期刊
SIAM JOURNAL ON APPLIED DYNAMICAL SYSTEMS
卷 8, 期 1, 页码 253-278出版社
SIAM PUBLICATIONS
DOI: 10.1137/080724010
关键词
canards; synchrony; weak coupling; clusters; neurons
资金
- National Science Foundation
Applying a low current to a recent biophysical model for inhibitory neurons in the cortex leads to mixed mode oscillations (MMOs), a mixture of spikes and subthreshold oscillations. At higher currents, the neurons. re regularly. We show that a specific slow potassium current underlies this behavior. Next we reduce this five-dimensional biophysical model for an inhibitory neuron to three dimensions with a slow/fast time-scale structure. We then show that there is a range of parameters under which the reduced model shows MMOs which can be explained by the canard phenomenon. Many inhibitory interneurons are coupled with electrical tight junctions (gap junctions). We show that such coupling combined with the underlying MMOs produces clustered solutions in large networks. We explain this using the theory of weakly coupled oscillators and show that the complex dynamics arises from sensitivity near the canard.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据