Article
Immunology
Yuxin Guo, Chenxi Zeng, Chenjie Ma, Hongjiao Cai, Xinglong Jiang, Shaowei Zhai, Xiaojin Xu, Mao Lin
Summary: The whole genome of multidrug-resistant Aeromonas hydrophila MX16A was analyzed and compared revealing diverse mechanisms of drug resistance. The study demonstrated a variety of resistance mechanisms in the strain, indicating rich genetic diversity in the genome.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Fisheries
Thao P. H. Ngo, Huong T. T. Vu, Thao T. T. Le, Hieu C. N. Bui, Mark R. Liles, Channarong Rodkhum
Summary: This study identified and characterized two hypervirulent Aeromonas hydrophila (vAh) strains isolated from striped catfish in Vietnam for the first time. Comparative genomic analysis revealed that attachment and motility mediated by pili/fimbriae are key factors underlying the hypervirulent nature of vAh strains. Additionally, the study found that Vietnamese vAh strains have a closer genetic relationship with vAh strains isolated from carp species in China.
Article
Microbiology
Vera Irene Erickson, Le Minh Khoi, Yaovi Mahuton Gildas Hounmanou, Tu Thanh Dung, Tran Minh Phu, Anders Dalsgaard
Summary: This study confirms that Aeromonas dhakensis is the main pathogen causing Motile Aeromonas septicemia (MAS) in striped catfish farmers in Vietnam, while the importance of Aeromonas hydrophila may have been overestimated. The differences in antimicrobial susceptibility between the two species suggest a need for targeted antimicrobial treatment plans. Further experiments are needed to determine if there is a difference in the efficacy of available vaccines against A. hydrophila and A. dhakensis.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Ignacio Vasquez, Ahmed Hossain, Hajarooba Gnanagobal, Katherinne Valderrama, Briony Campbell, Michael Ness, Steve J. Charette, Anthony K. Gamperl, Rocco Cipriano, Cristopher Segovia, Javier Santander
Summary: In this study, the complete closed genomes of four Aeromonas salmonicida strains were sequenced and compared to elucidate their molecular diversity and pathogenic evolution. The genomic differences between typical and atypical strains were found to be mainly related to insertion sequences (ISs) activity. The relationship between phenotype and A. salmonicida subspecies' taxonomy was not evident.
Article
Fisheries
Shipo Li, Weihua Chu
Summary: This study demonstrated that butyrate can inhibit the growth and virulence factor production of Aeromonas hydrophila, improving host resistance to infection. Results showed that sub-MIC butyrate significantly increased survival rates of Caenorhabditis elegans and zebrafish challenged with A. hydrophila.
AQUACULTURE NUTRITION
(2021)
Article
Multidisciplinary Sciences
Yuan Yuan, Yaolei Zhang, Peijun Zhang, Chang Liu, Jiahao Wang, Haiyu Gao, A. Rus Hoelzel, Inge Seim, Meiqi Lv, Mingli Lin, Lijun Dong, Haoyang Gao, Zixin Yang, Francesco Caruso, Wenzhi Lin, Rute R. da Fonseca, Ding Wang, Xianyan Wang, Marianne H. Rasmussen, Mingming Liu, Jinsong Zheng, Liyuan Zhao, Paula F. Campos, Hui Kang, Maria Iversen, Yue Song, Xinyu Guo, Jiao Guo, Yating Qin, Shanshan Pan, Qiwu Xu, Lingfeng Meng, A. Yunga, Shanshan Liu, Simon Ming-Yuen Lee, Xin Liu, Xun Xu, Huanming Yang, Guangyi Fan, Kun Wang, Songhai Li
Summary: The study generated high-quality genome assemblies of 17 marine mammals, revealing unique and convergent genomic variations associated with the transition to aquatic life in marine mammal lineages. The research advances understanding of the timing, pattern, and molecular changes associated with the evolution of mammalian lineages adapting to aquatic life.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Liushen Lu, Junwei Wang, Ting Qin, Kai Chen, Jun Xie, Bingwen Xi
Summary: In this study, it was found that carvacrol, a natural compound found in plants, can effectively inhibit bacterial communication and reduce the toxicity of pathogenic bacteria. Carvacrol was shown to reduce the production of violacein in Chromobacterium violaceum and the concentration of N-acyl-homoserine lactones (AHLs) in Aeromonas hydrophila NJ-35. These findings suggest that carvacrol could be a potential strategy for reducing the virulence of pathogenic bacteria.
