Article
Materials Science, Biomaterials
Cristina de la Encarnacion, Felix Jungwirth, David Vila-Liarte, Carlos Renero-Lecuna, Safiyye Kavak, Inaki Orue, Claire Wilhelm, Sara Bals, Malou Henriksen-Lacey, Dorleta Jimenez de Aberasturi, Luis M. Liz-Marzan
Summary: Hyperthermia has been shown to be an effective and selective cancer therapy strategy by heating malignant cells above 42 degrees C to trigger cell death. Magnetic and photothermal hyperthermia can benefit from the use of nanomaterials. This hybrid colloidal nanostructure, consisting of plasmonic gold nanorods covered by a silica shell and subsequently grown with iron oxide nanoparticles, is responsive to both external magnetic fields and near-infrared irradiation, enabling targeted magnetic separation and photothermal heating.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Xinyi Zhao, Gwendoline Smith, Bilal Javed, Garret Dee, Yurii K. Gun'ko, James Curtin, Hugh J. Byrne, Christine O'Connor, Furong Tian
Summary: The study developed two methods using nanoparticles and antibodies for detecting Salmonella. The ICGNP method showed higher sensitivity and specificity, providing effective detection of Salmonella.
Article
Engineering, Environmental
Xinhua Zhao, Lingling Du, Xiaxia Xing, Yingying Tian, Zhenxu Li, Chen Wang, Dongliang Feng, Huigang Liu, Dachi Yang
Summary: A stable and ppb-level hydrogen sensing has been developed using palladium and palladium oxide coated iron oxide nanoparticles (Pd/PdO@Fe2O3 NPs), which exhibit a low detection limit of 300 ppb, a fast response time of 3 seconds, and excellent selectivity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Bing Liu, Hanyu Tang, Qian Liu, Wenwen Wang, Haitao Li, Shiya Zheng, Fei Sun, Xiangwei Zhao
Summary: In this study, a novel surface-enhanced Raman scattering-based Western blot (SERS-WB) was proposed for accurate quantitative detection of low-abundance proteins. SERS nanotags were used as quantitative labels of proteins, and the target protein on the membrane could be directly identified by colorimetric signal due to the aggregation effect of nanoparticles.
Article
Chemistry, Physical
N. Liu, J. Guan
Summary: The rational fabrication of OER electrocatalysts using earth-abundant elements is important for sustainable energy applications. By creating a core-shell Co3O4@FeOx catalyst with an ultrathin FeOx coating, higher OER activity can be achieved due to the promotion of reaction, enhanced charge transfer ability, and accelerated diffusion attributed to the introduction of ultrathin FeOx.
MATERIALS TODAY ENERGY
(2021)
Article
Chemistry, Multidisciplinary
Sharafaldin Al-Musawi, Salim Albukhaty, Hassan Al-Karagoly, Faizah Almalki
Summary: A dual-targeting nanomedicine composed of pH-sensitive superparamagnetic iron oxide core-gold shell SPION@Au, chitosan (CS), and folate (FA) was developed for doxorubicin (DOX) antitumor medication. The nanocomposite exhibited elevated drug loading behavior and sustained drug release capacity, with long-term anti-cancer efficacy shown in SkBr3 cell lines. In vivo results demonstrated significant tumor size reduction in treated mice, indicating the potential of this formulation for clinical breast cancer treatment.
Article
Chemistry, Inorganic & Nuclear
Nuttaporn Pimpha, Noppawan Woramongkolchai, Panya Sunintaboon, Nattika Saengkrit
Summary: This study proposed a novel nanoparticle-based antimicrobial agent with recycle ability, showing effective antibacterial and antiviral properties against infectious pathogens in contaminated water, especially demonstrating strong antibacterial activity against waterborne pathogens.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Materials Science, Biomaterials
Mengye Li, Shengxiang Fu, Zhongyuan Cai, Danyang Li, Li Liu, Di Deng, Rongrong Jin, Hua Ai
Summary: Osteoporosis is a common skeletal disorder with significant structural and functional changes, and the development of new nanocomposites like SPIO@15HA shows promise in both promoting bone formation and preventing bone resorption. This dual-function material could potentially provide a new approach for the treatment of osteoporosis.
