Article
Multidisciplinary Sciences
Thi-Thu-Hien Pham, Thanh-Ngan Luu, Thao-Vi Nguyen, Ngoc-Trinh Huynh, Quoc-Hung Phan, Thanh-Hai Le
Summary: This study proposes a novel method combining machine learning algorithms and polarimetric imaging systems for classifying the progression of skin cancer. Experimental results show excellent accuracy of the proposed method.
Article
Food Science & Technology
Yifeng Luo, Xu Jiang, Xiaping Fu
Summary: Spatial frequency domain imaging (SFDI) is a non-contact wide-field optical imaging technique used for optical property detection. This study successfully established an SFDI system to measure optical properties of pears with different damage types, achieving high classification accuracy using linear discriminant analysis. The results suggest that SFDI has great potential in agricultural product quality inspection.
Article
Engineering, Chemical
L. Smeesters, I Magnus, M. Virte, H. Thienpont, W. Meulebroeck
Summary: The study utilizes broadband reflection spectroscopy and machine learning to non-destructively classify raw potatoes, identifying those unsuitable for French fries production, thus enhancing food safety and reducing food waste.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Food Science & Technology
Marco Caredda, Andrea Mara, Marco Ciulu, Ignazio Floris, Maria I. Pilo, Nadia Spano, Gavino Sanna
Summary: This study aims to evaluate a botanical classification method by analyzing 125 honeys using Fourier-Transform Mid-Infrared (FT-MIR) spectroscopy. A predictive model was developed using linear discriminant analysis (LDA) and spectral pretreatment techniques. The results were compared with other targeted and non-targeted approaches previously assessed by this research group.
Article
Chemistry, Analytical
Rossana O. Nobrega, Suelly F. da Silva, David D. S. Fernandes, Welligton S. Lyra, Taynna K. L. de Araujo, Paulo H. G. D. Diniz, Mario C. U. Araujo
Summary: In this study, near-infrared spectroscopy and multivariate classification tools were used to develop methods for authenticating and checking the compliance of decaffeinated instant coffees, as well as discriminating between regular instant coffees according to the roasting degree. The combination of these techniques proved to be valuable and fast for checking the quality of instant coffees.
MICROCHEMICAL JOURNAL
(2023)
Article
Mathematical & Computational Biology
Nora Yujia Payne, Johann A. Gagnon-Bartsch
Summary: Genomic data sets contain latent variables that can both help and add noise to classification. To address this issue, a cross-residualization classifier (CRC) is proposed, which adjusts and integrates latent variables without discarding potentially predictive information. Experimental results show that CRC performs well compared to existing classifiers.
Article
Optics
Guangxing Wu, Minghui Hong
Summary: Microsphere lens for nano-imaging has been widely studied for its superior resolving power and real-time imaging characteristic. The development of microsphere compound lenses (MCL) that allow enlarged magnification and field-of-view in non-contact imaging mode has been demonstrated. The MCL has a larger field-of-view compared to a single microsphere and can be further increased through scanning working manner.
Article
Agricultural Engineering
Feifei Tao, Li Liu, Christopher Kucha, Michael Ngadi
Summary: This study investigated the use of a low-cost, ultra-compact, handheld microNIR spectrometer to detect adulteration of wheat flour. Various classification models were established, achieving high accuracy in differentiating pure and adulterated flour samples, showcasing the potential of spectroscopy in food quality testing.