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Biotechnology & Applied Microbiology
Pedro G. Nachtigall, Luiz A. Bovolenta, James G. Patton, Bastian Fromm, Ney Lemke, Danillo Pinhal
Summary: Despite the differences in heart development among different vertebrate groups, both conserved and group-specific miRNAs play crucial roles in modulating the core and peripheral genes of heart GRNs. Conserved miRNAs have higher expression levels and more targets, while group-specific miRNAs have lower expression levels and fewer targets.
Article
Virology
Katarzyna Bujak, Przemyslaw Decewicz, Michal Kitowicz, Monika Radlinska
Summary: This study isolated and characterized three novel virulent Autographiviridae bacteriophages that infect different Aeromonas strains. Functional and comparative genomic analyses revealed their temperature adaptability and host discrimination capabilities.
Article
Microbiology
Lei Jin, Jingjiao Bao, Yu Chen, Wenge Yang, Wenyi Du
Summary: This study redefined AhyI as a multifunctional short- to long-chain AHL synthase, using C-4/C-6-ACP as preferred acyl substrates while also being able to synthesize medium- and long-chain AHLs. Structural comparison of AhyI revealed key residues driving the acyl-ACP substrate recognition, providing insights into the biosynthetic mechanism of AhyI.
Article
Multidisciplinary Sciences
Bahaa Abdella, Nourhan A. Abozahra, Nermeen M. Shokrak, Radi A. Mohamed, Ehab R. El-Helow
Summary: Aeromonas hydrophila is a common fish pathogen and opportunistic human pathogen. It causes diseases in fish and humans, and different factors influence its virulence. In this study, the genomes of 95 Aeromonas spp. strains were examined, and 53 strains were identified as A. hydrophila. The pan-genome analysis revealed 312 virulence genes, with effector delivery system category having the most number. Additionally, distinctive single-nucleotide polymorphisms (SNPs) were identified in four genes that can serve as molecular marker candidates for precise identification of A. hydrophila.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Hongbo Jiang, Jie Bao, Yuenan Xing, Xiaodong Li, Qijun Chen
Summary: This study sequenced the whole genome of the pathogenic yeast M. bicuspidata LNES0119 and performed comparative genomic analysis, identifying several characteristics related to pathogenicity and virulence. The findings provide valuable insights into understanding the molecular basis of M. bicuspidata pathogenicity and potential therapeutic targets.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Meng Wang, Yu Fan, Ping Liu, Yehua Liu, Jianlei Zhang, Yan Jiang, Chunlei Zhou, Lei Yang, Ce Wang, Chengqian Qian, Chao Yuan, Si Zhang, Xiaohang Zhang, Zhiqiu Yin, Hong Mu, Yuhui Du
Summary: Raoultella ornithinolytica is a poorly understood opportunistic pathogen with multidrug resistance mechanisms. The isolate WM1 exhibited resistance to multiple antimicrobials and carried two plasmids with multidrug resistance regions. In addition to virulence-related elements, the strain showed genetic diversity, emphasizing the importance of infection control and antimicrobial stewardship.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Microbiology
Xiaoqin Wu, Alexey E. Kazakov, Sara Gushgari-Doyle, Xingli Yu, Valentine Trotter, Rhona Kayra Stuart, Romy Chakraborty
Summary: This study investigated the genomic factors regulating violacein production in nine Janthinobacterium strains. Despite being closely related phylogenetically and containing essential genes for violacein biosynthesis, these strains showed variations in carbon usage and violacein production. Strains from sediment and groundwater exhibited weaker violacein production and fewer secondary metabolite biosynthesis genes than soil strains, indicating genome adaptation. The study also suggested that quorum sensing may play a role in regulating violacein in Janthinobacterium, with strains possessing both AHL QS and JQS systems showing stronger potential in violacein production.
