Article
Pharmacology & Pharmacy
Garima Sharma, Manuhaar Sharma, Rishav Sood, Jayanthi Neelamraju, Suvarna G. Lakshmi, Ratna Sudha Madempudi, Praveen Rishi, Indu Pal Kaur
Summary: The study successfully developed a novel emulgel incorporating probiotics for topical use, demonstrating self-preservation and safety. Animal experiments showed faster wound closure and reduced oxidative stress with the probiotic formulation.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Pharmacology & Pharmacy
Treepecth Prompetch, Akawat Chailorm, Saruda Tiwananthagorn, Nithidol Buranapim, Siriporn Okonogi, Hirotomo Kato, Wasan Katip, Raktham Mektrirat
Summary: This study aimed to evaluate a novel drug delivery system using modified rice hydrogel containing praziquantel (PZQ) against Philophthalmus gralli isolated from ostrich eyes and examine its toxicity on a chicken eye model. The results showed that the parasiticidal activity of PZQ against P. gralli was concentration- and time-dependent, with a concentration of 10 mu g/mL and exposure time of 24 h being sufficient to kill parasites. The rice hydrogel containing 10 mu g/mL PZQ demonstrated good parasitic killing effects compared to controls.
Article
Pharmacology & Pharmacy
Alison Cutts, Sultan Chowdhury, Laszlo G. Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A. Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb, Charles J. Cohen
Summary: Divalent metal transporter 1 (DMT1) is responsible for nonheme iron uptake in enterocytes. A potent inhibitor, XEN602, has been identified which effectively reduces dietary iron uptake without significant systemic exposure. This compound provides a valuable tool for studying the physiological function of DMT1 in the gut.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Krzysztof Nosek, Wojciech Leppert, Lukasz Puchala, Krzysztof Lon
Summary: Topical morphine may be effective in treating ulcers, erosions of inflammatory etiology, and painful skin lesions including post-mastectomy pain. However, its recommended use in everyday medical practice is limited.
Article
Biotechnology & Applied Microbiology
I. Rodriguez-Izquierdo, M. J. Serramia, R. Gomez, G. Espinosa, M. Genebat, M. Leal, M. A. Munoz-Fernandez
Summary: The study demonstrates the efficacy and biosafety of G2-S16 dendrimer in vaginal human explants, making it a promising candidate for the development of an effective microbicide against HIV-1 infection.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Natalia Makarova, Tyana Singletary, M. Melissa Peet, James Mitchell, Angela Holder, Chuong Dinh, Vivek Agrahari, Maria Mendoza, Yi Pan, Walid Heneine, Meredith R. Clark, J. Gerardo Garcia-Lerma, James M. Smith, Gustavo F. Doncel
Summary: This study assessed the pharmacokinetics and pre-exposure efficacy of rectally applied TAF/EVG inserts in macaques, with results showing that using two inserts is more effective in prevention compared to using one, achieving a success rate of 93.1%.
Article
Multidisciplinary Sciences
Ying Wang, Chen Yang, Yutong Song, J. Robert Coleman, Marcin Stawowczyk, Juliana Tafrova, Sybil Tasker, David Boltz, Robert Baker, Liliana Garcia, Olivia Seale, Anna Kushnir, Eckard Wimmer, Steffen Mueller
Summary: COVI-VAC is an attenuated SARS-CoV-2 vaccine currently in development, which was engineered by recoding a segment of the viral spike protein and deleting the furin cleavage site for added safety. Studies have shown that intranasal vaccination with COVI-VAC in Syrian golden hamsters resulted in lower tissue viral loads, milder lung pathology, and reduced weight loss compared to those inoculated with wild-type virus. Additionally, COVI-VAC generated similar levels of spike IgG antibodies and plaque reduction neutralization titers as wild-type virus inoculation, and provided protection against SARS-CoV-2 infection in hamsters.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Jinshi Zhao, C. Skyler Cochrane, Javaria Najeeb, David Gooden, Carly Sciandra, Ping Fan, Nadine Lemaitre, Kate Newns, Robert A. Nicholas, Ziqiang Guan, Joshua T. Thaden, Vance G. G. Fowler Jr, Ivan Spasojevic, Florent Sebbane, Eric J. Toone, Clayton Duncan, Richard Gammans, Pei Zhou
Summary: This article reports the preclinical characterization of a slow, tight-binding LpxC inhibitor, LPC-233, with low picomolar affinity. The compound is a rapid bactericidal antibiotic, unaffected by established resistance mechanisms to commercial antibiotics, and displays outstanding activity against a wide range of Gram-negative clinical isolates in vitro. It is orally bioavailable and efficiently eliminates infections caused by susceptible and multidrug-resistant Gram-negative bacterial pathogens in murine soft tissue, sepsis, and urinary tract infection models.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Shuo Zhang, Jiao Wang, Liu Liu, Xiaoying Sun, Yaqiong Zhou, Siting Chen, Yi Lu, Xiaoce Cai, Manqi Hu, Ge Yan, Xiao Miao, Xin Li
Summary: Curcumin (CUR) demonstrates excellent efficacy and broad potential in the treatment of psoriasis, improving the disease phenotype and reducing inflammatory responses through multiple mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jieyu Qi, Liyan Zhang, Fangzhi Tan, Yang Zhang, Yinyi Zhou, Ziyu Zhang, Hongyang Wang, Chaorong Yu, Lulu Jiang, Jiancheng Liu, Tian Chen, Lianqiu Wu, Shanzhong Zhang, Sijie Sun, Shan Sun, Ling Lu, Qiuju Wang, Renjie Chai
Summary: This study demonstrates the effectiveness and safety of OTOF gene therapy drugs in mice and nonhuman primates. The researchers developed a new strategy to deliver OTOF and successfully restored hearing in mice with profound deafness. The therapy also showed no impact on normal hearing and systemic toxicity in both mice and nonhuman primates.
