Review
Pharmacology & Pharmacy
Li Lu, Yuan Xiong, Ze Lin, Xiangyu Chu, Adriana C. Panayi, Yiqiang Hu, Juan Zhou, Bobin Mi, Guohui Liu
Summary: This review summarizes the multiple effects of kinsenoside (KD), including anti-inflammatory and anti-oxidative abilities, as well as protection for liver, blood vessels, and immune system. The article also discusses the physicochemical properties, pharmacokinetic profiles, and advances in cultivation and drug delivery systems of KD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Maria Graca Miguel, Carina Isabel da Silva, Luana Farah, Fernao Castro Braga, Ana Cristina Figueiredo
Summary: This study evaluated the effect of 20 essential oils on the release of CCL2 and TNF-alpha by LPS-stimulated THP-1 cells. Some essential oils showed toxicity to cells, while T. capitata and L. luisieri essential oils exhibited good inhibitory effects on TNF-alpha release.
Article
Pharmacology & Pharmacy
Yunduan Song, Yusen Gou, Jiameng Gao, Dongxin Chen, Haibo Zhang, Wenjuan Zhao, Feng Qian, Ajing Xu, Yao Shen
Summary: This study demonstrates that lomerizine (LMZ) effectively reduces pulmonary edema, neutrophil infiltration, and pro-inflammatory cytokine production in lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice. LMZ treatment attenuates the expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in macrophages, and inhibits the phosphorylation of p38 MAPK, ERK1/2, JNK, and NF-kappa B p65. Additionally, LMZ reduces LPS-induced Ca2+ influx and suppresses pro-inflammatory cytokine production.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
LuLu Qian, Jun-Zhao Li, XueMei Sun, Jie-Bin Chen, Ying Dai, Qiu-Xiang Huang, Ying-Ji Jin, Qing-Ning Duan
Summary: The study demonstrates that safinamide can inhibit the production of pro-inflammatory cytokines by macrophages, reduce the release of inflammatory mediators, prevent leukocyte migration, and decrease the generation of related enzymes. These effects are mainly achieved through safinamide's inhibition of the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elif Baris, Hande Efe, Mukaddes Gumustekin, Mualla Aylin Arici, Metiner Tosun
Summary: The study found that varenicline reduces levels of inflammatory cytokines and cell migration induced by LPS by activating alpha 7nAChRs, thus inhibiting the inflammatory response.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Integrative & Complementary Medicine
Tae-Yong Gil, Bo-Ram Jin, Jong-Hyun Lee, Hyo-Jin An
Summary: Peucedanum japonicum Thunberg has shown anti-inflammatory effects by inhibiting the production of inflammatory mediators and suppressing the NF-κB and JNK signaling pathways in macrophages, thereby reducing LPS-induced mortality.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Joseph J. Bivona, Madeleine M. Mank, Renee D. Stapleton, D. Clark Files, Michael J. Toth, Matthew E. Poynter
Summary: Skeletal muscle is an important contributor to local and systemic cytokine abundance during inflammatory events. The study reveals the critical involvement of muscle fibers in the early systemic inflammatory cytokine response to endotoxin, showing the direct contribution of myofibers to systemic cytokine production.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Avinash Sanap, Supriya Kheur, Avinash Kharat, Ramesh Bhonde
Summary: This study investigates the effect of Interferon gamma (IFN-γ) and Ascorbic Acid (AA) preconditioning on the secretome of Umbilical Cord Derived MSCs (UCMSCs) and their potential to ameliorate the lipopolysaccharide (LPS) induced cytokine storm. The results demonstrate that IFN-γ and AA preconditioning of UCMSCs can alleviate the cytokine storm and enhance angiogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Agronomy
Yong-Han Hong, Chieh Kao, Chi-Chang Chang, Fu-Kuei Chang, Tuzz-Ying Song, Jer-Yiing Houng, Chi-Hao Wu
Summary: This study isolated and identified the active fractions and compounds in banana peel that have anti-inflammatory effects. The BP-95E-H2O-BuOH subfractions were found to be the most effective at inhibiting IL-6 and TNF-alpha secretion and down-regulating iNOS and COX-2 protein expression. In a clinical trial, oral administration of BP-95E-H2O-BuOH extracts lowered IL-6 and TNF-alpha levels and improved T-cell abnormalities in mice with systemic inflammation, potentially delaying endotoxemia-associated disorders.