MICROBIOLOGY SPECTRUM
(2021)
Letter
Surgery
Lulu Gao, Jiang Shen, Baihan Jin, Xiaoying Zhang
ASIAN JOURNAL OF SURGERY
(2023)
Article
Geriatrics & Gerontology
Yuhang Zhang, Xuyan Peng, Mengjiao Xue, Jingjing Liu, Guohui Shang, Mingjun Jiang, Dandan Chen, Baixue Liu, Yuxuan Wang, Xiaolin Jia, Jianqing Xu, Fengyan Zhang, Yanzhong Hu
Summary: SARS-Cov-2 spike protein (S-protein) leads to cellular senescence in ARPE-19 cells and the expression of senescence-associated cytokines in zebrafish retina. The mechanisms involve activation of ER stress, ROS, and NF-kappa B pathway. These findings suggest a potential connection between SARS-Cov-2 infection and the development of AMD.
Article
Cardiac & Cardiovascular Systems
You Zhou, Xuewen Song, Jifang Ma, Xianqing Wang, Haixia Fu
Summary: This study analyzed the association between systemic inflammation measured by six indices and left atrial thrombus in patients with valvular atrial fibrillation (VAF). The selected inflammatory indices were significantly and independently associated with left atrial thrombus among patients with VAF.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Pediatrics
Youran Xu, Hsingwen Chung, Meng Shu, Yanfang Liu, Yongjing Zhang, Hong Qiu
Summary: This study aims to summarize and visualize the OROS-MPH titration patterns in children and adolescents with ADHD in the United States (US) and Japan. The study found that US patients had higher doses of OROS-MPH compared to Japanese patients, and a minority of patients in both countries underwent dose titration. Different titration patterns were observed between the two countries.
Article
Materials Science, Ceramics
Dongxin Gao, Deye Lin, Ke Ren, Shiliang Luan, Guangxu Zhao, William Yi Wang, Jinshan Li, Yiguang Wang
Summary: The oxygen diffusion behaviors through barium-strontium aluminosilicates (BSAS), a typical EBC material, were studied. It was found that interstitial oxygen can stably exist and diffuse through BSAS, forming a complete three-dimensional diffusion network. The bond length of Si-Al-O was found to serve as a measure of interstitial oxygen diffusion in BSAS. The oxygen permeability of BSAS can be decreased by adjusting the proportions of alkaline earth elements present in the structure.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Environmental
Guoxi Luo, Jiaqi Xie, Jielun Liu, Qiankun Zhang, Yunyun Luo, Min Li, Wenke Zhou, Ke Chen, Zhikang Li, Ping Yang, Libo Zhao, Kwok Siong Teh, Xiaozhang Wang, Linxi Dong, Ryutaro Maeda, Zhuangde Jiang
Summary: As the use of smart wearable electronics becomes more prevalent, there is a need for stretchable, durable, and breathable electrodes that can easily integrate with the electronics and provide comfort to users over extended periods. However, progress in developing a scalable fabrication process for such electrodes has been limited. In this study, a novel stretchable polymer-carbon nanotube composite electrode was developed using a fibrous polyurethane mat decorated with conductive carbon nanotubes. The fabricated electrodes exhibited superior stretchability, conductivity, stability, durability, and air permeability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Xiangjie Liu, Xin Li, Xiaotong Yang, Jingqi Lu, Xuan Zhang, Du Yuan, Yizhou Zhang
Summary: This review focuses on the influence of water on the physiochemical properties of gel electrolytes for aqueous rechargeable zinc-ion batteries. It presents the correlation between water activity and the fundamental properties of zinc electrolytes, summarizes current approaches and challenges in manipulating water activity, and provides an outlook on approaches to tuning and investigating water activity for the design of advanced gel electrolytes.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Paleontology
Jun Yang, Yanyan Zhao, Haotian Wei, Sheng Liu, Guanglu Zhang, Haiyan Long, Sanzhong Li, Jishang Xu
Summary: This study evaluates the variations of sea surface temperature and salinity in the South China Sea during the Holocene, and identifies the corresponding influencing factors. The results show that sea surface temperature changes are consistent with the long-term trend of the Asian monsoon, and salinity in the South China Sea increased during the mid-late Holocene due to high sea levels and ocean water exchange.
