Article
Gastroenterology & Hepatology
Jiangqiao Zhou, Lina Guo, Tengfei Ma, Tao Qiu, Sichen Wang, Song Tian, Li Zhang, Fengjiao Hu, Wei Li, Zhen Liu, Yufeng Hu, Tianyu Wang, Chenyang Kong, Juan Yang, Junjie Zhou, Hongliang Li
Summary: GALNT4 has been identified as a potential therapeutic target for liver I/R injury by inhibiting the ASK1-JNK/p38 signaling pathway, independent of its glycosyltransferase activity. This study highlights the importance of GALNT4 in protecting against hepatic ischemia-reperfusion injury and improving surgical outcomes for liver transplantation.
Article
Chemistry, Inorganic & Nuclear
Jaspreet S. Dhau, Avtar Singh, Paula Brandao, Vitor Felix
Summary: A new methodology for synthesizing bis[3-(4-chloro-N,N-diethylpyridine-2-carboxamide)] diselenide has been successfully achieved, characterized by various spectroscopic techniques and X-ray diffraction analysis. The compound showed antibacterial activity, with comparisons made to other pyridylselenium compounds and the standard drug Ampicillin.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Zhi-Ting Sun, Chi Ma, Guang-Jian Li, Xiang-Yu Zheng, Yi-Tong Hao, Yu Yang, Xu Wang
Summary: Alzheimer's disease is a common neurodegenerative disease with amyloid-beta peptide playing a key role in its pathogenesis. While monoclonal antibody studies face challenges, antibody fragments offer advantages and their combination with nanoparticles can be used for the diagnosis and treatment of AD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Naveenchandra Suryadevara, Andrea R. Shiakolas, Laura A. VanBlargan, Elad Binshtein, Rita E. Chen, James Brett Case, Kevin J. Kramer, Erica C. Armstrong, Luke Myers, Andrew Trivette, Christopher Gainza, Rachel S. Nargi, Christopher N. Selverian, Edgar Davidson, Benjamin J. Doranz, Summer M. Diaz, Laura S. Handal, Robert H. Carnahan, Michael S. Diamond, Ivelin S. Georgiev, James E. Crowe
Summary: This study identifies a rare human antibody, COV23434, that disrupts the integrity of the SARS-CoV-2 S protein and possesses a distinct class of functional activity. The findings suggest that the trimer interface region of the S protein may be a vulnerable site for the virus.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Materials Science, Multidisciplinary
A. Subashini, V. Veeramani, K. Thamaraiselvi, Aurelien Crochet, Priya Rose, Reji Philip, R. Ramesh Babu, K. Ramamurthi
Summary: Benzylideneaniline compounds BBFA and BBMOA were synthesized and characterized in terms of crystal structure, functional groups, thermal properties, optical performance, and biological activities through various experiments in this study.
Article
Biology
Songael Sahin
Summary: This study reports a newly synthesized crystalline molecule and calculates its structural, spectral, topological, and electronic properties using experimental and computational techniques. The study also presents computational approaches to the drug-like nature of the molecule and explores its therapeutic activity for Alzheimer's disease.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Elena I. Linkova, Vyacheslav S. Grinev, Oksana A. Mayorova, Alevtina Yu. Yegorova
Summary: Bicyclic pyrroloimidazolones and pyrrolopyrimidinones were synthesized by reacting aryl-substituted 4-oxobutanoic acids with aliphatic binucleophiles using a sealed vessels reactor. The reaction path was investigated by varying synthesis conditions and analyzing the formed intermediates. The structures of the obtained compounds were confirmed using various spectroscopy methods and X-ray diffraction data.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Efrain Polo-Cuadrado, Karoll Ferrer, Edison Osorio, Ivan Brito, Jonathan Cisterna, Margarita Gutierrez
Summary: The organo-crystalline compound N-(4-acetylphenyl)quinoline-3-carboxamide (4) was successfully synthesized and its structure was characterized using various spectroscopic methods and single crystal X-ray diffraction. Geometrical optimizations and theoretical UV-Vis spectrum analysis were carried out, showing good agreement with experimental results.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Engineering, Environmental
Qiaoyun Wen, Chenghao Duan, Feilin Zou, Dou Luo, Jiong Li, Zidan Liu, Jiarong Wang, Keyou Yan
Summary: In this work, dicyandiamide (DCD) is used as an antioxidative additive to address the pin-hole morphology and device instability issues in Sn-Pb mixed perovskite solar cells (PSCs). Through the addition of DCD, the crystallization and passivation of all-inorganic CsPb1-xSnxI2Br film is effectively regulated, resulting in improved efficiencies and stability in the inverted PSCs. Furthermore, by combining semitransparent PSCs and bottom PSCs, high efficiency 4-terminal tandem PSCs are demonstrated. This research paves the way for efficient all-inorganic perovskite tandem solar cells.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Mechanics
Zi Ding, Zhi Qin, Marcin Buchowiecki, Linhua Liu
Summary: In this study, theoretical investigations were conducted to obtain collision data between nitrogen (N) and nitrogen ion (N+), including scattering cross sections and collision integrals. The potential energy curves of N2+ were obtained using the ab initio method and used to calculate resonant charge exchange and elastic cross sections. The collision integrals for N(S-4)-N+(P-3) and N(S-4)-N+(D-1) interactions were computed, revealing the importance of elastic collision process at low temperatures. This is the first calculation of cross sections and collision integrals for the N(S-4)-N+(D-1) interaction using ab initio potential energy points, and the obtained results are crucial for modeling the transport properties of related plasmas.