BIOSYSTEMS ENGINEERING
(2021)
Article
Computer Science, Artificial Intelligence
Mina Kheirkhah, Stefan Brodoehl, Lutz Leistritz, Theresa Goetz, Philipp Baumbach, Ralph Huonker, Otto W. Witte, Carsten M. Klingner
Summary: The study demonstrated significant classification of emotional brain responses to unpleasant and neutral stimuli within the first 100-150 ms post-stimulus through MEG signal analysis in healthy volunteers. The proposed algorithm allowed for early classification of emotional processing in the human brain, suggesting that emotional differentiation occurs within the initial 100-150 ms after stimulus onset.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Michael Dapolito, Makoto Tsuneto, Wenjun Zheng, Lukas Wehmeier, Suheng Xu, Xinzhong Chen, Jiacheng Sun, Zengyi Du, Yinming Shao, Ran Jing, Shuai Zhang, Adrien Bercher, Yinan Dong, Dorri Halbertal, Vibhu Ravindran, Zijian Zhou, Mila Petrovic, Adrian Gozar, G. L. Carr, Qiang Li, Alexey B. Kuzmenko, Michael M. Fogler, D. N. Basov, Xu Du, Mengkun Liu
Summary: Magnetic fields can significantly affect electron motion in quantum materials. We have visualized the magnetic-field-tunable dispersion of propagating magnetoexciton polaritons in near-charge-neutral graphene. By imaging these collective modes and their associated nano-electro-optical responses, we have identified pronounced optical and photo-thermal electric effects at the sample edges, particularly near charge neutrality. Our nano-magneto-optics approach allows us to explore and manipulate magnetopolaritons in specimens with low carrier doping by utilizing high magnetic fields. The dispersion of Dirac magnetoexcitons in charge-neutral graphene has been directly imaged up to 7 T using a magneto cryogenic near-field microscope.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Carlos H. Junges, Celito C. Guerra, Natalia A. P. C. Reis, Adriano A. Gomes, Fernando S. Diogo, Marco F. Ferrao
Summary: In this study, visible spectra combined with chemometric methods were used to differentiate Brazilian grape juices by conventional and organic production systems. A new pH modulation approach was employed to build a more accurate classification model. Visible spectroscopy proved to be a simple, fast, and low-cost method for evaluating the quality of grape juice.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Analytical
Clement Grand, Camille Scotte, Herve Rigneault
Summary: This study successfully applies compressive Raman imaging technology in the field of pharmacy. By incorporating a digital micromirror device and a single-pixel detector, fast chemometric analysis and microscopic imaging are achieved. The results demonstrate the potential of this technology for fast pharmaceutical tablet quality control imaging.
ANALYTICAL CHEMISTRY
(2022)
Article
Computer Science, Artificial Intelligence
Hongchun Qu, Lin Li, Zhaoni Li, Jian Zheng
Summary: A novel dimensionality reduction method called supervised discriminant Isomap is proposed in this paper to solve the problems of Isomap, by partitioning data points into different manifolds based on class label information and enhancing discriminating capability. The method aims to create an optimal nonlinear subspace that preserves the geometrical structure of each manifold and maximizes distances between data points of different classes.
EXPERT SYSTEMS WITH APPLICATIONS
(2021)
Article
Spectroscopy
Sarath Ravi, Rakhi Sreedharan, K. R. Raghi, T. K. Manoj Kumar, K. Naseema
Summary: In this study, an organic non-linear optical crystal DNBAQ was successfully synthesized and characterized using various analytical techniques. The results demonstrated that DNBAQ material possesses promising non-linear optical properties, making it suitable for optical limiting and switching applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Computer Science, Software Engineering
Clara Callenberg, Zheng Shi, Felix Heide, Matthias B. Hullin
Summary: Time-correlated imaging has promising applications, but expensive optical setups have limited its accessibility. Cheaper commodity SPAD sensors, when modified and used with additional optics, can bring similar functions to a wider audience, overcoming the barriers of high cost and rarity in the field.
ACM TRANSACTIONS ON GRAPHICS
(2021)
Article
Optics
Pablo Roldan-Varona, Mauro Lomer, Jose Francisco Algorri, Luis Rodriguez-Cobo, Jose Miguel Lopez-Higuera
Summary: This paper presents the design, simulation, and manufacturing of a CYTOP-based refractive index sensor for aqueous solutions, which demonstrates high sensitivity in the range of 1.315-1.333 and remarkable insensitivity to temperature. The sensor utilizes a polished fiber and a diffraction grating to achieve sensing capabilities.
