Article
Immunology
Omnia Elebyary, Noah Fine, Chunxiang Sun, Sourav T. Saha, Shawn Robinson, Zahra Dorna Mojdami, Nicole Khoury, Erin Watson, Bryan Coburn, Jeffrey H. Lipton, Michael Glogauer
Summary: Allogeneic stem cell transplant recipients with <10% primed polymorphonuclear neutrophils (pPMNs) exhibited a greater risk of developing bloodstream infections, highlighting the potential use of pPMN quantification in monitoring susceptibility to these infectious complications.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Veterinary Sciences
Magdalena Grabbe, Ivan Conejeros, Zahady D. Velasquez, Seyed Sajjad Hasheminasab, Faustin Kamena, Axel Wehrend, Ulrich Gaertner, Anja Taubert, Carlos Rodrigo Hermosilla
Summary: In this study, it was shown for the first time that neonate bovine PMN are capable of forming NETs against C. parvum-sporozoites and oocysts, regardless of their stage. The research also found that C. parvum strongly induces suicidal neonatal NETosis in a P2X1-dependent manner, suggesting its anti-cryptosporidial effects through various mechanisms.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Ophthalmology
Emma M. Lessieur, Haitao Liu, Aicha Saadane, Yunpeng Du, Jie Tang, Jianying Kiser, Timothy S. Kern
Summary: Previous studies indicate that neutrophils, especially neutrophil elastase (NE), play a causal role in the capillary degeneration observed in diabetic retinopathy (DR). In this study, it was found that blocking NE activity could be a novel therapy to inhibit DR development.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Immunology
Andre Bredthauer, Angela Geiger, Michael Gruber, Sophie-Marie Pfaehler, Walter Petermichl, Diane Bitzinger, Thomas Metterlein, Timo Seyfried
Summary: Propofol has been shown to have an impact on the activity of neutrophils, accelerating NETosis and ROS production in sepsis. The drug demonstrates positive effects in improving immune function, but further research is needed to explore its potential benefits in septic patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Critical Care Medicine
Aida Meghraoui-Kheddar, Benjamin G. Chousterman, Noelline Guillou, Sierra M. Barone, Samuel Granjeaud, Helene Vallet, Aurelien Corneau, Karim Guessous, Charles de Roquetaillade, Alexandre Boissonnas, Jonathan M. Irish, Christophe Combadiere
Summary: This study aimed to identify early and specific immune signatures of sepsis severity, as well as to distinguish sepsis patients from those with noninfectious inflammatory syndrome. The results revealed two new subsets of neutrophils that are specific to sepsis and detectable through routine blood tests. This finding represents a key biological milestone that can lead to improvements in patient care.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Immunology
Lu Chen, Min Li, Yingyi Lin, Yanzhen Li, Min Liang, Kai Zeng
Summary: The research investigates the mechanism of neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats. It reveals that dexmedetomidine and neutrophil elastase can improve the color and morphology of renal tissue, reduce inflammatory cell infiltration, and alleviate renal tubular injury. By inhibiting the inflammatory response, neutrophil elastase actively reduces sepsis-related renal injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ankita Tulangekar, Tamar E. Sztal
Summary: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by mutations in the dystrophin gene. Lack of functional dystrophin protein leads to fragile muscle membranes and increased susceptibility to damage during contraction. Inflammation plays a crucial role in exacerbating muscle damage and impairing regeneration in DMD patients, with neutrophils releasing inflammatory compounds that prolong the inflammatory response.