Article
Plant Sciences
Yan-fang Deng, Qian-qian Xu, Tian-qi Chen, Jia-xiong Ming, Ya-fen Wang, Li-na Mao, Jia-jun Zhou, Wei-guang Sun, Qun Zhou, Hong Ren, Yong-hui Zhang
Summary: This study reveals that kinsenoside (KD) can alleviate non-alcoholic steatohepatitis (NASH) by inhibiting the NF-Kappa B/NLRP3 signaling pathway. KD shows hepatoprotective properties and has the potential to be a novel and effective drug for treating NASH.
Article
Cell Biology
Hyo-Jin An, Ji-Young Lee, Wansu Park
Summary: This study found that baicalin can inhibit the inflammatory response of macrophages activated by LPS, reduce the production of various inflammatory mediators, suppress oxidative stress, decrease the levels of phosphorylated p38 MAPK and Fas protein, and inhibit the expression of inflammatory genes.
Article
Biochemistry & Molecular Biology
Nguyen Khanh Hoang, Eiji Maegawa, Shigeru Murakami, Stephen W. Schaffer, Takashi Ito
Summary: This study evaluated the anti-inflammatory effect of the taurine derivative, TauCl, against pneumonia in obese mice. The results showed that TauCl treatment attenuated pulmonary and systemic inflammation caused by pneumonia, and improved skeletal muscle wasting.
Article
Chemistry, Medicinal
Laurence Balas, Sujit Kumar Dey, Sophie Beraud-Dufour, Dean Edward Riechers, Olivia Augusta Landau, Justine Bertrand-Michel, Thierry Durand, Nicolas Blondeau
Summary: Alpha-linolenic acid (ALA) and its metabolites linotrins have been found to exert neuroprotection and anti-inflammatory effects in chronic and acute CNS disease models. This study reports the synthesis of linotrins and confirms their occurrence in plants. The study also highlights the strong anti-inflammatory effects of linotrins on microglia and opens new perspectives for CNS therapeutics.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Amanda Mara Teles, Gabriel Silva Xavier, Wendel Fragoso de Freitas Moreira, Carla Junqueira Moragas-Tellis, Maria do Socorro dos Santos Chagas, Maria Dutra Behrens, Ana Lucia Abreu-Silva, Geusa Felipa de Barros Bezerra, Katia da Silva Calabrese, Maria do Desterro Soares Brandao Nascimento, Fernando Almeida-Souza
Summary: This study aims to investigate the chemical composition and anti-inflammatory effects of Talaromyces purpurogenus isolated from a marine-polluted environment. The results showed that the ethyl acetate extract of T. purpurogenus culture broth had a rich chemical composition and inhibited the production of cytokines and nitrites, demonstrating its anti-inflammatory properties.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Fisheries
Thi Mai Nguyen, Syaghalirwa N. M. Mandiki, Jean M. A. J. Salomon, Joel Bondekwe Baruti, Nang Thu Tran Thi, Thu Hang Nguyen, Truong Quynh Nhu, Patrick Kestemont
Summary: The study evaluated how to maximize the utilization of dietary plant oil for an efficient inflammatory response in common carp head kidney leukocytes (HKLs) exposed to a gram-negative bacterial endotoxin, Escherichia coli lipopolysaccharides (LPS). The results showed that fish fed plant oil mixture had immune competence comparable to those fed fish oil diet, and supplementation of ARA or DHA induced similar immunomodulation in common carp.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Cell Biology
Mei-Chih Chen, Kun-Chieh Chen, Gee-Chen Chang, Ho Lin, Chun-Chi Wu, Wei-Hsiang Kao, Chieh-Lin Jerry Teng, Shih-Lan Hsu, Tsung-Ying Yang
CELL DEATH & DISEASE
(2020)
Article
Environmental Sciences
Jou-Chun Chou, Fu-Kong Lieu, Donald Ming-Tak Ho, Heng-Yi Shen, Po-Han Lin, Sindy Hu, Shyi-Wu Wang, Ho Lin, Paulus S. Wang
Summary: This study revealed that PRL promotes NSCLC cell proliferation by upregulating GHR and JAK2/STAT3/VEGF pathway. NSCLC cells secrete PRL and GHR is the key receptor for PRL-induced cell proliferation.
