Article
Chemistry, Analytical
Yangyang Shao, Yanjie Dong, Lixia Fan, Weidong Xu, Liu Bin, Lei Wang, Dapeng Li, Shancang Zhao
Summary: In this study, an electrochemical aptasensor based on the stable T-Hg2+-T structure was developed for Hg2+ determination. The use of 3D-rGO/AuNPs as support material provided more immobilization sites for thiolated probes, and the hybridization chain reaction (HCR) between non-complementary sequences resulted in the formation of extended double-stranded DNA. The aptasensor showed high sensitivity and low detection limit for Hg2+ detection.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Yanwen Jin, Zhuochun Huang, Bingyan Xu, Junbo Chen
Summary: To overcome the limitations of traditional immunoassay methods, the concept of incorporating branchedzyme-powered nanodevices into immunoassays is proposed. This strategy simplifies the assay procedure, achieves isothermal detection, and enables the construction of nanodevices specific to different targets without extensive redesign. The branchedzyme-powered nanodevice has demonstrated successful quantification of tumor biomarkers at subpicomolar concentrations, making it suitable for clinical applications.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Hui Liu, Jinshui Wang, Huali Jin, Min Wei, Wenjie Ren, Yurong Zhang, Ligen Wu, Baoshan He
Summary: A sensitive electrochemical biosensor for Hg2+ detection was developed using a dual amplification signal strategy, showing linear detection range from 0.001-100 nM and a low detection limit of 0.52 pM. This biosensor was successfully applied in detecting Hg2+ in milk powder samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Rajaji Pavadai, Panneerselvam Perumal
Summary: In this study, a biochemical sensing platform was developed using a fluorescent probe and a Trimetallic-MOF for specific and sensitive recognition of Ag+ and Hg2+ ions. The detection was achieved through catalytic cleavage of DNAzyme and the FRET mechanism, resulting in low detection limits and satisfactory recovery in water samples.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Dmitriy Sotnikov, Nadezhda A. Byzova, Anatoly Zherdev, Boris B. Dzantiev
Summary: The study presents a method based on fluorescence registration to measure the number of antibodies and their antigen-binding properties in antibody-nanoparticle conjugates, as well as to validate the reliability and effectiveness of gold nanoparticle preparations.
Article
Chemistry, Multidisciplinary
Zihao Deng, Wenying Jin, Qiaobo Yin, Jinkun Huang, Ziheng Huang, Haiyan Fu, Yali Yuan, Jianmei Zou, Jinfang Nie, Yun Zhang
Summary: This work introduces a new method for naked-eye nanosensing of Hg2+ using the Tyndall effect of gold nanoparticles, achieving ultra-sensitive detection of the target with a 5461-fold improvement in sensitivity compared to conventional GNP-based methods with surface plasmon resonance signaling.
CHEMICAL COMMUNICATIONS
(2021)
Article
Engineering, Electrical & Electronic
Fatma Betul Bal, Esma Sari, Recep Uzek, Elif Logoglu
Summary: A novel visual sensing platform for the detection of mercury (II) ion (Hg2+) was developed in this study using a graphene quantum dots functionalized gold nanoparticles nanocomposite system. The platform achieved selective, sensitive, and rapid sensing of Hg2+ through the prevention of aggregation of AuNPs functionalized with GQDs in the presence of Hg2+.
IEEE SENSORS JOURNAL
(2021)
Article
Biochemical Research Methods
Dawei Li, Shen Ling, Xinru Cheng, Zhaoqi Yang, Bei Lv
Summary: A colorimetric biosensor assay has been developed for the detection of Cd2+ and Hg2+ based on Cd2+-dependent DNAzyme cleavage and Hg2+-binding-induced conformational switching of the G-quadruplex fragment. The assay exhibits excellent selectivity and high sensitivity, making it suitable for environmental water sample testing and further environmental monitoring.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ruike Wang, Chen Zong, Gairu Li, Junhong Wang, Tiantian Kong, Fei Li, Junmin Chang
Summary: A novel fluorescence imaging platform was developed for ultra-sensitive and rapid detection of cardiac troponin T, utilizing a high-throughput immunosensor chip and a DNA dendrimer capped with fluorescent dyes. The platform demonstrated excellent detection capabilities in serum samples, providing a new approach for early diagnosis of acute myocardial infarction.
Article
Biophysics
Wenting Cheng, Yanheng Yao, Dayong Li, Chengjie Duan, Zhongyun Wang, Yang Xiang
Summary: We have developed a dual-modal sensor for the detection of exosomal surface proteins from breast cancer patients. The sensor combines naked-eye detection and electrochemical assay, and has the capability to differentiate different stages of breast cancer and healthy individuals. With its universality, simplicity, and cost-effectiveness, it shows great potential as a diagnostic tool in breast cancer research and clinical practice.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Lulu Kong, Chongchong Wang, Weijie Yang, Lin Zhou, Shaohua Wei
Summary: The detection of mercury is important for assessing its toxicity and health risks. In this study, ultra-thin two-dimensional palladium nanosheets (PdNS) were synthesized for the simple, sensitive, accurate, and cheap detection of Hg2+. The PdNS showed high selectivity and sensitivity, and a detection kit was developed for Hg2+ detection using naked eye or cellphone at a low cost.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
XiaoTao Yan, JiaFeng Huang, Xiao Xiao, ChangBei Ma, Jiang Zhang, Olena Zhur, MingYang Zhou, HaiLun He, CuiLing Wu
Summary: A new label-free fluorescent sensor has been developed for detecting Hg2+ adsorbed by EPS. This sensor allows for the detection of Hg2+ in aqueous solution using fluorescence spectroscopy, and has been used to successfully analyze the adsorption properties of different EPS on Hg2+. It provides an effective detection technique for heavy metal pollution treatment using EPS.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Mohamed A. Abdou Mohamed, Hannah N. Kozlowski, Jisung Kim, Kyryl Zagorovsky, Melinda Kantor, Jordan J. Feld, Samira Mubareka, Tony Mazzulli, Warren C. W. Chan
Summary: The study developed a rapid, sensitive, and simple colorimetric nanodiagnostic platform for identifying disease-causing pathogens and their associated antibiotic resistance genes within 2 hours. The platform demonstrated high clinical sensitivity and specificity in detecting bacteria and antibiotic resistance markers from different biological samples, making it attractive for broad screening of microbial pathogens.
