Article
Chemistry, Analytical
Zhenyu Yuan, Fan Yang, Fanli Meng
Summary: This article introduces the classification and structural characteristics of micro-hotplate gas sensors, as well as the assembly process and characteristics of various gas-sensing materials and micro-hotplates. Research shows that high-quality gas-sensitive material films can improve the response speed, response value, and selectivity of the sensor.
Article
Chemistry, Multidisciplinary
Evan L. H. Thomas, Jaspa Stritt, Soumen Mandal, Matthias Imboden, Oliver A. Williams
Summary: Researchers have fabricated a series of hotplates using boron-doped polycrystalline diamond, which can reach temperatures of up to 2731K in high vacuum conditions. These devices demonstrate rapid response times and a gray-body like emission response when characterized. The study suggests that diamond and sp(2) carbon are promising materials for next-generation micro-hotplates.
Article
Chemistry, Analytical
Tianren Feng, Duli Yu, Bo Wu, Hui Wang
Summary: This paper introduces a chip-level oven-controlled system for improving the temperature stability of MEMS resonators. The proposed system uses a micro-hotplate and airgel insulation, combined with AlN film and temperature-sensing resistors, to monitor and control the temperature of the resonator. The proposed structure achieves a frequency drift of 3.5 ppm and can be applied to other MEMS devices without redesign or additional constraints.
Article
Chemistry, Inorganic & Nuclear
Yuanyuan Zhang, Xiang Cao, Liangliang Zhen, Xuesong Wang
Summary: A new fluorescent chemosensor was designed and prepared by immobilizing a bis-salicylaldehyde Schiff base on the surface of SBA-15 mesoporous silica for sensitive determination of Cu2+ ions in water. The nanosensor showed a low detection limit and excellent selectivity for Cu2+ ions.
JOURNAL OF SOLID STATE CHEMISTRY
(2021)
Article
Chemistry, Analytical
Rafael da Silva Fernandes, Ivo M. Raimundo Jr
Summary: The study developed a reusable fluorescent nanosensor for detecting Cu(ii) ions in aqueous solutions, which showed good selectivity and sensitivity, with the concentration of Cu(ii) ions being reflected through fluorescence quenching.
ANALYTICAL METHODS
(2021)
Article
Biochemistry & Molecular Biology
Ibtihel Marzouk, David Riassetto, Alain Morand, Davide Bucci, Michel Langlet
Summary: In this paper, we present a fluorescent micro-structured architecture entirely fabricated on glass using sol-gel processing. By optimizing the two-step deposition/insolation sol-gel procedure, we achieved reproducible and uniform grating/waveguide structures on a large scale. This architecture shows great potential for further fluorescence measurements in liquid medium and waveguiding configuration.
Article
Spectroscopy
Eliane A. Namikuchi, Rafael D. L. Gaspar, Ivo M. Raimundo Jr, Italo O. Mazali
Summary: A nanosensor based on magnetic core-shell nanoparticles functionalized with RhBCARB has been synthesized for the detection of Cu(II) ions in water. The sensor exhibits a linear response, a low detection limit, and no interference from other metal ions. The magnetic properties of the sensor allow for easy removal and reuse.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Morgane Bonnel, Ibtihel Marzouk, David Riassetto, Alain Morand, Davide Bucci, Michel Langlet
Summary: In this study, we report the fabrication of channel waveguides with diffraction gratings using sol-gel processing. The architecture demonstrated efficient coupling and propagation of fluorescence signals, with a large tolerance for fiber positioning and spatial positioning. The optimal conditions for excitation signal propagation and emission signal detection were determined. This work shows promise for integrating this architecture into a microfluidic platform for fluorescence measurement in a liquid medium and waveguiding configuration.
Review
Chemistry, Physical
Siddharth Gurung, Francesco Gucci, Gareth Cairns, Iva Chianella, Glenn J. T. Leighton
Summary: This review presents the current trends in synthesizing hollow silica nanospheres using hard and soft templates, highlighting the need for improvements in surface charge, surface modification, sol-gel parameters, and the interaction between silica and templates. Control over the physical structure of the nanospheres is crucial for their extensive use in various fields.
