Article
Pharmacology & Pharmacy
Michal Wronski, Jakub Trawinski, Robert Skibinski
Summary: Understanding the metabolism of pharmaceutical compounds is essential for their safety and efficacy. The application of electrochemistry in drug metabolism studies offers a promising approach for synthesizing and analyzing drug transformation products. This study investigated the hepatic metabolism of voriconazole and optimized the electrochemical parameters to simulate the biotransformation reactions. The findings highlight the potential of phthalocyanine electrodes as an efficient and cost-effective tool in drug biotransformation research.
Article
Biochemistry & Molecular Biology
Guilherme A. M. de Jesus, Sharise B. R. Berton, Bruno M. Simo, Rafael S. Zola, Johny P. Monteiro, Alessandro F. Martins, Elton G. Bonaf
Summary: This study proposes a method for preparing functional films using commercial kappa-carrageenan, poly(vinyl alcohol), and gallic acid. The films exhibit suitable mechanical properties and antimicrobial action, making them potential candidates for food coatings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zhili Sheng, Yueming Jiang, Junmei Liu, Bao Yang
Summary: Astragalus membranaceus is a valuable medicinal plant species widely distributed in Asia with its root being the main medicinal tissue rich in methoxylated flavonoids. The chemical composition and antioxidant activity of the plant can be influenced by its origin, as shown through UHPLC-MS/MS analysis of extracts from four different origins. The study identified key compounds that can differentiate A. membranaceus from different regions and found that extracts from Inner Mongolia exhibited the highest antioxidant activity.
Article
Chemistry, Analytical
David Majer, Matjaz Finsgar
Summary: This study demonstrated the analysis of epinephrine and uric acid using a novel method, validating the accuracy and effectiveness through data verification and comparison between OLS and WLR methods.
Article
Chemistry, Analytical
Ioana Silvia Hosu, Diana Constantinescu-Aruxandei, Florin Oancea, Mihaela Doni
Summary: The study examined the scavenging activity of myoglobin on peroxynitrite in meat extracts using a highly sensitive electrochemical method. The proposed biosensor demonstrated high selectivity and could be utilized in studying the kinetics of important oxidative processes.
Article
Chemistry, Analytical
Alejandro Fidel Alba, Roberto Fernandez-de Luis, Joseba Totoricaguena-Gorrino, Leire Ruiz-Rubio, Julia Sanchez, Jose Luis Vilas-Vilela, Senentxu Lanceros-Mendez, Francisco Javier Del Campo
Summary: Screen printed graphite electrodes are commonly used in electroanalysis and electrochemiluminescence (ECL) applications. This study investigates the ECL of the Ru(bpy)32+/TPrA system on different graphite electrodes printed from various graphite pastes. The ECL intensity of the graphite electrodes is found to depend on electrode kinetics and wettability, which are influenced by paste composition.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Jayendra Kumar Himanshu, G. B. V. S. Lakshmi, Awadhesh Kumar Verma, Amit Ahlawat, Pratima R. Solanki
Summary: Novel carbon quantum dots-graphite composite ink-based screen-printed electrodes were used to assemble a highly sensitive electrochemical aptasensor against chlorpyrifos. The aptasensor showed a broad linear range, good selectivity, and reliable applicability in real samples.
ENVIRONMENTAL RESEARCH
(2024)
Review
Chemistry, Analytical
Nathalia Florencia Barros Azeredo, Mauro S. Ferreira Santos, Juliane R. Sempionatto, Joseph Wang, Lucio Angnes
Summary: This overview provides an in-depth update on the trends and possibilities of using screen-printed electrodes (SPEs) coupled with flow systems in modern electroanalysis. The combination of SPEs and flow systems allows for increased measurement throughput, reduced reagent consumption, and minimal waste generation, making it attractive for future users with basic knowledge.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Isao Shitanda, Kaishi Miyazaki, Noya Loew, Ryosuke Esaka, Yoshinao Hoshi, Masayuki Itagaki
Summary: The novel sticker device developed can convert any metal or alloy into the working electrode of a three-electrode system, making measurements simple and accurate. By using this device, materials can be easily evaluated by dropping a small amount of solution.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Tomohiro Matsunaga, Takeshi Kondo, Isao Shitanda, Yoshinao Hoshi, Masayuki Itagaki, Toshifumi Tojo, Makoto Yuasa
Summary: The study found that hydrogen-terminated boron-doped diamond printed electrode was the most suitable for the sensitive detection of L-cysteine at low concentrations, exhibiting a steep slope in its calibration curve and low background current density. This printed electrode had a lower limit of detection and wider linear concentration range compared to a hydrogen-boron-doped diamond thin-film electrode.