REGENERATIVE BIOMATERIALS
(2021)
Article
Chemistry, Physical
Francisco J. Garza, Ramis Arbi, Muhammad Munir, Jong-Hyun Lim, Ayse Turak
Summary: In this study, the shell thickness of core-shell nanoparticles (CSNP) was analyzed using Shard's methodology, which allowed for the conversion of XPS peak intensities into shell thickness. By simulating XPS spectra, extracting parameters using Shard's methodology, and comparing with experimental spectra to quantify the shell thickness, insights into the morphology and composition of CSNP were obtained. The results demonstrate that simulation software can serve as a complementary tool to multitechnique analysis for a detailed understanding of CSNP.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Review
Chemistry, Multidisciplinary
Juan Esteban Montoya Cardona, Dounia Louaguef, Eric Gaffet, Nureddin Ashammakhi, Halima Alem
Summary: Despite some delays in clinical implementation, functionalized magnetic and photothermal nanostructures remain the most promising way to target hyperthermia treatment of cancer towards local tumor regions. The synthesis method and parameters play a crucial role in optimizing the physicochemical properties for efficient energy transduction into locally released heat. This review aims to provide the latest applications and prospects of nanomaterials for hyperthermia properties.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Elizabeth C. H. T. Lau, Michelle Ahlen, Ocean Cheung, Alexey Y. Ganin, David G. E. Smith, Humphrey H. P. Yiu
Summary: Nanomedicine plays a crucial role in developing next-generation therapies, with the use of nanoparticles as drug delivery platforms becoming a major area of research. By utilizing the coordination chemistry between organic molecules and transition metal centers, the self-assembly of drugs onto nanoparticle surfaces can simplify the materials synthesis process. This perspective focuses on gold-iron oxide nanoplatforms as an example and outlines the prospects and challenges of utilizing self-assembly to prepare drug-nanoparticle constructs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Aniruddha B. Patil, Chuanbao Zheng, Liyun Ma, Ronghui Wu, Sharwari K. Mengane, Yifan Zhang, Xiaotian Liu, Zhaohui Meng, Wenli Zhang, Zijie Xu, Caifeng Chen, Jiani Huang, Xiang Yang Liu
Summary: A gold nanoparticles-hosted mesoporous nitrogen-doped carbon matrix prepared using bovine serum albumin (BSA) exhibited effective, sensitive and selective properties in a flexible sensor system for simultaneous detection of uric acid and dopamine. The nanohybrid sensor showed excellent response towards both analytes, suggesting promising applications in the development of electrochemical biosensors.
Article
Chemistry, Multidisciplinary
Haotian Yang, Claron J. Ridge, Kyle Overdeep, C. Michael Lindsay, Xiao Tong, Alexander Orlov
Summary: In this study, the thermal stability of Au-Al2O3 core-shell and Au nanowires was investigated. The nanowires were synthesized using the helium droplets method and deposited on various substrates. The in situ characterization showed that the Au-Al2O3 system had significantly enhanced stability compared to pure Au nanowires, indicating its potential as a durable Au-based nanocatalyst. Moreover, strong metal-support bonding was observed in the Au/Al2O3 system.
CHEMICAL COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Afsaneh Orouji, Forough Ghasemi, Arafeh Bigdeli, Mohammad Reza Hormozi-Nezhad
Summary: A multicolor sensor array was designed to simultaneously monitor various biogenic amines by altering the surface properties of gold nanostructures for qualitative and quantitative determination of BAs. The method offers rapid and visual detection with successful application in BAs detection in meat and fish samples.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Javier Bonet-Aleta, Jose I. Garcia-Peiro, Silvia Irusta, Jose L. Hueso
Summary: Nanozymes are nanomaterials that mimic the catalytic activity of natural enzymes and are widely used in the development of biosensing analytical tools. In this study, a gold-platinum nanoparticle with core-shell configuration was synthesized and exhibited remarkable oxidase-like activity towards specific substrates. By exploiting the loss of activity, an analytical method was developed to detect and quantify glutathione levels.