Review
Cell Biology
Nan Zhang, Xiahenazi Aiyasiding, Wen-jing Li, Hai-han Liao, Qi-zhu Tang
Summary: Myocardial infarction is a common and life-threatening cardiac emergency. Neutrophils, through the release of granule proteins, play an important role in the inflammation and immune response associated with myocardial infarction.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Immunology
Pawel Piatek, Magdalena Namiecinska, Natalia Lewkowicz, Malgorzata Kulinska-Michalska, Zbigniew Jablonowski, Mariola Matysiak, Justyna Dulska, Sylwia Michlewska, Marek Wieczorek, Przemyslaw Lewkowicz
Summary: This study observed rapid changes in neutrophil status and identified transcriptional start sites associated with the plasticity and heterogeneity of neutrophils. Gene Ontology analysis showed these sites are responsible for various neutrophil functions. Additionally, the study discovered that IL-10-induced apoptotic neutrophils are transcriptionally active and capable of switching the cytokine expression profile required for resolving inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Chinchu Jagadan Ushakumari, Qiong L. Zhou, Yu-Hua Wang, Sijia Na, Michael C. Rigor, Cindy Y. Zhou, Max K. Kroll, Benjamin D. Lin, Zhen Y. Jiang
Summary: In this study, it was found that neutrophil elastase (NE) activates protease-activated receptor-2 (PAR2) signaling pathway and promotes changes in actomyosin and VE-cadherin, leading to increased vascular permeability and leukocyte infiltration in obesity-related inflammation. Inhibition of NE may be a potential approach to mitigate vascular injury and leukocyte infiltration in obesity-related systemic inflammation.
Article
Biochemistry & Molecular Biology
Yuko Ishida, Siying Zhang, Yumi Kuninaka, Akiko Ishigami, Mizuho Nosaka, Isui Harie, Akihiko Kimura, Naofumi Mukaida, Toshikazu Kondo
Summary: Intense neutrophil infiltration is a characteristic of acetaminophen-induced acute liver injury. In this study, the efficacy of a specific neutrophil elastase inhibitor, sivelestat, was investigated in mice with acetaminophen-induced liver injury. Treatment with sivelestat resulted in improved survival, reduced liver damage, decreased NOS-II expression, and diminished neutrophil infiltration. These findings suggest a new clinical application for sivelestat in the treatment of acetaminophen-induced liver failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yali Sun, Xianfei Ding, Yuqing Cui, Hongyi Li, Dong Wang, Huoyan Liang, Shaohua Liu, Xiaojuan Zhang, Haixu Wang, Tongwen Sun
Summary: This study demonstrates that the administration of Sivelestat in septic rats can improve survival, gut microbiota composition, and associated metabolites, providing new options for sepsis treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sanjay Pandey, Vandana Anang, Saurabh Singh, Saurabh Seth, Anant Narayan Bhatt, Namita Kalra, Kailash Manda, Ravi Soni, Bal Gangadhar Roy, K. Natarajan, Bilikere S. Dwarakanath
Summary: Pathogen-associated molecular patterns (PAMPs) are known ligands of innate inflammatory receptors that trigger acute inflammation and oxidative stress-driven tissue toxicity. Targeting the metabolism of inflammatory events, using an energy restriction approach, can be an effective strategy to prevent the detrimental effects of bacterial and other pathogenic exposures.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Anchit Bhagat, Pradeep Shrestha, Prince Jeyabal, Zhanglong Peng, Stephanie S. Watowich, Eugenie S. Kleinerman
Summary: This study reveals the roles of neutrophils and neutrophil elastase (NE) in Doxorubicin-induced cardiotoxicity for the first time, and suggests a new potential therapeutic intervention.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Shujing Zou, Hongyu Jie, Xinai Han, Jinghong Wang
