Article
Psychiatry
Kristin Torgersen, Shahram Bahrami, Oleksandr Frei, Alexey Shadrin, Kevin S. O' Connell, Olav B. Smeland, John Munkhaugen, Srdjan Djurovic, Toril Dammen, Ole A. Andreassen
Summary: The study revealed a polygenic overlap between neuroticism and CAD and CVD risk factors, with several genetic loci associated with both neuroticism and multiple CVD risk factors. Functional analysis of the shared genes implicated pathways related to cell division, nuclear receptors, elastic fiber formation, and starch and sucrose metabolism. These findings highlight the potential role of genetic factors in contributing to the comorbidity between neuroticism and cardiovascular diseases.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yeela Talmor-Barkan, Noam Bar, Aviv A. Shaul, Nir Shahaf, Anastasia Godneva, Yuval Bussi, Maya Lotan-Pompan, Adina Weinberger, Alon Shechter, Chava Chezar-Azerrad, Ziad Arow, Yoav Hammer, Kanta Chechi, Sofia K. Forslund, Sebastien Fromentin, Marc-Emmanuel Dumas, S. Dusko Ehrlich, Oluf Pedersen, Ran Kornowski, Eran Segal
Summary: Multi-omic profiling of patients with coronary artery disease reveals links between alterations in the serum metabolome with genetics, diet, and the microbiome. The study found that these metabolomic alterations are associated with metabolic impairment preceding clinically overt coronary artery disease. The results highlight the importance of understanding risk-factor heterogeneity in coronary artery disease through the serum metabolome.
Article
Biology
Flavia Hodel, Zhi Ming Xu, Christian Wandall Thorball, Roxane de la Harpe, Prunelle Letang-Mathieu, Nicole Brenner, Julia Butt, Noemi Bender, Tim Waterboer, Pedro Manuel Marques-Vidal, Peter Vollenweider, Julien Vaucher, Jacques Fellay
Summary: Coronary heart disease (CHD) is a major health problem, with complex interactions between genetic and environmental factors leading to its occurrence. A study using multiplex serological testing and genome-wide analysis on a population cohort revealed that high polygenic risk and infection with Fusobacterium nucleatum are independently associated with incident CHD.
Article
Medicine, General & Internal
Zuolin Lu, Elif Aribas, Sven Geurts, Jeanine E. Roeters van Lennep, M. Arfan Ikram, Maxime M. Bos, Natasja M. S. de Groot, Maryam Kavousi
Summary: This study found that irregular menstrual cycles, nulliparity, and multiparity were associated with a higher risk of new-onset AF among women.
Article
Multidisciplinary Sciences
Enas M. Hefzy, Noha A. Hassuna, Olfat G. Shaker, Mohamed Masoud, Tebyan A. Abelhameed, Tarek I. Ahmed, Nada F. Hemeda, Mohammed A. Abdelhakeem, Rania H. Mahmoud
Summary: Genetic variants in miR-155 and miR-146a genes may act as potential risk factors for Chronic HBV in the Egyptian population, highlighting the importance of studying miRNA polymorphisms in disease development.
Article
Medicine, General & Internal
Pawel Muszynski, Elzbieta Pawluczuk, Marta Paslawska, Maciej Kowalczuk, Julia Kozakiewicz, Natalia Sot-Muszynska, Marcin Kozuch, Slawomir Dobrzycki
Summary: This study found that women with chronic coronary syndrome have a higher prevalence of cardiovascular risk factors such as hypertension, dyslipidemia, and diabetes mellitus. Women were more often treated conservatively and had a lower frequency of achieving the LDL cholesterol goal. Additionally, women were more often treated with angiotensin receptor blockers and had a higher left ventricle ejection fraction. Men were diagnosed with coronary artery disease earlier and had more efficient prevention and therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Zhicheng Du, Philip Hopke, Tia Marks, Shao Lin, Wangjian Zhang, Yuantao Hao
Summary: This study investigated the relationship between meteorological factors and the risk of hand, foot, and mouth disease (HFMD) in four cities in Guangdong Province. The results showed nonlinear and interactive relationships between temperature, humidity, and HFMD risk, as well as the impact of wind speed and sunshine duration on other meteorological factors. Additionally, increased gross domestic product per capita and per capital area of parks and green land were found to strengthen the interactive effects of humidity on other meteorological factors.
