Article
Chemistry, Multidisciplinary
Elahe Haghighi, Sedigheh Zeinali
Summary: This study presents a simple method to create a metal-organic framework (MOF) MIL-101(Cr) coated quartz crystal microbalance (QCM) for detecting volatile organic compounds (VOCs) at room temperature. The MOF has a large surface area and higher adsorption capacity than other materials tested. The synthesized MOF was characterized and then used as a thin film on the QCM electrode. The sensor showed high sensitivity to o-xylene and toluene, along with short response/recovery time and low detection limits.
Review
Chemistry, Analytical
Kaimin Wu, Feizhi Kong, Jingjing Zhang, Ying Tang, Yao Chen, Long Chao, Libo Nie, Zhao Huang
Summary: Single-nucleotide polymorphisms (SNPs) are the most common form of genetic variation in the human genome, and are closely related to individual differences. SNP detection with simple preparation and operational procedures, high affinity and specificity, and cost-effectiveness has been a challenge. This review provides an overview on improvements for SNP biosensing based on fluorescent and electrochemical methods, and presents the advantages, disadvantages, and challenges of each method.
Article
Engineering, Electrical & Electronic
Ilia Chiniforooshan Esfahani, Hongwei Sun
Summary: The micropillar-enhanced QCM viscosity measurement device developed in this work achieves ultra-sensitive viscosity measurement of a sample droplet by utilizing the coupled vibration between micropillars and quartz substrate.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Multidisciplinary
Bastien Michel, Anne Imberty, Ellinor B. Heggset, Kristin Syverud, Julien Bras, Alain Dufresne
Summary: TEMPO-oxidized cellulose nanofibrils (toCNF), in the form of entangled networks like membranes or cryogels, have attracted attention for applications such as drug release and purification. Utilizing beta-cyclodextrins (beta-CDs) for inclusion complex formation with hydrophobic molecules can enhance the functionalities of these materials. This study focuses on the adsorption of beta-CDs onto toCNF cryogels, analyzing interactions through various methods and quantifying the binding capacity, which is crucial for optimizing the design of toCNF/beta-CDs materials.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Chemistry, Physical
Wael A. Amer, Ahmed F. Rehab, Mona E. Abdelghafar, Nagy L. Torad, Ahmed S. Atlam, Mohamad M. Ayad
Summary: Carbon quantum dots (CQDs) were synthesized using a green and economical hydrothermal method, and their optical and structural properties were studied. The sensing properties of CQDs, particularly towards volatile formaldehyde, were investigated, showing high sensitivity and potential for formaldehyde vapor detection.
Article
Chemistry, Applied
Matthew D. Eaton, Daniel Domene-Lopez, Qifeng Wang, Mercedes G. Montalban, Ignacio Martin-Gullon, Kenneth R. Shull
Summary: The quartz crystal microbalance (QCM) is used as a non-destructive and efficient tool to characterize thin thermoplastic starch (TPS) films, revealing that starch films plasticized with an ionic liquid show superior plasticization and stabilized properties at low humidity compared to those plasticized with glycerol.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Ezgi Gulcay-Ozcan, Paul Iacomi, Guillaume Maurin, Sabine Devautour-Vinot
Summary: The pollution of indoor air, particularly the presence of toluene, is a major concern for human health. Metal-organic frameworks have the potential to detect and monitor this contaminant at low concentrations. A screening method was used to identify DUT-4 as a promising MOF for the selective adsorption of toluene from air. Experimental investigation confirmed the sensing performance of DUT-4, highlighting the applicability of this methodology for porous material screening in sensing applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Umit Celik, Kuebra Celik, Ihsan Kehribar, Suleyman Celik, Mehmet Z. Baykara
Summary: Forming a fundamental understanding of tribological processes on the atomic scale has the potential to revolutionize the control of friction and wear in macroscopic mechanical systems. However, current methods for studying tribology at the nanoscale, such as atomic force microscopy, are limited in scanning speed compared to macroscopic mechanical processes. In this study, a new method combining atomic force microscopy with quartz crystal microbalance measurements is proposed for high-speed nanoscale tribology.
