Genetic Control of Testis Development

Excess DAX1 Leads to XY Ovotesticular Disorder of Sex Development (DSD) in Mice by Inhibiting Steroidogenic Factor-1 (SF1) Activation of the Testis Enhancer ofSRY-box-9(Sox9)

(2012) Louisa M. Ludbrook et al.   ENDOCRINOLOGY

SRY Directly Regulates the Neurotrophin 3 Promoter During Male Sex Determination and Testis Development in Rats1

(2011) Tracy M. Clement et al.   BIOLOGY OF REPRODUCTION

Initiating Meiosis: The Case for Retinoic Acid1

(2011) Michael D. Griswold et al.   BIOLOGY OF REPRODUCTION

Two distinct origins for Leydig cell progenitors in the fetal testis

(2011) Tony DeFalco et al.   DEVELOPMENTAL BIOLOGY

Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice

(2011) Kenichi Kashimada et al.   FASEB JOURNAL

XX males SRY negative: a confirmed cause of infertility

(2011) A. Vetro et al.   JOURNAL OF MEDICAL GENETICS

DMRT1 prevents female reprogramming in the postnatal mammalian testis

(2011) Clinton K. Matson et al.   NATURE

Reframing sexual differentiation of the brain

(2011) Margaret M McCarthy et al.   NATURE NEUROSCIENCE

ASOX9Duplication and Familial 46,XX Developmental Testicular Disorder

(2011) James J. Cox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Copy Number Variation in Patients with Disorders of Sex Development Due to 46,XY Gonadal Dysgenesis

(2011) Stefan White et al.   PLoS One

Basic Helix-Loop-Helix Transcription Factor TCF21 Is a Downstream Target of the Male Sex Determining Gene SRY

(2011) Ramji K. Bhandari et al.   PLoS One

Sex-specific timing of meiotic initiation is regulated by Cyp26b1 independent of retinoic acid signalling

(2011) Sandeep Kumar et al.   Nature Communications

Mutations in MAP3K1 Cause 46,XY Disorders of Sex Development and Implicate a Common Signal Transduction Pathway in Human Testis Determination

(2010) Alexander Pearlman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FGF9 Suppresses Meiosis and Promotes Male Germ Cell Fate in Mice

(2010) Josephine Bowles et al.   DEVELOPMENTAL CELL

A study of goat SRY protein expression suggests putative new roles for this gene in the developing testis of a species with long-lasting SRY expression

(2010) Fatemeh Montazer-Torbati et al.   DEVELOPMENTAL DYNAMICS

Identification of SOX3 as an XX male sex reversal gene in mice and humans

(2010) Edwina Sutton et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning

(2010) J. Cool et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations of the SRY-Responsive Enhancer of SOX9 Are Uncommon in XY Gonadal Dysgenesis

(2010) I. Georg et al.   Sexual Development

Ovaries and Female Phenotype in a Girl with 46,XY Karyotype and Mutations in the CBX2 Gene

(2009) Anna Biason-Lauber et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Cerebellin 4 Precursor Gene Is a Direct Target of SRY and SOX9 in Mice1

(2009) Stephen T. Bradford et al.   BIOLOGY OF REPRODUCTION

Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation

(2009) N. Henriette Uhlenhaut et al.   CELL

The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation

(2009) B. Moniot et al.   DEVELOPMENT

FGF signaling directs a center-to-pole expansion of tubulogenesis in mouse testis differentiation

(2009) Ryuji Hiramatsu et al.   DEVELOPMENT

Male-specific expression ofAldh1a1in mouse and chicken fetal testes: Implications for retinoid balance in gonad development

(2009) Josephine Bowles et al.   DEVELOPMENTAL DYNAMICS

Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal

(2009) S. C. Munger et al.   GENES & DEVELOPMENT

Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development

(2009) Juan Carlos Polanco et al.   HUMAN MOLECULAR GENETICS

Conserved regulatory modules in the Sox9 testis-specific enhancer predict roles for SOX, TCF/LEF, Forkhead, DMRT, and GATA proteins in vertebrate sex determination

(2009) Stefan Bagheri-Fam et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The avian Z-linked gene DMRT1 is required for male sex determination in the chicken

(2009) Craig A. Smith et al.   NATURE

Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination

(2009) Debora Bogani et al.   PLOS BIOLOGY

Sex determination in mammals — Before and after the evolution of SRY

(2008) M. C. Wallis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A critical time window of Sry action in gonadal sex determination in mice

(2008) R. Hiramatsu et al.   DEVELOPMENT

Notch signaling maintains Leydig progenitor cells in the mouse testis

(2008) H. Tang et al.   DEVELOPMENT

Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8

(2008) Francisco Barrionuevo et al.   DEVELOPMENTAL BIOLOGY

Endothelial cell migration directs testis cord formation

(2008) Alexander N. Combes et al.   DEVELOPMENTAL BIOLOGY

The Chromosome 11 Region From Strain 129 Provides Protection From Sex Reversal in XYPOS Mice

(2008) G. Nikolova et al.   GENETICS

Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

(2008) Ryohei Sekido et al.   NATURE

Four-dimensional analysis of vascularization during primary development of an organ, the gonad

(2008) D. Coveney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis

(2008) S. Yoshimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peritubular Myoid Cells Are Not the Migrating Population Required for Testis Cord Formation in the XY Gonad

(2008) J. Cool et al.   Sexual Development

Loss of Fgfr2 leads to partial XY sex reversal

(2007) Stefan Bagheri-Fam et al.   DEVELOPMENTAL BIOLOGY