Article
Chemistry, Analytical
Shihua Luo, Yuan Wu, Weilun Pan, Guangzhi Zhong, Bo Situ, Bo Li, Xinyi Ye, Xiujuan Jiang, Wenbin Li, Ye Zhang, Lei Zheng, Qian Wang
Summary: In this study, a new platform using an integrated magneto-fluorescent exosome (iMFEX) nanosensor was developed for rapid and sensitive detection of cancer-derived exosomes. The iMFEX nanosensor exhibited excellent specificity and sensitivity and showed potential for clinical application.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Tengyu He, David G. Bradley, Ming Xu, Shu-Ting Ko, Baiyan Qi, Yi Li, Yong Cheng, Zhicheng Jin, Jiajing Zhou, Lekshmi Sasi, Lei Fu, Zhuohong Wu, Jingcheng Zhou, Wonjun Yim, Yu-Ci Chang, John Hanna, Jian Luo, Jesse Jokerst
Summary: Inorganic nanomaterials show promise in theranostics, but their non-degradability limits their translation. We developed degradable PEI/calcium phosphate micro/nano-composites inspired by the biosilicification process in diatoms. These composites exhibit versatile sizes and morphologies without causing cell cytotoxicity.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Valeria Strokova, Ekaterina Gubareva, Yulia Ogurtsova, Roman Fediuk, Piqi Zhao, Nikolai Vatin, Yuriy Vasilev
Summary: A method for obtaining a photocatalytic composite material (PCM) by depositing titanium dioxide particles synthesized by the sol-gel method on a silica support has been developed. The study evaluated the effectiveness of using a photocatalytic agent as a carrier based on the properties of microsilica, gaize and diatomite. The photocatalytic activity of the developed composite materials was determined to be 86% for PCM based on diatomite, 85% for PCM based on microsilica, and 57% for PCM based on gaize in terms of the decomposition of rhodamine B.
Article
Materials Science, Ceramics
Yi-Chia Lee, Cheng-Che Tsai, Cheng-Ying Li, Yu-Cheng Liou, Cheng-Shong Hong, Sheng-Yuan Chu
Summary: The study utilized a hybrid sol-gel method to fabricate PNZT piezoelectric thick films with good performance. These films were applied in the design of piezoelectric cantilever beam MEMS accelerometers, successfully utilized for server hard-drive fault detection.
CERAMICS INTERNATIONAL
(2021)
Article
Polymer Science
Maria Zdonczyk, Bartlomiej Potaniec, Marta Fiedot-Tobola, Tomasz Baraniecki, Joanna Cybinska
Summary: The sol-gel technology enables the synthesis of multifunctional ceramic materials for nonlinear optics and photonics. This study explores the tunable emissions of SiO2 impregnated with organic dyes by annealing at different temperatures. The results suggest the potential protective role of sol-gel-derived silica and the use of dye-doped sol-gel layers as active components in photonics platforms.
Article
Polymer Science
Jameelah Al-Harby, Haja Tar, Sadeq M. Al-Hazmy
Summary: This study investigates the optical properties of a new fluorescent organic dye DBDMA based on boron difluoride complex, measuring parameters such as absorption, fluorescence, molar absorptivity, dipole moment, and oscillator strength. The research finds that immobilizing DBDMA in photosol-gel matrix produces the best results, with a large stokes shift and high fluorescence quantum yield. Additionally, the addition of gold nanoparticles into the hybrid material is discussed, with the organic-inorganic matrix showing the best host behavior for DBDMA fluorescence emission intensity.
