Article
Chemistry, Analytical
Bin Zhang, Xiaoming Wang, Wei Hu, Yiquan Liao, Yichang He, Bohua Dong, Minggang Zhao, Ye Ma
Summary: This work presents a photo-responsive Au@Fe3O4 nanozyme with excellent peroxidase-like activity based on gold nanoparticles (Au NPs). The hot electrons of Au NPs excited by a surface plasmon resonance (SPR) effect enhance the catalytic activity of Au@Fe3O4 in oxidizing 3,3′,5,5′-tetramethylbenzidine (TMB) and detecting hydroquinone (HQ). The magnetic separation and reusability of the nanozyme further contribute to its cost-effectiveness. The sensor exhibits a detection linear range of 0-30 μM and a lowest detection limit of 0.29 μM. Good recovery rates are achieved in the detection of real water samples, providing promising references for the development of HQ detection technology in seawater.
Article
Chemistry, Physical
Xue Han, Jingkun Tian, Zongwen Li, Tiange Wu, Guangmin Ji, Shilei Li, Fei Xing, Yonghui Zhang
Summary: This study presents an optical refractive index sensor based on the polarization sensitive response of localized surface plasmon resonance (LSPR) in gold nanoparticles. The sensor demonstrates high sensitivity for detecting fluid species and hydraulic pressure. It has broad application potential in various scenarios.
APPLIED SURFACE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Zilun Tang, Jianyu Wu, Xiaofeng Yu, Rui Hong, Xihong Zu, Xiaofeng Lin, Hongsheng Luo, Wenjing Lin, Guobin Yi
Summary: AuNP arrays on SMPU substrates were used for tunable LSPR, with LSPR increasing with negative bending and decreasing with positive bending. Mechanical uniaxial tension led to an initial increase followed by a decrease in LSPR. The resulting films showed excellent performance in SERS applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Yuanyang Xie, Yu Huang, Jiye Li, Jiangling Wu
Summary: A pH-triggered colorimetric assay using aptamer anchored gold nanoparticles has been developed to detect E. coli O157:H7. The movement of HS-Apt@AuNPs in different solvents triggers different responses due to the pH effect and aptamer's capturing ability, leading to changes in colorimetric signals. This pH-dependent trigger method provides flexibility in design for gold nanoparticle-based biosensing assays, showing great potential for highly sensitive bacterial sensors in public health defense.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Nur Afifah Ahmad Nazri, Nur Hidayah Azeman, Mohd Hafiz Abu Bakar, Nadhratun Naiim Mobarak, Tg Hasnan Tg Abd Aziz, Ahmad Rifqi Md Zain, Norhana Arsad, Yunhan Luo, Ahmad Ashrif A. Bakar
Summary: An optical sensor-based localized surface plasmon resonance (LSPR) sensor was demonstrated for sensitive and selective chlorophyll detection through the integration of amino-functionalized carbon quantum dots (NCQD) and triangle silver nanoparticles (AgNPs). The sensor showed high sensitivity and detection limits, with no interference from other ionic species.
Article
Chemistry, Analytical
Minghui Nan, Bobby Aditya Darmawan, Gwangjun Go, Shirong Zheng, Junhyeok Lee, Seokjae Kim, Taeksu Lee, Eunpyo Choi, Jong-Oh Park, Doyeon Bang
Summary: A flexible localized surface plasmon resonance biosensor was manufactured to detect cortisol levels in the human body. The biosensor exhibited excellent detection ability in cortisol solutions of various concentrations and demonstrated good stability under mechanical deformations. These biosensors can be versatile candidates for measuring human stress levels by combining flexible sensors with sensitive cortisol-detecting molecules.
Review
Chemistry, Analytical
Dong Min Kim, Jong Seong Park, Seung-Woon Jung, Jinho Yeom, Seung Min Yoo
Summary: Localized surface plasmon resonance (LSPR)-based biosensors have attracted increasing attention for their label-free, portable, low-cost, and real-time monitoring capabilities of diverse analytes. Recent advances in this technology focus on biochemical markers in clinical and environmental settings, utilizing advances in nanostructure technology. Exciting prospects for enhanced sensing performance in biosensors are also discussed in this review.
