Article
Chemistry, Analytical
Liya Zhou, Xitong Zhou, Congli Zhao, Yihang Liu, Yaoxuan Li, Li Ma, Ying He, Yanjun Jiang, Jing Gao
Summary: Mo2C/NCS, with excellent electron conduction channels and active sites, was used to fabricate AChE biosensors for OPs detection, showing wide linear ranges and outstanding detection limits.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Kai Niu, Yuying Zhang, Jiping Chen, Xianbo Lu
Summary: Covalent organic frameworks (COFs) are attractive materials for energy storage, catalysis, sorption, and sensing due to their porosity, stability, and tunable structure. However, their low conductivity limits their application in electrochemical sensing. In this study, an aza-fused x-conjugated COFs with carbonyl groups (COF1) was synthesized and used as electrode materials in electrochemical sensing for the first time. The COF1-based biosensor showed improved current response compared to the electrode without COF1, demonstrating the enhancing effect of carbonyl groups on signal detection.
Article
Chemistry, Analytical
Fariba Beigmoradi, Masoud Rohani Moghadam, Zahra Garkani-Nejad, Alireza Bazmandegan-Shamili, Hamid Reza Masoodi
Summary: This study developed a dual template electrochemical sensor for simultaneous detection of the commonly used pesticides malathion and carbendazim. The sensor utilized a graphite-epoxy composite electrode modified with molecularly imprinted polymers coated on graphene quantum dots. Several parameters affecting the sensor response were optimized, and the optimum pH values were verified using density functional theory calculations. The results showed that the sensor had a linear response and low detection limits for both malathion and carbendazim.
ANALYTICAL METHODS
(2023)
Article
Biophysics
Kai Niu, Zicheng Zuo, Xianbo Lu, Lili Zou, Jiping Chen
Summary: In this study, a Cu@GDY nanocomposite was synthesized and used to fabricate an AChE biosensor for rapid detection of organophosphorus pesticides. The Cu@GDY nanocomposite exhibited excellent catalytic activity and the ability to regulate enzyme inhibition kinetics, resulting in amplified electrochemical signal and reduced oxidation potential for the pesticides. The biosensor achieved sensitive detection with high reproducibility and stability.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemical Research Methods
Shuling Xu, Min Li, Xia Li, Yanhui Jiang, Linlin Yu, Yue Zhao, Liyuan Wen, Qingwang Xue
Summary: In this study, a biosensor based on Ag/Au bimetallic nanoparticles was developed for simple and sensitive in situ detection of organophosphorus pesticide residues in food. The combination of AChE and CHO, along with the use of Ag/Au bimetallic nanoprobes as SERS signal probes, allowed for high sensitivity and stability. The method does not require complicated pretreatments and employs readily available reagents, showing great potential for in situ detection of organophosphorus pesticides in the field of food safety.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Chunming He, Ru Yan, Qingwang Xue, Shuxian Li, Huaisheng Wang
Summary: In this work, polyaniline (PANI) and overoxidized polyaniline (oPANI) nanorods doped by phytic acid (PA) were prepared as non-enzymatic malathion sensors. PA doping had a significant influence on the structural and morphological properties, conductivity, and detection performance of the electrode materials. PA-PANI exhibited high affinity towards malathion, hindering the redox reaction of PANI molecules, while PA-oPANI showed good catalytic performance, enhancing the electron transfer process. Both enzyme-free electrochemical sensors exhibited excellent stability, anti-interference ability, recovery in real samples, and wide linear ranges with low detection limits, indicating their potential as malathion sensors. Further exploration is needed for the reproducibility of the PA-oPANI sensor through anodic polarity processing.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Analytical
Huzeyfe Celik, Saniye Soylemez
Summary: A novel conductive polymer biosensor based on Poly(BT) and AChE was developed for the determination of paraoxon. The biosensor showed good detection sensitivity and linear range, and was effectively used for pesticide detection in milk and tap water samples.
