Review
Chemistry, Multidisciplinary
Xinning Dong, Congcong Zhang, Xin Du, Zhenguo Zhang
Summary: Molecularly imprinted polymer (MIP) is a synthetic material that mimics the natural antibody-antigen system and is suitable for use in electrochemical sensors. However, the irregular shape and slow electron transfer rate of MIP limit the sensitivity and conductivity of the sensors. The integration of nanomaterials improves the sensing and recognition capability of MIP sensors.
Article
Biophysics
Shichao Ding, Zhaoyuan Lyu, Suiqiong Li, Xiaofan Ruan, Mingen Fei, Yang Zhou, Xiangheng Niu, Wenlei Zhu, Dan Du, Yuehe Lin
Summary: An electrochemical sensor based on molecularly imprinted polypyrrole nanotubes has been developed for the detection of glyphosate with high sensitivity and specificity. The sensor demonstrates a wide detection range, low limit of detection, excellent stability, reproducibility, and selectivity against interferents. The sensor's practicality has been verified by detecting glyphosate in orange juice and rice beverages, making it suitable for monitoring pesticides in actual food and environmental samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Linbo Deng, Jiawei Liu, Haiyan Huang, Changxi Deng, Limin Lu, Linyu Wang, Xiaoqiang Wang
Summary: Considering the serious side effects of chlortetracycline (CTC) on the human body, the development of rapid, sensitive, and selective detection technologies for CTC in food is of great importance. In this study, a molecularly imprinted electrochemical sensor was proposed for the highly sensitive and selective detection of CTC using [Fe(CN)6]3-/4- as a signal probe. The sensor, based on TiO2 and polypyrrole, exhibited excellent detection properties towards CTC, including ultra-low limits of detection, a wide linear range, and outstanding stability, reproducibility, selectivity, and feasibility in real samples.
Article
Chemistry, Analytical
Mengnan Jiang, Junyan Tang, Nuoyi Zhou, Juan Liu, Feifei Tao, Fei Wang, Caolong Li
Summary: Domoic acid is a highly neurotoxic substance requiring specific and rapid detection methods. An electrochemical MIP sensor based on PDA-rGO/PAM was successfully developed for domoic acid detection, showing potential for on-site monitoring of marine biotoxins. The sensor demonstrated high sensitivity and specificity, allowing direct detection of domoic acid content in mussel extracts without complex pretreatment.
Article
Chemistry, Analytical
Lite Yang, Bihong Zhang, Bingjie Xu, Faqiong Zhao, Baizhao Zeng
Summary: An innovative electrochemical sensor for paracetamol (PCM) determination was developed using a 3D AuPd nanoparticles-ionic liquid (IL) functionalized graphene-carbon nanotubes nanocomposite modified glassy carbon electrode. The sensor exhibited high sensitivity and selectivity, allowing for accurate detection of PCM in biological samples.
Article
Biophysics
Athira Mani, R. Suriya, T. S. Anirudhan
Summary: A highly sensitive and selective electrochemical sensor was developed for the detection of L-Tyrosine using a surface modified glassy carbon electrode. The sensor exhibited a wide linear range, low detection limit, excellent selectivity, and potential clinical applicability.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Analytical
Yanran Chen, Faqiong Zhao, Baizhao Zeng
Summary: A novel electrochemical sensor based on surface molecularly imprinted polymer (SMIP) was constructed for the quantitative detection of chlortetracycline (CTC). The sensor showed high selectivity, sensitivity, and reproducibility, and was successfully applied to determine CTC concentration in real samples.
