Article
Obstetrics & Gynecology
Lia A. Bernardi, Marissa Steinberg Weiss, Anne Waldo, Quaker Harmon, Mercedes R. Carnethon, Donna D. Baird, Lauren A. Wise, Erica E. Marsh
Summary: The study found that current users of hormonal contraceptives among African American women had significantly lower mean AMH levels. There was little difference in AMH levels between former users and non-users of hormonal contraceptives. Different types of hormonal contraceptives also had varying effects on AMH levels.
FERTILITY AND STERILITY
(2021)
Article
Oncology
M. Debaudringhien, J-Y Blay, A-M Bimbai, S. Bonvalot, A. Italiano, C. Rousset-Jablonski, N. Corradini, S. Piperno-Neumann, C. Chevreau, J-E Kurtz, C. Guillemet, E. Bompas, O. Collard, S. Salas, A. Le Cesne, D. Orbach, J. Thery, M-C Le Deley, O. Mir, N. Penel
Summary: A recent history of pregnancy was associated with an increased risk of progression/relapse in patients with newly diagnosed desmoid-type fibromatosis, while hormonal contraception did not show an association with progression/relapse.
Article
Pharmacology & Pharmacy
Kate Hogden, Frederick Mikelberg, Mohit Sodhi, Farzin Khosrow-Khavar, Mohammad Ali Mansournia, Abbas Kezouh, Mahyar Etminan
Summary: This retrospective cohort study investigated the association between hormonal contraceptive use and glaucoma incidence in females of reproductive age. Regular users of hormonal contraceptives had an elevated risk of glaucoma compared to non-users, with current users at the greatest risk. The risk of glaucoma increased with the number of prescriptions for hormonal contraceptives in the 2 years prior to diagnosis.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Rakhee Sachdeva, Narender Kumar, Vivian Brache, Barbara A. Friedland, Marlena Plagianos, Shimin Zhang, Larisa Kizima, Leila Cochon, Ana Sofia Tejada Tabar, Ann Blanc, Ruth B. Merkatz
Summary: In a pilot study, 30 women were given levonorgestrel (LNG) oral contraceptives or depot medroxyprogesterone acetate (DMPA) injections to identify biomarkers of hormonal contraceptive use. Serum and urine samples were collected at different time points, and liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to measure LNG and MPA levels. The results suggest that urine samples can be used to identify biomarkers of LNG and MPA use.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Biological
Courtney C. C. Louis, Chelsea Kneip, Tim P. P. Moran, Adriene M. M. Beltz, Kelly L. L. Klump, Jason S. S. Moser
Summary: This study found that there is a significant association between anxiety and error-related cognitive control mechanism called ERN in women. The relationship is more significant in women using hormonal contraceptives compared to those who are not.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Sharmila Brabaharan, Sajesh K. Veettil, Jennifer E. Kaiser, Vrosha Rau Raja Rao, Rujira Wattanayingcharoenchai, Marikannan Maharajan, Putsarat Insin, Pattarawalai Talungchit, Thunyarat Anothaisintawee, Ammarin Thakkinstian, Nathorn Chaiyakunapruk
Summary: The results of this umbrella review support preexisting understandings of the risks and benefits associated with hormonal contraceptive use. Overall, there is a lack of high-quality evidence supporting the associations between hormonal contraceptive use and cardiovascular risk, cancer risk, and other major adverse health outcomes.
Article
Sport Sciences
Essi K. Ahokas, Helen G. Hanstock, Ida Lofberg, Mari Nyman, Piia Wenning, Heikki Kyrolainen, Ritva S. Mikkonen, Johanna K. Ihalainen
Summary: The aim of this study was to investigate within-cycle differences in nocturnal heart rate (HR) and heart rate variability (HRV) in naturally menstruating women (NM) and women using combined hormonal contraceptives (CU) or progestin-only hormonal contraceptives (PU). The results showed that the menstrual cycle and hormonal cycle phases influence autonomic nervous system balance, which is reflected in measurements of nocturnal HR and HRV.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Psychology, Developmental
Cecilia Lundin, Anna Wikman, Per Wikman, Helena Kopp Kallner, Inger Sundstrom-Poromaa, Charlotte Skoglund
Summary: Women with ADHD have an increased risk of developing depression when using hormonal contraception, especially oral combined HC. Information on risks and benefits of different contraception methods should be provided to young women with ADHD. Rating: 7/10.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Soren Vinther Larsen, Anders Pretzmann Mikkelsen, Ojvind Lidegaard, Vibe Gedso Frokjaer
Summary: Hormonal sensitivity may contribute to depression risk in women during certain reproductive phases, such as the premenstrual, postpartum, and perimenopausal phases, and when initiating hormonal contraception. This study aimed to investigate whether prior depression associated with the initiation of hormonal contraception is linked to a higher risk of postpartum depression.
