Review
Pharmacology & Pharmacy
Antonio Corsello, Marina Macchi, Veronica D'Oria, Chiara Pigazzi, Ilaria Alberti, Giorgio Treglia, Valentina De Cosmi, Alessandra Mazzocchi, Carlo Agostoni, Gregorio Paolo Milani
Summary: Due to the lipophilic nature of vitamin D, overweight and obese patients have an increased risk of inadequate circulating 25-hydroxy-vitamin D concentrations. Although supplementation strategies of vitamin D for pediatric subjects with excessive body weight have been proposed, the efficacy remains controversial. This systematic review and meta-analysis found that vitamin D supplementation slightly increases 25-hydroxy-vitamin D levels in overweight and obese children and adolescents, but its effects on metabolic and cardiovascular outcomes remain controversial.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Nutrition & Dietetics
Jessica Lewgood, Barbara Oliveira, Marie Korzepa, Scott C. Forbes, Jonathan P. Little, Leigh Breen, Robert Bailie, Darren G. Candow
Summary: The prevalence of Type 2 diabetes (T2D) is increasing and creating a large economic burden. This review critically evaluates the effects of various dietary strategies on diabetes management as well as examines several purported supplements aiming to improve glucose control and body composition.
Article
Nutrition & Dietetics
Milena Burhop, Jan Philipp Schuchardt, Josefine Nebl, Mattea Mueller, Ralf Lichtinghagen, Andreas Hahn
Summary: The study found that Calanus oil has beneficial effects on glucose metabolism and insulin resistance in obese patients, but further research is needed to verify its clinical relevance and explore its mechanisms of action.
Article
Nutrition & Dietetics
Max L. Eckstein, Antonia Brockfeld, Sandra Haupt, Janis R. Schierbauer, Rebecca T. Zimmer, Nadine Wachsmuth, Beate Zunner, Paul Zimmermann, Barbara Obermayer-Pietsch, Othmar Moser
Summary: The study found that fructose led to lower peak blood glucose levels compared to glucose and glucose and fructose supplementation, with no significant difference between glucose and glucose and fructose supplementation in terms of peak values. Additionally, all conditions resulted in significantly higher peak blood glucose values compared to sucralose.
Article
Gastroenterology & Hepatology
Kalliopi Pafili, Sabine Kahl, Lucia Mastrototaro, Klaus Strassburger, Dominik Pesta, Christian Herder, Jennifer Putzer, Bedair Dewidar, Mona Hendlinger, Cesare Granata, Nina Saatmann, Aslihan Yavas, Sofiya Gancheva, Geronimo Heilmann, Irene Esposito, Matthias Schlensak, Michael Roden
Summary: Impaired mitochondrial function is a common feature of subcutaneous and visceral adipose tissue in obesity, non-alcoholic fatty liver, and steatohepatitis. Dysfunction specifically in visceral adipose tissue is associated with fatty liver disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Pediatrics
Hao Gou, Ya Wang, Yan Liu, Cai Peng, Weijia He, Xiangjuan Sun
Summary: The prevalence of overweight and obesity in children and adolescents is increasing globally. Vitamin D deficiency has been partially associated with child and adolescent overweight/obesity. This systematic review and meta-analysis assesses the effectiveness of vitamin D supplementation on child and adolescent overweight/obesity. Overall, high-dose vitamin D supplementation may reduce cardiometabolic risk and improve insulin resistance.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Maria Krajewska, Ewelina Witkowska-Sedek, Malgorzata Ruminska, Anna M. Kucharska, Anna Stelmaszczyk-Emmel, Maria Sobol, Anna Majcher, Beata Pyrzak
Summary: This study aimed to investigate the relationship between vitamin D, chemerin, and metabolic profile in overweight and obese children. The results showed that vitamin D supplementation led to improvements in CRP, total cholesterol, ALT, and OGTT 150-minute glucose levels. Additionally, there was a tendency for a negative association between 25(OH)D and chemerin levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sahar Foshati, Sajjad Moradi, Mohammad Tavassoly, Mohammad Hossein Rouhani
Summary: Both long-term and short-term capsaicin supplementation do not have significant effects on blood glucose and insulin levels. The dose and ingestion form of capsaicin may contribute to the heterogeneity between studies.