ENVIRONMENTAL RESEARCH LETTERS
(2022)
Article
Cardiac & Cardiovascular Systems
Yang Hu, Yanping Li, Laura Sampson, Molin Wang, E. JoAnn Manson, Eric Rimm, Qi Sun
Summary: Increased long-term intake of lignans was significantly associated with a lower risk of total CHD in both men and women. The inverse associations were more apparent among participants with higher total lignan intake, and lignan intake was more strongly associated with plasma concentrations of enterolactone when fiber intake was higher.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Qiqi Shi, Ran Wang, Huifeng Zhang, Yaping Shan, Ming Ye, Bing Jia
Summary: The study revealed that elevated SUA levels were associated with increased cardiovascular risk factors in American adolescents, especially in females.
Article
Medicine, General & Internal
David R. Jacobs, Jessica G. Woo, Alan R. Sinaiko, Stephen R. Daniels, Johanna Ikonen, Markus Juonala, Noora Kartiosuo, Terho Lehtimaki, Costan G. Magnussen, Jorma S. A. Viikari, Nanhua Zhang, Lydia A. Bazzano, Trudy L. Burns, Ronald J. Prineas, Julia Steinberger, Elaine M. Urbina, Alison J. Venn, Olli T. Raitakari, Terence Dwyer
Summary: This prospective cohort study found that childhood cardiovascular risk factors, including BMI, systolic blood pressure, lipid levels, and smoking, were associated with cardiovascular events in adulthood. Childhood risk factors and the change in risk score between childhood and adulthood were associated with midlife cardiovascular events.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aniruddh P. Patel, Minxian Wang, Yunfeng Ruan, Satoshi Koyama, Shoa L. Clarke, Xiong Yang, Catherine Tcheandjieu, Saaket Agrawal, Akl C. Fahed, Patrick T. Ellinor, Philip Tsao, Yan Sun, Kelly Cho, Peter W. F. L. Wilson, Themistocles L. Assimes, David A. van Heel, Adam S. Butterworth, Krishna G. Aragam, Pradeep Natarajan, Amit V. Khera
Summary: A new polygenic risk score for coronary artery disease called GPS(Mult) has been developed using data from individuals of five different ancestries, which has increased accuracy across diverse populations. The GPS(Mult) strongly associates with prevalent and incident CAD events, and outperforms previously published CAD polygenic scores in multiethnic validation datasets. These findings contribute to the field of polygenic risk prediction for CAD and provide a framework for integrating genetic association data from diverse populations.
Article
Biochemistry & Molecular Biology
Yazmin Estela Torres-Paz, Ricardo Gamboa, Giovanny Fuentevilla-Alvarez, Maria Elena Soto, Nadia Gonzalez-Moyotl, Rocio Martinez-Alvarado, Margarita Torres-Tamayo, Edgar Samuel Ramirez-Marroquin, Xicotencatl Vasquez-Jimenez, Victor Sainz-Escarrega, Claudia Huesca-Gomez
Summary: This study investigated the expression and role of microRNAs (miRs) in monocytes in coronary arterial disease (CAD). The results showed that miR-21-5p and miR-221-5p were significantly upregulated in CAD patients, while miR-155-5p was significantly downregulated. Furthermore, the upregulation of miR-21-5p and miR-221-5p was associated with an increased risk of CAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ignacio Fernando Hall, Montserrat Climent, Chiara Viviani Anselmi, Laura Papa, Vinicius Tragante, Luca Lambroia, Floriana Maria Farina, Marcus E. Kleber, Winfried Maerz, Carlo Biguori, Gianluigi Condorelli, Leonardo Elia
Summary: The study identifies a SNP, rs41291957 (A), near the miR-143/145 cluster that upregulates miR-143 and miR-145, modulating vascular smooth cell phenotype and acting as a protective factor against coronary artery disease.
EMBO MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Jianping Zheng, Maozhi Huang, Qilei Huang, Qiaoxing Chen, Ziguo Chen
Summary: The study found that serum fetuin-A is related to the onset risk of CHD, and shows a significant correlation with age. Gender, age, blood pressure, and diabetes are also related to the onset of CHD.
Article
Medicine, General & Internal
Afrose Liaquat, Ameerdad Khan, Saeed Ullah Shah, Hania Iqbal, Safa Iqbal, Atif Iqbal Rana, Habib Ur Rahman
Summary: This study investigates the use of coronary artery calcium scoring (CACS) as a tool for coronary artery disease (CAD) risk stratification and its association with conventional cardiovascular risk factors. The results demonstrate a strong positive correlation between CACS and coronary artery stenosis, indicating the potential of CACS as a useful tool for CAD risk assessment.