Article
Chemistry, Multidisciplinary
Somayeh Tajik, Hadi Beitollahi, Sayed ali Ahmadi, Mohammad Bagher Askari, Antonio Di Bartolomeo
Summary: We successfully developed a sensor for hydroxylamine with high sensitivity and a broad linear dynamic range through surface modification, which can be used for detecting hydroxylamine in water samples.
Article
Biochemical Research Methods
Kuangnan Fang, Rui Ren, Qingzhao Zhang, Shuangge Ma
Summary: Dimension reduction techniques like PCA, PLS, and CCA are extensively used in the analysis of high-dimensional omics data. Integrative analysis, which outperforms meta-analysis and individual-data analysis, has been developed for multiple datasets with compatible designs. We developed the R package iSFun to facilitate integrative dimension reduction analysis, offering comprehensive analysis options under different models and penalties.
Article
Chemistry, Analytical
Chang Zhang, Chao Li, Xiaojun Han
Summary: Heavy metal pollution is a global environmental issue. In this study, a screen printed electrode modified with bismuth powder (Bi-SPE) was prepared for the detection of Cd2+. The Bi-SPE exhibited a linear detection range of 5-50 μg/L and a detection limit of 4.80 μg/L for Cd2+. Compared to the bare screen printed electrode, Bi-SPE showed better detection performance by providing more active sites for heavy metal ion predeposition. The advantage of Bi-SPE is its ability to detect heavy metal ions without the addition of bismuth ions in the solution, enabling in-situ detection. The prepared Bi-SPE holds great potential for the detection of heavy metal ions in real water samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Elena Alberto, Julio Bastos-Arrieta, Clara Perez-Rafols, Nuria Serrano, M. Silvia Diaz-Cruz, Jose Manuel Diaz-Cruz
Summary: A DPV method using SPCEs was developed for the determination of SMX, showing a good detection limit (15 μg/L) and a wide linear range (50-600 μg/L) with good repeatability and reproducibility. The method was successfully applied to the analysis of a spiked tap water sample, demonstrating high reproducibility and good trueness. Additional considerations were made on the pH-dependent electrochemical oxidation of SMX and the role of the free terminal amino group in oxidation.
MICROCHEMICAL JOURNAL
(2023)
Article
Environmental Sciences
Hadi Beitollahi, Fariba Garkani Nejad, Zahra Dourandish, Somayeh Tajik
Summary: This study developed an electrochemical sensor for the detection of amaranth, a potentially toxic dye used in the textile industry. The sensor utilized polypyrrole nanotubes to enhance the electrocatalytic activity for amaranth detection. The results showed that the sensor had a wide linear dynamic range and a low limit of detection, making it suitable for practical applications.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Analytical
Mbulelo Jokazi, Lekhetho S. Mpeta, Tebello Nyokong
Summary: Manganese and cobalt metalated porphyrins attached to graphene quantum dots showed improved electrocatalytic activity for the oxidation of hydrazine, with CoTA(3)CPP-GQDs exhibiting the best catalytic rate constants and lowest limits of detection.