Article
Nutrition & Dietetics
Christopher Morrissey, Marie-Josephe Amiot, Aurelie Goncalves, Cecile Raverdy, Delphine Masson, Catherine Tardivel, Sandrine Gayrard, Myriam Carrere, Jean-Francois Landrier, Agnes Vinet, Antonia Perez-Martin
Summary: This study assessed the effects of vitamin D supplementation on arterial stiffness in obese adolescents. The researchers found that a high proportion of obese adolescents had vitamin D deficiency and supplementation improved carotid intima-media thickness (IMT) and reduced the risk of arterial stiffness.
Review
Nutrition & Dietetics
Ricardo Usategui-Martin, Daniel-Antonio De Luis-Roman, Jose Maria Fernandez-Gomez, Marta Ruiz-Mambrilla, Jose-Luis Perez-Castrillon
Summary: This study evaluated the impact of polymorphisms in the vitamin D receptor gene on the response to vitamin D supplementation through a systematic review and meta-analysis. The results suggest that the TaqI and FokI polymorphisms may play a role in modulating the response to vitamin D supplementation.
Article
Agriculture, Multidisciplinary
Shuhua Tian, Yunfan Wang, Xiangfei Li, Jie Liu, Jing Wang, Yingjian Lu
Summary: Sulforaphane (SFN) can alleviate obesity complications through various mechanisms, including reducing NAFLD, inflammation, oxidative stress, adipose tissue hypertrophy, and insulin resistance, as well as regulating glucose and lipid metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Massimiliano Peana, Pavan Kumar Mujawdiya, Lyudmila Pivina, Adrien Ongenae, Salva Piscopo, Beatrice Severin
Summary: Calcium is essential for bone health and nerve signaling, while phosphorus is a key component of ATP and helps regulate metabolic energy. Vitamins D and K are crucial for the absorption and excretion of calcium and phosphorus, with vitamin D playing a regulatory role in various bodily functions.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Marion Valle, Patricia L. Mitchell, Genevieve Pilon, Philippe St-Pierre, Thibault Varin, Denis Richard, Marie-Claude Vohl, Helene Jacques, Edgar Delvin, Emile Levy, Claudia Gagnon, Laurent Bazinet, Andre Marette
Summary: Supplementation with D-3 did not prevent cardiometabolic diseases or enhance the beneficial effects of omega-3 fatty acids in vitamin D-sufficient obese mice. D-3 supplementation altered the gut microbiota in the omega-3FA groups, but not in the omega-6FA groups.
JOURNAL OF NUTRITION
(2021)
Review
Nutrition & Dietetics
Manuel Rupprecht, Stefan Wagenpfeil, Jakob Schoepe, Reinhold Vieth, Thomas Vogt, Joerg Reichrath
Summary: A meta-analysis was conducted to investigate the impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in healthy adults in Europe. The findings suggest that vitamin D supplementation can significantly increase serum 25(OH)D levels, with the effect influenced by dosage and baseline serum levels.
Article
Nutrition & Dietetics
Rodrigo Fernandez-Verdejo, Lorena Malo-Vintimilla, Juan Gutierrez-Pino, Antonio Lopez-Fuenzalida, Pablo Olmos, Pablo Irarrazaval, Jose E. Galgani
Summary: The study compared individuals with low and high metabolic flexibility in response to an oral glucose tolerance test and found that while metabolic health markers were similar between the two groups, individuals with high metabolic flexibility had higher diastolic blood pressure, enhanced circulating triglyceride clearance, and increased subcutaneous fat.
