期刊
SHOCK
卷 33, 期 1, 页码 5-13出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SHK.0b013e3181af0494
关键词
Burns; intensive insulin; glucose modulation; metformin; fenofibrate
资金
- Shriner's Hospital for Children [9490, 8460, 8480, 8505, 8507, 8640, 8660, 8740, 8760]
- National Institutes of Health [R01-GM56687, T32 GM008256, P50 GM60338]
- National Institute on Disability and Rehabilitation Research [H133A020102, H133A70019]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM060338, T32GM008256, R01GM056687] Funding Source: NIH RePORTER
Severely burned patients typically experience a systemic response expressed as increased metabolism, inflammation, alteration of cardiac and immune function, and associated hyperglycemia. Hyperglycemia has been associated with an increased risk of morbidity and mortality in critically ill patients. Until recently and for many years, hyperglycemia has been expectantly managed and considered a normal and desired response of an organism to stress. However, findings reported from recent studies now suggest beneficial effects of intensive insulin treatment of critically ill patients. The literature on the management of hyperglycemia in severely burned patients is sparse, with most of the available studies involving only small numbers of burned patients. The purpose of this article is to describe the pathophysiology of hyperglycemia after severe burns and to review the available literature on the outcome of intensive insulin treatment and other anti-hyperglycemic modalities in burned patients in an evidence-based medical approach.
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