Article
Chemistry, Medicinal
Michael Tully, Niklas Hauptstein, Kai Licha, Lorenz Meinel, Tessa Luhmann, Rainer Haag
Summary: Polymer conjugation to biologics is crucial for the development of potent and long acting biotherapeutics. In this study, the potential of linear polyglycerol (LPG) as an alternative polymer to poly(ethylene glycol) (PEG) was investigated. The results showed that LPG and PEG bioconjugates exhibited similar conjugation yields, hydrodynamic sizes, and protein activity. These findings provide promising insights for future pharmacokinetic evaluation of LPG-bioconjugates of therapeutic proteins.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Physical
Rhys P. King, William Levason, Gillian Reid
Summary: The tetra-alkylammonium tetrathioantimonate(V) salts were prepared and characterized. The alkylammonium salts showed solubility in water and weakly polar organic solvents, and [N(n-Bu)4]3[SbS4] was found to be suitable for studying coordination chemistry or materials applications that cannot use water as a solvent. Furthermore, a thiosulfate complex of a p-block element was obtained through the decomposition of [N(n-Bu)4]3[SbS4] in acidic media.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Medicinal
Mingyan Cao, Niluka De Mel, Jihong Wang, Conner Parthemore, Yang Jiao, Weimin Chen, Shihua Lin, Dengfeng Liu, Greg Kilby, Xiaoyu Chen
Summary: In this study, N-terminal E cyclization was identified as the major degradation pathway for monoclonal antibodies and bispecific antibodies in lyophilized formulations. The use of salt-gradient ion exchange chromatography and hydrophobic interaction chromatography effectively separated pE, and pE did not affect the binding activity of the antibodies. In vitro experiments suggested a potential role of serum matrix in pE conversion.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Srinu Tumpara, Elena Korenbaum, Mark Kuehnel, Danny Jonigk, Beata Olejnicka, Michael Davids, Tobias Welte, Beatriz Martinez-Delgado, Sabina Janciauskiene
Summary: The study identified a novel antibody, C42, which specifically recognizes the C-36 peptide of AAT in various immunoassay formats. The antibody showed effectiveness in dot- and Western blotting, confocal laser microscopy, and flow cytometry assays, suggesting its potential as an important tool in AAT-related research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Leonardo S. A. Carneiro, Fernando Almeida-Souza, Yanne S. C. Lopes, Rachel C. Novas, Kaique B. A. Santos, Carolina B. P. Ligiero, Katia da S. Calabrese, Camilla D. Buarque
Summary: The new series of compounds showed promising activity against Leishmania parasites in vitro, with compound 17x identified as a potential candidate for anti-leishmaniasis drugs.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Parul Goel, Thorsten Jumpertz, Anezka Ticha, Isabella Ogorek, David C. Mikles, Martin Hubalek, Claus U. Pietrzik, Kvido Strisovsky, Boris Schmidt, Sascha Weggen
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Psychiatry
Sylvie L. Lesuis, Sascha Weggen, Sandra Baches, Paul J. Lucassen, Harm J. Krugers
TRANSLATIONAL PSYCHIATRY
(2018)
Article
Clinical Neurology
Susanne Walter, Thorsten Jumpertz, Melanie Huettenrauch, Isabella Ogorek, Hermeto Gerber, Steffen E. Storck, Silvia Zampar, Mitko Dimitrov, Sandra Lehmann, Klaudia Lepka, Carsten Berndt, Jens Wiltfang, Christoph Becker-Pauly, Dirk Beher, Claus U. Pietrzik, Patrick C. Fraering, Oliver Wirths, Sascha Weggen
ACTA NEUROPATHOLOGICA
(2019)
Article
Neurosciences
Melanie Huettenrauch, Isabella Ogorek, Hans Klafki, Markus Otto, Christine Stadelmann, Sascha Weggen, Jens Wiltfang, Oliver Wirths
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2018)
Article
Clinical Neurology
Freyja Aichholzer, Hans-Wolfgang Klafki, Isabella Ogorek, Jonathan Vogelgsang, Jens Wiltfang, Norbert Scherbaum, Sascha Weggen, Oliver Wirths
Summary: Despite the correlation between CSF GPNMB levels and other parameters such as aging and CSF pTau levels, the study results indicate that GPNMB levels in CSF cannot distinguish between AD or other neurological diseases. The findings do not support GPNMB as a valuable neurochemical diagnostic biomarker of AD, suggesting the need for further studies involving healthy control individuals.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Review
Geriatrics & Gerontology
Thomas A. Bayer
Summary: Recent studies on Alzheimer's disease have suggested that N-truncated Aβ may be an effective therapeutic target and warrant further research. While past research has mainly focused on the contribution of N-terminal pyroglutamate Aβ to pathology, the potential role of Aβ(4-42) has been overlooked.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Martina Stazi, Sandra Lehmann, M. Sadman Sakib, Tonatiuh Pena-Centeno, Luca Buschgens, Andre Fischer, Sascha Weggen, Oliver Wirths