Article
Optics
J. F. Algorri, F. Dell'Olio, P. Roldan-Varona, L. Rodriguez-Cobo, J. M. Lopez-Higuera, J. M. Sanchez-Pena, V Dmitriev, D. C. Zografopoulos
Summary: A silicon metasurface supporting electromagnetically induced transparency (EIT) based on quasi-bound states in the continuum (qBIC) is proposed and demonstrated theoretically, showing sharp high-transmittance peaks within a low-transmittance spectral window. The metasurface, with its high quality factor qBIC resonances, can be used in biosensing applications due to its simple bulk geometry. The proposed metasurface's strong energy confinement and sharp EIT-effect have potential applications in nonlinear devices, lasing, biological sensors, optical trapping, and optical communications.
Article
Optics
R. A. Perez-Herrera, P. Roldan-Varona, A. Sanchez-Gonzalez, L. Rodriguez-Cobo, J. M. Lopez-Higuera, M. Lopez-Amo
Summary: A wavelength-switchable L-band erbium-doped fiber laser (EDFL) has been achieved with the assistance of an artificially controlled backscattering (ACB) fiber reflector. The reflector was created through femtosecond laser direct writing on a multimode fiber, and its rotation angle was accurately controlled using a high-precision rotation mount. By rotating the mount, three different output spectra were obtained: a single wavelength lasing, a dual wavelength lasing, and another single wavelength lasing. The optical signal-to-noise ratio (OSNR) for all spectra was around 60 dB at a pumping power of 300 mW.
JOURNAL OF THE EUROPEAN OPTICAL SOCIETY-RAPID PUBLICATIONS
(2023)
Article
Chemistry, Analytical
Marina Martinez-Minchero, Adolfo Cobo, Ana Mendez-Vicente, Jorge Pisonero, Nerea Bordel, Igor Gutierrez-Zugasti, Patrick Roberts, Alvaro Arrizabalaga, Jose Valdiande, Jesus Mirapeix, Jose Miguel Lopez-Higuera, Asier Garcia-Escarzaga
Summary: The elemental composition of marine mollusk shells can provide valuable information about environmental conditions. This study proposes the use of Laser-Induced Breakdown Spectroscopy (LIBS) for rapid measurement and estimation of Mg/Ca concentration profiles within limpet shells. The results show a significant correlation between LIBS and traditional analytical methods, indicating the accuracy of LIBS in inferring Mg/Ca concentrations in shells.
Article
Optics
Pablo Roldan-Varona, Calum A. A. Ross, Luis Rodriguez-Cobo, Jose Miguel Lopez-Higuera, Erin Gaughan, Kevin Dhaliwal, Michael G. G. Tanner, Robert R. R. Thomson, Helen E. E. Parker
Summary: Imaging fibers are used to perform real-time fluorescence endomicroscopy, in vivo, in situ, with the goal of increasing diagnostic information for a plethora of organ systems and diseases. Widefield fiber endomicroscopy systems are simple, cost-effective, and come with fast image acquisition times. However, alternative approaches such as scanning systems produce higher contrast images with intrinsic optical sectioning, improving the visibility of histological features, albeit at the expense of simplicity, cost, and acquisition rate. We developed a selective plane illumination microscopy endoscopic fiber platform, consisting of an ultrafast laser fabricated end-cap, integrated with a polymer coherent fiber bundle, and an epifluorescence microscope. Polymer fibers are known to fluoresce when pumped with blue light, enhancing the background and noise in images. Our end-cap design circumvents this challenge. We demonstrate a reduction of out-of-focus features, along with improved contrast of in-focus features, in images of a tissue phantom. Moreover, we demonstrate the utility of our platform for endomicroscopy using a whole, ex vivo human lung model.
