Article
Cardiac & Cardiovascular Systems
Xiangyu Zhang, Trent D. Evans, Sunny Chen, Ismail Sergin, Jeremiah Stitham, Se-Jin Jeong, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Arick Park, In-Hyuk Jung, Abhinav Diwan, Joel D. Schilling, Oren Rom, Arif Yurdagul, Slava Epelman, Jaehyung Cho, Irfan J. Lodhi, Bettina Mittendorfer, Babak Razani
Summary: The mTOR pathway plays a significant role in atherosclerosis, with mTORC1 promoting lesion formation and mTORC2 inhibiting inflammatory response and regulating plaque complexity. The balanced and opposing roles of these two arms of mTOR signaling have important implications for plaque size and complexity.
CIRCULATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Panagiotis Theofilis, Evangelos Oikonomou, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Atherosclerotic diseases are a major global health issue, and understanding the role of macrophages in the development and regression of atherosclerosis is crucial for improving patient care. Tissue-resident and monocyte-derived macrophages have distinct functions in the atherosclerotic cascade, and targeting pathways such as M2 polarization and macrophage autophagy shows promise in preventing or treating atherosclerosis. Recent experimental studies have also identified macrophage receptors as potential drug targets, and macrophage-membrane-coated carriers have shown promising results as well.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Laura A. Bosmans, Claudia M. van Tiel, Suzanne A. B. M. Aarts, Lisa Willemsen, Jeroen Baardman, Bram W. van Os, Myrthe den Toom, Linda Beckers, David J. Ahern, Johannes H. M. Levels, Aldo Jongejan, Perry D. Moerland, Sanne G. S. Verberk, Jan van den Bossche, Menno M. P. J. de Winther, Christian Weber, Dorothee Atzler, Claudia Monaco, Norbert Gerdes, Annelie Shami, Esther Lutgens
Summary: This study investigates the role of CD40 in atherosclerosis and shows that inhibiting CD40 signaling can reduce atherosclerosis. The researchers used myeloid-specific CD40-deficient mice and found that the absence of CD40 in myeloid cells reduces atherosclerosis and systemic inflammation by preventing pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Bin Wen, Yuan-ye Dang, Su-hua Wu, Yi-min Huang, Kong-yang Ma, Yi-ming Xu, Xi-Long Zheng, Xiao-yan Dai
Summary: DHC ameliorates atherosclerosis in ApoE(-/-) mice by inhibiting inflammation, likely by targeting macrophage p65- and ERK1/2-mediated pathways.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Ning Huangfu, Yong Wang, Zhenyu Xu, Wenyuan Zheng, Chunlan Tao, Zhenwei Li, Yewen Hu, Xiaomin Chen
Summary: The study found that TDP43 promotes NF-κB activation, leading to increased expression of inflammatory factors in macrophages by triggering mitochondrial DNA release to activate the cGAS-STING signaling pathway. Additionally, TDP43 enhances lipid uptake in macrophages by regulating the beta-catenin and PPAR-γ complex, thereby promoting CD36 transcription and exacerbating atherosclerosis progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Phuong Tran Pham, Daiju Fukuda, Sachiko Nishimoto, Joo-Ri Kim-Kaneyama, Xiao-Feng Lei, Yutaka Takahashi, Tomohito Sato, Kimie Tanaka, Kumiko Suto, Yutaka Kawabata, Koji Yamaguchi, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi, Michio Shimabukuro, Mitsutoshi Setou, Glen N. Barber, Masataka Sata
Summary: The study indicates that the stimulator of interferon genes (STING) plays a role in atherosclerosis, and its signaling may serve as a potential therapeutic target for the disease by inhibiting STING activation to improve atherosclerosis progression.
EUROPEAN HEART JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Nikita G. Nikiforov, Antonina Starodubova, Tatyana Popkova, Alexander N. Orekhov
Summary: Atherosclerosis remains a major cause of death globally, primarily due to the lack of effective preventive and therapeutic measures. Lifestyle and genetic factors play significant roles in the development of the disease.