Article
Polymer Science
Mohammad Al-Natour, Mohamed D. Yousif, Robert Cavanagh, Amjad Abouselo, Edward A. Apebende, Amir M. Ghaemmaghami, Dong-Hyun Kim, Jonathan W. Aylott, Vincenzo Taresco, Veeren M. Chauhan, Cameron Alexander
Article
Pharmacology & Pharmacy
Cameron Webb, Neil Forbes, Carla B. Roces, Giulia Anderluzzi, Gustavo Lou, Suraj Abraham, Logan Ingalls, Keara Marshall, Timothy J. Leaver, Julie A. Watts, Jonathan W. Aylott, Yvonne Perrie
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Carla B. Roces, Emily Charlotte Port, Nikolaos N. Daskalakis, Julia A. Watts, Jonathan W. Aylott, Gavin W. Halbert, Yvonne Perrie
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Review
Chemistry, Multidisciplinary
Veeren M. Chauhan, Hongyu Zhang, Paul A. Dalby, Jonathan W. Aylott
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Biochemistry & Molecular Biology
J. M. Hicks, N. J. Silman, S. K. Jackson, J. W. Aylott, F. J. Rawson
BIOELECTROCHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Anna M. Kotowska, Gustavo F. Trindade, Paula M. Mendes, Philip M. Williams, Jonathan W. Aylott, Alexander G. Shard, Morgan R. Alexander, David J. Scurr
NATURE COMMUNICATIONS
(2020)
Article
Medicine, Research & Experimental
Amjad Abouselo, Graham A. Rance, Francesco Tres, Lynne S. Taylor, Ana Kwokal, Ludovic Renou, David J. Scurr, Jonathan C. Burley, Jonathan W. Aylott
Summary: The study investigated the effect of excipients on the disproportionation kinetics of Pioglitazone HCl in tablets during dissolution using confocal Raman microscopy and UV-Vis spectroscopy. Different excipients were found to have varying effects on the rate of salt disproportionation and dissolution performance in different pH environments. Incorporating citric acid preserved the salt form and enhanced dissolution in acidic medium, while lactose and magnesium stearate induced salt disproportionation in the same acidic medium.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Birte Hollmann, Mark Perkins, Veeren M. Chauhan, Jonathan W. Aylott, Kim R. Hardie
Summary: Understanding the dynamic environmental microniches of biofilms will help us detect, manage, and exploit these communities, although there is still limited knowledge about the existing microniches. The use of ratiometric fluorescent pH-sensitive nanosensors allows real-time observation of physiological pH changes in biofilms, offering a potential application for identifying therapeutic solutions. This technology can be applied to analyze real-time three-dimensional pH variations in different biofilm formers like opportunistic pathogens and oral pathogens, providing insights into improving oral health.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Chemistry, Analytical
Veeren M. Chauhan, Mohamed M. Elsutohy, C. Patrick McClure, William L. Irving, Neil Roddis, Jonathan W. Aylott
Summary: A multimodal biosensor has been developed for detecting enteroviral nucleic acid sequences, with rapid, accurate, and economical features. The sensor can detect conserved enteroviral nucleic acid sequences and has potential applications in clinical disease evaluation and overcoming antimicrobial resistance.
Article
Chemistry, Analytical
Max K. Edney, Anna M. Kotowska, Matteo Spanu, Gustavo F. Trindade, Edward Wilmot, Jacqueline Reid, Jim Barker, Jonathan W. Aylott, Alexander G. Shard, Morgan R. Alexander, Colin E. Snape, David J. Scurr
Summary: Modern mass spectrometry techniques produce a wealth of spectral data, but the volume and complexity of data can hinder interpretation. This study applies molecular formula prediction to interpret 3D OrbiSIMS data and achieves successful results on different samples.
ANALYTICAL CHEMISTRY
(2022)
Correction
Polymer Science
Mohamed D. Yousif, Mohammad A. Al-Natour, Robert Cavanagh, Amjad Abouselo, Edward A. Apebende, Amir Ghaemmaghami, Dong-Hyun Kim, Jonathan W. Aylott, Vincenzo Taresco, Veeren M. Chauhan, Cameron Alexander
Article
Chemistry, Multidisciplinary
Claudia Martins, Veeren M. Chauhan, Amjad A. Selo, Mohammad Al-Natour, Jonathan W. Aylott, Bruno Sarmento
REACTION CHEMISTRY & ENGINEERING
(2020)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)