APPLIED SURFACE SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Zhiqiong Li, Baohui Zhang, Chen Fu, Ran Tao, Honglang Li, Jingting Luo
Summary: MXenes are attractive nanomaterials for humidity-sensitive materials due to their active sites, surface chemistry, and stability. Surface modification of Ti3C2Tx MXene through sulfurization enhances its humidity sensing performance, with the sulfurized MXene QCM sensor exhibiting high humidity sensitivity and ultrafast response and recovery time. It also shows a 20 times higher water absorption ratio compared to the as-synthesized MXene, indicating its potential for high-performance and fast humidity sensors.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
David Toth, Manuel Kasper, Ivan Alic, Mohamed Awadein, Andreas Ebner, Doug Baney, Georg Gramse, Ferry Kienberger
Summary: In this study, a dual electrochemical QCM (dual EC-QCM) is presented for monitoring mass deposition and viscous loading on two crystals simultaneously. A novel correction approach and a three standard complex impedance calibration are employed to overcome the effect of dampening while maintaining high spectral sensitivity. The validation results show potential applications of the method in mass detection with multiple electrodes.
Article
Chemistry, Applied
Seyda Ceylan Comert, Erdogan Ozgur, Lokman Uzun, Mehmet Odabasi
Summary: The study successfully synthesized molecularly imprinted polymer nanofilms on the QCM electrode surface for specific detection of melamine, with characterizations done using various analytical techniques. Results showed that pH 6.0 was optimal for melamine detection, and the prepared MIP QCM electrode exhibited linearity within a certain concentration range, fitting best with the Langmuir-Freundlich hybrid model for adsorption isotherm analysis.
Article
Biochemistry & Molecular Biology
Stellee M. P. Biscaia, Cassiano Pires, Francislaine A. R. Livero, Daniel L. Bellan, Israel Bini, Silvina O. Bustos, Renata O. Vasconcelos, Alexandra Acco, Marcello Iacomini, Elaine R. Carbonero, Martin K. Amstalden, Fabio R. Kubata, Richard D. Cummings, Marcelo Dias-Baruffi, Fernanda F. Simas, Carolina C. Oliveira, Rilton A. Freitas, Celia Regina Cavichiolo Franco, Roger Chammas, Edvaldo S. Trindade
Summary: Melanoma is a highly metastatic and rapidly progressing cancer. The melanoma microenvironment plays a crucial role in drug resistance and tumor recurrence. The study found that MG-Pe can bind to Galectin-3 and has antitumor and antimetastatic effects, especially when used in combination with chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Electrical & Electronic
Dongyu Chen, Yumei Wen, Ping Li, Yao Wang
Summary: This method introduces a low-concentration magnetic beads sensor and a dynamic magnetic excitation detection method, which measures the concentration of magnetic beads by detecting the magnetization motion intensity using QCM. Experimental results show that the LOD of this sensor is 10 ng/mL with approximately linear detection characteristics.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Electrical & Electronic
Seydiren Seeneevassen, Mohammad Ali Mohammadzadeh Kashan, Yun Mun Lim, Narayanan Ramakrishnan
Summary: We propose a novel ultraviolet (UVA and UVC) sensing technique based on changes in parallel resonance frequency (f(p)) of a ZnO film-coated quartz crystal microbalance (QCM). By measuring the changes in impedance and frequency, we can detect UVA and UVC exposure. The rate of change in f(p) values within the first 10 seconds of measurement shows linear characteristics and allows for the detection of different intensities. The proposed method has the potential for broad industrial and domestic applications where UV radiation is crucial, such as water purification and disinfection.
IEEE SENSORS JOURNAL
(2022)
Article
Chemistry, Analytical
Wei Pan, Xianhe Huang, Qiao Chen
Summary: This study theoretically analyzes the impact of different sizes of dot ring and dot double-ring electrodes on the mass sensitivity distribution of the quartz crystal microbalance (QCM), and proposes a dot triple-ring electrode to enhance uniformity. The research provides a new direction for improving the uniformization of QCM mass sensitivity distribution.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)