Article
Biochemistry & Molecular Biology
Abilene Rodrigues Correia, Isabella Sampaio, Edson Jose Comparetti, Nirton Cristi Silva Vieira, Valtencir Zucolotto
Summary: An electrochemical biosensor for FR alpha detection was developed using nanostructured layer-by-layer films on modified electrodes, showing good reproducibility and stability. The biosensor exhibited a linear response to FRa concentration and could differentiate tumor cells from healthy cells, demonstrating excellent selectivity. This biosensor provides a promising strategy for simple, rapid, and low-cost cancer diagnosis through FRa quantification on cancer cell surfaces.
BIOELECTROCHEMISTRY
(2021)
Article
Environmental Sciences
Jaqueline P. Souza, Adrislaine S. Mansano, Francine P. Venturini, Valeria S. Marangoni, Paula M. P. Lins, Barbara P. C. Silva, Barbara Dressler, Valtencir Zucolotto
Summary: This study evaluated the toxic effects of gold nanorods (AuNRs) on aquatic organisms, finding decreases in neonate production and filtration rate in cladocerans after exposure. The toxic mechanism in cladocerans was attributed to increased reactive oxygen species (ROS) generation. Enzymatic biomarkers in fish showed recovery after exposure to AuNRs, indicating the impacts of this novel nanomaterial on aquatic biota.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Analytical
Alexander Rodriguez, Francisco Burgos-Florez, Jose D. Posada, Eliana Cervera, Valtencir Zucolotto, Homero Sanjuan, Marco Sanjuan, Pedro J. Villalba
Summary: Neuronal damage caused by traumatic brain injury (TBI) is a rapidly progressing condition. The study successfully immobilized anti-S100B monoclonal antibodies on gold electrodes for early identification of clinical deterioration in TBI patients. Results showed that the AuIDEs platform has lower detection limits and a simpler manufacturing process.
Article
Polymer Science
Thiers M. Uehara, Fernanda L. Migliorini, Murilo H. M. Facure, Nicolau B. Palma Filho, Paulo B. Miranda, Valtencir Zucolotto, Daniel S. Correa
Summary: The study investigates the application of graphene oxide (GO) in medical devices, focusing on its interactions with liver cancer cells on different scaffold platforms. Spectroscopic and electrochemical analysis reveal the characteristics of GO-cell interactions, providing insights for regenerative medicine research.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Nanoscience & Nanotechnology
Glenn Quek, Yude Su, Ricardo K. Donato, Ricardo J. Vazquez, Valeria S. Marangoni, Pei Rou Ng, Mariana C. F. Costa, Binu Kundukad, Konstantin S. Novoselov, Antonio H. Castro Neto, Guillermo C. Bazan
Summary: This study demonstrates the use of 2D electrolytes as additives to enhance the pseudocapacitive performance of conducting polymer hydrogels (CPHs). The results show that the addition of 2D electrolytes improves cycling stability, specific capacitance, and working voltage window, with positively charged electrolytes being more effective than negatively charged ones.
ADVANCED ELECTRONIC MATERIALS
(2022)
Article
Engineering, Biomedical
Edson J. Comparetti, Paula M. P. Lins, Joao Quitiba, Valtencir Zucolotto
Summary: In this study, nanocarriers were used to transport siRNA into cancer cells and leukocytes to modulate the activity of tumor microenvironment cells. The results showed that the nanostructures were stable and could reduce the expression of CD47 and PD-L1 on cancer cells, and switch APC activity for an anti-tumor response.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Marine & Freshwater Biology
Priscila Rodrigues Siqueira, Jaqueline Perola Souza, Bianca Martins Estevao, Wanessa Fernanda Altei, Talita Laurie Lustosa Carmo, Fabricio Aparecido Santos, Heloisa Sobreiro Selistre Araujo, Valtecir Zucolotto, Marisa Narciso Fernandes
Summary: This study investigated the effects of graphene oxide (GO) and reduced graphene oxide (rGO) on zebrafish hepatocytes using in vitro assays. The results showed that the internalization of GO increased with increasing concentrations, while rGO had stronger interaction with the cell membrane due to its hydrophobic characteristic. After 72 hours of exposure, both GO and rGO showed harmful effects on the cells, but with different mechanisms of toxicity.