Article
Biochemistry & Molecular Biology
Pinar Sen, Azole Sindelo, Nnaemeka Nnaji, John Mack, Tebello Nyokong
Summary: Novel mono- and dipyridylvinyl boron dipyrromethene dyes were prepared and compared to the corresponding core dyes for their photodynamic antimicrobial chemotherapy (PACT) activities. Results showed that the spectral properties of the dyes and the generation of singlet oxygen could be controlled through pyridylvinyl substitution and iodine atom incorporation, but the pi-extended dyes had lower activities compared to the core dye.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Oncology
Yolande Ikala Openda, Tebello Nyokong
Summary: Photodynamic antimicrobial chemotherapy (PACT) combined with ciprofloxacin (CIP) effectively reduces the biofilm cell survival of antibiotic-resistant S. aureus and E. coli strains. PACT alone shows no significant activity, while CIP alone exhibits some inhibitory activity. The combination treatment completely eradicates mature biofilms.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Chemistry, Physical
Omotayo Adeniyi, Nnamdi Nwahara, Daniel Mwanza, Tebello Nyokong, Philani Mashazi
Summary: This study developed a highly efficient and stable electrocatalyst material, N-rGONs|NiPcNRs, and successfully applied it in a glucose biosensor, demonstrating excellent analytical performance and potential.
APPLIED SURFACE SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Lindokuhle Cindy Nene, Tebello Nyokong
Summary: This study presents the preparation of cationic thiazole phthalocyanines (Pcs) conjugates with nitrogen doped (NGQDs) and nitrogen/sulfur co-doped (NSGQDs) graphene quantum dots (GQDs). The photo-sonodynamic combinatorial therapy (PSDT) activities of the conjugates were tested in vitro with cancer cell lines. The conjugates exhibited the production of reactive oxygen species (ROS) through the treatment technique. The Pc-GQDs generated singlet oxygen and hydroxyl radicals when exposed to light and low frequency ultrasound in PSDT. Cancer eradication was observed in vitro for the PSDT treatment using the Pc-GQDs conjugates. The NGQDs conjugates performed better in terms of ROS generation and cell eradication compared to the NSGQDs conjugates. The PSDT treatments showed increased ROS generation and cancer eradication efficiencies compared to PDT and SDT monotreatments.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Nobuhle Ndebele, Tebello Nyokong
Summary: This study presents the non-covalent conjugation of carbon-based nanomaterial with tris(4-tert-butylphenoxy)-(5-phenoxylpicolinic acid) phthalocyanato cobalt (II) (CoPc). The hybrids of CoPc with graphene quantum dots (GQDs), nitrogen-doped quantum dots (NGQDs), and single-walled carbon nanotubes (SWCNTs) were successfully synthesized and characterized. The electrochemical analysis showed that the CoPc and its conjugates exhibited good nitrite detection capabilities, with sensitivities (3-28 mu A mu M-1), catalytic rate constants (1.8 x 102-5.42 x 104 M-1 s-1), and limits of detection (0.17-1.70 mu M) comparable to those in literature.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Lindokuhle Cindy Nene, Tebello Nyokong
Summary: This study investigates the effects of ultrasonic frequency and power on the stability, reactive oxygen species yields, and cytotoxicity activities of different substituted ionic phthalocyanines (Pcs) in sonodynamic therapy (SDT). The degradation of Pcs increases with increasing power at Par II. Two reactive oxygen species, singlet oxygen and hydroxyl radicals, were detected in ultrasound treated Pcs. Par I was chosen for SDT, photodynamic therapy (PDT), and photo-sonodynamic therapy (PSDT) due to minimal degradation of most Pcs. PSDT generally shows improved therapeutic efficacies compared to SDT and PDT mono treatments.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Physical
Sithi Mgidlana, Yolande Ikala Openda, Tebello Nyokong
Summary: Zinc phthalocyanine complexes are covalently linked to metallic nanoparticles through amide and ester bonds. The photocatalytic activity of these conjugates is evaluated for the degradation of methylene blue, tetracycline, and diben-zothiophene. The results show that the prepared phthalocyanine complexes exhibit enhanced photocatalytic efficiency in the presence of nanoparticles. Furthermore, the conjugates also demonstrate promising photodynamic antimicrobial chemotherapy activity against Staphylococcus aureus bacteria, with Ag2WO4-based nanoconjugates showing the highest antimicrobial activity compared to other materials.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Azole Sindelo, Pinar Sen, Tebello Nyokong
