similar to loss of adipose insulin receptors, leads to a lipodystrophy-like phenotype and systemic insulin resistance.
MOLECULAR METABOLISM
(2021)
Article
Food Science & Technology
Evangelia E. Tsakiridis, Marisa R. Morrow, Eric M. Desjardins, Dongdong Wang, Andrea Llanos, Bo Wang, Michael G. Wade, Katherine M. Morrison, Alison C. Holloway, Gregory R. Steinberg
Summary: Metabolic diseases are increasing worldwide and exposure to pesticides and pollutants may contribute to this trend. This study investigated the effects of the pesticide deltamethrin on metabolic disease development in mice fed a high-fat diet and housed at different temperatures. The results showed that low doses of deltamethrin improved metabolic parameters, while higher doses had no effect. Importantly, deltamethrin did not alter BAT thermogenesis markers or worsen obesity and insulin resistance in mice.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xincen Wang, Haohui Lan, Tong Sun, Peixu Cong, Changhu Xue, Jie Xu
Summary: Sea cucumber ether phospholipids (ether-PLs) have been found to modulate metabolic disorders caused by high-fat diet (HFD), and their effects are associated with oxidative stress and inflammation-related metabolic pathways.
Article
Biochemistry & Molecular Biology
Daniel Castellano-Castillo, Bruno Ramos-Molina, Wilfredo Oliva-Olivera, Luis Ocana-Wilhelmi, Maria Isabel Queipo-Ortuno, Fernando Cardona
Summary: This study aimed to analyze the changes in H3K4me3 histone mark in human adipose tissue under obesity and insulin resistance conditions. The results showed that H3K4me3 enrichment in gene promoters was closely related to higher mRNA levels, and differentially enriched H3K4me3 could regulate genes in adipose tissue, affecting its function during obesity and insulin resistance.
Article
Nutrition & Dietetics
Xin Shu, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Zuoqin Du, Jin Xu, Jingcan You, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu
Summary: The study suggests that PCSK9 expression in adipose tissue may mediate statin-induced adipocyte insulin resistance. PCSK9 deficiency could protect against statin-induced impairments in insulin signaling.
Review
Multidisciplinary Sciences
Chao Liao, Xinyin Liang, Xiao Zhang, Yao Li
Summary: The study found that GLP-1 receptor agonists significantly reduce visceral and liver fat content in adults. This has important implications for individuals with diabetes and non-alcoholic fatty liver disease.
Article
Multidisciplinary Sciences
Chun-Wei Lee, Chun-Ho Yun, Wen-Hung Huang, Ta-Chuan Hung, Cheng-Ting Tsai, Jen-Yuan Kuo, Cheng-Huang Su, Han-En Cheng, Chung-Lieh Hung, Charles Jia-Yin Hou
Summary: Visceral adipose tissue (VAT) is associated with central obesity, insulin resistance and metabolic syndrome. This study investigated the association between pericardial (PCF) and thoracic peri-aortic adipose tissue (TAT) with non-alcoholic fatty liver disease (NAFLD) and its relationship with cardiometabolic risk profiles. The study found that the accumulation of PCF and TAT was strongly correlated with the severity of NAFLD and provided incremental value for NAFLD diagnosis. TAT showed a stronger association with NAFLD diagnosis in the Asian population compared to PCF.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Aina Lluch, Sonia R. Veiga, Jessica Latorre, Jose M. Moreno-Navarrete, Nuria Bonifaci, Van Dien Nguyen, You Zhou, Marcus Hoering, Gerhard Liebisch, Vesa M. Olkkonen, David Llobet-Navas, George Thomas, Ruth Rodriguez-Barrueco, Jose M. Fernandez-Real, Sara C. Kozma, Francisco J. Ortega
Summary: Inhibiting the activity of ribosomal protein S6 kinase 1 (S6K1) can reduce fat mass expansion, improve dyslipidemia and hepatic steatosis. Additionally, decreased S6K1 activity is associated with defective epithelial-mesenchymal transition and impaired expression of fatty acid translocase and Galectin 1.
