Review
Microbiology
Hongyan Guo, Heather S. Koehler, Richard D. Dix, Edward S. Mocarski
Summary: HSV1 is a common human pathogen that can cause oral and ocular diseases. Host immune mechanisms and cell death pathways play important roles in controlling HSV1 infection, while the virus has evolved strategies to evade host cell death.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Abigail L. Whitford, Corinne A. Clinton, E. B. Lane Kennedy, Sara A. Dochnal, Jon B. Suzich, Anna R. Cliffe
Summary: The cellular protein DLK plays an essential role in the reactivation of herpes simplex virus, and the mechanisms of gene expression during reactivation are distinct from replication.
JOURNAL OF VIROLOGY
(2022)
Review
Immunology
Iara M. M. Backes, David A. A. Leib, Margaret E. E. Ackerman
Summary: The fetal/neonatal period is a critical stage for interventions and also a vulnerable period for viral infections. Maternal transfer of antibodies can reduce the risk of neonatal herpes simplex virus (nHSV) infections. Exploring the combination of antibody-based interventions and antiviral therapy is important for reducing infant mortality and long-term morbidity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Johanna Laakso, Tytti Vuorinen, Jaana Rautava, Katja Kero, Stina Syrjanen, Veijo Hukkanen
Summary: This study evaluated the HSV seroprevalence and seroconversion among pregnant women and their spouses in Finland over a six-year follow-up period. Results showed a higher overall HSV seroprevalence in women compared to their spouses, with similar seroconversion rates between spouses. Factors associated with HSV seropositivity varied between women and male spouses, with women's age and history of genital warts being significant factors, while male spouses' HSV seropositivity was linked to the practice of oral sex.
Article
Microbiology
Dor Rafael, Enosh Tomer, Oren Kobiler
Summary: Latent infection is a characteristic feature of herpesviruses, where the number of latent viral genomes reactivating per cell is limited and typically only one genome reactivates in each cell.
MICROBIOLOGY SPECTRUM
(2022)
Article
Critical Care Medicine
Tanguy Chaumette, Raphael Cinotti, Alice Molle, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish E. G. McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cedric Jacqueline, Mickael Vourc'h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Regis Josien, Jose A. Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, Jeremie Poschmann, Antoine Roquilly
Summary: Brain injury induces immunosuppression, increasing the risk of viral reactivations and impairing neurological recovery. This study found that lung replication of herpesviridae is associated with poor recovery after brain injury, and a specific monocyte signature can predict the neurological outcome at 6 months.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Virology
Suzy Teutsch, Angela Berkhout, Camille Raynes-Greenow, Yvonne Zurynski, Philip N. Britton, Cheryl A. Jones, APSU Neonatal HSV Study Advisory Grp
Summary: A study in Australia over 24 years reveals the characteristics of neonatal herpes simplex virus (HSV) central nervous system (CNS) disease. The incidence rate of HSV CNS disease is 1.29 cases per 100,000 live births per year, and male neonates are more susceptible to the disease. Despite the use of antiviral agents, morbidity and mortality from HSV CNS disease remain high, highlighting the need for evaluation of adjunctive therapies to improve outcomes.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Kerry J. Laing, Werner J. D. Ouwendijk, Victoria L. Campbell, Christopher L. McClurkan, Shahin Mortazavi, Michael Elder Waters, Maxwell P. Krist, Richard Tu, Nhi Nguyen, Krithi Basu, Congrong Miao, D. Scott Schmid, Christine Johnston, Georges M. G. M. Verjans, David M. Koelle
Summary: This study reveals that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in the rash-involved skin after recovery from zoster, indicating their importance in controlling skin infections.