Summary: Research suggests that moderate caffeine consumption reduces the risk of Alzheimer's disease and can improve neuronal loss, behavioral deficits, and neurogenesis in mouse models of the disease. The study challenges the belief that caffeine is anti-amyloidogenic and highlights the potential role of promoting neurogenesis in its beneficial effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Thomas A. Bayer
Summary: Identifying clinically relevant drug targets in Alzheimer's disease research is a central aim, although there have been advances in preclinical models, translating these results into clinical settings remains a challenging endeavor.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Preeti Bakrania, Gareth Hall, Yvonne Bouter, Caroline Bouter, Nicola Beindorff, Richard Cowan, Sarah Davies, Jemma Price, Chido Mpamhanga, Elizabeth Love, David Matthews, Mark D. Carr, Thomas A. Bayer
Summary: New routes for active and passive immunisation against Alzheimer's disease (AD) have been discovered through the identification of a unique conformational epitope in the N-terminal region of the A beta protein. A vaccine called TAPAS showed promising results in reducing amyloid-plaque formation, rescuing brain glucose metabolism, stabilizing neuron loss, and improving memory deficiencies in mouse models of AD. Treatment with a humanised version of the TAP01 antibody also had positive effects in both models.
MOLECULAR PSYCHIATRY
(2022)
Letter
Clinical Neurology
Yvonne Bouter, Hendrik Liekefeld, Steffen Pichlo, Anna Celine Westhoff, Lydia Fenn, Preeti Bakrania, Thomas A. Bayer
ACTA NEUROPATHOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Liana Marengo, Fred Armbrust, Caroline Schoenherr, Steffen E. Storck, Ulrich Schmitt, Silvia Zampar, Oliver Wirths, Hermann Altmeppen, Markus Glatzel, Christoph Kaether, Sascha Weggen, Christoph Becker-Pauly, Claus U. Pietrzik
Summary: This study reports the generation of a transgenic mouse model of AD lacking the functional Mep1b gene (APP/lon x Mep1b(-/-)). The results showed that when meprin beta is absent, the levels of A beta 1-40 and 1-42 are reduced in APP/lon mice, and the deposition of N-terminally truncated A beta 2-x peptide is also decreased. Importantly, the loss of meprin beta improved cognitive abilities in APP/lon mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alexander D. Mazura, Anke Ohler, Steffen E. Storck, Magdalena Kurtyka, Franka Scharfenberg, Sascha Weggen, Christoph Becker-Pauly, Claus U. Pietrzik
Summary: Despite the lack of available therapies for Alzheimer's disease, research has found that reducing circulating PCSK9 levels can improve the clearance of cerebral amyloid-beta and reduce the burden of disease-related pathology in the brain, as well as improve memory processing.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Philip H. H. Klecker, Laura Fritzen, Alexander D. D. Mazura, Sascha Weggen, Claus U. U. Pietrzik
Summary: The preferred therapy for acute ischemic stroke is the use of Alteplase, a drug containing the enzyme tPA which destabilizes blood clots. BBB breakdown, associated with TJ protein degradation, is a significant issue in stroke pathology and appears to be more severe during therapy. The exact mechanisms of how tPA causes BBB breakdown are not fully understood, but it is believed that interaction with LRP1 is necessary for this effect. This study found that tPA does not change the barrier properties of microvascular endothelial cells but does affect microglial activation and BBB breakdown.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Biology
Angelika Sabine Bader, Marius-Uwe Gnaedig, Merle Fricke, Luca Bueschgens, Lena Josefine Berger, Hans-Wolfgang Klafki, Thomas Meyer, Olaf Jahn, Sascha Weggen, Oliver Wirths
Summary: Senile plaques consisting of amyloid-beta (A beta) peptides are a major pathological hallmark of Alzheimer's disease (AD). A beta 1-40 and A beta 1-42 are considered canonical full-length A beta species. In 5XFAD mice, overall plaque load increased in the subiculum, hippocampus, and cortex, with the subiculum having the highest plaque coverage. The load of A beta 1-x peaked at five months and decreased thereafter in the subiculum, while plaques positive for truncated A beta 4-x species increased continuously over time. We hypothesize ongoing plaque remodeling leads to conversion of A beta 1-x peptides into A beta 4-x peptides in brain regions with high A beta plaque burden.
Article
Medicine, Research & Experimental
Anfei Huang, Prashant Shinde, Jun Huang, Tina Senff, Haifeng C. Xu, Cassandra Margotta, Dieter Hussinger, Thomas E. Willnow, Jinping Zhang, Aleksandra A. Pandyra, Jorg Timm, Sascha Weggen, Karl S. Lang, Philipp A. Lang