Article
Cardiac & Cardiovascular Systems
Kyoungmin Park, Qian Li, Matthew D. Lynes, Hisashi Yokomizo, Ernesto Maddaloni, Takanori Shinjo, Ronald St-Louis, Qin Li, Sayaka Katagiri, Jialin Fu, Allen Clermont, Hyunseok Park, I-Hsien Wu, Marc Gregory Yu, Hetal Shah, Yu-Hua Tseng, George L. King
Summary: This study found that activation of endothelial cells and eNOS by insulin can promote differentiation of PPCs into BAT, improving systemic bioenergetics and reducing atherosclerosis. This suggests that endothelial dysfunction is a major contributor of energy disequilibrium in obesity.
CIRCULATION RESEARCH
(2022)
Review
Endocrinology & Metabolism
Ulf Smith, Qian Li, Mikael Ryden, Kirsty L. Spalding
Summary: Cell senescence results in irreversible cell cycle arrest and the induction of a senescence-associated secretory phenotype (SASP), impacting cell proliferation and influencing the development of chronic diseases like diabetes and cardiovascular disease. Efforts to target senescent cells using senolytic compounds show promise in improving chronic disorders in experimental animal models.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Multidisciplinary Sciences
Roxana Khatib Shahidi, Jenny M. Hoffmann, Shahram Hedjazifar, Laurianne Bonnet, Ritesh K. Baboota, Stephanie Heasman, Christopher Church, Ivet Elias, Fatima Bosch, Jeremie Boucher, Ann Hammarstedt, Ulf Smith
Summary: GREM1 accumulates intracellularly when overexpressed in the liver cells of mature mice and is apparently not normally processed/secreted. However, repeated intraperitoneal injections were without effects on body weight and insulin sensitivity and adipose tissue UCP1 levels were only marginally reduced.
Article
Cell Biology
Lovisa I. Lyngfelt, Malin C. Erlandsson, Mitra Nadali, Shahram Hedjazifar, Rille Pullerits, Karin M. Andersson, Petra Brembeck, Sofia Toyra Silfversward, Ulf Smith, Maria I. Bokarewa
Summary: This study investigated the relationship between UCP1 expression and cardiovascular health in female RA patients. The results showed that high UCP1 transcription in adipose tissue was associated with active RA disease, high IL6 levels, and overweight status. Patients with high UCP1 levels displayed unfavorable metabolic profiles but had no significant difference in new cardiovascular and metabolic events compared to other RA patients.
Article
Multidisciplinary Sciences
Josefin Henninger, Bjorn Eliasson, Ulf Smith, Aidin Rawshani
Summary: The study utilized a multi-modal machine learning approach to investigate markers of adipose tissue morphology, insulin and glucose metabolism in non-obese male individuals. Different serum metabolites were found to be associated with various physiological markers, enhancing our understanding of type 2 diabetes.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Rosa Spinelli, Pasqualina Florese, Luca Parrillo, Federica Zatterale, Michele Longo, Vittoria D'Esposito, Antonella Desiderio, Annika Nerstedt, Birgit Gustafson, Pietro Formisano, Claudia Miele, Gregory Alexander Raciti, Raffaele Napoli, Ulf Smith, Francesco Beguinot
Summary: This study reveals that senescence of adipose precursor cells causes upregulation of the senescence-related gene ZMAT3, leading to impaired adipogenesis and increased risk of type 2 diabetes. The senescence of these cells is also accompanied by DNA hypomethylation at ZMAT3.
Article
Cell Biology
Luca Parrillo, Rosa Spinelli, Mattia Costanzo, Pasqualina Florese, Serena Cabaro, Antonella Desiderio, Immacolata Prevenzano, Gregory Alexander Raciti, Ulf Smith, Claudia Miele, Pietro Formisano, Raffaele Napoli, Francesco Beguinot
Summary: Impaired adipogenesis in relatives of type 2 diabetics is associated with reduced HOXA5 expression and altered DNA methylation, leading to subcutaneous adipocyte hypertrophy and increased diabetes risk.
Article
Cardiac & Cardiovascular Systems
Araz Rawshani, Naveed Sattar, Darren K. McGuire, Oskar Wallstrom, Ulf Smith, Jan Boren, Goran Bergstrom, Elmir Omerovic, Annika Rosengren, Bjorn Eliasson, Deepak L. Bhatt, Aidin Rawshani
Summary: The study found that the incidence of valvular disease is increasing among patients with diabetes. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were found to be associated with valvular lesions.