Article
Chemistry, Analytical
Melkamu Biyana Regasa, Tebello Nyokong
Summary: A highly selective and sensitive electrochemical sensor based on synthetic molecularly imprinted polymers (MIPs) was developed for the detection of 17-ss-estradiol. The sensor was prepared using MIP-graphene oxide (GO)-silver nanoparticle (AgNP) nanocomposite functional materials and exhibited a wide linear range and low detection limit.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Viknasvarri Ayerdurai, Maciej Cieplak, Wlodzimierz Kutner
Summary: Food safety assessment plays a crucial role in the modern food industry, driven by increased public awareness and the rise in food pollutants due to globalization, industrialization, and population growth. Electrochemical sensors with molecularly imprinted polymer (MIP) recognition units have become a popular choice for food analysis. These sensors offer simplicity in preparation and measurement, cost-efficiency, and a high affinity for target contaminants. The review highlights recent developments in MIP-based electrochemical sensors and their applications in detecting contaminants in various food and drink samples.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Energy & Fuels
Max Fabricio Falone, Edervaldo Buffon, Nelson Ramos Stradiotto
Summary: This study presented the development and application of a molecularly imprinted electrochemical sensor for monitoring mercaptan sulfur in aviation biofuel. The sensor showed linear working ranges and excellent selectivity, repeatability, and stability for butanethiol detection after optimization. Additionally, the sensor exhibited good accuracy and can be successfully applied for monitoring mercaptan sulfur in aviation biofuel samples.
Article
Materials Science, Multidisciplinary
Sadia Ata, Momina Feroz, Ismat Bibi, Ijaz-ul Mohsin, Norah Alwadai, Munawar Iqbal
Summary: A selective and sensitive electrochemical sensor based on molecular imprinted polymer (MIP) was developed for the detection of p-nitrophenol (p-NP). The sensor showed good linear response and low detection limit, making it applicable for monitoring and detecting p-NP in wastewater.
Article
Chemistry, Analytical
M. Asuncion Alonso-Lomillo, Olga Dominguez-Renedo
Summary: This work presents a molecularly imprinted (MIP) sensor for the determination of ethanethiol. The MIP/GCE sensor showed a linear range of 6.1-32.4 mg L-1 with good detection capability and reproducibility. The sensitivity of the sensor was enhanced by incorporating gold nano-particles. The sensor was successfully applied to determine ethanethiol in spiked wine samples.
Article
Chemistry, Multidisciplinary
Hugues Charlier, Mariel David, Driss Lahem, Marc Debliquy
Summary: The excessive or inadequate use of antibiotics can lead to the proliferation of resistant strains and reduce their effectiveness. Limiting antibiotic intake, especially through animal food, is crucial. The sensor developed based on molecularly imprinted conductive polymer shows promise in detecting antibiotics.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Peihong Tong, Yongjuan Meng, Junyu Liang, Jianping Li
Summary: A highly sensitive MIP-ECL sensor was constructed using ZIF-8-NH2 as the imprinted membrane, showing excellent recognition performance for CCN and a practical application for detecting CCN in human serum with recoveries ranging from 96.0%-103.0%.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biophysics
A. Hammoud, D. Chhin, D. K. Nguyen, M. Sawan
Summary: An electrochemical sensor for carbamazepine detection was fabricated by electropolymerization of PEDOT on glassy carbon electrodes, with molecular imprinted polymer sites providing high selectivity and sensitivity. The sensor showed high sensitivity to carbamazepine molecules, simplified construction, and easy operation.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Automation & Control Systems
Zekui Lyu, Qingsong Xu, Limin Zhu
Summary: In this paper, a new piezoelectric-actuated biaxial compliant microgripper with long strokes is proposed for automatically gripping and rolling tiny rigid objects. The microgripper has been optimized structurally and its performance has been simulated using finite element analysis. Experimental results show that the developed microgripper has the capability to grasp and roll tiny rigid objects, making it promising for precision micromanipulation tasks such as optical fiber alignment.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Article
Statistics & Probability
Runze Li, Kai Xu, Yeqing Zhou, Liping Zhu
Summary: In this article, we propose a novel test based on an aggregation of the marginal cumulative covariances to accommodate heteroscedasticity and high dimensionality in high-dimensional data. Our proposed test statistic is scale-invariance, tuning-free, and easy to implement, with established asymptotic normality under the null hypothesis. We find that our proposed test is much more powerful than existing competitors for covariates with heterogeneous variances, even under high-dimensional linear models, while maintaining high efficiency for homoscedastic covariates.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Psychology, Multidisciplinary
Sicheng Xiong, Yi Xu, Bin Zhang, Lihui Zhu, Jianhui Xie
Summary: This study identified three patterns of restrained eating in adolescents and found that these patterns were associated with interpersonal factors such as parental monitoring, deviant peer affiliation, and peer relationships. The results can inform targeted prevention and intervention strategies.
