期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 170, 期 -, 页码 189-195出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2011.06.081
关键词
Quantum cascade laser; Physical chemosensor; Glucose; Lactate; Albumin; Urea; Phosphate; Blood; Serum; Mid-infrared; Spectroscopy; Large pathlengths
资金
- RSA (Research Studios Austria) programme of the FFG (Austrian Research Promotion Agency)
Mid-infrared (mid-IR) laser spectroscopy is introduced as a physical chemosensor for liquids. Mid-IR sensor systems measure vibrational spectra of samples under investigation and thus are able to directly access chemical information. In this work, a pulsed External-Cavity Quantum-Cascade Laser (EC-QCL) with a 350 mW maximum emission power at 1180 cm(-1) and tunable from 1030 cm(-1) to 1230 cm(-1), was used for transmission measurements of physiological solutions with pathlengths > 130 mu m, thus significantly improving the measurement capabilities of mid-IR sensors employing thermal emitters. The first part of this paper discusses the characterization of the EC-QCL using time-resolved FTIR spectroscopy. Moreover, a comparison of the achievable performance of the physical chemosensor as opposed to a standard FTIR spectrometer is included. Results on the direct determination of glucose in spiked human serum in the physiologically relevant concentration range from 30 mg/dL to 400 mg/dL are reported. Furthermore, spectra of albumin, urea, lactate and phosphate in aqueous solution recorded with the EC-QCL chemosensor are shown. indicating its capability for simultaneous multi-analyte detection. (C) 2011 Elsevier B.V. All rights reserved.
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