Article
Endocrinology & Metabolism
Birgit Gustafson, Annika Nerstedt, Rosa Spinelli, Francesco Beguinot, Ulf Smith
Summary: Obesity and type 2 diabetes (T2D) lead to increased senescence in adipose cells, resulting in dysfunctional cells and elevated levels of the cell cycle regulator cyclin D1 and senescence markers. These findings suggest a crucial role of senescent adipose cells in the development of obesity and diabetes.
Article
Endocrinology & Metabolism
Ritesh K. Baboota, Rosa Spinelli, Malin C. Erlandsson, Bruna B. Brandao, Marsel Lino, Hong Yang, Adil Mardinoglu, Maria I. Bokarewa, Jeremie Boucher, C. Ronald Kahn, Ulf Smith
Summary: Chronic hyperinsulinemia is directly linked to the onset and progression of hepatocyte senescence, as shown by increased expression of p53 and p21. This effect can be counteracted by reducing insulin receptor levels or using senolytic drugs such as dasatinib and quercetin.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Laurianne Bonnet, Ida Alexandersson, Ritesh K. K. Baboota, Tobias Kroon, Jan Oscarsson, Ulf Smith, Jeremie Boucher
Summary: Cellular senescence plays a causal role in the development of non-alcoholic steatohepatitis (NASH) by modulating glucose and lipid metabolism, favoring hepatic steatosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Araz Rawshani, Darren K. McGuire, Elmir Omerovic, Naveed Sattar, John J. V. McMurray, Ulf Smith, Bjorn Redfors, Lennart Bergfeldt, Bjorn Eliasson, Jan Boren, Deepak L. Bhatt, Goran Bergstrom, Aidin Rawshani
Summary: This study investigated the association between type 2 diabetes and cardiac arrhythmias and conduction disturbances. The results showed that patients with diabetes had a higher risk of arrhythmias and conduction abnormalities, but among patients with all risk factors controlled within target range, the excess risk associated with diabetes was virtually not evident.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Annika Nerstedt, Ulf Smith
Summary: In recent years, there has been a significant increase in the prevalence of obesity, leading to a growing interest in adipose tissue as a metabolically dynamic and endocrine organ. Obesity can lead to the development of metabolic diseases such as type 2 diabetes. Cellular senescence, a mechanism of aging, has been found to play a role in metabolic tissues and age-related conditions, including obesity.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Havard Attramadal, Sushanta K. Banerjee, Brahim Chaqour, Gary Fisher, Lester Lau, Bernard Perbal, Ulf Smith, Herman Yeger
Summary: To celebrate the 20th anniversary of the CCN society and hold the first post-Covid-19 live meeting, the ICCNS executive board chose Nice as the venue for the 11th International workshop on the CCN family of genes. Colleagues from other cell signaling fields were invited to present their work overview and future directions of their laboratory. Additionally, the JCCS Editorial Board members were invited to a special session for open discussions on all aspects of the journal.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Review
Medicine, Research & Experimental
Rosa Spinelli, Ritesh Kumar Baboota, Silvia Gogg, Francesco Beguinot, Matthias Bluher, Annika Nerstedt, Ulf Smith
Summary: Cell senescence (CS) plays a crucial role in the connection between aging and chronic disorders, and CS is more prevalent in major metabolic tissues with aging. However, CS is also increased in adult obesity, type 2 diabetes (T2D), and nonalcoholic fatty liver disease, regardless of aging. Dysfunction and inflammation are common features of senescent tissues, affecting both progenitor cells and mature differentiated cells. Recent studies have found that hyperinsulinemia and insulin resistance (IR) can promote CS in human adipose and liver cells. Conversely, increased CS also promotes cellular IR, indicating their interdependence. Additionally, increased adipose CS in T2D is not solely determined by age, BMI, or hyperinsulinemia, suggesting premature aging. These findings suggest that senomorphic/senolytic therapy could be important for treating common metabolic disorders.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Ritesh K. Baboota, Aidin Rawshani, Laurianne Bonnet, Xiangyu Li, Hong Yang, Adil Mardinoglu, Tamar Tchkonia, James L. Kirkland, Anne Hoffmann, Arne Dietrich, Jeremie Boucher, Matthias Bluher, Ulf Smith
Summary: Hepatic cell senescence is a key factor in human NAFLD/NASH. BMP4 and Gremlin 1 are identified as novel therapeutic targets.