Article
Clinical Neurology
Julia Gawronska, Catherine Meads, Lee Smith, Chao Cao, Nan Wang, Susan Walker
Summary: This study analyzed the relationship between oral contraceptive pill (OCP) use and major depression in US women. The results showed that current OCP users had a lower prevalence of major depression compared to former users and never users of OCP. However, the burden of depression remains high among women using OCP. Further longitudinal research is needed to understand the real world effect of OCP on depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Public, Environmental & Occupational Health
Izidora Skracic, Amy B. Lewin, Julia R. Steinberg
Summary: The study found that women who experienced behavioral reproductive coercion were more likely to use highly effective contraceptive methods compared to moderate or low effective methods. This may indicate two contrasting ways of managing behavioral reproductive coercion experiences: controlling fertility by choosing less detectable but highly effective methods or feeling disempowered and using partner-dependent methods.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Psychiatry
Sharlene D. Newman
Summary: This study examined the impact of hormonal birth control, cannabis, and alcohol on depression symptoms. The results suggest that hormonal birth control use may help reduce depressive symptoms, and there may be an interaction between cannabis and hormonal birth control use on depression symptoms. The findings also imply that alcohol and cannabis may be linked to depression through different mechanisms.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Multidisciplinary Sciences
Tasnima Akter, Mario Festin, Angela Dawson
Summary: The use of hormonal contraceptive methods is positively associated with the risk of chlamydia and herpes, while it is negatively associated with the risk of trichomoniasis and bacterial vaginosis.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Morgan Anne Whitney, Donna Nicole Schultz, Larissa R. Brunner Huber, Ashley Finke, Anna Fitzgerald, Ashlyn Hyde
Summary: This study investigates the impact of hormonal contraceptive use on sleep outcomes and finds that women who use hormonal contraceptives have a 6% higher prevalence of sleep disturbances and a 17% lower prevalence of not meeting sleep duration recommendations compared to those who use non-hormonal contraceptives.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dongling Luo, Hezhi Li, Pengyuan Chen, Nanshan Xie, Ziyang Yang, Caojin Zhang
Summary: This study found that the use of oral contraceptives in women of reproductive age does not increase the risk of heart failure. However, further research is needed to investigate whether different formulations or dosages may impact this association.
Article
Multidisciplinary Sciences
Eliana Marcia Wendland, Luisa Lina Villa, Elizabeth R. Unger, Carla Magda Domingues, Adele Schwartz Benzaken
SCIENTIFIC REPORTS
(2020)
Editorial Material
Infectious Diseases
Khalil G. Ghanem, Edward W. Hook
SEXUALLY TRANSMITTED DISEASES
(2021)
Article
Virology
Mangalathu S. Rajeevan, Sonya Patel, Tengguo Li, Elizabeth R. Unger
Summary: High-throughput HPV typing assays with increased automation, faster turnaround and type-specific digital readout would facilitate studies monitoring the impact of HPV vaccination. The NanoString nCounter platform showed good efficacy in detecting and digitally reading 48 HPV types in a single reaction. Further studies are needed to evaluate the reproducibility and analytic validation of the assay with a larger number of samples.
Article
Oncology
Sharon L. Sauter, Xue Zhang, Lindsey Romick-Rosendale, Susanne I. Wells, Kasiani C. Myers, Marion G. Brusadelli, Charles B. Poff, Darron R. Brown, Gitika Panicker, Elizabeth R. Unger, Parinda A. Mehta, Jack Bleesing, Stella M. Davies, Melinda Butsch Kovacic
Summary: This study found that individuals with Fanconi anemia have a significantly higher oral HPV positivity compared to family and unrelated controls, but respond similarly to HPV vaccination. Unlike unrelated controls, common risk factors associated with HPV in the general population did not predict oral DNA positivity in individuals with FA.