CURRENT PSYCHOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Zenghui Xie, Fugui Xie, Limin Zhu, Xin-Jun Liu
Summary: Robotization, miniaturization, and portability are the new development trends in milling equipment for large-scale complex structures. The robotic mobile and mirror milling technology has made remarkable progress in practical production.
NATIONAL SCIENCE REVIEW
(2023)
Article
Automation & Control Systems
Peng Guo, Yang Zhang, Weiwei Huang, Nuodi Huang, Long Zhang, Limin Zhu
Summary: In this paper, a generalized reaching-law-based discrete-time integral sliding-mode controller is designed to achieve high output tracking accuracy and avoid significant control efforts for both matched and mismatched disturbances. By synthesizing a disturbance-related integral term based on disturbance decomposition, the proposed sliding surface differs from existing integral sliding surfaces and is crucial for disturbance attenuation. The proposed reaching law introduces an adaptive exponential term into the control gains, which allows for the integration of conventional RL-based DISMC and EC-based DISMC.
ASIAN JOURNAL OF CONTROL
(2023)
Article
Plant Sciences
Meiyu Sun, Li Zhu, Yanan Zhang, Ningning Liu, Jinzheng Zhang, Hui Li, Hongtong Bai, Lei Shi
Summary: This study created new germplasm resources of thyme through hybridization, developed SSR markers based on the whole-genome sequence of T. quinquecostatus, and screened the expression of monoterpene synthase genes in thyme. The results provide a strong foundation for the creation of new germplasm resources, construction of genetic linkage maps, and identification of quantitative trait loci (QTLs), and also help gain insight into the mechanism of monoterpenoid biosynthesis in thyme.
Article
Cell Biology
Ya-Lan Wei, Yu-Qing Lei, Zhou-Jie Ye, Xu-Dong Zhuang, Li-Ping Zhu, Xin-Rui Wang, Hua Cao
Summary: Bepridil, a commonly used medication for arrhythmia and heart failure, has been found to have toxic effects on rat myocardial cells and zebrafish embryos. The treatment with bepridil resulted in calcium overload, morphological abnormalities, and developmental abnormalities. RNA-seq analysis provided insights into the gene expression profiles and metabolic responses. This study evaluates the use of antiarrhythmic agents in prenatal heart patients.
CELL AND TISSUE RESEARCH
(2023)
Article
Automation & Control Systems
Li Hua, Nuodi Huang, Bowen Yi, Yanzheng Zhao, Limin Zhu
Summary: B-spline curve approximation with tool tip position adjustment is proposed to reduce the maximum curve curvature and improve machining efficiency without exceeding tolerance in CNC machining. Toolpaths are divided into subdivisions based on discrete curvature, and tool tip positions are adjusted to minimize maximum discrete curvature. The improved ELSPIA method fits the adjusted toolpaths and lowers chord errors by searching appropriate foot point parameters.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Engineering, Manufacturing
Zi-Hui Zhu, Peng Huang, Suet To, Li-Min Zhu, Zhiwei Zhu
Summary: A fast-tool-servo-controlled shear-thickening micropolishing method is proposed for removing undesired surface diffraction on diamond-turned microstructured surfaces. The method allows for controllable material removal by adjusting the gap width and achieves improved surface quality.
