期刊
SEXUAL DEVELOPMENT
卷 3, 期 1, 页码 16-25出版社
KARGER
DOI: 10.1159/000200078
关键词
Blood-testis barrier; Male fertility; Sertoli cell; SRY-box; Spermatogenesis
资金
- NIH, National Institute of Environmental Health Sciences [ES071003-11]
- Indo-US Collaboration on Environment and Occupational Health Grant
- RIKEN Brain Science Institute [833-3944]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [Z01ES071003] Funding Source: NIH RePORTER
Sertoli cells provide nutritional and physical support to germ cells during spermatogenesis. Sox8 encodes a high mobility group transcription factor closely related to Sox9 and Sox10. Sertoli cells produce SOX8 protein, and its elimination results in an age-dependent deregulation of spermatogenesis resulting in male infertility. This suggests that Sox8 is a critical regulator of Sertoli cell function for the maintenance of male fertility beyond the first wave of spermatogenesis. To better understand the roles of Sox8 in testicular development and maintenance of male fertility, we have performed a detailed analysis to explore its downstream genes. We have used mRNA expression profiling to identify affected genes in Sertoli cells in the mutant testes of 2-month-old mice. Expression profiling of the heterozygous and homozygous Sox8 mutant testes indicates alterations in several important spermatogenesis and blood-testis barrier genes, providing insight into the molecular basis of the defects in Sox8(-/-) testes beyond the first wave of spermatogenesis. Copyright (C) 2009 S. Karger AG, Basel
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