Article
Immunology
Sirui Shen, Zhuqi Huang, Liming Lin, Zimin Fang, Weixin Li, Wu Luo, Gaojun Wu, Zhouqing Huang, Guang Liang
Summary: This study suggests that TUS, a natural product with anti-inflammatory activities, can alleviate inflammation and reduce atherosclerotic plaque areas. The mechanism involves the inhibition of MAPK pathway phosphorylation. TUS may be a potential therapeutic candidate for atherosclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Jiayong Wu, Shengping He, Zhengkun Song, Sikai Chen, Xuefeng Lin, Huimei Sun, Pengyu Zhou, Qinbao Peng, Songlin Du, Shaoyi Zheng, Xiu Liu
Summary: Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries, with macrophages playing a crucial role in the inflammatory response. Modulating macrophage polarization has shown potential in controlling the progression of atherosclerosis. This review explores the role of macrophage polarization in atherosclerosis and summarizes emerging therapies for its regulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Hongxia Li, Zhiqiang Cao, Lili Wang, Chang Liu, Hongkun Lin, Yuhan Tang, Ping Yao
Summary: Cardiovascular diseases are mainly caused by atherosclerosis, and macrophages play a crucial role in its progression. The polarization phenotypes and death pathways of macrophages have an impact on plaque formation and cardiovascular vulnerability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Xiaorong Hu, Ruisong Ma, Jianlei Cao, Xianjin Du, Xinyong Cai, Yongzhen Fan
Summary: This study revealed the negative role of PTPN2 in atherosclerosis and provided a new potential target for its treatment.
Article
Biochemistry & Molecular Biology
Mathias Jensen, Nicoline W. Thorsen, Line A. E. Hallberg, Per Hagglund, Clare L. Hawkins
Summary: Neutrophil extracellular trap (NET) release plays a key role in chronic diseases like atherosclerosis, but the release of macrophage extracellular traps (METs) and their composition are less understood. This study investigated MET release from human THP-1 macrophages exposed to different stimuli and discovered that METs were composed of histones, various proteins involved in different cellular processes, and the absence of proteases. These findings provide new insights into the implications of MET formation in immune defense and pathology.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Christina Kassiteridi, Jennifer E. Cole, Thibault Griseri, Mika Falck-Hansen, Michael E. Goddard, Anusha N. Seneviratne, Patricia A. Green, Inhye Park, Annelie G. Shami, Tanyaporn Pattarabanjird, Aditi Upadhye, Angela M. Taylor, Ashok Handa, Keith M. Channon, Esther Lutgens, Coleen A. McNamara, Richard O. Williams, Claudia Monaco
Summary: The study demonstrates the significant role of CD200 in atherosclerosis, where CD200 deficiency increases atherosclerotic lesion formation. The CD200/CD200R pathway restrains macrophage activation and monocyte recruitment, limiting the progression of atherosclerosis.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Liangwei Duan, Yucong Zhao, Jing Jia, Tianzhu Chao, Hao Wang, Yinming Liang, Yunwei Lou, Qianqian Zheng, Hui Wang
Summary: In atherosclerosis, macrophages play an important role in inflammation. CD68, a specific receptor in macrophages, regulates the occurrence and development of atherosclerosis. CD68 deficiency can reduce atherosclerosis, decrease inflammation and necrotic content, and increase smooth muscle cell content in atherosclerotic plaques.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Immunology
Jan Nagenborg, Han Jin, Adele V. Ruder, Lieve Temmerman, Barend Mees, Casper Schalkwijk, Daniel Mueller-Klieser, Thorsten Berg, Pieter Goossens, Marjo M. P. C. Donners, Erik A. L. Biessen
Summary: In this study, the researchers identified STAT5A as an important determinant of macrophage functions and inflammation in the context of human atherosclerosis, highlighting its potential as a therapeutic target for plaque inflammation in human atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Hematology
Atsushi Sakamoto, Rika Kawakami, Kenji Kawai, Andrea Gianatti, Dario Pellegrini, Robert Kutys, Liang Guo, Masayuki Mori, Anne Cornelissen, Yu Sato, Antonio Bellasi, Lara Faggi, Charles Hong, Maria Romero, Giulio Guagliumi, Renu Virmani, Aloke V. Finn
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Denuja Karunakaran, My-Anh Nguyen, Michele Geoffrion, Dianne Vreeken, Zachary Lister, Henry S. Cheng, Nicola Otte, Patricia Essebier, Hailey Wyatt, Joshua W. Kandiah, Richard Jung, Francis J. Alenghat, Ana Mompeon, Richard Lee, Calvin Pan, Emma Gordon, Adil Rasheed, Aldons J. Lusis, Peter Liu, Ljubica Perisic Matic, Ulf Hedin, Jason E. Fish, Liang Guo, Frank Kolodgie, Renu Virmani, Janine M. van Gils, Katey J. Rayner
Summary: The study indicates that RIPK1 plays a central role in driving inflammation in atherosclerosis by activating the NF-kappa B pathway and promoting the release of inflammatory cytokines. Knockdown of RIPK1 reduces inflammatory cell activation and protects against the progression of atherosclerosis. These findings suggest RIPK1 as a potential therapeutic target to reduce residual inflammation in patients at high risk of coronary artery disease.