AQUATIC TOXICOLOGY
(2022)
Article
Biophysics
Isabella Sampaio, Felipe Domingues Quatroni, Juliana Naomi Yamauti Costa, Valtencir Zucolotto
Summary: A single chip that distinguishes between Zika and Dengue infections has been developed. The chip uses the non-structural protein 1 (NS1) as biomarkers and can also detect the spike proteins present in the SARS-CoV-2. This portable diagnostic test offers a point-of-care solution for the simultaneous detection of Zika, Dengue, and other viral infections.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Oncology
Bianca M. Estevao, Raquel R. C. Vilela, Isabella P. Geremias, Kassio P. S. Zanoni, Andrea S. S. de Camargo, Valtencir Zucolotto
Summary: In this study, organically modified mesoporous silica nanoparticles containing Ir complexes were synthesized successfully, showing promising potential for photodynamic therapy applications. In vitro tests demonstrated the ability of the nanoparticles to reduce cell proliferation in liver cancer cells after blue-light irradiation.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Chemistry, Analytical
Juliana Cancino-Bernardi, Edson Jose Comparetti, Natalia Noronha Ferreira, Renata Rank Miranda, Marco Montero Tuesta, Isabella Sampaio, Paulo Inacio Da Costa, Valtencir Zucolotto
Summary: A SARS-CoV-2 biosensor based on spike protein recognition of the ACE-2 receptor was developed using cell membranes. The biosensor showed a linear response and high selectivity, making it suitable for SARS-CoV-2 detection.
Article
Chemistry, Analytical
Jairo Pinto de Oliveira, Francisco Burgos-Florez, Isabella Sampaio, Pedro Villalba, Valtencir Zucolotto
Summary: In this study, a label-free impedimetric immunosensor was developed to detect OTA in coffee. The biosensor showed high selectivity and was not affected by matrix interference in coffee samples. It has the advantages of small sample volume, short analysis time, and potential miniaturization.
Review
Polymer Science
Luiza A. Mercante, Kelcilene B. R. Teodoro, Danilo M. dos Santos, Francisco V. dos Santos, Camilo A. S. Ballesteros, Tian Ju, Gareth R. Williams, Daniel S. Correa
Summary: This review highlights the significant advancements in stimuli-responsive antimicrobial electrospun nanofibers, triggered by light, temperature, pH, humidity, and electric field. The strategies employed to design smart electrospun nanofibers with antimicrobial properties are introduced. Recent examples of nanofibers based on different polymers and antimicrobial agents are explored within each stimulus category. The constraints and future directions of stimuli-responsive nanofibrous materials are discussed.
Article
Materials Science, Biomaterials
Luana Corsi Antonio, Lais Ribovski, Paula Maria Pincela Lins, Valtencir Zucolotto
Summary: Polymeric nanocarriers are effective drug delivery tools, but their toxic effects on cellular processes and interactions with cells still need further evaluation. This study assessed the interaction of nanocarriers prepared with different concentrations of Dex with myocardial cells, breast adenocarcinoma cells, and macrophages. The results showed that Dex concentration affected the uptake of nanocarriers and the formation of protein corona, and different carriers had varying mechanisms of cellular damage.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Renata Rank Miranda, Natalia Noronha Ferreira, Edmarcia Elisa de Souza, Paula Maria Pincela Lins, Leonardo Miziara Barboza Ferreira, Arne Kruger, Valeria Maria de Oliveira Cardoso, Edison Luiz Durigon, Carsten Wrenger, Valtencir Zucolotto
Summary: This study explores a drug repurposing strategy using nanotechnology to develop a therapy for COVID-19 treatment. By encapsulating the drug in nanoparticles, the toxicity of the drug is reduced while its antiviral activity is enhanced. This approach shows great potential as a new strategy in the fight against COVID-19.
ACS APPLIED BIO MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Camilo A. S. Ballesteros, Luiza A. Mercante, Augusto D. Alvarenga, Murilo H. M. Facure, Rodrigo Schneider, Daniel S. Correa
Summary: The review explores the recent advances in nanozymes for environmental applications, including different types of artificial enzymes based on nanomaterials and their comparison with standard natural enzymes, progress in detecting and removing environmental contaminants using nanozymes, as well as strategies for modulating nanozyme properties for environmental sensing and remediation, along with challenges and current opportunities in the field.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