Article
Chemistry, Analytical
Devendra Bhandari, Fur-Chi Chen, Roger C. Bridgman
Summary: This study developed a method utilizing magnetic nanoparticles and surface plasmon resonance for rapid detection of Salmonella. The results showed that the sequential two-step sandwich assay and preincubation one-step sandwich assay had higher detection signals compared to the direct assay, with detection limits reaching a high level.
Article
Chemistry, Analytical
Lukas Wunderlich, Peter Hausler, Susanne Maerkl, Rudolf Bierl, Thomas Hirsch
Summary: A label-free sensor based on SPR imaging was proposed to monitor nanoparticles in fresh water, with improved sensitivity by enhancing the detector and using LED excitation for the light source. Different self-assembled monolayers were screened as receptors, with the best system being a dodecanethiol monolayer on the gold sensor surface. The sensor successfully detected lanthanide-doped nanoparticles of 29 nm in water.
Article
Chemistry, Analytical
Hong Lei, Shenghu Zhu, Chang Liu, Wei Zhang, Chong Chen, Hui Yan
Summary: In this study, the signal strength of a localized surface plasmon resonance (LSPR) biosensor based on optical fiber end-face was enhanced by designing an AuNP multimer structure. The biosensor showed higher sensitivity and lower limit of detection compared to biosensors with AuNPs alone. This strategy can be applied in the research and development of various biosensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Crystallography
Hafiz Zeeshan Mahmood, Asim Jilani, Sajid Farooq, Yasir Javed, Yasir Jamil, Javed Iqbal, Sami Ullah, Swelm Wageh
Summary: A novel label-free immunosensor platform based on localized surface plasmon resonance (LSPR) phenomenon has been developed, utilizing gold nanospheres probe to detect dengue NS1 antigen concentrations. The results confirm its potential application in plasmonic sensing.
Article
Nanoscience & Nanotechnology
Nathan J. Spear, Yueming Yan, Joshua M. Queen, Mahi R. Singh, Janet E. Macdonald, Richard F. Haglund
Summary: A class of nonlinear materials using localized surface plasmonic resonance (LSPR) of nanoparticles has been employed to enhance harmonic generation. In this study, the effect of dual plasmonic interactions in bilayer CuS and Au nanoparticle films on third harmonic generation (THG) was explored. The results showed that detuning the CuS LSPR and changing the size of the Au nanoparticle can alter the dominant upconversion pathway and eliminate the enhancement effect. Simultaneous excitation of CuS-Au nanoparticle films at the resonant frequency of each nanoparticle species enhances the generation of third harmonic light. An analytic model of incoherent dipolar interactions between the plasmonic nanoparticles is also presented.
Article
Engineering, Electrical & Electronic
H. Akafzade, N. Hozhabri, S. C. Sharma
Summary: This study presents a new type of SPR sensor fabricated using a multi-layer nanostructure Ag/Si3N4/Au, showing excellent performance in monitoring relative concentration of glucose. The sensor's performance is significantly enhanced by high strength of the evanescent electric fields associated with surface plasmon resonance, resolving glucose concentrations down to about a percent. Strong evanescent fields with long decay lengths contribute to the sensor's performance, facilitating the detection of changes in optical properties at large distances.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Chemistry, Physical
Po-Ting Chen, Ming-Wei Liao, Tsong-Pyng Perng
Summary: Polystyrene nanospheres were used as a template to form hexagonal close-packed Ta2O5 nanohoneycombs, and then Au nanoparticle arrays of different sizes were deposited on them to enhance surface plasmon resonance and visible-light photocatalytic hydrogen evolution. FDTD simulation showed that the 100-nm Ta2O5 nanohoneycombs with smaller Au nanoparticles exhibited more effective localized surface plasmon resonance effect. The photocatalytic hydrogen evolution results were consistent with the simulation and tests, and the concept of effective yield ratio was proposed to explain the effects of Au nanoparticle size and spacing on hydrogen evolution efficiency.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Chemistry, Analytical
Kan Wang, Qian Li, Yan Wang, Yuanyuan Wu, Zewen Liu, Songqin Liu
Summary: In this work, a dual-signal visual biosensor was designed using DNA functionalized Ag/Au bimetallic nanoparticles as a multifunctional nanoprobe for the detection of organophosphorus pesticides. The biosensor showed high selectivity and sensitivity through the inhibition of enzyme-induced H2O2 generation by the pesticides. The nanoprobe exhibited significant localized surface plasmon resonance and fluorescence signal responses, allowing for simultaneous quantitative measurement of the pesticides.
