Graphite oxide film-modified electrode as an electrochemical sensor for acetaminophen

The graphite oxide (GO) was prepared via the chemical oxidation of natural graphite powder, and then used to modify the surface of glassy carbon electrode (GCE). The electrochemical behavior of acetaminophen was examined. In 0.01 mol L(-1) HCl, an irreversible oxidation peak is observed for acetaminophen, and the peak current remarkably increases at the GO film-modified GCE. The influences of supporting electrolyte, amount of GO suspension, accumulation potential and time were studied on the oxidation peak current of acetaminophen. As a result, a new electrochemical method was developed for the detection of acetaminophen. The linear range is from 25 mu g L(-1) to 4 mg L(-1), and the limit of detection is 6 mu g L(-1) based on three signal-noise ratio. Finally, it was successfully used to detect acetaminophen in tablets. (C) 2010 Elsevier B.V. All rights reserved.