Summary: Neutrophil extracellular traps (NETs) play a critical role in the inflammatory response and bacterial clearance, but their excessive activation can cause an inflammatory storm and organ dysfunction. Acute lung injury caused by sepsis is the main cause of organ damage. NET formation can accelerate the development of acute lung injury through the release of cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Critical Care Medicine
Yuka Sumi, Carola Ledderose, Linglin Li, Yoshiaki Inoue, Ken Okamoto, Yutaka Kondo, Koichiro Sueyoshi, Wolfgang G. Junger, Hiroshi Tanaka
Article
Biochemistry & Molecular Biology
Koichiro Sueyoshi, Carola Ledderose, Yong Shen, Albert H. Lee, Nathan I. Shapiro, Wolfgang G. Junger
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Tobias Woehrle, Carola Ledderose, Jessica Rink, Christian Slubowski, Wolfgang G. Junger
PURINERGIC SIGNALLING
(2019)
Article
Biochemistry & Molecular Biology
Severin Muehleder, Christiane Fuchs, Jose Basilio, Dorota Szwarc, Karoline Pill, Krystyna Labuda, Paul Slezak, Christian Siehs, Johannes Proell, Eleni Priglinger, Carsten Hoffmann, Wolfgang G. Junger, Heinz Redl, Wolfgang Holnthoner
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Cell Biology
Yutaka Kondo, Carola Ledderose, Christian J. Slubowski, Mahtab Fakhari, Yuka Sumi, Koichiro Sueyoshi, Ann-Katrin Bezler, Dilan Aytan, Mona Arbab, Wolfgang G. Junger
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Critical Care Medicine
Yutaka Kondo, Koichiro Sueyoshi, Jingping Zhang, Yi Bao, Xiaoou Li, Mahtab Fakhari, Christian J. Slubowski, Soheyl Bahrami, Carola Ledderose, Wolfgang G. Junger
Article
Allergy
Tanya Novak, Mark W. Hall, Douglas R. McDonald, Margaret M. Newhams, Anushay J. Mistry, Angela Panoskaltsis-Mortari, Peter M. Mourani, Laura L. Loftis, Scott L. Weiss, Keiko M. Tarquinio, Barry Markovitz, Mary E. Hartman, Adam Schwarz, Wolfgang G. Junger, Adrienne G. Randolph
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Immunology
Saltanat Ualiyeva, Nils Hallen, Yoshihide Kanaoka, Carola Ledderose, Ichiro Matsumoto, Wolfgang G. Junger, Nora A. Barrett, Lora G. Bankova
SCIENCE IMMUNOLOGY
(2020)
Article
Cell Biology
Carola Ledderose, Sophie Bromberger, Christian J. Slubowski, Koichiro Sueyoshi, Wolfgang G. Junger
Summary: This study demonstrates the importance of P2Y11 receptors in sustaining T cell activation mechanisms by promoting mitochondrial trafficking to the IS through cAMP/PKA signaling.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Correction
Multidisciplinary Sciences
Aiping Bai, Alan Moss, Sonja Rothweiler, Maria Serena Longhi, Yan Wu, Wolfgang G. Junger, Simon C. Robson
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Elizabeth H. Zhong, Carola Ledderose, Paola De Andrade Mello, Keiichi Enjyoji, Justin Mark Lunderberg, Wolfgang Junger, Simon C. Robson
Summary: This study demonstrates the synergistic effects of ectoenzymes such as CD39 and CD73 in reducing inflammatory responses, suggesting that these bifunctional enzymes could serve as therapeutic agents in inflammatory diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ana Badimon, Hayley J. Strasburger, Pinar Ayata, Xinhong Chen, Aditya Nair, Ako Ikegami, Philip Hwang, Andrew T. Chan, Steven M. Graves, Joseph O. Uweru, Carola Ledderose, Munir Gunes Kutlu, Michael A. Wheeler, Anat Kahan, Masago Ishikawa, Ying-Chih Wang, Yong-Hwee E. Loh, Jean X. Jiang, D. James Surmeier, Simon C. Robson, Wolfgang G. Junger, Robert Sebra, Erin S. Calipari, Paul J. Kenny, Ukpong B. Eyo, Marco Colonna, Francisco J. Quintana, Hiroaki Wake, Viviana Gradinaru, Anne Schaefer
Article
Biochemistry & Molecular Biology
Carola Ledderose, Sophie Bromberger, Christian J. Slubowski, Koichiro Sueyoshi, Dilan Aytan, Yong Shen, Wolfgang G. Junger
Review
Immunology
Carola Ledderose, Wolfgang G. Junger
FRONTIERS IN IMMUNOLOGY
(2020)
Meeting Abstract
Allergy
Saltanat Ualiyeva, Nils Hallen, Wolfgang Junger, Carola Ledderose, Nora Barrett, Lora Bankova
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)