Correction
Environmental Sciences
Jou-Chun Chou, Fu-Kong Lieu, Donald Ming-Tak Ho, Heng-Yi Shen, Po-Han Lin, Sindy Hu, Shyi-Wu Wang, Ho Lin, Paulus S. Wang
Article
Biochemistry & Molecular Biology
Yu-An Chen, Yi-Ru Lai, Hui-Yu Wu, Yen-Ju Lo, Yu-Fang Chang, Chiu-Lien Hung, Chun-Jung Lin, U-Ging Lo, Ho Lin, Jer-Tsong Hsieh, Cheng-Hsun Chiu, Yu-Hsin Lin, Chih-Ho Lai
Summary: The study identified HA-CdtB-NPs as a promising targeted therapy against radioresistant PCa cells, enhancing DNA double-strand breaks and inducing cell-cycle arrest to increase cell sensitivity. These nanoparticles demonstrate maximum target specificity and delivery efficiency, enhancing the radiation effect in radioresistant PCa cells. Their target specificity and radiomimetic activity suggest that they could be developed as an effective strategy against radioresistant PCa.
Article
Biochemistry & Molecular Biology
Chia-Herng Yue, Muhammet Oner, Chih-Yuan Chiu, Mei-Chih Chen, Chieh-Lin Teng, Hsin-Yi Wang, Jer-Tsong Hsieh, Chih-Ho Lai, Ho Lin
Summary: In our study, we investigated the RET activation and its biochemical interaction with CDK5 in GDNF-induced medullary thyroid cancer proliferation. Additionally, we identified the physical interaction between CDK5 and RET protein in MTC for the first time.Overall, our results suggest that targeting CDK5 may be a promising therapeutic candidate for human medullary thyroid cancer in the near future.
Article
Oncology
Cheng-Fan Lee, Yu-An Chen, Elizabeth Hernandez, Rey-Chen Pong, Shihong Ma, Mia Hofstad, Payal Kapur, Haiyen Zhau, Leland W. K. Chung, Chih-Ho Lai, Ho Lin, Ming-Shyue Lee, Ganesh Raj, Jer-Tsong Hsieh
Summary: This study reveals the important role of SphK1 in NEPC development, providing a new target for the treatment of NEPC using SphK1 inhibitors.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Bo-Ren Wang, Yu-An Chen, Wei-Hsiang Kao, Chih-Ho Lai, Ho Lin, Jer-Tsong Hsieh
Summary: Prostate cancer is a common cancer among men, and a significant percentage of patients develop metastatic prostate cancer. Treating castration-resistant prostate cancer (CRPC) is challenging, but recent research has identified new anti-androgen agents and targeting drugs that can prolong the survival of CRPC patients.
