期刊
SCIENTIFIC REPORTS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep09104
关键词
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资金
- Department of Defense Prostate Cancer Research Program [W81XWH-12-1-0289, W81XWH-12-1-0134]
- National Institutes of Health [P41EB015908, R37 HL34557]
- Robert A. Welch Foundation [AT-584]
Highly sensitive MR imaging agents that can accurately and rapidly monitor changes in pH would have diagnostic and prognostic value for many diseases. Here, we report an investigation of hyperpolarized N-15-pyridine derivatives as ultrasensitive pH-sensitive imaging probes. These molecules are easily polarized to high levels using standard dynamic nuclear polarization (DNP) techniques and their N-15 chemical shifts were found to be highly sensitive to pH. These probes displayed sharp N-15 resonances and large differences in chemical shifts (Delta delta>90 ppm) between their free base and protonated forms. These favorable features make these agents highly suitable candidates for the detection of small changes in tissue pH near physiological values.
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