Article
Chemistry, Medicinal
Elena Iurova, Eugenia Rastorgueva, Evgenii Beloborodov, Evgeniya Pogodina, Aleksandr Fomin, Dmitrii Sugak, Denis Viktorov, Ivan Tumozov, Yury Saenko
Summary: In this study, the researchers investigated the effect of the omega-hexatoxin-Hv1a peptide toxin on the development of ischemia-reperfusion injury (IRI). They found that the toxin, at nanomolar concentrations, was able to prevent apoptosis and necrosis in epithelial cells by reducing the concentration of calcium, sodium, and potassium ions, as well as delaying pH level normalization. It also affected mitochondrial potential and oxidative stress. The low-dose requirement and high bioavailability of this toxin make it a potential alternative to chemical calcium channel blockers for preventing tissue and organ IRI.
Review
Pharmacology & Pharmacy
Ya-Qun Huang, Rui-Ting Wen, Xiao-Tong Li, Jiao Zhang, Zhi-Ying Yu, Yu-Fei Feng
Summary: Perioperative administration of dexmedetomidine can protect against liver ischemia-reperfusion injury after hepatectomy by reducing serum markers, decreasing oxidative damage, and alleviating liver injury. Further studies are needed to explore the impact of dexmedetomidine on postoperative recovery outcomes with different dosing regimens.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carlos Andres Pantanali, Vinicius Rocha-Santos, Marcia Saldanha Kubrusly, Inar Alves Castro, Luiz Augusto Carneiro-D'Albuquerque, Flavio Henrique Galvao
Summary: Nutraceuticals are bioactive compounds found in food that can improve health, prevent diseases, and support the normal functioning of the human body. They are able to target multiple pathways, acting as antioxidants, anti-inflammatory agents, and immune response and cell death modulators. This study investigated the effect of a nutraceutical solution on liver ischemia-reperfusion injury (IRI), and found that it decreased apoptosis and histologic injury in liver tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jing Mu, Chunxiao Li, Shi Yu, Guoyong Liu, Jianhua Zou, Dong-Yang Zhang, Chao Jiang, Xiuli Wang, Liangcan He, Peng Huang, Yuxin Yin, Xiaoyuan Chen
Summary: This study presents a novel strategy for protecting the liver against ischemia-reperfusion injury using nanotherapeutics. By combining reactive oxygen species scavenging and nitric oxide modulation, the researchers demonstrated that the nanotherapeutics effectively reduced oxidative stress and inflammation in the liver.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mathias Clarysse, Alison Accarie, Ricard Farre, Emilio Canovai, Diethard Monbaliu, Jan Gunst, Gert De Hertogh, Tim Vanuytsel, Jacques Pirenne, Laurens J. J. Ceulemans
Summary: Animal research on intestinal ischemia-reperfusion injury (IRI) is mainly done using rodent models. Previously, intraperitoneal injections with ketamine-xylazine mixtures were common, but now volatile anesthetics like isoflurane are more commonly used. However, the impact of the anesthetic method on intestinal IRI has not been studied. This study aims to analyze the different anesthetic methods and their influence on the extent of intestinal IRI in a rat model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Junya Matsumi, Tetsufumi Sato
Summary: Propofol has a greater hepatoprotective effect than sevoflurane in patients undergoing elective hepatectomies, as evidenced by lower postoperative transaminase levels.
Article
Reproductive Biology
Vahid Ganjiani, Nasrollah Ahmadi, Mohammad Reza Divar, Hassan Sharifiyazdi, Abdolhamid Meimandi-Parizi
Summary: The study revealed that I/R injury significantly affects sperm parameters, but crocin treatment did not significantly improve them. Crocin significantly improved histopathological parameters and hormone levels, reversing oxidative stress injuries caused by torsion/detorsion.
Article
Medicine, Research & Experimental
Zexin Li, Ying Wang, Yu Zhang, Xiao Wang, Baoqin Gao, Yan Li, Rong Li, Jianguo Wang
Summary: Fisetin was found to alleviate liver damage, cell apoptosis, and oxidative stress induced by liver IRI, at least through the Nrf2/HO-1 signaling pathway, suggesting its potential as a targeted drug for liver IRI treatment.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Dou Huang, Changwei Chen, Yunxia Zuo, Lei Du, Ting Liu, Geoffrey W. Abbott, Zhaoyang Hu
Summary: This study found that RLIPost reduces pulmonary damage induced by ischemia-reperfusion in both non-diabetic and diabetic rats. The protective mechanism in non-diabetic rats is associated with STAT-3, while in diabetic rats it is independent of STAT-3.
