期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 188, 期 -, 页码 1155-1157出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2013.08.039
关键词
Aptamer; Electrochemical; Potassium ion; G-quadruplex
A one-step electrochemical sensor for sensing of potassium ion (K+) based on the conformational change of a single stranded DNA (ssDNA) with G-rich sequence was presented. The introduction of K+ induced folding of the aptamer, and the Fc moiety approached the electrode surface to produce measurable electrochemical signals. The aptasensor had a lower detection limit at 0.1 nM, which was an excellent sensitivity compared with other methods for K+ detection. The proposed approach showed high selectivity and minimized the nonspecific adsorption, so that it was used for the detection of target K+ in the human serum sample. (C) 2013 Elsevier B. V. All rights reserved.
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