Article
Chemistry, Medicinal
Juliana Tonini Mesquita, Maiara Maria Romanelli, Cristiana de Melo C. M. Trinconi Trinconi, Juliana Mariotti Guerra, Noemi Nosomi Taniwaki, Silvia Reni Bortolin Uliana, Juliana Quero Reimao, Andre Gustavo Tempone
Summary: This study evaluated the antimicrobial activity of triclosan against Leishmania amazonensis and found its ability to form pores in the parasite, affecting mitochondrial and reactive oxygen species levels. Additionally, treating Leishmania-infected mice with topical triclosan resulted in a significant reduction in parasite burden. These findings contribute to the search for new treatments for cutaneous leishmaniasis and suggest further investigation of the coadministration of triclosan and miltefosine in animal models.
DRUG DEVELOPMENT RESEARCH
(2022)
Review
Dermatology
Nasrin Saki, Maliheh Amani, Nazanin Zeinali Nezhad, Amirhossein Shahpar, Mohadeseh Shafiei, Seyed Ali Hosseini, Najmeh Ahramiyanpour
Summary: Brimonidine is a beneficial drug used to treat various dermatologic disorders, including rosacea and erythema. Research has shown that it can improve facial erythema, reduce erythema associated with alcohol flushing syndrome, intense pulsed light therapy, and photodynamic therapy, and also used as a hemostatic agent in dermatosurgery procedures.
DERMATOLOGIC THERAPY
(2022)
Article
Multidisciplinary Sciences
Gozde Sir Karakus, Cihan Tastan, Derya Dilek Kancagi, Bulut Yurtsever, Gamze Tumentemur, Sevda Demir, Raife Dilek Turan, Selen Abanuz, Didem Cakirsoy, Utku Seyis, Samed Ozer, Omer Elibol, Muhammer Elek, Gurcan Ertop, Serap Arbale, Merve Acikel Elmas, Canso Hermsinlioglu, Ayse Sesin Kocagoz, Ozden Hatirnaz Ng, Sezer Akyoney, Ilayda Sahin, Ugur Ozbek, Dilek Telci, Fikrettin Sahin, Koray Yalcin, Siret Ratip, Ercument Ovali
Summary: The SARS-CoV-2 vaccines are crucial for reducing disease incidence and mortality. Vaccine models containing GM-CSF induced significant antibody production with neutralization capacity, and the presence of adjuvant was more important in T cell response.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Jiale Zou, Ningli Chai, Enqiang Linghu, Yaqi Zhai, Zantao Wang, Longsong Li
Summary: The study found that compared to ESD, ESTD has a higher dissection speed and larger specimen area for rectal LSTs. This remained true even after propensity score matching was conducted.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Kae Nakamura, Nobuhisa Yoshikawa, Yuko Mizuno, Miwa Ito, Hiromasa Tanaka, Masaaki Mizuno, Shinya Toyokuni, Masaru Hori, Fumitaka Kikkawa, Hiroaki Kajiyama
Summary: Ovarian cancer is a highly malignant gynecologic cancer with frequent intraperitoneal recurrence due to occult metastasis. Plasma-activated medium (PAM) and plasma-activated lactate Ringer's solution (PAL) showed inhibitory effects on metastasis and improved overall survival rate in an ovarian cancer mouse model, suggesting potential clinical applications for treating ovarian cancer.