Article
Biochemical Research Methods
Pablo C. Serrano, Gisele E. Nunes, Lindiomar B. Avila Jr, Carleane P. S. Reis, Aldo M. C. Gomes, Francoise T. Reis, Maria L. Sartorelli, Silvia Pedroso Melegari, William G. Matias, Ivan H. Bechtold
Summary: Saxitoxin, a harmful cyanotoxin, requires monitoring in water bodies. An electrochemical impedimetric biosensor using a specific aptamer was developed for its detection, showing high sensitivity and selectivity.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Kyungsoon Park
Summary: An impedance technique-based aptasensor was developed for the detection of thrombin using a single-walled carbon nanotube-modified screen-printed carbon electrode. Thrombin-binding aptamer was immobilized on the carbon nanotube surface and its detachment was affected by the concentration of thrombin. The sensing layer was characterized by cyclic voltammetry and the change in charge-transfer resistance was investigated for thrombin detection using electrochemical impedance spectroscopy.
Article
Chemistry, Analytical
Rongrong Yuan, Zhuojun Yan, Alateng Shaga, Hongming He
Summary: A novel porous organic polymer (POP) with high surface area and stability was successfully prepared and used to fabricate an ultrasensitive electrochemical aptasensor for detecting trace ampicillin. The biosensor exhibited a low detection limit and accurate monitoring ability for detecting amp in multiple real samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemical Research Methods
Canan Ozyurt, Inci Uludag, Mustafa Kemal Sezginturk
Summary: This study developed a disposable electrochemical aptasensor based on ITO-PET film for sensitive and selective detection of prostate-specific antigen (PSA) in real serum samples. The biosensor exhibited excellent sensitivity, precision, repeatability, and storage stability, making it a potential candidate for clinical applications.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Ian Ivar Suni
Summary: Electrochemical biosensors have potential applications in various fields, but one of the primary challenges lies in immobilizing biomolecular probes onto solid substrate materials with adequate stability and reproducibility. Recent research has focused on transition metal dichalcogenides and electrically conductive polymers as new materials for covalent bonding of biomolecules.
Article
Chemistry, Multidisciplinary
Man Zhu, Fan Xu, Siyuan Miao, Chongyu Xie, Hui Li, Shaoguang Li, Fan Xia
Summary: This study reports the design of an E-AB biosensor with dual recognition sites for rapid detection of thrombin. The biosensor showed faster response time and good performance in terms of dynamic range and specificity.
Article
Chemistry, Analytical
Tao Hu, Zeyang Bai, Di Wang, Ying Bai, Xiao Li, Zhonghua Ni
Summary: This study reported a 3D graphene aerogel (GA)/AuNPs/Nafion electrochemical platform for highly sensitive quantification of PSA. By immobilizing aptamers on the modified electrode surface and using electrocatalysts for signal amplification, this electrochemical immunosensor exhibited sensitive and stable responses for PSA detection in the concentration range of 0.05 to 50 ngemL-1.
MICROCHEMICAL JOURNAL
(2023)
Review
Chemistry, Analytical
Reza Eivazzadeh-Keihan, Zahra Saadatidizaji, Ali Maleki, Miguel de la Guardia, Mohammad Mahdavi, Sajjad Barzegar, Samad Ahadian
Summary: Thrombin is a serine protease that plays a crucial role in blood clotting and homeostasis. Detecting thrombin quickly and accurately is important for biological analysis and clinical diagnosis. Various biosensors have been developed to achieve highly selective and specific detection of thrombin. Aptasensors, which use DNA or RNA aptamers as biological recognition elements, have shown great sensitivity and affinity in identifying thrombin.
Article
Chemistry, Analytical
Shahrzad Forouzanfar, Nezih Pala, Chunlei Wang
Summary: Electrochemical label-free aptasensors are highly suitable for point-of-care applications. This study investigates the integration of bipolar exfoliated reduced graphene oxide (BPE-rGO) with 3D C-MEMS microelectrodes for developing PDGF-BB label-free aptasensors. The results demonstrate the successful deposition of BPE-rGO and highlight its high potential in developing high-performance graphene-based cancer diagnosis technologies.
Article
Biophysics
Hongwei Chu, Xiaokang Hu, Cheng-Yu Lee, Anning Zhang, Yang Ye, Yuxin Wang, Yangyang Chen, Xiao Yan, Xinzhong Wang, Jun Wei, Sisi He, Yingchun Li
Summary: This article introduces a novel electrochemical fabric for real-time monitoring of cytokines. The fabric is flexible, breathable, and can be applied to different body parts. It can also track other biomarkers by replacing the coupling aptamer, serving as a universal platform for sweat analysis. Rating: 9/10.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Alexei Nabok, Hisham Abu-Ali, Sarra Takita, David P. Smith
Summary: This study reports on the feasibility of electrochemical detection of the prostate cancer biomarker PCA3 using a specific RNA aptamer labelled with ferrocene on a screen-printed gold electrode. The results demonstrate successful detection in buffer solutions, with kinetics studies showing high specificity and a potential affinity constant for future diagnostic applications in prostate cancer detection.