ANALYTICA CHIMICA ACTA
(2022)
Article
Physics, Applied
Nima Karimitari, Bin Ai, Yiping Zhao
Summary: A detailed analysis was conducted on the Born-Kuhn model for two coupled oscillators and compared to the chiral optical properties of the corner-stacked plasmonic nanorods (CSPNs). The study found that the Born-Kuhn model, based on normalized coupling constant and damping constant, could accurately predict the chiral optical response of CSPNs.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Review
Chemistry, Multidisciplinary
Bin Ai, Yujing Sun, Yiping Zhao
Summary: This review provides an overview of plasmonic hydrogen sensors (PHS) based on nanostructures. PHS offer high sensitivity, fast response speed, miniaturization, and high-degree of integration. The review discusses the working principle, sensing properties, and the effects of resonance mode, configuration, material, and structure on the sensing performances. It also summarizes the advantages and disadvantages of different types of plasmonic nanostructures and proposes potential development directions. The aim of this review is to clarify current strategies for PHS and provide a comprehensive understanding of their working principle to inspire innovative designs and execution of advanced hydrogen sensors.
Article
Nanoscience & Nanotechnology
Yanfeng Wang, Shen Ao, Fei Yang, Zhengjun Zhang, Yiping Zhao
Summary: By independently tuning the structure parameters of the nanorods in nanohole arrays, a mode splitting phenomenon can be introduced, which improves the performance of plasmonic sensors.
ACS APPLIED NANO MATERIALS
(2022)
Article
Spectroscopy
Lauren Hanna, Edgar Movsesian, Miguel Orozco, Anthony R. Bernot, Mona Asadinamin, Learnmore Shenje, Susanne Ullrich, Yiping Zhao, Nicholas Marshall, Jason A. Weeks, Michael B. Thomas, Joseph A. Teprovich, Patrick A. Ward
Summary: This study investigates the electronic and excited state effects of porphyrin functionalization by synthesizing and characterizing four meso-substituted porphyrins. The results reveal the significant influence of different para substituents (-hydroxy, -carboxy, and -nitro) on the spectral features, electrochemical behavior, and fluorescence behavior of the porphyrins.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Polymer Science
Nicholas Filla, Yiping Zhao, Xianqiao Wang
Summary: This article proposes innovative methods to address the issues in stochastic modeling of fibrous materials, such as estimating 3D fiber orientation distributions, achieving desired fiber tortuosity distributions, and dealing with fiber-fiber penetration. The methods introduced provide a mapping from 2D to 3D fiber orientation data and a means to select parameters for random walks to generate desired fiber tortuosity. These methods enhance the empirical consistency and tractability of stochastic modeling of fibrous materials.
Article
Biophysics
Nicholas Filla, Yiping Zhao, Xianqiao Wang
Summary: In this paper, a phenomenological, bilinear, force-strain model is derived to accurately reproduce the fibrin fiber force-strain curve. The model assumes that the initial linear response is due to entropic extension of polypeptide chains, and the final linear response is due to enthalpic extension of protofibrils. The model provides strong support to a previously proposed deformation mechanism and offers a rigorous tool for analyzing fibrin fiber force-strain data and simulating fibrin fibers in tension.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Biophysics
Yanjun Yang, Beibei Xu, Jackelyn Murray, James Haverstick, Xianyan Chen, Ralph A. Tripp, Yiping Zhao
Summary: This study presents a label-free diagnostic platform combining surface-enhanced Raman scattering (SERS) and machine learning for rapid and accurate detection of respiratory viruses. The combination of SERS, machine learning algorithms, and regression enables classification, quantification, and estimation of unknown virus concentrations. This technology has potential applications in medical diagnosis and therapeutic intervention.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Physics, Applied
Andrei Galiautdinov, Yiping Zhao
Summary: During the operation of a core-shell nanoparticle based localized surface plasmon resonance (LSPR) sensor, target molecules penetrate into the shell layer, resulting in nonuniform distribution of molecules or reactants. This phenomenon is observed in composition graded plasmonic particles, which exhibit different LSPR characteristics compared to uniform core-shell particles. A perturbation theory is developed to predict the LSPR properties of composition graded plasmonic particles, considering the effects of composition gradient caused by metal hydride, dielectric, and effective medium. The results demonstrate the tunability of LSPR peak location and amplitude by different configurations of the composition gradient. These findings are crucial for understanding the sensing performance of composition graded plasmonic particles and can be applied to other composition graded structures.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Article