Article
Optics
J. F. Algorri, F. Dell'Olio, Y. Ding, F. Labbe, V. Dmitriev, J. M. Lopez-Higuera, J. M. Sanchez-Pena, L. C. Andreani, M. Galli, D. C. Zografopoulos
Summary: We investigate a metasurface supporting a silicon-slot quasi-bound state in the continuum (qBIC) mode resonating in the near-infrared spectrum both theoretically and experimentally. The metasurface is composed of circular slots etched in a silicon layer on a sapphire substrate. By reducing the symmetry of the metasurface unit cell, we access the symmetry-protected mode and analyze its properties through finite-element full-wave and eigenfrequency analysis. The measured transmittance spectra confirm the excitation of the investigated qBIC mode with experimental quality factors exceeding 700. The resonant qBIC mode exhibits strong field confinement in the slots, leading to high sensitivity values for refractometry.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Spectroscopy
Maria Gabriela Fernandez-Manteca, Alain A. Ocampo-Sosa, Carlos Ruiz de Alegria-Puig, Maria Pia Roiz, Jorge Rodriguez-Grande, Fidel Madrazo, Jorge Calvo, Luis Rodriguez-Cobo, Jose Miguel Lopez-Higuera, Maria Carmen Farinas, Adolfo Cobo
Summary: In this study, Raman spectroscopy combined with machine learning algorithms was used to explore the automatic identification of eleven species of Candida. The findings showed that a one-dimensional convolutional neural network achieved accurate identification of these pathogenic yeasts.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Maria Gabriela Fernandez-Manteca, Marina Martinez-Minchero, Asier Garcia-Escarzaga, Alain A. Ocampo-Sosa, Jesus Mirapeix, Jose J. Valdiande, Jose Miguel Lopez-Higuera, Luis Rodriguez-Cobo, Adolfo Cobo
Summary: The LIBS technique requires spectroscopic analysis of the light emitted by a laser-induced plasma plume. One challenge is the significant shot-to-shot variations of the plume's inhomogeneities, position, and morphology, especially when using multichannel CCD spectrometers. This study evaluates the performance of various collection optics in terms of capturing efficiency and channel-to-channel variations due to changes in plasma morphology.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2023)
Article
Biology
Cristina L. L. Saratxaga, Aintzane Asumendi, Jesus Gardeazabal, Rosa M. M. Izu, Ana Sanchez, Goikoana Cancho-Galan, Celia Morales, Sergio Lage, Maria D. D. Boyano, Olga M. M. Conde, Estibaliz Garrote
Summary: The use of optical coherence tomography (OCT) for the diagnosis of melanoma is still controversial. This study compares OCT images with histopathological features and extracts optical and textural properties to identify subtle features that could enhance the usefulness of OCT in identifying the invasiveness of the lesion. Preliminary findings show promise in discriminating melanoma in-situ and superficial spreading melanoma, as well as differentiating melanoma from nevus subtypes, providing a basis for further research.
Article
Chemistry, Multidisciplinary
Jose Francisco Algorri, Victor Dmitriev, Jose Miguel Lopez-Higuera, Dimitrios C. Zografopoulos
Summary: This study proposes a novel dielectric metasurface that addresses the two main problems in sensing and spectroscopy based on electromagnetic field enhancement. By supporting delocalized modes and quasi-bound states in the continuum, the metasurface achieves polarization-insensitive, high-Q-factor resonances with very high electric field enhancements. This work opens up new research opportunities in optical sensing and advanced spectroscopy.
Review
Pharmacology & Pharmacy
Jose Francisco Algorri, Jose Miguel Lopez-Higuera, Luis Rodriguez-Cobo, Adolfo Cobo
Summary: Photodynamic therapy (PDT) is a popular dermatological treatment used for both life-threatening skin conditions and cosmetic purposes. It utilizes a photosensitizer and visible light to generate reactive oxygen species that can cause cell death. This review focuses on the latest advancements in light technology for PDT in skin cancer treatment.
Article
Biochemical Research Methods
Mario Ochoa, Pablo Roldan-Varona, Jose Francisco Algorri, Jose Miguel Lopez-Higuera, Luis Rodriguez-Cobo
Summary: In fused silica, ultrafast laser assisted etching achieves high etching rates (>300 μm h(-1)) by adjusting the light polarisation. However, for non-planar surfaces and 3D structures, achieving dynamic polarisation control is difficult. In this study, a laser inscription regime is identified to achieve high etching rates independently of light polarisation. The capabilities of this processing are demonstrated through the fabrication of curved and square-wave microchannels, as well as a complex 3D geometrical structure.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