Article
Integrative & Complementary Medicine
Chieh-Yin Chen, Yu-Hsuan Li, Wan-Ling Liao, Muhammet Oner, Yu-Chiao Cheng, Fang-Ling Liu, Pang-Ting Cheng, Ayse Celik, Jyh-Horng Wu, Chih-Ho Lai, Jer-Tsong Hsieh, Ho Lin, Ting-Chieh Chang, Chih-Ying Chang, Mei-Chih Chen
Summary: Antrodia salmonea extracts inhibit the proliferation of prostate cancer cells and induce apoptosis through the reverse regulation of p53 and androgen receptor (AR), suggesting their potential therapeutic use for androgen-dependent prostate cancer.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Immunology
Ngoc-Niem Bui, Chen-Yi Li, Ling-Yu Wang, Yu-An Chen, Wei-Hsiang Kao, Li-Fang Chou, Jer-Tsong Hsieh, Ho Lin, Chih-Ho Lai
Summary: Prostate cancer is a common malignancy in men, and its mortality has been increasing globally. This study investigated the effect of C. scindens, a member of the gut microbiota, on the progression of prostate cancer. The results showed that metabolites derived from C. scindens promoted the proliferation and migration of prostate cancer cells, accompanied by the activation of the androgen receptor (AR). These findings suggest that C. scindens may contribute to prostate cancer progression via the activation of AR signaling.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Po-Hsin Lee, Yen-Hsiang Huang, Yu-Wei Hsu, Kun-Chieh Chen, Kuo-Hsuan Hsu, Ho Lin, Teng-Yu Lee, Jeng-Sen Tseng, Gee-Chen Chang, Tsung-Ying Yang
Summary: This study evaluated the risk of HBV reactivation in lung cancer patients treated with TKI, particularly in those with resolved HBV infection. The results showed that HBsAg-positive TKI users had a higher risk of HBV reactivation, and NUC prophylaxis is recommended. In patients with resolved HBV infection, the risk is lower, and regular monitoring is recommended.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
Pang-Ting Cheng, Yu-Chiao Cheng, Muhammet Oner, Yu-Hsuan Li, Mei-Chih Chen, Jyh-Horng Wu, Ting-Chieh Chang, Ayse Celik, Fang-Ling Liu, Hsin-Yi Wang, Chih-Ho Lai, Jer-Tsong Hsieh, Chieh-Yin Chen, Ho Lin
Summary: The study found that Antrodia salmonea can inhibit the proliferation of prostate cancer cells by regulating the cell cycle and apoptosis pathways.
CHINESE JOURNAL OF PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Po-Hsin Lee, Yen-Hsiang Huang, Ho Lin, Kuo-Hsuan Hsu, Kun-Chieh Chen, Jeng-Sen Tseng, Gee-Chen Chang, Tsung-Ying Yang
Summary: This study aimed to investigate the incidence of histological transformation and its impact on treatment outcomes in patients with EGFR-mutant lung adenocarcinoma receiving third-generation EGFR-TKI therapy. The results revealed that a subset of patients experienced histological transformation, which rendered the treatment ineffective and was associated with shorter overall survival. Therefore, repeating biopsy to identify histological transformation should be considered to guide treatment decisions.
MEDICINA-LITHUANIA
(2022)
Article
Oncology
Jou-Chun Chou, Jie-Hau Li, Chih-Chieh Chen, Chien-Wei Chen, Ho Lin, Paulus S. Wang
Summary: The study revealed that CGs can reduce proliferation and increase cytotoxicity in ovarian cancer cells (SKOV-3) by inducing cell cycle arrest at the G(0)/G(1) phase. CGs have anti-tumor effects in SKOV-3 cells and may be a potential therapeutic drug for ovarian cancer. Further experiments and investigations with more ovarian cancer cell lines are needed to confirm the efficacy of CGs in ovarian cancer treatment.
INTEGRATIVE CANCER THERAPIES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Su-Tang Lo, Daniel Parrott, M. Veronica Clavijo Jordan, Diya Binoy Joseph, Douglas Strand, U-Ging Lo, Ho Lin, Anza Darehshouri, A. Dean Sherry
Summary: Fluorescent studies demonstrate that ZnT1 is the major zinc efflux transporter in prostate epithelial cells, and loss of ZnT1 via mRNA knockdown combined with lysosomal storage disruption leads to a significant increase in cytosolic zinc. Knockdown of ZnT1 dramatically reduces zinc efflux during glucose-stimulated zinc secretion. Electron microscopy shows that glucose stimulation increases lysosomal storage of zinc, and disruption of lysosomes via Baf or ZnT4 mRNA knockdown results in increased multi-vesicular body formation and cytosolic zinc levels. In human BPH tissue, only the luminal epithelial cells contain significant zinc storage granules.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Medicine, General & Internal
Chen-Cheng Huang, Jin-Ming Hwang, Jen-Hsiang Tsai, Jing Huei Chen, Ho Lin, Geng-Jhih Lin, Hsin-Ling Yang, Jer-Yuh Liu, Chiou-Ying Yang, Je-Chiuan Ye
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2020)