期刊
SEXUAL DEVELOPMENT
卷 3, 期 1, 页码 38-42出版社
KARGER
DOI: 10.1159/000200080
关键词
Aromatase; DM-W; Feminization; Ovary; Sex determination; Xenopus laevis; ZZ/ZW
资金
- Ministry of Education Culture, Sports, Science, and Technology
The molecular mechanisms of vertebrate ZZ/ZW-type sex-determining systems remain unclear. We recently indicated that a W-linked gene, DM-W is a likely ovary-determining gene in Xenopus laevis. We first examined whether Cyp19 for estrogen-synthesizing enzyme P450 aromatase and Foxl2 showed female-specific expression in developing gonads. Both genes showed much higher expression in ZW than in ZZ gonads during and after sex determination. Importantly, transgenic ZZ gonads expressing exogenous DM-W at the sex-determining stage showed a ZW-type pattern of Cyp19 and Foxl2 expression. These results suggest that DM-W up-regulates Cyp19 and Foxl2 expression to guide primary ovary development in X. laevis. Copyright (C) 2009 S. Karger AG, Basel
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