NATURE COMMUNICATIONS
(2022)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Microbiology
Sajal Deea Shukla, Tibor Valyi-Nagy
Summary: HSV-1 is a human virus that causes lifelong infections and can lead to various diseases, including blindness and central nervous system diseases. Host molecules play important roles in the infection process, including immune response, autophagy, and inflammation. Understanding the interaction between the virus and host molecules is essential for developing effective treatments.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Malgorzata Krzyzowska, Anders Jarneborn, Karolina Thorn, Kristina Eriksson, Tao Jin
Summary: This study provides evidence that treatment with tofacitinib may increase the risk of disease aggravation and severe encephalitis in primary herpes simplex infection by impairing antiviral response induced by monocytes and microglia.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Noor Motea Abdo, Irfan Aslam, Shazia Irfan, Junu A. A. George, Ahmed R. R. Alsuwaidi, Luai A. A. Ahmed, Rami H. H. Al-Rifai
Summary: This study investigated the prevalence of HSV-2 infection among patients seeking fertility treatment in the UAE and found that approximately 10% of patients were exposed to HSV-2. HSV-2 infection was more common in males, patients with secondary infertility, and those with abnormal semen analysis.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Giorgia Napoletani, Virginia Protto, Maria Elena Marcocci, Lucia Nencioni, Anna Teresa Palamara, Giovanna De Chiara
Summary: This study investigated the impact of recurrent HSV-1 infection on neuronal aging, revealing a significant increase in H4K16ac, Sin3, and HDAC1 levels, which are related to aging markers. There was a significant decrease in H3K56ac specifically linked to viral reactivation, and a complex modulation of HIRA expression and localization in HSV-1 infected mouse brains, suggesting a specific role of this protein in viral latency and reactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Multidisciplinary Sciences
Thomas R. Frieden
Article
Primary Health Care
Hemalatha Murugan, Clarence Spigner, Christy M. McKinney, Christopher J. Wong
PRIMARY HEALTH CARE RESEARCH AND DEVELOPMENT
(2018)
Article
Developmental Biology
Vu H. A. Dien, Christy M. McKinney, Araya Pisek, Waranuch Pitiphat
BIRTH DEFECTS RESEARCH
(2018)
Letter
Medicine, General & Internal
Sandeep P. Kishore, Abdul Salam, Anthony Rodgers, Marc G. Jaffe, Tom Frieden
Article
Cardiac & Cardiovascular Systems
Vasilis Kontis, Laura K. Cobb, Cohn D. Mathers, Thomas R. Frieden, Majid Ezzati, Goodarz Danaei
Article
Medicine, General & Internal
Christy M. McKinney, Somnath Mookherjee, Stephan D. Fihn, Thomas H. Gallagher
JOURNAL OF HOSPITAL MEDICINE
(2019)
Letter
Medicine, General & Internal
Ivor J. Benjamin, Reinhold Kreutz, Michael H. Olsen, Aletta E. Schutte, Patricio Lopez-Jaramillo, Thomas R. Frieden, Karen Sliwa, Daniel T. Lackland, Michael Brainin
Article
Peripheral Vascular Disease
Thomas R. Frieden, Cherian V. Varghese, Sandeep P. Kishore, Norman R. C. Campbell, Andrew E. Moran, Raj Padwal, Marc G. Jaffe
JOURNAL OF CLINICAL HYPERTENSION
(2019)
Article
Health Care Sciences & Services
Jocelyn R. James, JoAnna M. Scott, Jared W. Klein, Sara Jackson, Christy McKinney, Matthew Novack, Lisa Chew, Joseph O. Merrill
JOURNAL OF GENERAL INTERNAL MEDICINE
(2019)
Editorial Material
Public, Environmental & Occupational Health
Samuel W. Dooley, Thomas R. Frieden
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2020)
Article
Peripheral Vascular Disease
Laura K. Cobb, Thomas R. Frieden, Lawrence J. Appel
JOURNAL OF CLINICAL HYPERTENSION
(2020)
Review
Nutrition & Dietetics
Nicole Ide, Adefunke Ajenikoko, Lindsay Steele, Jennifer Cohn, Christine J. Curtis, Thomas R. Frieden, Laura K. Cobb
Editorial Material
Medicine, General & Internal
Thomas R. Frieden, Shama Cash-Goldwasser
ANNALS OF INTERNAL MEDICINE
(2021)
Editorial Material
Public, Environmental & Occupational Health
Thomas R. Frieden, Marine Buissonniere, Amanda McClelland
Review
Dentistry, Oral Surgery & Medicine
T. Marzouk, S. Sathyanarayana, A. S. Kim, A. L. Seminario, C. M. McKinney
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2019)