Article
Public, Environmental & Occupational Health
Jacqueline M. Mix, Mona Saraiya, Virginia Senkomago, Elizabeth R. Unger
Summary: This study analyzed the incidence rates of high-grade vulvar, vaginal, and anal precancers among individuals aged 15-39 years using data from select cancer registries in the U.S. The results showed a significant decrease in high-grade vulvar and vaginal precancer rates among females aged 15-29 years after the introduction of the human papillomavirus vaccine, while anal precancer rates stabilized in both females aged 15-29 years and males aged 30-39 years.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Oncology
Jacqueline Mix, Mona Saraiya, Benjamin D. Hallowell, Brian Befano, Li C. Cheung, Elizabeth R. Unger, Julia W. Gargano, Lauri E. Markowitz, Philip E. Castle, Tina Raine-Bennett, Joan Walker, Rosemary Zuna, Mark Schiffman, Nicolas Wentzensen, Julia C. Gage
Summary: Racial and ethnic differences exist in the attribution of cervical precancer and cancer to HPV types. The 9-valent HPV vaccine is effective in preventing most cases of precancers and invasive cancers among major racial and ethnic groups. Adding HPV35 to vaccines could provide additional protection, particularly for Black women.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Medicine, General & Internal
Hannah G. Rosenblum, Rayleen M. Lewis, Julia W. Gargano, Troy D. Querec, Elizabeth R. Unger, Lauri E. Markowitz
Summary: This study estimated the impact and effectiveness of HPV vaccination on sexually experienced females and males in the United States. The results showed significant impact of the vaccine on the prevalence of quadrivalent HPV types, but no significant impact on non-quadrivalent HPV types. Vaccine effectiveness varied across different time periods and genders. The nationally representative data demonstrate the increasing effectiveness of the vaccination program and herd protection.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Infectious Diseases
Sarah Elizabeth Brown, Xin He, Michelle D. Shardell, Jacques Ravel, Khalil G. Ghanem, Jonathan M. Zenilman, Rebecca M. Brotman
Summary: In this pilot study, cessation of douching was not found to have significant effects on the composition and structure of the vaginal microbiota. Additional interventions may be necessary to restore optimal vaginal microbiota among women who practice douching.
SEXUALLY TRANSMITTED INFECTIONS
(2023)
Article
Chemistry, Medicinal
Trinh Phuong Vo, Gitika Panicker, Kimberly Braz-Gomes, Ashwin C. Parenky, Ira Rajbhandari, Mangalathu S. Rajeevan, Elizabeth R. Unger, Martin J. D'Souza, Mohammad N. Uddin
Summary: This research developed a microparticulate HPV16 vaccine for transdermal administration and evaluated its immunogenicity in a pre-clinical mouse model. The results showed a significant increase in HPV16 IgG antibodies in the microparticle group and expansion of CD4+, CD45R, CD27 and CD62L cell populations in the vaccinated mice group. This suggests the high efficacy of the microparticulate vaccine when administered via transdermal route.
Article
Pathology
Hem R. Thapa, Elizabeth R. Unger, Troy D. Querec
Summary: Prophylactic human papillomavirus (HPV) vaccines are recommended for preventing HPV-associated cancers. However, there is a need for validated typing assays for the detection of HPV in formalin-fixed, paraffin-embedded (FFPE) tissues. The Novaplex II HPV28 Detection assay showed high concordance with the reference method and can be considered as a suitable method for HPV detection in FFPE tissues.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2023)
Article
Virology
Laura Teblick, Jade Pattyn, Severien Van Keer, Annemie De Smet, Ilse De Coster, Wiebren A. A. Tjalma, Ira Rajbhandari, Gitika Panicker, Elizabeth R. Unger, Alex Vorsters
Summary: This study explores the potential use of first-void urine as a noninvasive alternative sample for assessing humoral immune responses following HPV vaccination. The results show that first-void urine can detect HPV-specific antibody concentrations, with significant correlations to serum samples at different time points.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Tengguo Li, Elizabeth R. Unger, Mangalathu S. Rajeevan
Summary: This study performed whole-genome sequencing to detect all known and novel HPV types in male genital samples. The results showed that HPV was detected in nearly all samples, with a high number of types per sample. The most frequently detected types were alpha, beta, and gamma, and a novel gamma type and several unclassified types were identified. The study suggests a higher type diversity in males compared to females and calls for further research.
Article
Infectious Diseases
Raiza Amiling, Elissa Meites, Troy D. Querec, Laura Stone, Vidisha Singh, Elizabeth R. Unger, Craig S. Derkay, Lauri E. Markowitz
Summary: This study found that children with JORRP were commonly firstborn, delivered vaginally to young mothers, and most of the mothers reported no HPV vaccination before delivery. Disease severity was associated with younger diagnosis age and detection of HPV type 11.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Letter
Infectious Diseases
Matthew A. Crane, Aleksandra Popovic, Andrew Stolbach, Khalil G. Ghanem
SEXUALLY TRANSMITTED INFECTIONS
(2021)
Letter
Medicine, General & Internal
Khalil G. Ghanem, Sanjay Ram, Peter A. Rice
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
