Article
Chemistry, Analytical
Qiyi He, Yanxiong Fang, Huiyi Yang, Ding Shen, Yingshan Chen, Yingying Zhong, Xiangguang Li, Sergei A. Eremin, Xiping Cui, Suqing Zhao
Summary: A label-free competitive inhibition immunoassay based on SPR technology was developed for the determination of glycocholic acid. The method showed excellent sensitivity, reusability, and potential for rapid and sensitive quantitative detection of GCA in real urine samples to meet clinical needs.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Analytical
Jihong Wang, Songlin Liu, Zhen Meng, Xiao Xia Han, Linjun Cai, Baofeng Xu, Rui Liu, Lina Song, Chengyan He, Ziyi Cheng, Bing Zhao
Summary: A SERS-based biosensor was developed using PVDF membranes as a flexible support for the sensitive detection of GADA and IAA in T1DM. Two types of silver-gold core-shell nanotags were synthesized and used to capture the targets, enabling highly sensitive and highly selective detection of GADA and IAA. The embedded Raman probes between silver and gold layers ensured spectral stability and reliability, and the utilization of two Raman probes allowed simultaneous and multiplexing detection of both GADA and IAA, improving the detection accuracy for T1DM.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xingxing Meng, Tianxiang Hang, Hui Zhou, Zongrui Zhang, Chuanping Li
Summary: In order to achieve reliable and ultrasensitive detection for disease markers in PEC bioanalysis, constructing and nanoengineering of ideal photoelectrodes and signal transduction strategies are of vital importance. This study tactically designed a non-/ noble metal coupled plasmonic nanostructure (TiO2/r-STO/Au) with high-efficient PEC performance. The research proposed a new type of plasmonic nanomaterial for ultrasensitive PEC bioanalysis, showing excellent detection performance with a LOD as low as 1.1 fg/mL.
ANALYTICA CHIMICA ACTA
(2023)
Article
Optics
Haoyuan Cai, Mengwei Wang, Jing Liu, Xiaoping Wang
Summary: A high-sensitivity surface plasmon resonance (SPR) sensor based on the coupling of Au grating and Au film is investigated through simulations and experiments. The sensor, designed using a hybrid method of genetic algorithm (GA) and rigorous coupled wave analysis (RCWA), exhibits significantly higher angular sensitivity compared to conventional Au-based sensors. Theoretical analysis reveals enhanced sensitivity through the co-coupling of surface plasmon polaritons (SPPs) propagating on the Au film surface and localized surface plasmons (LSPs) in the Au grating nanostructure. The proposed sensor, fabricated using e-beam lithography and magnetron sputtering, demonstrates high sensitivity for the detection of small molecules, with a lower limit of detection (LOD) compared to conventional Au sensors. This high-sensitivity SPR biosensor shows potential in immunoassays and clinical diagnosis applications.
Article
Chemistry, Applied
Min Jia, Shuang Chen, Tingting Shi, Chunyang Li, Yanping Wang, Hongyan Zhang
Summary: The PBELISA method using plasmonic biomimetic technology combined with MIP film and CAT-mediated AuNPs growth achieved ultra-sensitive visual detection of BPA; with a visual limit of detection of 40 pg/mL, the method showed good dynamic linear response and high recovery rates.
Article
Chemistry, Multidisciplinary
F. Mousseau, C. Feraudet Tarisse, S. Simon, T. Gacoin, A. Alexandrou, C. I. Bouzigues
Summary: The use of lanthanide-doped nanoparticles as luminescent LFA probes offers higher sensitivity and measurement accuracy for detecting various biomolecules, including enterotoxins. Compared to gold nanoparticle-based LFAs, this method shows at least an order of magnitude improvement in analytical sensitivity and enables simultaneous quantitative detection of multiple biological toxins.
Article
Chemistry, Analytical
Xiaojun Hu, Ruhui Hu, Han Zhu, Qiang Chen, Yongkai Lu, Jie Chen, Yawen Liu, Hongxia Chen
Summary: A nanozyme-based biosensing platform using self-assembled iron porphyrin mediated supramolecular modified gold nanoparticles was developed for the early diagnosis of Parkinson's disease. The sensor achieved sensitive detection of nitrated alpha-synuclein as a potential biomarker, showing promising results in distinguishing healthy individuals from PD patients using actual samples.