Article
Cardiac & Cardiovascular Systems
Dario Pellegrini, Rika Kawakami, Giulio Guagliumi, Atsushi Sakamoto, Kenji Kawai, Andrea Gianatti, Ahmed Nasr, Robert Kutys, Liang Guo, Anne Cornelissen, Lara Faggi, Masayuki Mori, Yu Sato, Irene Pescetelli, Matteo Brivio, Maria Romero, Renu Virmani, Aloke V. Finn
Summary: Analysis of heart tissue from 40 deceased COVID-19 patients revealed that microthrombi were the most common pathological cause of myocyte necrosis. Female patients with chronic kidney disease and shorter symptom onset to admission time were more likely to have myocyte necrosis. Tailored antithrombotic strategies may be useful to counteract the cardiac effects of COVID-19 infection.
Article
Hematology
Celestine N. Wanjalla, Mona Mashayekhi, Samuel Bailin, Curtis L. Gabriel, Leslie M. Meenderink, Tecla Temu, Daniella T. Fuller, Liang Guo, Kenji Kawai, Renu Virmani, Cathy Jenkins, Chike O. Abana, Christian M. Warren, Rama Gangula, Rita Smith, Meena S. Madhur, Aloke Finn, Alexander H. Gelbard, Yan Ru Su, Matthew J. Tyska, Spyros A. Kalams, David G. Harrison, Simon A. Mallal, Tarek S. Absi, Joshua A. Beckman, John R. Koethe
Summary: HIV-positive individuals with carotid atheroma show a higher proportion of circulating CD4(+) T-cells expressing the C similar to G similar to C surface marker combination associated with antiviral and cytotoxic responses. These cells can be cytomegalovirus-specific and are also present in the aorta.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mitchell J. Silver, Rika Kawakami, Michael A. Jolly, Christopher M. Huff, John A. Phillips, Atsushi Sakamoto, Kenji Kawai, Bob Kutys, Liang Guo, Anne Cornelissen, Masayuki Mori, Yu Sato, Maria Romero, Renu Virmani, Aloke V. Finn
Summary: Mechanical thrombectomy is increasingly used in the treatment of DVT and PE, allowing histopathologic comparison of extracted thrombi. The study found that thrombi from DVT cases were heavier and had different healing stages compared to PE cases, with PE cases having more red blood cell components.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Hiroyuki Jinnouchi, Yu Sato, Qi Cheng, Christine Janifer, Matthew Kutyna, Anne Cornelissen, Rashmi Wijeratne, Atsushi Sakamoto, Liang Guo, Frank D. Kolodgie, Stefan Tunev, Renu Virmani, Aloke V. Finn
Summary: The study showed that Onyx-DES demonstrated superior thromboresistance compared to PF-BES and Onyx-BMS, while its healing profile was equivalent to PF-BES. These findings suggest that Onyx-DES may offer advantages when considering short-term DAPT, especially in patients at high risk of bleeding.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yu Sato, Rika Kawakami, Hiroyuki Jinnouchi, Atsushi Sakamoto, Anne Cornelissen, Masayuki Mori, Kenji Kawai, Liang Guo, Leslie Coleman, Shannon Nash, Lisa Claude, Neil C. Barman, Maria Romero, Frank D. Kolodgie, Renu Virmani, Aloke Finn
Summary: This study aimed to understand the anatomy of periarterial nerve distribution in human accessory renal arteries. It found that ARAs have a smaller number of nerves compared to DRAs, but this difference depends on the size of the ARA.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Hematology
Anne Cornelissen, Liang Guo, Raquel Fernandez, Michael C. Kelly, Christine Janifer, Salome Kuntz, Atsushi Sakamoto, Hiroyuki Jinnouchi, Yu Sato, Ka Hyun Paek, Frank D. Kolodgie, Maria E. Romero, Dipti Surve, Renu Virmani, Aloke Finn
Summary: The study compared endothelialization in bare metal stents (BMS) and drug-eluting stents (DES) using a rabbit iliac artery model. It found that BMS had significantly greater stent coverage than DES. Single-cell RNA sequencing showed that DES-derived endothelial cells had upregulated genes associated with angiogenesis inhibition and endothelial activation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Instruments & Instrumentation
A. Habib, L. Habib, K. Habib
Summary: A fluid mechanics model was established to study the protection of COVID-19 virus through a facial mask, with semiempirical solutions predicting the efficiency of N95 masks under various parameters. The concept of an optimum unitless number Nr was introduced to describe gas flow through porous membranes, aiding in testing mask performance and designing new protective equipment.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2021)
Article
Medicine, Research & Experimental
Atsushi Sakamoto, Rika Kawakami, Masayuki Mori, Liang Guo, Ka Hyun Paek, Jose Verdezoto Mosquera, Anne Cornelissen, Saikat Kumar B. Ghosh, Kenji Kawai, Takao Konishi, Raquel Fernandez, Daniela T. Fuller, Weili Xu, Aimee E. Vozenilek, Yu Sato, Hiroyuki Jinnouchi, Sho Torii, Adam W. Turner, Hirokuni Akahori, Salome Kuntz, Craig C. Weinkauf, Parker J. Lee, Robert Kutys, Kathryn Harris, Alfred Lawrence Killey, Christina M. Mayhew, Matthew Ellis, Leah M. Weinstein, Neel V. Gadhoke, Roma Dhingra, Jeremy Ullman, Armella Dikongue, Maria E. Romero, Frank D. Kolodgie, Clint I. Miller, Renu Virmani, Aloke V. Finn
Summary: Vascular calcification (VC) and atherosclerosis coexist, but it is unclear why rupture-prone high-risk plaques do not typically calcify extensively. In this study, the researchers found that CD163+ macrophages, which are involved in atherosclerosis, have an inverse correlation with VC in human arteries. They also discovered that these macrophages inhibit VC through NF-KB-induced hyaluronan synthase (HAS), an enzyme that plays a role in the formation of the extracellular matrix. These findings provide insights into the mechanism by which CD163+ macrophages promote high-risk plaque development by inhibiting VC.