Article
Chemistry, Analytical
Maria G. Sande, Debora Ferreira, Joana L. Rodrigues, Luis D. R. Melo, Dirk Linke, Carla J. Silva, Felismina T. C. Moreira, Maria Goreti F. Sales, Ligia R. Rodrigues
Summary: In this study, new aptamers that bind to the virulence factor Yersinia adhesin A (YadA) of Yersinia enterocolitica were identified using cell-systematic evolution of ligands by exponential enrichment (cell-SELEX). A simple electrochemical biosensor was developed using the most promising aptamer candidate (Apt1) to detect YadA. The biosensor showed a linear range of detection and could potentially be used as a sensitive point-of-care detection system for Y. enterocolitica infections.
Article
Electrochemistry
Yating Chen, Wei Chen, Yulan Tian, Ping Zhu, Shu Kong, Liping Du, Chunsheng Wu
Summary: In this study, a label-free electrochemical impedance aptasensor was developed for the sensitive detection of OA in shellfish. The aptasensor showed a wide linearity range and a low limit of detection for OA, as well as good selectivity towards other toxins. It also exhibited good reproducibility and stability. Real mussel samples demonstrated a good recovery rate. This simple and cost-effective sensing strategy for marine toxins could be applied in the fields of seafood safety and water quality control.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Yijian Wang, Liqin Kong, Guoqiang Shu, Guanqquan Sun, Yaoze Feng, Ming Zhu
Summary: An electrochemical impedimetric biosensor was developed for detecting umami substances. The biosensor showed low detection limits and wide linear ranges for monosodium glutamate and inosine-5'-monophosphate. It also exhibited high specificity in real food samples and desirable storability.
Article
Chemistry, Analytical
Bassam Bachour Junior, Marina Ribeiro Batistuti, Aline Sanches Pereira, Elisa Maria de Sousa Russo, Marcelo Mulato
Summary: An electrochemical biosensor for NS1 detection was developed in this study by optimizing the molar ratio between aptamers and MCH, achieving high sensitivity and low detection limits for NS1 detection in the early stages of disease. By adding bovine serum albumin to stabilize NS1, the sensor accurately detected NS1 from different Dengue serotypes.
Article
Chemistry, Multidisciplinary
Yonghwang Ha, Dhiraj P. Murale, Changsuk Yun, Sudesh T. Manjare, Hyungjun Kim, Juhyoun Kwak, Yoon Sup Leea, David G. Churchill
CHEMICAL COMMUNICATIONS
(2015)
Article
Chemistry, Multidisciplinary
Hosuk Kang, Seongpil Hwang, Juhyoun Kwak
Article
Electrochemistry
Seungjin Park, Jun Hui Park, Seongpil Hwang, Juhyoun Kwak
ELECTROCHEMISTRY COMMUNICATIONS
(2016)
Article
Chemistry, Multidisciplinary
Changsuk Yun, Seongpil Hwang, Juhyoun Kwak
Article
Chemistry, Multidisciplinary
Mijeong Kang, Seungmoon Jung, Huanan Zhang, Taejoon Kang, Hosuk Kang, Youngdong Yoo, Jin-Pyo Hong, Jae-Pyoung Ahn, Juhyoun Kwak, Daejong Jeon, Nicholas A. Kotov, Bongsoo Kim
Article
Chemistry, Analytical
Kyungsoon Park, Seong Jung Kwon, Juhyoun Kwak
Article
Electrochemistry
Jun Hui Park, Seongpil Hwang, Byung-Kwon Kim, Juhyoun Kwak
ELECTROCHEMISTRY COMMUNICATIONS
(2013)
Article
Chemistry, Inorganic & Nuclear
Olga G. Tsay, Byung-Kwon Kim, Tuong Loan Luu, Juhyoun Kwak, David G. Churchill
INORGANIC CHEMISTRY
(2013)
Article
Nanoscience & Nanotechnology
Hye Young Jung, Jun Hui Park, Seongpil Hwang, Juhyoun Kwak
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2013)
Article
Chemistry, Analytical
Byung-Kwon Kim, Ji Young Lee, Jun Hui Park, Juhyoun Kwak
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2013)
Article
Polymer Science
Jinhee Lee, Jaewon Heo, Changjun Park, Byung-Kwon Kim, Juhyoun Kwak, Myungeun Seo, Sang Youl Kim
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Sunae Jo, Sung Min Kang, Su A. Park, Wan Doo Kim, Juhyoun Kwak, Haeshin Lee
MACROMOLECULAR BIOSCIENCE
(2013)
Article
Chemistry, Multidisciplinary
Changsuk Yun, Seung-Hoon Lee, Jehyeok Ryu, Kyungsoon Park, Jae-Won Jang, Juhyoun Kwak, Seongpil Hwang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Multidisciplinary
Changsuk Yun, Hosuk Kang, Juhyoun Kwak, Seongpil Hwang
Article
Nanoscience & Nanotechnology
Seungjin Park, Jun Hui Park, Seongpil Hwang, Juhyoun Kwak
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)