Article
Nanoscience & Nanotechnology
Asta Kausaite-Minkstimiene, Anton Popov, Almira Ramanaviciene
Summary: A surface plasmon resonance (SPR) immunosensor signal amplification strategy based on antibody-functionalized gold-coated magnetic nanoparticles (mAuNPs) was developed for ultrasensitive and quantitative detection of the CD5 biomarker. The sandwich immunoassay utilizing mAuNPs-anti-CD5(2B) significantly improved the detection sensitivity and showed satisfactory performance in human blood serum.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Lishuang Yu, Lu Lin, Yuanyuan Yao, Binyong Lin, Wen Xu, Longhua Guo, Wei Xu, Yu Lin
Summary: The gene fusion of NTRK promotes tumor formation and is closely related to multiple cancers. A multicolor immunosensor has been developed for rapid detection of NTRK1 gene fusion by the naked eye, allowing for qualitative and semi-quantitative assessment within 20 minutes. This innovative method could be valuable for quick detection of NTRK gene fusion markers in remote areas with limited medical resources.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Optics
Bijaya Saha, Nabamita Goswami, Ardhendu Saha
Summary: This study proposes an analytical investigation of an SPR-based fiber optic sensor for breast cancer detection using a wave-theory-based technique with a radially polarized Bessel-Gauss beam. The validity of the proposed theory is validated with experimental data, and the use of a radially polarized beam achieves higher sensitivity and resolution compared to previous results. This method shows promise for early diagnosis of breast cancer by optically assessing it at its earlier stage.
Article
Chemistry, Analytical
Yu Huang, Shengqiang Li, Cuiying Liu, Ligang Chen, Husun Qian, Ho-Pui Ho, Jiangling Wu, Jiang Wu, Xiaoyin Pu
Summary: In this study, a simple, sensitive, and cost-effective sensing strategy for thrombin was developed. The strategy involved the use of polyadenine diblock oligonucleotides anchored on gold nanoparticles (AuNPs) to detect thrombin. Binding of thrombin to its aptamer triggered the disassembly of AuNP aggregates, resulting in a significant signal change. The assay demonstrated a detection limit of 0.81 pM and a dynamic range from 10 pM to 10 nM, and could be performed in diluted serum solutions without sophisticated instruments.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Meng-Qi He, Yongjian Ai, Wanting Hu, Xiaomeng Jia, Lei Wu, Mingyu Ding, Qionglin Liang
Summary: By using DNA as an etching agent, it is possible to control the morphology and optical properties of plasmonic nanoparticles, while also introducing fluorescence properties. This strategy allows for precise tuning of localized surface plasmon resonance (LSPR) and fluorescence-composited dual-mode signals.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Edwin J. Ortiz-Riano, Diana L. Mancera-Zapata, Martha Ulloa-Ramirez, Fernando Arce-Vega, Eden Morales-Narvaez
Summary: Macromolecular association is important in biomedical sciences. This study presents a real-time biosensing platform using graphene oxide-modified microwell plates and fluorophore-labeled proteins to determine protein-binding constants. The platform proves to be comparable and consistent with existing methods in determining protein kinetics constants.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Nilay Bereli, Monireh Bakhshpour, Aykut Arif Topcu, Adil Denizli
Summary: In this study, an SPR-based immunosensor utilizing amine-functionalized gold nanoparticles was developed for IgM antibody detection in aqueous solution and artificial plasma, demonstrating high sensitivity and detection limits. Additionally, the immunosensor showed good reusability and was validated using the ELISA method.
Article
Instruments & Instrumentation
Koji Toma, Chisato Kishikawa, Takahiro Arakawa, Kohji Mitsubayashi
Summary: This study developed a reusable immunosensor utilizing SPR and a pH-resistant protein for rapid and repeated immunoassays. The sensor demonstrated a detection limit of 14.2 ng/mL for a-mIgG, a dynamic range of 138-30000 ng/mL, and potential for semicontinuous measurement, suggesting its application in monitoring systems for early disease detection and prevention.
SENSORS AND MATERIALS
(2021)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)