期刊
SEXUALLY TRANSMITTED DISEASES
卷 40, 期 8, 页码 611-618出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.OLQ.0000430798.61475.08
关键词
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资金
- Red de Investigacion en SIDA
- ART AIDS Foundation
- Gilead Sciences
- Obra Social Caixa Sabadell
- Gala contra la SIDA-Barcelona
Background: We studied the type-specific infection of human papillomavirus (HPV) at the anal canal and penile site in a cohort of HIV-infected men. Methods: Prevalence, clearance, and incidence of specific HPV types in the anal canal and penis were determined in 733 HIV-infected men from the Spanish CAn Ruti HIV+ Men ([CARH& MEN]) cohort (538 men who have sex with men [MSM] and 195 heterosexual men). Results: In both groups, the most prevalent high-risk type was HPV-16 (anal canal [31.6% MSM; 6.8% heterosexual] and penis [4.8% MSM; 6.8% heterosexual]). The most prevalent low-risk type was HPV-6 (anal canal [23.2% MSM; 12.8% heterosexual], penis [8.1% MSM; 8.9% heterosexual]). Anal prevalence was significantly higher in MSM, as was incidence, except for HPV-16, which was similar between male groups (5.9 new cases per 1000 person-months [95% confidence interval, 4.3Y7.9] in MSM; 4.4 [95% confidence interval, 2.5Y7.2] in heterosexual men; P 9 0.05). The anal clearance rate of the different HPV types and retention time of infection were similar in both groups, as well as the HPV infection of the penis. Conclusions: HIV-infected MSM had a high prevalence of HPV infection at the anal canal; however, heterosexual HIV-infected men were also at risk for acquiring and sustaining persistent high-risk HPV types at the anal and penile site and are at risk for developing dysplasia in the future. All HIV-infected men should be recommended for routinely anal HPV screening.
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