MARINE MICROPALEONTOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Zhi Ni, Fan Zhu, Yucheng Fan, Jinlong Yang, Ziyan Hang, Chuang Feng, Jie Yang
Summary: This paper investigates the damped nonlinear vibration of the functionally graded graphene nanoplatelet-reinforced composite (FG-GNPRC) dielectric membrane. The effects of damping and dielectric properties are considered, and the governing equations are discretized and numerically solved. The influences of functionally graded distribution, damping, stretching ratio, dimensions of the membrane, and the attributes of the electrical field and GNP fillers on the nonlinear vibration of the structure are comprehensively investigated.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Article
Medicine, General & Internal
Ming-Jun Wu, Yu-Chun Chen, Xiao-Li Cui, Qian Yang, Qing-Liang Xue
Summary: This case study demonstrates the positive effect of the PD-1 immunosuppressant tislelizumab in treating basal cell carcinoma.
Article
Oncology
Yuqin Zang, Ruqian Zhao, Tao Wang, Yueqian Gao, Lingli Chen, Shiqi Liu, Yingmei Wang, Fengxia Xue
Summary: This study aimed to identify the key genes in cervical cancer progression using integrated bioinformatics analysis and experimental validation. Through analysis of gene expression and miRNA expression data, differentially expressed genes and miRNAs in the progression of cervical cancer were identified. It was found that SMC4, ATAD2, and POLQ genes play a crucial role in cervical cancer. Knocking down POLQ expression was shown to inhibit cell proliferation, migration, and invasion, and promote apoptosis and G2 phase cell cycle arrest. In conclusion, POLQ may have a close interaction with SMC4 and ATAD2 and play a vital role in the progression of cervical cancer.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hui Ye, Yuqin Luo, Yanjie Li, Xiangyun Wang, Hongmei He, Jinhua Jiang, Jianzhong Yu, Changpeng Zhang
Summary: A simple and sensitive method using solid-phase extraction (SPE) with polymer anion exchange (PAX) and Florisil followed by LC-MS/MS was established for the simultaneous quantitation of prohexadione-Ca and uniconazole in the field experiment of Oryza sativa L. and Citrus reticulata Blanco. Residue tests conducted at 12 representative sites in China showed that the final concentrations of prohexadione-Ca and uniconazole in rice crops and citrus fruits were below the maximum residue limits specified in China. The chronic dietary risks associated with the daily consumption of rice crops and citrus fruits at the recommended dosage were calculated to be acceptable.
Article
Biochemistry & Molecular Biology
Yan Chen, Jian-Qiang Zhao, Yan-Ping Zhang, Ming-Qiang Zhou, Xiao-Mei Zhang, Wei-Cheng Yuan
Summary: A catalytic asymmetric dearomative [3+2] cycloaddition of a-imino ?-lactones with 3-nitroindoles or 2-nitrobenzofurans using a chiral copper complex as the catalyst has been developed. This method allows for the smooth synthesis of structurally diverse polyheterocyclic compounds with spirocyclic-fused butyrolactone-pyrrolidine-indoline and butyrolactone-pyrrolidine-dihydrobenzofuran skeletons, showing excellent results (>99:1 dr and 98% ee). The scalability and potential synthetic applications of this methodology were also demonstrated.
Article
Plant Sciences
Xiuyuan Wang, Chong Teng, Kaidi Lyu, Qianqian Li, Wentao Peng, Lijuan Fan, Shanhua Lyu, Yinglun Fan
Summary: Composite plants with transgenic hairy roots produced by Agrobacterium rhizogenes-mediated transformation have provided an important means to study the interaction between plants and arbuscular mycorrhizal fungi (AMF). However, not all the hairy roots induced by A. rhizogenes are transgenic, necessitating the use of a binary vector carrying a reporter gene to distinguish transgenic roots. In this study, AtMYB75 was successfully used as a reporter gene in tomato hairy root transformation, resulting in anthocyanin accumulation without affecting AMF colonization.
Article
Geosciences, Multidisciplinary
Wanpeng Ding, Zhijian Wu, Beilei Zhan, Jian Liu, Jun Bi
Summary: On May 22, 2021, a 7.4 magnitude earthquake with a focal depth of 17 km struck Maduo County, Qinghai Province, China. The earthquake occurred near the northern boundary of the Bayan Har block and caused the collapse of two highway bridges, including the Yematan bridge. Analysis of the seismic damage characteristics of the Yematan bridge revealed that the main causes of the bridge damage were the large beam displacement caused by the velocity pulse and the low-frequency components of ground motion.