Summary: New tetra-substituted zinc and indium Schiff base phthalocyanines (ZnPc and InPc) were synthesized and characterized. Cationic derivatives of these Pcs were obtained by reacting ethyl pyrrolidine (ZnPc-2, InPc-2) and propyl pyrrolidine (ZnPc-3, InPc-3) substituted Schiff base Pcs with methyl iodide. The cationic Pcs exhibited higher singlet oxygen quantum yield in aqueous media and showed effective photoinactivation against Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA) strains, depending on the singlet oxygen ability, charges, and alkyl group extension.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Physical
Sithi Mgidlana, Pinar Sen, Tebello Nyokong
Summary: Synthetic compounds of asymmetric (A3B) Zn(II) phthalocyanines with dimethoxy phenoxy as the main substituent and (phenoxy) propanoic acid, (phenoxy) acetic acid, and (phenoxy) acrylic acid as other substituents were linked to silver tungstate nanoparticles. The photocatalytic and photodynamic antimicrobial chemotherapy activities of these compounds were evaluated for the degradation of tetracycline and inactivation of S. aureus under visible light irradiation. The results showed that compound 3 exhibited the best performance, attributed to its higher singlet oxygen quantum yield. The mechanism of singlet oxygen generation under visible light was confirmed using EPR. Furthermore, the photoinactivation of S. aureus was enhanced in the presence of tetracycline.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rodah Soy, Balaji Babu, John Mack, Tebello Nyokong
Summary: A series of tetraarylchlorins with different meso-aryl rings and their Sn(IV) complexes were synthesized and assessed for their potential as photosensitizer dyes for use in photodynamic therapy and photodynamic antimicrobial chemotherapy. The Sn(IV) complexes showed high singlet oxygen quantum yield values and exhibited significant activities against breast cancer cells, as well as planktonic bacteria.
Article
Oncology
Aviwe Magadla, Yolande Ikala Openda, Lekhetho S. Mpeta, Tebello Nyokong
Summary: In this study, we synthesized three phthalocyanine complexes and investigated their effects on photodynamic antimicrobial chemotherapy (PACT) against E.coli and S.aureus in both planktonic and biofilm forms. Complex 4, with 8 cationic charges, showed the highest activity against the biofilms. Surface stability of E.coli and S.aureus biofilms in the presence of complex 4 was analyzed using cyclic voltammetry, and conformational and biochemical changes within the biofilm were studied using scanning electron microscopy (SEM) and Raman spectra.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Azole Sindelo, Pinar Sen, Tebello Nyokong
Summary: Antimicrobial photodynamic inactivation (aPDI) is an effective method for eradicating drug-resistant microorganisms due to its minimal possibility of microbial resistance. This study focuses on the preparation and characterization of novel neutral and cationic morpholine containing Schiff base phthalocyanines. The cationic complexes show promising photodynamic activity against various microorganisms, while the neutral complexes are not suitable for antimicrobial studies. The effectiveness of aPDI is dependent on the concentration and light dose.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Review
Chemistry, Analytical
Batoul Hosseinzadeh, Maria Luz Rodriguez-Mendez
Summary: Feeding the increasing world population requires high-quality food, and it is necessary to control food quality parameters throughout the fresh produce supply chain. Electrochemical sensors (ECSs) based on metal-organic frameworks (MOFs) have emerged as a powerful and reliable method for food evaluation, overcoming the limitations of traditional analytical techniques. MOF-based ECSs offer fast and effective detection of food contaminants or nutrients, with the potential for diverse applications in monitoring food quality.
Review
Chemistry, Inorganic & Nuclear
Balaji Babu, John Mack, Tebello Nyokong
Summary: Photodynamic therapy is a cancer treatment that involves a nontoxic photosensitizer, a light source, and ground-state molecular oxygen. Activation of the photosensitizer by light generates reactive oxygen species, which destroy cancer cells.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)