Article
Biochemical Research Methods
Mengmeng Liu, Fei Wang, Xueli Zhang, Xiuhai Mao, Lihua Wang, Yang Tian, Chunhai Fan, Qian Li
Summary: This method provides a step-by-step correlative imaging approach to investigate plasmonic NPs of different aggregation states in single cells. By using dark-field microscopy, fluorescence microscopy, and scanning electron microscopy, the clustering states of SNAs in a single cell can be efficiently distinguished and tracked in real time within 20 seconds. The entire procedure can be completed in 3-5 days and requires standard imaging and data analysis skills and equipment.
Article
Chemistry, Analytical
Yinjun Tang, Yu Wu, Weiqing Xu, Lei Jiao, Yifeng Chen, Meng Sha, Hua-Rong Ye, Wenling Gu, Chengzhou Zhu
Summary: Phase engineering is promising for the design of novel noble-metal-based nanomaterials, with specific crystalline degree playing a significant role in optimizing activity; the inhibition effect of mercapto molecules on nanozyme activity was further investigated; colorimetric sensing arrays were developed for distinguishing mercapto molecules.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhengwei Xiong, Haixia Zhong, Shuang Zheng, Pengxi Deng, Ning Li, Wen Yun, Lizhu Yang
ANALYTICAL METHODS
(2018)
Article
Spectroscopy
Wen Yun, Linfeng You, Fukun Li, Hong Wu, Lin Chen, Lizhu Yang
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2019)
Article
Chemistry, Analytical
Wen Yun, Ning Li, Ruiqi Wang, Lizhu Yang, Lin Chen, Yongjian Tang
ANALYTICA CHIMICA ACTA
(2019)
Article
Spectroscopy
Pengxi Deng, Shuang Zheng, Wen Yun, Weilu Zhang, Lizhu Yang
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2019)
Article
Chemistry, Analytical
Wen Yun, Hong Wu, Zhehan Yang, Ruiqi Wang, Chongjun Wang, Lizhu Yang, Yongjian Tang
ANALYTICA CHIMICA ACTA
(2019)
Article
Chemistry, Analytical
Wen Yun, Lin Chen, Zao Yi, Yong Yi, Yongjian Tang, Lizhu Yang
Article
Spectroscopy
Wen Yun, Yuan Hu, Qiulin Liu, Yan Li, Xingmin Wang, Yongjian Tang, Lizhu Yang
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2019)
Article
Chemistry, Analytical
Xiang Li, Wen Yun, Wenlin Guo, Weilu Zhang, Lizhu Yang
SENSORS AND ACTUATORS B-CHEMICAL
(2019)
Article
Spectroscopy
Zhengwei Xiong, Qiang Wang, Jiafeng Zhang, Wen Yun, Xingmin Wang, Xia Ha, Lizhu Yang
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2020)
Article
Chemistry, Applied
Zhengwei Xiong, Qiang Wang, Yuejie Xie, Ning Li, Wen Yun, Lizhu Yang
Summary: A dual DNA tweezers nanomachine was developed for simultaneous detection of AFB1 and OTA in food samples, achieving high sensitivity and accuracy through the binding of aptamers with their targets to control the fluorescent signals. The method demonstrated satisfactory recoveries and precision, with detection uncertainties within 5% at a 95% confidence level.
Article
Food Science & Technology
Zhengwei Xiong, Yanrong Ren, Cun Wang, Ge Wu, Wen Yun, Hong Chen, Lizhu Yang
Summary: A programmed, autonomous, and self-powered DNA motor was developed for one-step amplification detection of ochratoxin A. The motor undergoes autonomous and processive movement by circular cleaving fluorophore-labeled DNA on gold nanoparticles. This self-powered strategy shows great potential in food security supervision or biological imaging of OTA.
FOOD ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Wen Yun, Yiyan Lin, Ruiqi Wang, Xia Ha, Nana Xie, Xiaoli Xiong, Zhengwei Xiong, Ning Li, Xingmin Wang, Lizhu Yang
Summary: An efficient and innovative strategy for colorimetric detection of bisphenol A (BPA) is presented, based on target-induced catalytic hairpin assembly (CHA) and DNAzyme-caused fragment self-assembly hybridization chain reaction (HCR). The biosensor has high sensitivity for BPA detection at concentrations ranging from 0.8 pM to 500 pM, with a detection limit as low as 0.2 pM, providing a promising prospective ultrasensitive detection of BPA.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Zhengwei Xiong, Qiulin Liu, Wen Yun, Yuan Hu, Xingmin Wang, Lizhu Yang
Article
Chemistry, Multidisciplinary
Yuanyang Xie, Yu Huang, Dongyun Tang, Hongliang Cui, Lizhu Yang, Haiyan Cao, Wen Yun
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