FRONTIERS IN NUTRITION
(2021)
Review
Biology
Julia Drozdzynska, Wiktoria Jakubowska, Marika Kemus, Martyna Krokowska, Konrad Karpezo, Marcelina Wisniewska, Pawel Bogdanski, Damian Skrypnik
Summary: This review examines the effectiveness of SARS-CoV-2 and influenza vaccines in overweight and obese patients and highlights the impact of excess body weight on the immune system. It suggests that while vaccines can reduce morbidity in normal-weight and excess body mass individuals, patients with higher BMI tend to lose antibodies more quickly.
Article
Biochemistry & Molecular Biology
Marcelina Sperling, Teresa Grzelak, Marta Pelczynska, Pawel Bogdanski, Dorota Formanowicz, Krystyna Czyzewska
Summary: Omentin-1 levels are associated with central obesity and abnormal glucose tolerance, with lower levels found in obese patients and men with abnormal glucose tolerance. Gender, tissue insulin sensitivity, WHR, and body fat amount all have significant effects on serum omentin-1 concentration. High omentin-1 levels in men with obesity and normal glucose tolerance suggest a protective effect against metabolic disorders associated with obesity in males.
Article
Nutrition & Dietetics
Igor Loniewski, Monika Szulinska, Mariusz Kaczmarczyk, Konrad Podsiadlo, Daniel Styburski, Karolina Skonieczna-Zydecka, Pawel Bogdanski
Summary: This study aimed to assess the effects of a multi-strain probiotic formula on fecal short-chain fatty acids (SCFAs). The results showed that the probiotic dose was positively correlated with SCFA content in the stool, and this may lead to a reduction in cardiovascular risk factors by decreasing blood uric acid levels.
Review
Nutrition & Dietetics
Malgorzata Moszak, Marta Pelczynska, Agnieszka Wesolek, Dominika Stenclik, Pawel Bogdanski
Summary: Obesity is a chronic condition characterized by the accumulation of excessive fat in the body, and is often accompanied by health consequences. The treatment of obesity involves a comprehensive approach that includes diet, exercise, medication, surgery, and psychological support. The effectiveness of probiotics, prebiotics, and synbiotics in weight control has been studied, but the findings are inconclusive due to the heterogeneity of the studies.
Review
Endocrinology & Metabolism
Damian Skrypnik, Katarzyna Skrypnik, Joanna Suliburska, Pawel Bogdanski
Summary: By 2030, it is estimated that there will be a billion people suffering from obesity. Adipose tissue produces leptin, which affects cardiovascular risk by intensifying the synthesis of vascular endothelial growth factor (VEGF). Recent studies have shown the significant role of leptin-VEGF crosstalk in obesity and related disorders. In vitro, animal, and human research have demonstrated the importance of endothelial cell and adipocyte interaction, hypoxia, high-fat diet, and genetic and epigenetic mechanisms in this crosstalk.
Article
Nutrition & Dietetics
Jolanta Korczak, Marcin Mardas, Maria Litwiniuk, Pawel Bogdanski, Marta Stelmach-Mardas
Summary: This study aimed to assess the nutritional status, including sarcopenia development based on CT scans, in prostate cancer patients and its association with progression-free survival (PFS). The results showed that nutritional status was significantly related to PFS. There was a significant reduction in muscle tissue and increase in fat tissue in patients, but it had no impact on PFS. The study recommends assessing nutritional status and body composition using CT after castration therapy.
Article
Genetics & Heredity
Anna Andrzejczak, Agata Witkowicz, Dorota Kujawa, Damian Skrypnik, Monika Szulinska, Pawel Bogdanski, Lukasz Laczmanski, Lidia Karabon
Summary: The number of people suffering from metabolic syndrome (MetS), including type 2 diabetes (T2DM), hypertension, and obesity, has increased over 10 times in the last 30 years, posing a severe public health concern worldwide. Uncoupling protein 1 (UCP1) is a mitochondrial carrier protein found in brown adipose tissue and is involved in thermogenesis and energy expenditure. This study aimed to identify new UCP1 gene variants potentially associated with MetS and/or T2DM risk by performing NGS sequencing of the entire UCP1 gene. The results revealed 12 new variants, including rs3811787 which has been previously studied, that may have implications for MetS and/or T2DM risk in the Polish population.