Review
Chemistry, Applied
Utkarsh Jain, Kirti Saxena, Vinita Hooda, Sapna Balayan, Amar Pal Singh, Mayukh Tikadar, Nidhi Chauhan
Summary: The use of organophosphates and carbamates pesticides poses a threat to human health and the environment, necessitating the monitoring of pesticide residues in food and soil for sensitive detection. Electrochemical biosensors offer a solution to overcome the limitations of conventional detection techniques, providing higher sensitivity, faster detection, reliability, and ease of use for pesticide detection.
Article
Electrochemistry
Changhua Chen, Jianping Zhou, Zhilei Li, Yan Xu, Tongtong Ran, Junhao Gen
Summary: This study presents a wearable biosensor for on-site monitoring of pesticide presence on crop surfaces. The biosensor shows excellent selectivity and recognition for methyl parathion and successfully detects it within a linear range of 1 ppb to 2 ppm. The combination of electrospinning and screen printing processes makes this sensor straightforward, sensitive, and efficient.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Zhenfeng Lin, Xin Liu, Yangzi Li, Changxiang Li, Liu Yang, Keke Ma, Zhenwei Zhang, Huayu Huang
Summary: Two-dimensional Mo2C/Mo2N composites were successfully synthesized and used for fabricating a biosensor with ultra-low detection limit for CPF. The biosensor showed satisfactory recoveries for CPF in real samples with acceptable relative standard deviations.
Article
Environmental Sciences
Danial Abdollahdokht, Gholamreza Asadikaram, Moslem Abolhassani, Hossein Pourghadamyari, Mojtaba Abbasi-Jorjandi, Sanaz Faramarz, Mohammad Hadi Nematollahi
Summary: The study evaluated the exposure of organophosphate pesticides (OPPs) and organochlorine pesticides (OCPs) in farmworkers' children aged 6 to 11 years in Jiroft city in southeastern Iran, finding harmful effects on the participants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Spectroscopy
Yingfeng Qin, Gaojie Ye, Hao Liang, Ming Li, Jingjin Zhao
Summary: A novel amplified fluorescence polarization biosensor was developed for highly sensitive detection of organophosphorus pesticides using MnO2 nanosheets as the signal enhancer. The method efficiently suppresses AChE activity and decomposes MnO2 nanosheets to enhance FP signal, tremendously improving the sensitivity of detection for OPs such as diazinon.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Barbara B. Gerbelli, Pedro L. O. Filho, Bruna Cortez, Pedro T. Sodre, Mauricio D. Coutinho-Neto, Ian W. Hamley, Jani Seitsonen, Wendel A. Alves
Summary: The use of lipopeptide sequences as biomimetic microenvironments of acetylcholinesterase (AChE) has shown higher catalytic activities than natural enzymes in water solution, potentially valuable for pesticide detection.
NANOSCALE ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Rani, Faiz Ali, Mian Muhammad, Behisht Ara, Aftab Ali Shah
Summary: A simple and sensitive fluorescent sensor for chlortoluron detection was developed using fluorescent carbon dots synthesized via a hydrothermal protocol. The interaction between fructose carbon dots and Fe(iii) resulted in a fluorescent metastable state, which showed remarkable fluorescence quenching at 454 nm, further quenching occurred upon the addition of chlortoluron. The sensor exhibited a concentration range of 0.2-5.0 μg mL(-1) for chlortoluron detection, with a limit of detection of 0.0467 μg mL(-1), a limit of quantification of 0.14 μg mL(-1), and a relative standard deviation of 0.568%. The sensor also showed selective and specific recognition towards chlortoluron in real samples, with recoveries ranging from 95% to 104.3% in soil, water, and wheat samples.
Article
Multidisciplinary Sciences
Niloofar Mahmoudi, Fataneh Fatemi, Moones Rahmandoust, Fateme Mirzajani, Seyed Omid Ranaei Siadat
Summary: This study presents a fluorometric method using carbon quantum dots (CQDs) as a signal reporter for screening acetylcholinesterase (AChE) and its inhibitors. Different types of CQDs were synthesized and their fluorescence quenching properties were observed when exposed to various quenching ions. S-doped CQDs were found to be the most suitable fluorescent probe. The designed sensor showed low detection limits for malathion and chlorpyrifos.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)