Article
Immunology
Behzad Lotfi, Yasin Bagheri, Abdollah Abdollahpour, Elham Ahmadian, Samira Matin, Amirhossein Firouzfar, Sepideh Zununi Vahed, Fateme Khajepour
Summary: This study aimed to evaluate the effect of Eprosartan, an AT-1 antagonist, on kidney I/R injury in rats. Results showed that Eprosartan significantly improved kidney function and increased antioxidant markers. Eprosartan exhibited anti-inflammatory activity by downregulating NF-kappa B and pro-inflammatory factors. It also prevented I/R-induced changes in apoptotic parameters. Additionally, Eprosartan + I/R rats showed higher levels of Sirtuin 1. In conclusion, Eprosartan has nephroprotective effects against I/R-induced kidney damage in rats by reducing oxidative stress, inflammation, and apoptosis, as well as increasing Sirtuin 1 levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Mei Li, Zhi Zheng
Summary: Parecoxib sodium attenuates intestinal injury induced by ischemia reperfusion by increasing antioxidant levels, suppressing oxidative damage, reducing inflammation, and promoting cell survival. It also improves the survival rate of rats post-reperfusion by inhibiting apoptosis and inflammation caused by I/R.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Maria Antonietta Grignano, Stefania Bruno, Simona Viglio, Maria Antonietta Avanzini, Marta Tapparo, Marina Ramus, Stefania Croce, Chiara Valsecchi, Eleonora Francesca Pattonieri, Gabriele Ceccarelli, Federica Manzoni, Annalia Asti, Carmelo Libetta, Vincenzo Sepe, Paolo Iadarola, Marilena Gregorini, Teresa Rampino
Summary: In this study, a new organ-conditioning strategy based on MSCs/EVs delivery was proposed. The results demonstrated that EVs can protect against renal ischemia-reperfusion injury by activating the CD73/ADO system, suggesting potential clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Milomir O. Simovic, Michael J. Falabella, Tuan D. Le, Jurandir J. DalleLucca, Yansong Li
Summary: This study investigated the effects of early administration of DAF on hemorrhage-induced organ damage. The results suggest that DAF treatment can alleviate organ injury and improve metabolic acidosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
C. Koseoglu Toksoy, Z. K. Sarita, U. Turk Boru, G. zeytin Demiral, F. Gorucu, A. Bulbul, H. H. Demirel, Y. Koc
Summary: The study demonstrates that anzer propolis, unique to Turkey’s Eastern Black Sea region, has a neuroprotective effect against ischemia-reperfusion injury and may have beneficial effects on neurodegenerative diseases.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elena Iurova, Evgenii Beloborodov, Eugenia Rastorgueva, Aleksandr Fomin, Yury Saenko
Summary: In this article, the effects of the sodium channel modulator mu-agatoxin-Aa1a on cells damaged by ischemia-reperfusion injury (IRI) were studied. The experiments showed that mu-agatoxin-Aa1a effectively prevented IRI by reducing apoptosis and maintaining intracellular ion concentrations, pH, ROS, NO, and mitochondrial potential.
Letter
Dermatology
Akiko Sekiguchi, Sei-ichiro Motegi, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2016)
Article
Dermatology
Sei-ichiro Motegi, Kazuya Yamada, Sayaka Toki, Akihiko Uchiyama, Yuka Kubota, Tetsuya Nakamura, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2016)
Article
Oncology
Akira Shimizu, Kyoichi Kaira, Keita Mori, Madoka Kato, Kimihiro Shimizu, Masahito Yasuda, Ayumi Takahashi, Tetsunari Oyama, Takayuki Asao, Osamu Ishikawa
Editorial Material
Dermatology
Mai Hattori, Sei-ichiro Motegi, Hiroo Amano, Norihisa Ishii, Osamu Ishikawa
ACTA DERMATO-VENEREOLOGICA
(2016)
Review
Dermatology
Sei-ichiro Motegi, Masahito Yasuda, Masayoshi Yamanaka, Hiroo Amano, Osamu Ishikawa
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
Sei-Ichiro Motegi, Akiko Sekiguchi, Sayaka Toki, Hiroo Amano, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
Mai Hattori, Akira Shimizu, Kyoichi Kaira, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
Sei-ichiro Motegi, Akihiko Uchiyama, Sayaka Toki, Kazuya Yamada, Hiroo Amano, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2016)
Letter
Dermatology
Hirohisa Ishibuchi, Sei-ichiro Motegi, Chikako Kishi, Hiroo Amano, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2016)
Letter
Dermatology
Masahito Yasuda, Akiko Sekiguchi, Sahori Kanai, Chikako Kishi, Ayumi Takahashi, Masayoshi Yamanaka, Takeki Mitsui, Norifumi Tsukamoto, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2016)
Letter
Dermatology
Akira Shimizu, Mai Hattori, Yuko Takeuchi, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2016)
Article
Oncology
Akira Shimizu, Kyoichi Kaira, Masahito Yasuda, Takayuki Asao, Osamu Ishikawa
Article
Oncology
Akira Shimizu, Kyoichi Kaira, Masahito Yasuda, Takayuki Asao, Osamu Ishikawa
PATHOLOGY & ONCOLOGY RESEARCH
(2017)
Article
Multidisciplinary Sciences
Yoshiki Yamakoshi, Sei-ichiro Motegi, Osamu Ishikawa
Article
Oncology
A. Shimizu, K. Kaira, M. Yasuda, T. Asao, O. Ishikawa