Article
Biochemistry & Molecular Biology
Lukasz Pilarski, Marta Pelczynska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulinska, Pawel Bogdanski
Summary: This study aimed to determine the association between vaspin concentration and metabolic disorders in obese individuals. The results showed that serum vaspin concentrations were significantly higher in the obese group compared to the control group. The findings suggest that vaspin may be a useful diagnostic parameter for obesity-related complications.
Review
Biochemistry & Molecular Biology
Marta Pelczynska, Malgorzata Moszak, Agnieszka Wesolek, Pawel Bogdanski
Summary: Dietary patterns, specifically those containing bioactive food compounds such as polyphenols, unsaturated fatty acids, and probiotics, show promise in preventing and treating obesity-induced inflammation. These compounds modulate the secretion of inflammatory molecules, regulate gene expression, and modify signaling pathways involved in the inflammatory response. However, further research is needed to determine optimal strategies for their intake, and global education is necessary to promote the advantages of consuming bioactive food compounds and combat unhealthy dietary patterns.
Article
Biochemistry & Molecular Biology
Malgorzata Mirr, Anna Braszak-Cymerman, Aleksandra Ludziejewska, Matylda Kregielska-Narozna, Pawel Bogdanski, Wieslaw Bryl, Maciej Owecki
Summary: This study aimed to investigate the correlation between serum asprosin levels and insulin resistance indices, as well as the correlation between asprosin and obesity indices. The results showed that asprosin concentrations were significantly higher in obese patients, and there was a positive correlation between asprosin concentrations and body mass index, waist circumference, and all tested indices of insulin resistance. Therefore, asprosin can be considered a marker of obesity and insulin resistance.
Article
Chemistry, Multidisciplinary
Marcelina Sperling, Teresa Grzelak, Marta Pelczynska, Pawel Bogdanski, Krystyna Czyzewska, Dorota Formanowicz
Summary: Adipolin, neprilysin, and chemerin have pleiotropic properties that can influence health complications associated with obesity. This study aimed to investigate the relationship between adipokine levels and anthropometric and metabolic parameters, as well as blood pressure values, while considering gender and age. The results showed correlations between chemerin concentration and glucose levels in obese women, adipolin concentration and LDL-C serum concentration in obese individuals with normal glucose tolerance, and chemerin concentration and triglyceride levels in men. High chemerin levels were also associated with elevated triglyceride levels in men. Furthermore, age was found to affect the frequency of high plasma adipolin concentrations, but only in individuals with a BMI less than 30 kg/m(2). The study also revealed interrelationships between the concentrations of the studied adipokines.
APPLIED SCIENCES-BASEL
(2023)
Review
Health Care Sciences & Services
Kamila Bokayeva, Malgorzata Jamka, Michalina Banaszak, Aleksandra Makarewicz-Bukowska, Ada Adamczak, Maria Chrobot, Adrianna Janicka, Natalia Jaworska, Jaroslaw Walkowiak
Summary: Folic acid may have a positive effect on endothelial function but may not affect arterial stiffness. Further studies are needed to confirm these results.
Article
Surgery
Mikolaj Kaminski, Maja Mietkiewska-Dolecka, Matylda Kregielska-Narozna, Pawel Bogdanski
Summary: By analyzing Google users' search behavior, it was found that recommended pharmacological methods have gained increasing attention in obesity treatment. Although global users are more interested in weight loss surgery, dietary supplements with uncertain weight loss effects remain the most popular topics.
Article
Medicine, General & Internal
Malgorzata Jamka, Agata Czochralska-Duszynska, Edyta Madry, Aleksandra Lisowska, Katarzyna Jonczyk-Potoczna, Judyta Cielecka-Piontek, Pawel Bogdanski, Jaroslaw Walkowiak
Summary: This study aimed to evaluate the effects of CLA supplementation on bone mineral density and content in overweight or obese women. The results showed that three-month CLA supplementation did not improve bone health in this population. However, long-term intervention studies are needed to further investigate the potential benefits of CLA on bone health.
MEDICINA-LITHUANIA
(2023)