Multidisciplinary Sciences
Mary M. Bajomo, Yilong Ju, Jingyi Zhou, Simina Elefterescu, Corbin Farr, Yiping Zhao, Oara Neumann, Peter Nordlander, Ankit Patel, Naomi J. Halas
Summary: The combination of surface-enhanced Raman spectroscopy (SERS) with machine learning (ML) shows promise in detecting and identifying priority pollutants in complex multicomponent mixtures. By using an unsupervised ML algorithm, characteristic SERS peaks of unknown components can be extracted from the spectra and identified against a spectral library.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Yanjun Yang, Hao Li, Les Jones, Jackelyn Murray, James Haverstick, Hemant K. Naikare, Yung-Yi C. Mosley, Ralph A. Tripp, Bin Ai, Yiping Zhao
Summary: A rapid and cost-effective method for detecting SARS-CoV-2 infection has been developed using a deep learning algorithm. The method utilizes a DNA-functionalized AgNR array SERS sensor to rapidly detect SARS-CoV-2 RNA in human nasopharyngeal swab specimens. The detection process can be completed within 25 minutes and achieves high accuracy in classifying positive and negative samples. This method shows promise as a potential rapid point-of-care COVID-19 diagnostic platform.
Article
Nanoscience & Nanotechnology
Mona Asadinamin, Aleksandar Zivkovic, Susanne Ullrich, Henning Meyer, Yiping Zhao
Summary: The study provides insights into the charge dynamics of a CuO thin film using transient absorption spectroscopy, revealing the role of different excitation energies in the photocatalytic process. This information is crucial for designing and optimizing materials for renewable energy applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Hoang Mai Luong, Tu Anh Ngo, Minh Thien Pham, Yiping Zhao, George Keefe Larsen, Thuc-Quyen Nguyen, Tho Duc Nguyen
Summary: Magnetism in curved nano-geometries has led to the exploration of a hexagonally-packed array of magnetic nano-caps as a sensing element for the spark-free magnetic-circular-dichroism (MCD) H-2 sensor. The MCD H-2 sensor outperforms current optical sensors and meets the performance targets set by the US Department of Energy. The sensor exhibits fast response time, high selectivity, and low limit of detection.
Article
Chemistry, Multidisciplinary
Yilong Ju, Oara Neumann, Mary Bajomo, Yiping Zhao, Peter Nordlander, Naomi J. Halas, Ankit Patel
Summary: This article presents a machine learning algorithm that can identify chemicals by matching their SERS spectra to a standard Raman spectral library. The algorithm uses a facial recognition-like approach for spectral recognition and quantifies the degree of similarity to a Raman spectrum using a metric called Characteristic Peak Similarity (CaPSim). The analysis shows that CaPSim outperforms existing spectral matching algorithms in terms of accuracy. This machine learning-based approach could greatly facilitate the spectroscopic identification of molecules in fieldable SERS applications.
Article
Chemistry, Multidisciplinary
Shahab Razavi, Yiping Zhao
Summary: This study demonstrates that a hybridized plasmonic mode in a compound nanohole structure can be described as a quasi-dipole oscillator. By introducing two nanorods into a nanohole, these two quasi-dipoles can couple and hybridize, resulting in additional transmission peaks. The intensities and separations of these peaks can be controlled by adjusting the incident polarization and modifying the nanorod length. This concept can be extended to predict the behavior of more complex compound configurations, allowing for precise engineering of transmission peaks.
Article
Chemistry, Multidisciplinary
Yiping Zhao
Summary: This paper presents a comprehensive theoretical framework for understanding surface-enhanced Raman scattering (SERS) measurements, focusing on the principles of electromagnetic enhancement. The study investigates different types of SERS substrates and their interactions with molecules, providing explanations for various phenomena observed in SERS measurements. The findings offer valuable guidance for optimizing SERS substrate design and improving the accuracy of SERS detection.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