Article
Cardiac & Cardiovascular Systems
Atsushi Sakamoto, Sho Torii, Hiroyuki Jinnouchi, Liang Guo, Anne Cornelissen, Salome Kuntz, Qi Cheng, Raquel Fernandez, Ka Hyun Paek, Kathryn Harris, Mukta C. Srivastava, Frank D. Kolodgie, Renu Virmani, Aloke Finn
Summary: This study compared the neointimal formation and endothelial barrier function of biodegradable-polymer drug-eluting stents with other contemporary stents. While the neointimal formation was similar among the different stents, there were differences in endothelial barrier function.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2021)
Article
Cell Biology
Celestine N. Wanjalla, Wyatt J. McDonnell, Ramesh Ram, Abha Chopra, Rama Gangula, Shay Leary, Mona Mashayekhi, Joshua D. Simmons, Christian M. Warren, Samuel Bailin, Curtis L. Gabriel, Liang Guo, Briana D. Furch, Morgan C. Lima, Beverly O. Woodward, LaToya Hannah, Mark A. Pilkinton, Daniela T. Fuller, Kenji Kawai, Renu Virmani, Aloke Finn, Alyssa H. Hasty, Simon A. Mallal, Spyros A. Kalams, John R. Koethe
Summary: Individuals with HIV are at higher risk for diabetes compared to those without HIV, and T cells in adipose tissue play an important role in regulating glucose and lipid metabolism in both groups. The different subsets of T cells in adipose tissue of HIV and diabetes patients may have distinct characteristics and functions, with potential implications for future research on viral antigens and immune responses.
CELL REPORTS MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Atsushi Sakamoto, Yu Sato, Rika Kawakami, Anne Cornelissen, Masayuki Mori, Kenji Kawai, Raquel Fernandez, Daniela Fuller, Neel Gadhoke, Liang Guo, Maria E. Romero, Frank D. Kolodgie, Renu Virmani, Aloke V. Finn
Summary: In-stent restenosis is a major limitation to the success of percutaneous coronary intervention for the treatment of coronary artery disease. Drug-eluting stents have significantly reduced ISR rates, but late ISR, especially neoatherosclerosis, remains a challenge. Improved designs and further innovation are needed to address this issue for better long-term clinical outcomes.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2021)
Article
Endocrinology & Metabolism
Alexandra A. C. Newman, Vlad Serbulea, Richard A. Baylis, Laura S. Shankman, Xenia Bradley, Gabriel F. Alencar, Katherine Owsiany, Rebecca A. Deaton, Santosh Karnewar, Sohel Shamsuzzaman, Anita Salamon, Mahima S. Reddy, Liang Guo, Aloke Finn, Renu Virmani, Olga A. Cherepanova, Gary K. Owens
Summary: The study found that stable atherosclerotic plaques are composed of cells from various origins, including smooth muscle cells, endothelial cells, and macrophages that undergo different transitions to produce myofibroblast-like cells. Additionally, it was shown that myofibroblasts derived from endothelial-to-mesenchymal transition and macrophage-to-mesenchymal transition cannot indefinitely compensate for the loss of smooth muscle cell-derived myofibroblasts. Furthermore, the transitions from smooth muscle cells to myofibroblasts are induced by PDGF and TGF-beta, while endothelial-to-mesenchymal transition is induced by interleukin-1 beta and TGF-beta.