INTERNATIONAL JOURNAL OF MACHINE TOOLS & MANUFACTURE
(2023)
Article
Optics
Bingxin Chen, Hong Pan, Liping Zhu, Hongtao Xu, Hengliang Wang, Lijian Zhang, Xiaomi Yan, Chiyuan Ma, Xuguang Xu, Wei Lu, Zhenghua An, Yanru Song
Summary: Superconducting photodetection offers wide spectral coverage and single photon sensitivity, but the detection efficiency is low in the longer wavelength infrared range. By using a superconducting metamaterial, we achieved nearly perfect absorption at dual color infrared wavelengths and enhanced light coupling efficiency. Our infrared detector demonstrated peak responsivity of 1.2 x 106 V/W and 3.2 x 106 V/W at two resonant frequencies, significantly higher than the non-resonant frequency. This work provides a way to improve the sensitivity of superconducting photodetectors in the infrared range.
Article
Computer Science, Artificial Intelligence
Chengyang Li, Liping Zhu, Gangyi Tian, Yi Hou, Heng Zhou
Summary: This paper investigates the localization problem of referring relationships and proposes a mask-level relational reasoning perspective to improve model interpretability. Specific modules and methods are designed for text-to-image and image-to-text reasoning processes, and multimodal relational reasoning is achieved through bi-directional reasoning. Experimental results demonstrate that the proposed method achieves state-of-the-art performance on two datasets.
PATTERN RECOGNITION
(2023)
Article
Engineering, Environmental
Xiao-Bo Yang, Wei Li, Ze-Zhong Lin, Jing-Qi Liu, Hong-Xin Jiang, Hao Jia, Wei-Liang Jin, Xin-Long Hou, Bing-Xuan Du, Li-Na Zhu, De-Ming Kong
Summary: Efficient and selective adsorption/removal of Cs+ is crucial for resource utilization and radioactive pollution control. A PAN/PB aerogel with enhanced PB-loading capacity was prepared by pre-doping Fe3+ in PAN nanofibers. The PAN/PB aerogel exhibited interconnected porous structure, ultralight density, improved water stability, increased thermal stability, robust mechanical elasticity, high hydrophilicity, and excellent Cs+ adsorption selectivity. Its practical application potential was demonstrated by the highly efficient and selective adsorption/removal of Cs+ from simulated seawater and salt lake brine.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Computer Science, Interdisciplinary Applications
Jinlong Liu, Yuancheng Shao, Junyang Li, Limin Zhu, Xiaolei Gong, Lianyan Xue, Juanya Shen, Youjin Li
Summary: This study used computer-aided design and computational fluid dynamics to simulate upper airway flow characteristics, providing guidance for surgeons in treating infants with vallecular cyst and coexisting laryngomalacia.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Engineering, Chemical
Dong-xiao Cao, Yan Chen, Wei-liang Jin, Wei Li, Rui Wang, Ke Wang, An-na Tang, Li-na Zhu, De-ming Kong
Summary: Rapid and efficient removal of organic dyes from polluted water is important for environmental protection and water resources management. A new anionic covalent organic polymer (COP), named COPOH+CO, with the fastest dye adsorption kinetics so far, was synthesized. COPOH+CO showed a higher adsorption capacity for the cationic dye methylene blue (MB) compared to other COPs, indicating a synergy between its functional groups.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shengmiao Sun, Bixuan Wang, Molan Qing, Danbi Tian, Ling Jiang, Liying Zhu
Summary: A modified screen-printed electrode based on ZIF-8, Ag NPs, and ErGO was developed for dopamine detection. The synthesized ErGO/Ag-ZIF-8 composites maintained the structure of ZIF-8. The oxidation current of dopamine increased linearly in the range of 0.1-200 mu M with a detection limit of 0.03 mu M (S/N=3). The sensor exhibited good reproducibility and selectivity, and it was successfully applied for dopamine detection in goat serum with satisfactory recovery range.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
